April 11 (EPO), April 5 (WO); April 11 (UK)
Academia Sinica EP 1 090 994
Pseudomonas exotoxin therapeutics
Taipei, Taiwan
Receptor binding domain of Pseudomonas exotoxin A linked to two copies of a peptide sequence; for therapeutics.
Active Biotech WO 01/23422
Papillomavirus vaccines
Lund, Sweden
Human papillomavirus major capsid L1 protein with its type-specific epitopes removed, encoding gene; for vaccines.
Affymetrix WO 01/23614
Gene expression analysis
Santa Clara, Calif.
Methods and computer software products for multiple probe relative gene expression analysis.
Alexion Pharma WO 01/23541
Generating knockouts
New Haven, Conn.
Alteration of gene expression in a target gene by insertion of exogenous DNA sequences; for generating knockouts.
Aventis Pharma WO 01/22811
Alzheimer's transgenics
Antony, France
Transgenics expressing multiple mutated forms of presenilin 1; for use as an Alzheimer's model.
Battelle Mem. Inst. WO 01/24147
Analyzing sequence strings
Columbus, Ohio
Methods and apparatus for analyzing sequence strings; for creating domains that can be linked together.
Bayer WO 01/23420
PACAP receptor 3 agonists
Berkeley, Calif.
Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 agonists; for stimulating insulin release.
Boiocache Pharma WO 01/23882
Diagnosing inflammation
Richmond, Va.
Detection of polypeptide fragments and modified forms of a1-antitrypsin for diagnosing inflammation.
Brosens, J.J. GB 2 355 010
Expression control by splicing
London
Use of cell specific splicing mechanisms to control transfected gene expression; for gene therapy.
California, Univ. of WO 01/22922
Irreversibly binding antibodies
Oakland, Calif.
Mutant antibodies with a non-wild type reactive site that binds to a metal chelate; for irreversible binding.
California, Univ. of WO 01/23524
Cancer-associated serine protease
San Francisco, Calif.
Membrane-type serine protease whose elevated expression is associated with cancer; for developing therapeutics.
California, Univ. of WO 01/23602
Protein solubility determination
Los Alamos, N.M.
Reporter molecule used in a single living cell to determine if a soluble version of a specific protein is present.
Chugai EP 1 090 987
Cell cycle regulation
Tokyo
Human Cds 1 homolog, encoding gene sequences; for developing cell cycle regulatory agents.
Chugai EP 1 090 996
Antiviral therapeutic assays
Tokyo
Vector expressing a full-length gene of an RNA virus; for developing antiviral therapeutics.
Chugai Res. Inst. Molec. Med. WO 01/23555
Prolonging cell life span
Ibaraki, Japan
Prolonging fibroblast cell life span without immortalization by the expression of mot-2; for making liver cells.
Chugai Res. Inst. Molec. Med. WO 01/23556
Hematopoietin receptor
Ibaraki, Japan
Hematopoietin receptor, encoding gene, modulator assays; for treating immune system and hematopoietic diseases.
Corixa WO 01/23421
Stress protein complex
Seattle
Stress protein complexes; for inducing an immune response to cancer or infectious disease.
Cornell Univ. WO 01/23003
Tissue flap angiogenesis
Ithaca, N.Y.
Administering viral gene therapy vectors encoding angiogenic factors to a tissue flap; for increasing vascularity.
CuraGen WO 01/23561
Thrombospondin repeat proteins
New Haven, Conn.
Proteins having thrombospondin type 1 repeats, encoding gene sequences, antibodies; for diagnostics and therapeutics.
CuraGen WO 01/23572
PTMAX proteins
New Haven, Conn.
PTMAX proteins, encoding gene sequences, antibodies, variants, mutants, fragments; for therapeutics.
Diagnocure WO 01/23550
Prostate cancer markers
Ste.-Foy, Que.
PCA3 mRNA species in benign and malignant prostate tissues; for diagnostics and therapeutics.
Du Pont WO 01/23575
Wuschel gene homologs
Wilmington, Del.
Wuschel protein gene homologs, encoded proteins, chimeras, antisense; for altering Wuschel protein levels.
Eli Lilly WO 01/23559 & 23562
Osteoclast gene regulation
Indianapolis
Osteoclast differentiation factor gene regulatory region; for use in identifying bone therapeutics.
Florida, Univ. of WO 01/23528
Islet stem cell transplants
Gainesville, Fla.
Growth of islet-producing stem cells in culture; for transplantation to treat insulin-dependent diabetes.
Fox Chase Cancer Ctr. WO 01/23522
Repressing p53 expression
Philadelphia
Identifying therapeutics that repress the expression of p53; for cancer therapy.
Freiburg Univ. Clinic WO 01/23554
PRV-1 gene
Freiburg, Germany
PRV-1 gene, encoded proteins; methods for detecting the gene and its mRNA.
Galilaeus WO 01/23578
Aclacinomycin antibiotics
Piispanristi, Finland
Streptomyces galilaeus genes involved in aclacinomycin biosynthesis; for increasing antibiotic yields.
Genaissance Pharma WO 01/23404 & 23410
Interleukin gene SNPs
New Haven, Conn.
Polymorphisms in the interleukin-4 and 13 gene; for determining susceptibility to various therapeutics.
Genentech WO 01/23592
Increased protein production
S. San Francisco
Making recombinant proteins in cell culture using apoptosis inhibitors to decrease cell death and increase yield.
Genzyme Transgenics WO 01/23525
Transgenic production
Framingham, Mass.
Forming reconstructed embryos having tetraploid cells; for producing transgenic mammals.
Henry Jackson Fdn. WO 01/23621
Prostate cancer chromosomal changes
Rockville, Md.
Chromosome changes characteristic of abnormalities and changes associated with prostate cancer.
Hobom, G. EP 1 091 000
Attenuated viruses
Glessen, Germany
Expression of viral RNA encoding chloramphenicol acetyltransferase; for making attenuated viruses.
Hong Kong, Univ. of WO 01/22916
Hepatitis E antigenic peptide
Hong Kong
Hepatitis E virus antigenic peptide derived from the C-terminal region of ORF2; for diagnostics and therapeutics.
Human Genome Sciences WO 01/22920
Colon cancer genes
Rockville, Md.
Colon- and colon cancer-associated gene sequences, encoded proteins, antibodies; for diagnostics and therapeutics.
Human Genome Sciences WO 01/23402, 23409, 23546, 23547 & 23598
185 secreted proteins
Rockville, Md.
185 human secreted proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.
Hyseq WO 01/23569
Cytokine receptors
Sunnyvale, Calif.
Cytokine receptor proteins, encoding gene sequences; for diagnostics and therapeutics.
Icos WO 01/23430
Chitinase immunoglobulin fusions
Bothell, Wash.
Chitinase immunoglobulin fusion products having improved serum half-life and formulation properties.
Imperial Coll. Sci. & Technol. GB 2 355 074
Prion genotyping
London
Determining the genotype at prion protein residue 129; for predicting susceptibility to spongiform encephalopathy.
Incyte Genomics WO 01/23538
Disease-related proteins
Palo Alto, Calif.
Disease detection and treatment proteins, encoding genes, antibodies, microarrays.
Incyte Genomics WO 01/23558
Secretory proteins
Palo Alto, Calif.
Secretory proteins, encoding gene sequences, antibodies, microarrays; for diagnostics and therapeutics.
Intl. Reagents EP 1 090 997
Hepatitis polymerase modulators
Kobe, Japan
Hepatitis C virus-derived RNA polymerase gene, encoded protein; for modulator screens.
Isis Pharma WO 01/23613
Enhanced antisense
Carlsbad, Calif.
Oligonucleotides that are substrates for human Type 2 RNAse II; for enhancing oligo antisense therapies.
JCR Pharma EP 1 090 986
Neuron-related disease protein
Ahiya, Japan
Protein associated with neuron- and endocrine cell-related diseases, encoding gene; for developing therapeutics.
Krebs Res. Ctr. WO 01/23553
Metastasis-associated antigen
Heidelberg, Germany
Metastasis-associated antigen, encoding gene, antibodies, recombinant production methods; for cancer therapy.
Kyowa Hakko Kogyo WO 01/23431, 23432 & 23573
Ganglioside antibodies
Tokyo
Ganglioside GM2, GD2, and GD3 antibodies, cytokine fusions; for cancer and transplantation therapeutics.
Lexicon Genetics WO 01/23566
Organic anion transporter homologs
The Woodlands, Texas
Human organic anion transporter-like proteins, encoding gene sequences; for diagnostics and therapeutics.
Lexicon Genetics WO 01/23579
Human kinase proteins
The Woodlands, Texas
Human kinase proteins, encoding gene sequences; for developing diagnostics and therapeutics.
Lexicon Genetics WO 01/23588
Human carboxypeptidases
The Woodlands, Texas
Human carboxypeptidases, encoding gene sequences; for developing diagnostics and therapeutics.
Librach, C.L., et al. WO 01/23893
Selecting IVF embryos
Toronto
Detection of HLA-G antibodies; for selecting embryos for in vitro fertilization.
Lifespan Biosciences WO 01/23615
Developing anti-aging therapies
Seattle
Genes associated with the aging process, encoded proteins; for developing anti-aging therapeutics.
Ludwig Inst. Cancer Res. WO 01/23560
MHC Class II antigen binding peptides
New York
Isolated peptides that bind to MHC Class II molecules that are tumor antigen precursors; for causing CD4+ cell growth.
Luminis WO 01/23531
Manipulating stem cells
Adelaide, Australia
Identification, separation, and manipulation of stem and differentiated cells; for regulation and reprogramming.
Mass. Gen. Hosp. WO 01/23427 & 23521
Parathyroid hormone peptide derivatives
Boston
Polypeptide derivatives of parathyroid hormone, encoding gene sequences, production methods; for modulator screens.
Mass. Inst. Technol. WO 01/23412
Inhibiting _-amyloid aggregation
Cambridge, Mass.
Screening for agents that inhibit the aggregation of polypeptides such as huntingtin and _-amyloid proteins.
Maxygen WO 01/23401
Artificial sequence evolution
Redwood City, Calif.
Use of codon-varied oligonucleotide synthesis for synthetic sequence recombination to enhance artificial evolution.
Merck WO 01/23552
Cytoplasmic calcium binding factor
Darmstadt, Germany
Human paralog of head trauma-induced cytoplasmic calcium binding factor, encoding gene; for therapeutics.
Michigan, Univ. of WO 01/23570 & 23571
Sodium channel subunit
Ann Arbor, Mich.
Voltage-gated sodium channel subunit, encoding gene sequences; for developing neural pain therapeutics.
Millennium Pharma WO 01/23523
CD33-related protein families
Cambridge, Mass.
CD33 and OB-BP-1 related protein families, encoding genes, antisense, antibodies; for modulator screens.
Millennium Pharma WO 01/23584, 23585 & 23589
Ubiquitin protease
Cambridge, Mass.
Human ubiquitin protease, encoding gene sequences; for modulator screens and therapeutic development.
Millennium Pharma WO 01/23590
Aminopeptidase
Cambridge, Mass.
Human aminopeptidase, encoding gene sequences; for modulator screens and therapeutic development.
Monash Univ. WO 01/23424
Phosphatidylethanolamine binding protein
Clayton, Australia
Phosphatidylethanolamine binding protein, encoding gene, analogs, variants; for diagnostics and therapeutics.
Monash Univ. WO 01/23429
Latex allergy therapy
Clayton, Australia
Proteins that interact immunologically with T cells in individuals with latex allergies, antibodies; for therapy.
NIH (Natl. Inst. Hlth.) WO 01/23428
IL-2 receptor associated polypeptides
Bethesda, Md.
Interleukin-2 receptor associated polypeptides, encoding genes, antibodies; for developing detection assays.
NIH (Natl. Inst. Hlth.) WO 01/23568
Apoptosis modulation
Bethesda, Md.
IAP gene family members, encoding gene sequences; for modulating apoptosis and activating JNK activity.
Natl. Jewish Med. Res. Ctr. WO 01/23002
Inhibiting pathogenic microorganisms
Denver
High efficiency transfection of human host cells with genes encoding antimicrobial agents; for treating infections.
Natl. Jewish Med. Res. Ctr. WO 01/23617
Growth modulator assays
Denver
Measuring reduced cdk6 expression to indicate increased cell growth; modulator assays; for treating cancer.
Ono Pharma EP 1 090 992
Smooth muscle cell protein
Osaka, Japan
Smooth muscle cell proliferation-related protein, encoding gene sequences; for developing therapeutics.
Pasteur Inst. WO 01/23577
Chimeric hepatitis B genes
Paris
Chimeric hepatitis B virus gene sequences, encoded proteins; for developing cancer immunotherapeutics.
Pennsylvania, Univ. of WO 01/23001
PEG-modified vectors
Philadelphia
Methods for rapid polyethylene glycol modification of viral vectors; for enhanced expression and physical stability.
Pennsylvania, Univ. of WO 01/23004 & 23597
Cancer gene therapy vectors
Philadelphia
Replication selective adenovirus mutants having selectivity for tumor cells, production cell lines; for cancer therapy.
Pfizer EP 1 090 925, 1 090 926, 1 090 989 & 1 090 990
G-protein coupled receptors
Sandwich, UK
G-protein coupled receptors, encoding gene sequences, variants, fragments, homologs; for developing therapeutics.
Pfizer EP 1 090 995
Mycoplasma vaccines
Groton, Conn.
Mycoplasma hyopneumoniae antigen MHP3, encoding gene sequences, recombinant production methods; for vaccines.
Pharmacia & Upjohn WO 01/23533
Alzheimer's secretase
Kalamazoo, Mich.
Alzheimer's disease secretase, amyloid precursor protein substrates, encoding genes; for identifying therapeutics.
Quark Biotech WO 01/22864
Bladder cancer gene
Pleasanton, Calif.
Genes expressed in bladder cancer, encoded proteins; for diagnostics and therapeutics.
Rosetta Inpharmatics WO 01/23600
Hybridization specificity analysis
Kirkland, Wash.
Computer systems for determining the specificity with which gene sequences hybridize to specific probes.
Sanofi-Synthelabo EP 1 090 991 & WO 01/23551
Acetylcholine receptor subunit
Paris
Nicotinic acetylcholine receptor subunit, encoding gene sequences, antibodies; for developing modulators.
Scios WO 01/23419 & 23564
Secreted factors
Sunnyvale, Calif.
Secreted factors, encoding genes; production methods; for cardiac, renal, and inflammation therapeutics.
Shanghai Biorigin Gene Develop. WO 01/23423
Huntingtin interacting polypeptide
Shanghai, China
Human huntingtin interacting WW domain polypeptide, encoding gene sequences, production methods; for therapeutics.
SmithKline Beecham WO 01/23403, 23418 & 23599
Antibacterial screens
Philadelphia
Bacterial ypga clade, yphC, and ykqC genes, encoded proteins, production methods; for antibacterial screens.
SmithKline Beecham WO 01/23416
Moraxella antigens
Rixensart, Belgium
Moraxella proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 01/23417 & 23587
Cancer-related proteins
Rixensart, Belgium
Cancer-related proteins, encoding genes, recombinant production methods; for diagnostics and therapeutics.
Stryker WO 01/23563
Enhanced morphogenesis
Kalamazoo, Mich.
Compositions having a morphogenic protein, a cytokine, and a soluble cytokine receptor; for enhancing morphogenesis.
Sumitomo Pharma EP 1 090 924
Tumor antigen peptides
Osaka, Japan
Tumor antigen peptides derived from cyclophilin B, antibodies; for cancer therapeutics.
Sumitomo Pharma WO 01/23545
Variant FRT sequences
Osaka, Japan
DNA encoding variant FRT sequences having spacer sequences; for FLP recombinase-mediated recombination in transgenics.
Teijin WO 01/23557
Chondromodulin-1 homologs
Osaka, Japan
Chondromodulin-1 homologs, encoding gene sequences; for controlling cartilage cell growth and differentiation.
Tsakas, S., et al. WO 01/23532
Cryopreserved amniotic cells
Athens, Greece
Cryopreserved amniotic human cells; for use in future therapeutic cell and tissue replacement procedures.
U.S. Transgenics WO 01/22810
Transgenic von Willebrand Factor
Washington, DC
Transgenics that make von Willebrand Factor and related polypeptides, encoding genes; for expression in milk.
Varian WO 01/23426
Hypoxia-related gene expression
Palo Alto, Calif.
Hypoxia-related human genes, encoded proteins, microarrays, gene expression patterns; for developing therapeutics.
Washington State Univ. WO 01/23586
Taxol production
Pullman, Wash.
Transacylase enzymes, encoding gene sequences; for producing taxol and related taxoids.
Washington, Univ. of WO 01/23414
Herpes vaccines
Seattle
Herpes simplex virus protein epitopes that are recognized by T cells derived from lesions, encoding genes; for vaccines.
Western Australia, Univ. of WO 01/23549
Osteoclast differentiation factor
Nedlands, Australia
Rat osteoclast differentiation factor, encoding gene sequences, biologically active fragments; for therapeutics.
Xenoport WO 01/23619
Phage display
Palo Alto, Calif.
Replicable genetic packages that display synthetic compounds on phage surfaces; for screening for therapeutics.
Yale Univ. WO 01/23548
DNA-cleaving RNAse P RNA
New Haven, Conn.
DNA-cleaving variant RNAse P RNA; for genome mapping and developing diagnostics and therapeutics.
Zurich Univ. WO 01/23425
Prion-binding factors
Zurich, Switzerland
Factors having prion-binding activity in serum and plasma; for detecting transmissible spongiform encephalopathies.
ZymoGenetics WO 01/23567
Pituitary-related protein
Seattle
Membrane-bound protein that can be used to image and separate pituitary cells, encoding gene, antibodies.