March 28 (EPO), March 22 (WO)

Affymetrix WO 01/20043

Gene expression analysis

Santa Clara, Calif.

Methods for cluster analysis of gene expression profiles using computer software systems.

Albany Med. Coll. WO 01/20033

Selecting prostate cancer treatment

Albany, N.Y.

Determination of HER-2/neu gene copy number in prostate cancer cells; for selecting therapy regimens.

American Home Products WO 01/19855

Bone formation regulation

Madison, N.J.

Regulating bone formation using secreted frizzled-related proteins that are Wnt receptors.

Amsterdam Univ. Acad. Med. Ctr. WO 01/20013

Attenuated HIV

Amsterdam, Netherlands

Viral replicons that can be used to produce an attenuated HIV; for treating AIDS.

AstraZeneca WO 01/20327

Diabetes therapeutics assay

London

Measuring the binding between glucokinase, its regulatory protein, and fructose-6-phosphate; for finding modulators.

Bander, N.H. WO 01/19956

Prostate cancer diagnosis

Chappaqua, N.Y.

Methods for isolating prostate cancer epithelial cells from semen using a magnetic activated cell sorter; for diagnosis.

BASF WO 01/20034

Cell cycle modulation

Ludwigshafen, Germany

Screening compounds that can modulate Cdc25-mediated gene regulation; for cell cycle control.

Baxter WO 01/19992

Factor IX/IXa antibodies

Vienna, Austria

Factor IX/IXa antibodies and antibody derivatives; for increasing the procoagulant activity of Factor IXa.

Biogen WO 01/19396

Renal failure therapy

Cambridge, Mass.

Therapy for chronic renal failure that involves using integrin antagonists.

Bios Biotech WO 01/19183

Sperm cell transfection

Schonow, Germany

Effective gene transfer into sperm cells using virosomal vectors.

British Defense Ministry WO 01/19974

Bacterial mucosal vaccines

Farnborough, UK

Recombinant microorganisms expressing therapeutic proteins; for delivery to mucosal surfaces as vaccines.

California, Univ. of WO 01/19967

Breast carcinoma xenograft

Oakland, Calif.

Human transplantable breast carcinoma xenograft; for lymphovascular invasion in animal model systems.

Canfield, W.M. WO 01/19955

Lysosomal targeting pathway enzymes

Oklahoma City

Lysosomal targeting pathway enzymes that phosphorylate lysosomal hydrolases; for lysosomal storage diseases.

Cedars-Sinai Med. Ctr. WO 01/20036

Diagnosing Crohn's disease

Los Angeles

Methods for using a major histocompatibility class III haplotype to diagnose Crohn's disease.

CNRS (Natl. Ctr. Sci. Res.) WO 01/20030

Bacterial gene assay

Paris

Nucleotide sequences derived from genes coding for trimethylamine N-oxide reductase; for detecting bacteria.

Chemogen WO 01/19968

Protein production in eggs

Scarborough, Maine

Recombinant eggs, gene cloning, and expression vectors based on avian adenoviruses; for protein production in eggs.

Children's Hosp. WO 01/19379

Muscular dystrophy gene therapy

Boston

Bone marrow transplantation using hematopoietic stem cells expressing dystrophin; for treating muscular dystrophy.

Children's Hosp. WO 01/19966

Muscle disease gene therapy

Boston

Methods for purifying muscle stem cells from skeletal muscle; for gene therapy for muscle diseases.

Concordia Univ. WO 01/20007

Protein production in fungi

Montreal

Multifunctional system of expression modules for efficient manipulation of protein expression in filamentous fungi.

Cornell Univ. WO 01/19393

Therapeutic delivery

Ithaca, N.Y.

Delivering bacterial proteins using an effector protein fused to the protein transduction domain of HIV TAT.

Cornell Univ. WO 01/19978

Animal cloning

Ithaca, N.Y.

Microfabrication of nuclear transfer arrays; for high-throughput animal cloning.

CuraGen WO 01/19856

POLYX polypeptides

New Haven, Conn.

POLYX polypeptides, encoding gene sequences, antibodies; for developing diagnostics and therapeutics.

CuraGen WO 01/20039

Nucleic acid sequencing

New Haven, Conn.

Nucleic acid sequencing using circular nucleic acid molecules and anchor primers.

Curie, Univ. Pierre & Marie WO 01/19964 & 19965

Chondrocyte preparations

Paris

Production and preparation of autologous human chondrocyte preparations; for repairing cartilage defects.

Dana-Farber Cancer Inst. WO 01/19958

HIV env trimers

Boston

Stabilized soluble HIV envelope glycoprotein trimers, encoding gene sequences; for identifying modulators.

Entremed WO 01/19989

Endostatin production

Rockville, Md.

Methods for producing and purifying recombinant endostatin protein; for large-scale recovery.

Epidauros Biotech WO 01/20026

Drug metabolism gene SNPs

Bernried, Germany

Polymorphisms in the human PXR gene which is associated with insufficient metabolism of drugs; for therapeutics.

Exon-Hit Therapeutics WO 01/20027

Pathology diagnosis

Paris

Detection of blood cells having physiologic characteristics of pathological conditions.

Exon-Hit Therapeutics WO 01/20029

Genetic toxicity markers

Paris

Generating libraries of nucleic acids for use as genetic markers of toxicity.

Genentech WO 01/19861

Apoptosis-modulating antibodies

S. San Francisco

Apo-2 receptor antibodies, chimeras, encoding gene sequences; for modulating apoptosis.

Genentech WO 01/19987

Angiogenesis modulation

S. San Francisco

Modulation of angiogenesis and cardiovascularization using therapeutic proteins and their gene sequences.

Genentech WO 01/19991

Immune-related disease proteins

S. San Francisco

Proteins and encoding gene sequences for the diagnosis and treatment of immune-related disease.

Genetics Inst. WO 01/19988

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences; for developing diagnostics and therapeutics.

Genzyme Transgenics WO 01/19842

Subunit optimized fusion proteins

Framingham, Mass.

Fusion proteins in which subunit assembly produces a multimer having optimized activity.

Genzyme Transgenics WO 01/19846

Transgenic fusion proteins

Framingham, Mass.

Transgenics that have a gene encoding a fusion protein; for expression in and recovery from milk.

Immunex WO 01/19990

Cell death-associated kinase

Seattle

RIP-3-like death-associated kinase, encoding gene sequences, antibodies, modulators; for developing therapeutics.

Incyte Genomics WO 01/19860

Cell differentiation proteins

Palo Alto, Calif.

Proteins associated with cell differentiation, encoding gene sequences, antibodies, modulators; for therapeutics.

Incyte Genomics WO 01/20004

Protein phosphatases

Palo Alto, Calif.

Protein phosphatase and kinase proteins, encoding gene sequences, antibodies, modulators; for therapeutics.

INRA (Natl. Inst. Agron. Res.) WO 01/20003

AMP-activated kinase subunit variants

Paris

Vertebrate AMP-activated kinase gamma chain variants, encoding gene; for energy metabolism dysfunction therapy.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 01/20001

Thyroid NADPH oxidase

Paris

NADPH oxidase thyroid enzyme, encoding gene sequences; for hyperthyroid diagnosis and therapy.

Introgene WO 01/20014

Modified adenoviral vectors

Leiden, Netherlands

Adenoviral vectors having modified E2B or E4 functions; for use as gene therapy vectors.

Isis Pharma WO 01/19161

TGF-_ antisense

Carlsbad, Calif.

Antisense modulation of TGF-_ expression; for treating associated diseases.

Janssen Pharma WO 01/19973

Nicotinic acetylcholine receptor

Turnhoutseweg, Belgium

Human a-nicotinic acetylcholine receptor, encoding gene sequences; for developing therapeutics.

Japan Sci. & Technol. EP 1 087 012

Dendritic cell-expressed genes

Kawaguchi, Japan

High- and low-expression gene groups from human dendritic cells; for developing immune diagnostics and therapeutics.

Johns Hopkins Univ. WO 01/19845

T-type calcium channel

Baltimore

T-type calcium channel, encoding gene sequences, methylation patterns; for correlation to various cancer phenotypes.

Karlsruhe Res. Ctr. WO 01/20021

Cell regulation control

Karlsruhe, Germany

Complexes with phosphorylating and dephosphorylating enzymes; for controlling cell regulation.

Kyowa Hakko Kogyo EP 1 086 956

VEGF receptor antibodies

Tokyo

Recombinant antibodies to the human VEGF receptor Flt-1; for angiogenesis diagnostics and therapeutics.

Kyowa Hakko Kogyo WO 01/20031

Klotho gene polymorphisms

Tokyo

Klotho gene polymorphisms; for diagnosing predisposition to osteoporosis and age-related diseases.

Maryland, Univ. of WO 01/19993

Mycobacterial virulence genes

Baltimore

Mycobacterial virulence genes, methods of mutagenesis; for developing attenuated strains for vaccines.

Massachusetts, Univ. of WO 01/19181

Cloning pluripotent pigs

Amherst, Mass.

Cloning pigs using donor cells or nuclei from differentiated cells; for producing pluripotent pigs.

Massachusetts, Univ. of WO 01/19977

Stem-like cell production

Amherst, Mass.

Embryonic or stem-like cells lines produced by cross species nuclear transplantation; for genetic manipulation.

Max Planck Inst. WO 01/20022

Cancer cell cytoskeleton modulation

Munich, Germany

Methods for identifying Rab and Rho ATPase modulators; for modulating membrane-cytoskeletal interactions in cancer.

McGill Univ. WO 01/19850 & 20335

Cell proliferation control

Montreal

NRAGE genes, encoded proteins; finding modulators of NRAGE-E2F protein interaction; for cell proliferation control.

Mediterranean Univ. WO 01/20028

Spirochete detection

Marseille, France

Single-stranded oligonucleotides, probes, and primers for detecting spirochetes.

Medvet Science WO 01/19847

Modulating receptor activity

Adelaide, Australia

Cytoplasmic domain binding motif of a receptor; for modulating receptor activity.

Meiji WO 01/19985

Leukotriene pathway receptors

Tokyo

Receptors involved in leukotriene-related pathways, encoding gene sequences, modulators; for therapeutics.

Memorec Stoffel WO 01/19867

Prion-related protein

Cologne, Germany

Prion-related protein; for developing prion-related disease diagnostics and therapeutics.

Merck WO 01/19843 & 19979

Pseudomonas antibacterials

Rahway, N.J.

Pseudomonas aeroginosa MurE and MurC protein, encoding gene sequences; for identifying modulators as antibacterials.

Microbiol. Res. Auth. WO 01/19863

Purified toxin fragments

Salisbury, UK

Preparation of highly pure toxin fragments by proteolytic treatment of holotoxins.

Millennium WO 01/19410

Human Flash genes

Cambridge, Mass.

Human Flash genes, encoded proteins, antibodies, recombinant production methods; for developing therapeutics.

Mitokor WO 01/20018

Altered mitochondrial function

San Diego

Measuring altered mitochondrial function; for detection of arthritic disorders.

Mitokor WO 01/20536

Analyzing gene arrays

San Diego

Computer systems and methods for hierarchical analysis of large sets of highly dense gene array data.

Mogam Biotech Res. Inst. WO 01/19868

Angiogenesis inhibitor

Kyonggi-do, S. Korea

Angiogenesis inhibitor whose amino acid sequence is identical to human apolipoprotein kringle domains.

Mogam Biotech Res. Inst. WO 01/19998

Pathogenic E. coli vaccines

Kyonggi-do, S. Korea

Detoxified and immunologically active E. coli heat-labile enterotoxin; for vaccines.

NIH (Natl. Inst. Hlth.) WO 01/19858

Ubiquitin-like proteins

Bethesda, Md.

Family of ubiquitin-like proteins that bind the ATPase domain of Hsp70-like chaperone proteins.

NIH (Natl. Inst. Hlth.) WO 01/20044

In situ hybridization analysis

Bethesda, Md.

Computer-assisted graphics software system for signal counting for in situ hybridization.

New York Soc. Crippled WO 01/19844

CD40 ligand promoter variation

New York

Alterations in the nucleic acid sequence of the CD40 ligand promoter; for diagnosing autoimmune disease susceptibility.

Pangene WO 01/19397

Rad51 gene profiling

Mountain View, Calif.

Rad51 gene expression profiling; for treating disease states associated with apoptosis.

Pasteur Inst. WO 01/19395

Anthrax vaccines

Paris

Acellular immunogenic compositions containing anthrax spores and a protective antigen; for vaccines.

Pro-Virus WO 01/19380

Oncolytic virus therapy

Gaithersburg, Md.

Use of vesicular stomatitis virus infection in conjunction with interferon to reduce tumor cell viability.

Queensland Inst. Med. Res. WO 01/19869

Immunomodulatory protein

Herston, Australia

Dendritic cell type II integral membrane protein, encoding gene sequences, antibodies; for modulating immune responses.

Sagamie Hosp. WO 01/20037

Lipid metabolism gene SNPs

Chicoutimi, Que.

Polymorphisms of the peroxisome proliferator-activated receptor a; for diagnosing lipid metabolism disorders.

Sangamo Biosciences WO 01/19981

Gene expression regulation

Richmond, Calif.

Methods for regulating gene expression using zinc finger proteins; for functional genomics and target validation.

Scripps Res. Inst. WO 01/20038

Cell cycle checkpoint genes

La Jolla, Calif.

Cell cycle checkpoint genes, encoded proteins; for developing therapeutics.

Shanghai Biorigin Gene Develop. WO 01/19864

Angiotensin II-1 receptor

Shanghai, China

Human angiotensin II-1 receptor, encoding gene, antibodies, modulators, production methods; for developing therapeutics.

Shanghai Biorigin Gene Develop. WO 01/19865

Muskelin

Shanghai, China

Muskelin, encoding gene sequences, antibodies, modulators, production methods; for developing therapeutics.

Shanghai Biorigin Gene Develop. WO 01/19999

Threonyl-tRNA synthetase

Shanghai, China

Human threonyl-tRNA synthetase, encoding gene, antibodies, modulators, production methods; for cancer therapeutics.

Sheffield, Univ. of WO 01/19853

Blasticidin resistance gene transfection

Sheffield, UK

Transfecting cells with the functional part of the blasticidin resistance gene linked to a selected gene.

SmithKline Beecham WO 01/19854

NTT7 polypeptides

Brentford, UK

NTT7 polypeptides, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 01/19862, 19996 & 19997

Moraxella antibacterials

Rixensart, Belgium

Moraxella polypeptides, encoding gene sequences, production methods; for developing antibacterials.

SmithKline Beecham WO 01/19971

Pseudomonas antibacterials

Philadelphia

Pseudomonas aeroginosa IMP-1 metallo _-lactamase, crystal structure of enzyme/inhibitor complex; for antibacterials.

SmithKline Beecham WO 01/19984

G-protein coupled receptor

Brentford, UK

G-protein coupled receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.

Solvay Pharma WO 01/19983

G-protein coupled receptor

Weesp, Netherlands

Human G-protein coupled receptor, encoding gene sequences, modulators, knockout animals; for developing therapeutics.

Sydney, Univ. of WO 01/19866

Dipeptidyl aminopeptidases

Sydney, Australia

Human dipeptidyl aminopeptidases with similarities to fibroblast activation protein, encoding gene sequences.

Tad Pharma WO 01/20005

Protein production system

Cuxhaven, Germany

Regulatory sequences and expression cassettes for yeasts; for producing heterologous proteins.

Therapeutic Human Polyclonals WO 01/19394

Human antibodies from birds

Tucson, Ariz.

Immunotherapy with substantially human polyclonal antibody preparations purified from genetically engineered birds.

Victoria Univ. WO 01/20337

Periodontal disease diagnosis

Manchester, UK

Assays for reduced levels of cathepsin; for diagnosing and treating periodontal disease.

Warner-Lambert WO 01/19870

Calcium channel subunits

Morris Plains, N.J.

Secreted soluble calcium channel subunit polypeptides, encoding gene sequences; for modulator screens.

Warner-Lambert WO 01/20336

a2-gamma-1 subtype polypeptide ligands

Morris Plains, N.J.

Methods for screening ligands that bind to soluble a2-gamma-1 subtype polypeptides; for developing therapeutics.

Wells, D. WO 01/19182

G1 cell nuclear transfer

Hamilton, New Zealand

Nuclear transfer using segregated G1 phase cells; for producing transgenics.

Whitehead Inst. Biomed. Res. WO 01/20015

Reverse transfection

Cambridge, Mass.

Reverse transfection methods for introducing DNA of interest into cells from microarrays.

Women's & Children's Hosp. WO 01/19960

Pathogen binding inhibition

N. Adelaide, Australia

Recombinant microorganisms that express an oligosaccharide receptor mimic; for inhibiting binding of pathogens.

Xenoport WO 01/20331

Transport protein modulator screen

Palo Alto, Calif.

Screening methods for identifying modulators of transport proteins and genes that encode these proteins.

Xtrana WO 01/20041

RNA transcript quantitation

Denver

Quantitation of RNA transcripts using genomic DNA as the internal amplification competitor.

Yamanouchi Pharma WO 01/19986

Peptide leukotriene receptor

Tokyo

Peptide leukotriene receptor, encoding gene sequences; for modulator screens.

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