March 8 (WO)

Abdelouahed, M., et al. WO 01/16184

Thrombocytopenia diagnostic antibodies

Worcester, Mass.

Detection of antibodies to PF4/heparin/TSP-1 complexes; for diagnosing Type 2 heparin-induced thrombocytopenia.

Akzo Nobel WO 01/16374

In situ DNA amplification

Arnhem, Netherlands

Methods and reagents for in situ amplification of target nucleic acids; for detection.

BASF WO 01/16300

Cdc25 modulator screens

Ludwigshafen, Germany

Polypeptide binding domains of Cdc25, crystalline structures; for identifying modulators.

Bayer WO 01/16303

Spinosyn biosynthesis

Leverkusen, Germany

Spinosyn biosynthetic enzymes, encoding gene sequences; for making spinosyn precursors and derivatives.

Bio-Rad Labs WO 01/16365

Nucleic acid therapeutics

Hercules, Calif.

Polyether moieties linked to nucleic acid bases; for developing therapeutics.

Biogen WO 01/16169

Ret ligand 5

Cambridge, Mass.

Ret ligand 5, encoding gene sequences; for developing diagnostics and therapeutics.

BioMerieux WO 01/16171

Viral cancer therapeutics

Marcy l'Etoile

Protein for detecting expression of envelope proteins of a human endogenous retrovirus; for cancer therapeutics.

Boston Univ. WO 01/16601

NMDA receptor modulators

Boston

Methods for identifying subunit-specific modulators of N-methyl-D-aspartate (NMDA) receptors.

Bristol-Myers Squibb WO 01/16368

In vitro transcription systems

Princeton, N.J.

In vitro chromatin-based transcription systems for finding agents that interact with retinoid X receptor dimers.

Burnham Inst. WO 01/16170

CARD-containing proteins

La Jolla, Calif.

CARD-containing proteins, encoding genes, antisense; for apoptosis-related diagnostics and therapeutics.

California, Univ. of WO 01/16342

Activating T cells

Oakland, Calif.

Transfecting dendritic cells with lentiviral vectors encoding antigens; for activating T cells.

Chiron WO 01/16306

Chimeric oligonucleotides

Emeryville, Calif.

Chimeric oligonucleotides that are resistant to nuclease activity and have the ability to activate RNase.

CSIRO (Comm. Sci. & Ind. Res. Org.) WO 01/16172

Moraxella vaccines

Campbell, Australia

Moraxella antigens, encoding gene sequences; for developing vaccines.

Corning WO 01/16376

Porous DNA array substrates

Corning, N.Y.

Planar porous substrates having a cationic polymer layer bound to the top surface; for DNA arrays.

Droge, P. WO 01/16345

Sequence-specific recombination

Cologne, Germany

Methods for sequence-specific recombination in eukaryotic cells using bacteriophage integrase Int.

Erasmus Univ. WO 01/16341

Retroviral vector gene delivery

Rotterdam, Netherlands

Collecting and concentrating CD34 positive cells for optimal transfection using retroviral vectors.

Euro-Diagnostica WO 01/16163

Chronic viral infection vaccine

Malmo, Sweden

Peptides derived from hepatitis and herpes simplex virus antigens; for chronic viral infection vaccine.

European Community WO 01/16304

Neurotoxicity cell model

Luxembourg

Cell lines tranfected with p53 and bcl-2 genes; for studying cell death in neurotoxicity.

European Molec. Biol. Lab WO 01/16810

Engineering therapeutics

Heidelberg, Germany

Computer-based methods for engineering and designing macromolecules; for developing therapeutics.

Evotec Neurosciences WO 01/16364

Macular degeneration diagnosis

Hamburg, Germany

Use of cystatin C gene expression patterns to diagnose age-related macular degeneration.

Florida, Univ. of WO 01/16178

Inhibiting IgE production

Gainesville, Fla.

Administration of interferon tau or chimeric versions; for inhibiting IgE production and resultant allergic reactions.

Gen-Probe WO 01/16371

Nucleic acid phosphoramide assay

San Diego

Methods for identifying nucleic acid phosporamides by fluorescent spectroscopy.

Gene Logic WO 01/16354

Renal inflammation marker

Gaithersburg, Md.

HE4 gene expressed in inflamed renal tissue, encoded protein; for diagnostics and therapeutics

Genentech WO 01/16318

Secreted proteins

S. San Francisco

Secreted and transmembrane proteins, encoding gene sequences, antibodies, recombinant production methods.

Genentech WO 01/16319

Immune system therapeutics

S. San Francisco

Proteins for the treatment of immune system-related diseases, encoded proteins; for therapeutic development.

Genetics Inst. WO 01/16861

Finding protein coding regions

Cambridge, Mass.

Methods an apparatus for analyzing nucleic acid sequences to find protein coding regions.

Genome Technologies WO 01/16350

Signal-flanking sequence amplification

Madison, Wis.

Methods for amplifying signal-flanking sequences from unknown genomic DNA.

German Hlth. & Welfare Res. Ctr. WO 01/16363

Psudomonas detection

Oberschleissheim, Germany

Rapid, highly specific methods for detecting Pseudomonas aeruginosa using multi-probe detection.

Glaxo WO 01/16596

GABAB receptor modulator screen

London

Methods for identifying modulators of GABAB receptor-mediated activity; for developing therapeutics.

Hisamitsu Pharma WO 01/16311

Tumor suppressor gene

Saga, Japan

Tumor suppressor genes from the short arm of the chromosome 1 that are found in neuroblastoma cells.

Human Genome Sciences WO 01/16156

Attractin-like polypeptides

Rockville, Md.

Attractin-like polypeptides, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Human Genome Sciences WO 01/16292

37 Staphylococcus genes

Rockville, Md.

37 Staphylococcus aureus genes, encoded proteins, antibodies; for diagnostics and vaccines.

Incyte Genomics WO 01/16317

Hydrolytic enzymes

Palo Alto, Calif.

Human hydrolytic enzymes, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 01/16334

Polycyclic aromatic hydrocarbon-induced proteins

Palo Alto, Calif.

Polycyclic aromatic hydrocarbon-induced proteins, encoding genes, antibodies; for modulator screens.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 01/16597

Finding retinoid receptor ligands

Paris

In vitro chromatin-based DNA template transcription systems; for identifying retinoid X receptor dimer ligands.

Interleukin Genetics WO 01/16377

Osteoporosis therapy

Waltham, Mass.

Determination of the interleukin-1 haplotype pattern of an individual; for diagnosing and treating osteoporosis.

Japan Sci. & Technol. WO 01/16310

Gene mutation detection

Saitama, Japan

Detection of gene mutations using a mutation detecting primer for hybridization to target genes.

Japan Sci. & Technol. WO 01/16315

Choline transporter

Saitama, Japan

High affinity choline transporter, encoding gene sequences; for modulator screens.

Johns Hopkins Univ. WO 01/16167

Tumor suppression

Baltimore

Adenovirus expressing the central third of APC which includes b-catenin binding repeats; for tumor suppression.

Kiessling, R., et al. WO 01/16174

T cell response induction

Bromma, Sweden

Induction of cytotoxic T cell responses by HLA Class IA restricted epitopes of mycobacterial heat shock protein 65.

Leuven Res. & Develop. WO 01/16357

Antiparasitic agent assays

Leuven, Belgium

Methods for identifying modulators of trehalose-6-phosphate phosphatase; for developing antiparasitic agents.

Lexicon Genetics WO 01/16336

Calcium-dependent proteases

The Woodlands, Texas

Human calcium-dependent proteases, encoding gene sequences; for diagnostics and therapeutics.

Ludwig Inst. Cancer Res. WO 01/16320

HLA antigen ligands

New York

Nona- and deca-peptides that bind to HLA histocompatibility antigens; for developing tumor rejection therapeutics.

Mass. Gen. Hosp. WO 01/16331

Tumor cell targeting

Boston

Herpes virus mutants with tumor-specific promoters linked to the viral gamma 34.5 gene; for tumor cell targeting.

Mayo Clinic WO 01/16299

Preventing bone disorders

Rochester, Minn.

Use of DNA encoding osteoprotegerin to prevent or inhibit metabolic bone disorders.

Merck WO 01/16379

Inhibiting hepatitis C replication

Rahway, N.J.

Identifying the NS4A binding site on NS3/3; for inhibiting protease activity and hepatitis C virus replication.

Mitokor WO 01/16373

Mitochondrial protein translocation

San Diego

Methods for assaying for modulators of mitochondrial intermembrane space protein translocation.

Mitsubishi Chemical WO 01/16600

Analyzing protein interactions

Tokyo

Methods of analyzing a mutual interaction between a protein and another molecule using C-terminal end labels.

Mosaic Technologies WO 01/16372

Immobilizing ligands

Waltham, Mass.

Methods for immobilizing ligands on solid supports using thiol groups; for attaching nucleic acids.

Myriad Genetics WO 01/16291

Prostate cancer marker

Salt Lake City

Human gene that has been identified as a marker for prostate cancer; for developing diagnostics and therapeutics.

NIH (Natl. Inst. Hlth.) WO 01/16166

IL-6 ligand peptides

Bethesda, Md.

Interleukin-6 ligand binding domain peptides, encoding gene sequences, antibodies; for diagnostics and therapeutics.

NIH (Natl. Inst. Hlth.) WO 01/16182

HIV gp120 binding polypeptides

Bethesda, Md.

Polypeptides that bind HIV gp120, encoding gene sequences, antibodies; for AIDS diagnostics and therapeutics.

NIH (Natl. Inst. Hlth.) WO 01/16326

Malaria treatment

Bethesda, Md.

Plasmodium erythrocyte membrane protein 1 domain mediating adhesion to chondroitin sulfate A; for treating malaria.

NIH (Natl. Inst. Hlth.) WO 01/16375

Parallel sequencing

Bethesda, Md.

High speed, automated, parallel molecular nucleic acid sequencing using fluorophore detection methods.

New Jersey, Univ. of Med. & Dent. WO 01/16153

IL-10 homolog

New Brunswick, N.J.

Cytomegalovirus-encoded interleukin-10 homolog; for developing immunotherapeutics.

New York Univ. Sch. Med. WO 01/16181

xReceptor protein tyrosine kinase structures

New York

Crystal structures of domains of receptor protein tyrosine kinases and their ligands; for developing therapeutics.

Niederweis, M., et al. WO 01/16327 & 16328

Channel forming protein nanostructures

Erlangen, Germany

Methods for producing a channel forming protein from gram-positive bacteria in order to make nanostructures.

North Carolina, Univ. of WO 01/16343

Inducing immunoresponse

Chapel Hill, N.C.

Alphavirus vectors complexed with antibodies that bind the vector; for transfecting dendritic cells for immunoresponse.

Ortho-McNeil Pharma WO 01/16288, 16290 & 16293

Human serine proteases

Raritan, N.J.

Human serine proteases C-E, EOS, and T, encoding genes; for modulator screens.

Ortho-McNeil Pharma WO 01/16289

Zymogen activation system

Raritan, N.J.

Controlled activation of zymogen precursor serine proteases using a vector encoding genes causing limited proteolysis.

Ortho-McNeil Pharma WO 01/16297

5-HT serotonin receptor subunit

Raritan, N.J.

Subunit of human 5-HT serotonin receptor, encoding gene sequences; for identifying modulators.

Otsuka Pharma WO 01/16321

Hemostasis therapeutics

Osaka, Japan

Platelet membrane glycoprotein VI, encoding gene sequences, antibodies; for developing hemostasis therapeutics.

Paley, E. WO 01/16286

Alzheimer's cell model

Surfside, Fla.

Tryptamine-treated, human differentiated neuronal cell that shows Alzheimer's-like structures; for disease modeling.

Perkin-Elmer WO 01/16367

Internal amplification controls

Foster City, Calif.

Methods for using exogenous, internal controls during nucleic acid amplification.

Perkin-Elmer WO 01/16369

Fluorescent energy transfer dyes

Foster City, Calif.

UV-excitable fluorescent energy transfer dyes; for nucleic acid sequencing methods.

Phylos WO 01/16352

Encoding translated proteins

Lexington, Mass.

Methods for encoding and sorting in vitro translated proteins.

Pierre Fabre Medicament WO 01/16335

Matrix metalloproteinase

Boulogne-Billancourt, France

Stromelysin-homologous MMP-27 matrix metalloproteinase; for modulator screens and inhibiting tumor cell metastases.

Proteome Sciences WO 01/16603

Body weight modifier screen

Cobham, UK

Proteins that are differentially expressed in body weight-related conditions; for identifying therapeutics.

Ribozyme Pharma WO 01/16312

Gene expression modulators

Boulder, Colo.

Nucleic acid-based modulators of gene expression; for controlling transcription.

Rockefeller Univ. WO 01/16605

Transcriptional activator modulator screens

New York

Methods for identifying modulators of transcriptional activator protein interactions.

Shanghai Bioroad Gene Develop. WO 01/16175

Human Rab protein

Shanghai, China

Human Rab protein, encoding gene, production methods; for developing AIDS diagnostics and therapeutics.

Signal Pharma WO 01/16604

Modifying TGF-b cell signaling

San Diego

Screening methods for identifying modulators of TGF-b cell signaling.

SmithKline Beecham WO 01/16159

G protein-coupled receptor

Philadelphia

G protein-coupled receptor called TheAnt, encoding gene, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 01/16177 & 16298

Mouse G protein-coupled receptor

Philadelphia

Mouse G protein-coupled receptor CanoMan, encoding gene, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 01/16313

GS protein regulator gene

Brentford, UK

Human GS protein regulator gene, encoded protein, production methods; for diagnostics and therapeutics.

Stratagene WO 01/16333

DNA polymerase purification

La Jolla, Calif.

Methods for purifying DNA polymerase using poly-U sepharose chromatography.

Takeda Chemical WO 01/16179, 16309 & 16316

G protein-coupled receptor

Osaka, Japan

G protein-coupled receptor, encoding gene sequences; for modulator screens.

Texas, Univ. of WO 01/16168

Tumor cell apoptosis

Austin, Texas

Induction of tumor cell death by the N5 gene whose product interacts with the neuroblastoma gene encoded protein.

Texas, Univ. of WO 01/16180

CD40 agonists

Austin, Texas

CD40 agonists such as CD40 ligands or CD40 antibodies; for preventing cell death and bone loss.

Texas, Univ. of WO 01/16324

Serine protease inhibitor

Austin, Texas

Serpin serine protease inhibitor headpin, encoding gene sequences, antibodies; for diagnostics and therapeutics.

3M Innovative Properties WO 01/16370

Microarrays

St. Paul, Minn.

Arrays having mask layers, methods for manufacturing; for fluorescent detection.

Transgene WO 01/16344

Modified adenoviral fibers

Strasbourg, France

Modified adenoviral fibers; for changing the tropism of gene therapy vectors.

Tufts Univ. WO 01/16301

Peptidase apoptosis modulation

Boston

Quiescent cell dipeptidyl peptidase expressed in T cells and neurons that prevents cell death; for apoptosis modulation.

U.S. Army Med. Res. Inst. WO 01/16183

Ebola virus vaccines

Frederick, Md.

Monoclonal antibodies against Ebola virus glycoprotein epitopes; for vaccines.

Utah, Univ. of WO 01/16154

Hypertension-related gene

Salt Lake City

Variants of the T/C(67)AGT gene; for determining predisposition to hypertension.

Whitehead Inst. Biomed. Res. WO 01/16378

Protein-DNA interactions

Cambridge, Mass.

Chromosome-wide analysis of protein-DNA interactions using methods to covalently link DNA binding proteins.

Wistar Inst. Anatomy & Biol. WO 01/16158

Bridging integrator-2 gene

Philadelphia

Bridging integrator-2 gene sequences, encoded protein; for developing liver carcinoma therapeutics.

Yeda Res. & Develop. WO 01/16314

TRAF binding protein

Rehovot, Israel

IREN, a TRAF binding protein, encoding gene sequences; for treating diseases associated with NF-kappaB induction.

Yeda Res. & Develop. WO 01/16366

Template-dependent polymerization

Rehovot, Israel

Template-dependent nucleic acid polymerization using oligonucleotide triphosphate building blocks.

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