March 8 (WO)
Abdelouahed, M., et al. WO 01/16184
Thrombocytopenia diagnostic antibodies
Detection of antibodies to PF4/heparin/TSP-1 complexes; for diagnosing Type 2 heparin-induced thrombocytopenia.
Akzo Nobel WO 01/16374
In situ DNA amplification
Methods and reagents for in situ amplification of target nucleic acids; for detection.
BASF WO 01/16300
Cdc25 modulator screens
Polypeptide binding domains of Cdc25, crystalline structures; for identifying modulators.
Bayer WO 01/16303
Spinosyn biosynthetic enzymes, encoding gene sequences; for making spinosyn precursors and derivatives.
Bio-Rad Labs WO 01/16365
Nucleic acid therapeutics
Polyether moieties linked to nucleic acid bases; for developing therapeutics.
Biogen WO 01/16169
Ret ligand 5
Ret ligand 5, encoding gene sequences; for developing diagnostics and therapeutics.
BioMerieux WO 01/16171
Viral cancer therapeutics
Protein for detecting expression of envelope proteins of a human endogenous retrovirus; for cancer therapeutics.
Boston Univ. WO 01/16601
NMDA receptor modulators
Methods for identifying subunit-specific modulators of N-methyl-D-aspartate (NMDA) receptors.
Bristol-Myers Squibb WO 01/16368
In vitro transcription systems
In vitro chromatin-based transcription systems for finding agents that interact with retinoid X receptor dimers.
Burnham Inst. WO 01/16170
La Jolla, Calif.
CARD-containing proteins, encoding genes, antisense; for apoptosis-related diagnostics and therapeutics.
California, Univ. of WO 01/16342
Activating T cells
Transfecting dendritic cells with lentiviral vectors encoding antigens; for activating T cells.
Chiron WO 01/16306
Chimeric oligonucleotides that are resistant to nuclease activity and have the ability to activate RNase.
CSIRO (Comm. Sci. & Ind. Res. Org.) WO 01/16172
Moraxella antigens, encoding gene sequences; for developing vaccines.
Corning WO 01/16376
Porous DNA array substrates
Planar porous substrates having a cationic polymer layer bound to the top surface; for DNA arrays.
Droge, P. WO 01/16345
Methods for sequence-specific recombination in eukaryotic cells using bacteriophage integrase Int.
Erasmus Univ. WO 01/16341
Retroviral vector gene delivery
Collecting and concentrating CD34 positive cells for optimal transfection using retroviral vectors.
Euro-Diagnostica WO 01/16163
Chronic viral infection vaccine
Peptides derived from hepatitis and herpes simplex virus antigens; for chronic viral infection vaccine.
European Community WO 01/16304
Neurotoxicity cell model
Cell lines tranfected with p53 and bcl-2 genes; for studying cell death in neurotoxicity.
European Molec. Biol. Lab WO 01/16810
Computer-based methods for engineering and designing macromolecules; for developing therapeutics.
Evotec Neurosciences WO 01/16364
Macular degeneration diagnosis
Use of cystatin C gene expression patterns to diagnose age-related macular degeneration.
Florida, Univ. of WO 01/16178
Inhibiting IgE production
Administration of interferon tau or chimeric versions; for inhibiting IgE production and resultant allergic reactions.
Gen-Probe WO 01/16371
Nucleic acid phosphoramide assay
Methods for identifying nucleic acid phosporamides by fluorescent spectroscopy.
Gene Logic WO 01/16354
Renal inflammation marker
HE4 gene expressed in inflamed renal tissue, encoded protein; for diagnostics and therapeutics
Genentech WO 01/16318
S. San Francisco
Secreted and transmembrane proteins, encoding gene sequences, antibodies, recombinant production methods.
Genentech WO 01/16319
Immune system therapeutics
S. San Francisco
Proteins for the treatment of immune system-related diseases, encoded proteins; for therapeutic development.
Genetics Inst. WO 01/16861
Finding protein coding regions
Methods an apparatus for analyzing nucleic acid sequences to find protein coding regions.
Genome Technologies WO 01/16350
Signal-flanking sequence amplification
Methods for amplifying signal-flanking sequences from unknown genomic DNA.
German Hlth. & Welfare Res. Ctr. WO 01/16363
Rapid, highly specific methods for detecting Pseudomonas aeruginosa using multi-probe detection.
Glaxo WO 01/16596
GABAB receptor modulator screen
Methods for identifying modulators of GABAB receptor-mediated activity; for developing therapeutics.
Hisamitsu Pharma WO 01/16311
Tumor suppressor gene
Tumor suppressor genes from the short arm of the chromosome 1 that are found in neuroblastoma cells.
Human Genome Sciences WO 01/16156
Attractin-like polypeptides, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Human Genome Sciences WO 01/16292
37 Staphylococcus genes
37 Staphylococcus aureus genes, encoded proteins, antibodies; for diagnostics and vaccines.
Incyte Genomics WO 01/16317
Palo Alto, Calif.
Human hydrolytic enzymes, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 01/16334
Polycyclic aromatic hydrocarbon-induced proteins
Palo Alto, Calif.
Polycyclic aromatic hydrocarbon-induced proteins, encoding genes, antibodies; for modulator screens.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 01/16597
Finding retinoid receptor ligands
In vitro chromatin-based DNA template transcription systems; for identifying retinoid X receptor dimer ligands.
Interleukin Genetics WO 01/16377
Determination of the interleukin-1 haplotype pattern of an individual; for diagnosing and treating osteoporosis.
Japan Sci. & Technol. WO 01/16310
Gene mutation detection
Detection of gene mutations using a mutation detecting primer for hybridization to target genes.
Japan Sci. & Technol. WO 01/16315
High affinity choline transporter, encoding gene sequences; for modulator screens.
Johns Hopkins Univ. WO 01/16167
Adenovirus expressing the central third of APC which includes b-catenin binding repeats; for tumor suppression.
Kiessling, R., et al. WO 01/16174
T cell response induction
Induction of cytotoxic T cell responses by HLA Class IA restricted epitopes of mycobacterial heat shock protein 65.
Leuven Res. & Develop. WO 01/16357
Antiparasitic agent assays
Methods for identifying modulators of trehalose-6-phosphate phosphatase; for developing antiparasitic agents.
Lexicon Genetics WO 01/16336
The Woodlands, Texas
Human calcium-dependent proteases, encoding gene sequences; for diagnostics and therapeutics.
Ludwig Inst. Cancer Res. WO 01/16320
HLA antigen ligands
Nona- and deca-peptides that bind to HLA histocompatibility antigens; for developing tumor rejection therapeutics.
Mass. Gen. Hosp. WO 01/16331
Tumor cell targeting
Herpes virus mutants with tumor-specific promoters linked to the viral gamma 34.5 gene; for tumor cell targeting.
Mayo Clinic WO 01/16299
Preventing bone disorders
Use of DNA encoding osteoprotegerin to prevent or inhibit metabolic bone disorders.
Merck WO 01/16379
Inhibiting hepatitis C replication
Identifying the NS4A binding site on NS3/3; for inhibiting protease activity and hepatitis C virus replication.
Mitokor WO 01/16373
Mitochondrial protein translocation
Methods for assaying for modulators of mitochondrial intermembrane space protein translocation.
Mitsubishi Chemical WO 01/16600
Analyzing protein interactions
Methods of analyzing a mutual interaction between a protein and another molecule using C-terminal end labels.
Mosaic Technologies WO 01/16372
Methods for immobilizing ligands on solid supports using thiol groups; for attaching nucleic acids.
Myriad Genetics WO 01/16291
Prostate cancer marker
Salt Lake City
Human gene that has been identified as a marker for prostate cancer; for developing diagnostics and therapeutics.
NIH (Natl. Inst. Hlth.) WO 01/16166
IL-6 ligand peptides
Interleukin-6 ligand binding domain peptides, encoding gene sequences, antibodies; for diagnostics and therapeutics.
NIH (Natl. Inst. Hlth.) WO 01/16182
HIV gp120 binding polypeptides
Polypeptides that bind HIV gp120, encoding gene sequences, antibodies; for AIDS diagnostics and therapeutics.
NIH (Natl. Inst. Hlth.) WO 01/16326
Plasmodium erythrocyte membrane protein 1 domain mediating adhesion to chondroitin sulfate A; for treating malaria.
NIH (Natl. Inst. Hlth.) WO 01/16375
High speed, automated, parallel molecular nucleic acid sequencing using fluorophore detection methods.
New Jersey, Univ. of Med. & Dent. WO 01/16153
New Brunswick, N.J.
Cytomegalovirus-encoded interleukin-10 homolog; for developing immunotherapeutics.
New York Univ. Sch. Med. WO 01/16181
xReceptor protein tyrosine kinase structures
Crystal structures of domains of receptor protein tyrosine kinases and their ligands; for developing therapeutics.
Niederweis, M., et al. WO 01/16327 & 16328
Channel forming protein nanostructures
Methods for producing a channel forming protein from gram-positive bacteria in order to make nanostructures.
North Carolina, Univ. of WO 01/16343
Chapel Hill, N.C.
Alphavirus vectors complexed with antibodies that bind the vector; for transfecting dendritic cells for immunoresponse.
Ortho-McNeil Pharma WO 01/16288, 16290 & 16293
Human serine proteases
Human serine proteases C-E, EOS, and T, encoding genes; for modulator screens.
Ortho-McNeil Pharma WO 01/16289
Zymogen activation system
Controlled activation of zymogen precursor serine proteases using a vector encoding genes causing limited proteolysis.
Ortho-McNeil Pharma WO 01/16297
5-HT serotonin receptor subunit
Subunit of human 5-HT serotonin receptor, encoding gene sequences; for identifying modulators.
Otsuka Pharma WO 01/16321
Platelet membrane glycoprotein VI, encoding gene sequences, antibodies; for developing hemostasis therapeutics.
Paley, E. WO 01/16286
Alzheimer's cell model
Tryptamine-treated, human differentiated neuronal cell that shows Alzheimer's-like structures; for disease modeling.
Perkin-Elmer WO 01/16367
Internal amplification controls
Foster City, Calif.
Methods for using exogenous, internal controls during nucleic acid amplification.
Perkin-Elmer WO 01/16369
Fluorescent energy transfer dyes
Foster City, Calif.
UV-excitable fluorescent energy transfer dyes; for nucleic acid sequencing methods.
Phylos WO 01/16352
Encoding translated proteins
Methods for encoding and sorting in vitro translated proteins.
Pierre Fabre Medicament WO 01/16335
Stromelysin-homologous MMP-27 matrix metalloproteinase; for modulator screens and inhibiting tumor cell metastases.
Proteome Sciences WO 01/16603
Body weight modifier screen
Proteins that are differentially expressed in body weight-related conditions; for identifying therapeutics.
Ribozyme Pharma WO 01/16312
Gene expression modulators
Nucleic acid-based modulators of gene expression; for controlling transcription.
Rockefeller Univ. WO 01/16605
Transcriptional activator modulator screens
Methods for identifying modulators of transcriptional activator protein interactions.
Shanghai Bioroad Gene Develop. WO 01/16175
Human Rab protein
Human Rab protein, encoding gene, production methods; for developing AIDS diagnostics and therapeutics.
Signal Pharma WO 01/16604
Modifying TGF-b cell signaling
Screening methods for identifying modulators of TGF-b cell signaling.
SmithKline Beecham WO 01/16159
G protein-coupled receptor
G protein-coupled receptor called TheAnt, encoding gene, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 01/16177 & 16298
Mouse G protein-coupled receptor
Mouse G protein-coupled receptor CanoMan, encoding gene, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 01/16313
GS protein regulator gene
Human GS protein regulator gene, encoded protein, production methods; for diagnostics and therapeutics.
Stratagene WO 01/16333
DNA polymerase purification
La Jolla, Calif.
Methods for purifying DNA polymerase using poly-U sepharose chromatography.
Takeda Chemical WO 01/16179, 16309 & 16316
G protein-coupled receptor
G protein-coupled receptor, encoding gene sequences; for modulator screens.
Texas, Univ. of WO 01/16168
Tumor cell apoptosis
Induction of tumor cell death by the N5 gene whose product interacts with the neuroblastoma gene encoded protein.
Texas, Univ. of WO 01/16180
CD40 agonists such as CD40 ligands or CD40 antibodies; for preventing cell death and bone loss.
Texas, Univ. of WO 01/16324
Serine protease inhibitor
Serpin serine protease inhibitor headpin, encoding gene sequences, antibodies; for diagnostics and therapeutics.
3M Innovative Properties WO 01/16370
St. Paul, Minn.
Arrays having mask layers, methods for manufacturing; for fluorescent detection.
Transgene WO 01/16344
Modified adenoviral fibers
Modified adenoviral fibers; for changing the tropism of gene therapy vectors.
Tufts Univ. WO 01/16301
Peptidase apoptosis modulation
Quiescent cell dipeptidyl peptidase expressed in T cells and neurons that prevents cell death; for apoptosis modulation.
U.S. Army Med. Res. Inst. WO 01/16183
Ebola virus vaccines
Monoclonal antibodies against Ebola virus glycoprotein epitopes; for vaccines.
Utah, Univ. of WO 01/16154
Salt Lake City
Variants of the T/C(67)AGT gene; for determining predisposition to hypertension.
Whitehead Inst. Biomed. Res. WO 01/16378
Chromosome-wide analysis of protein-DNA interactions using methods to covalently link DNA binding proteins.
Wistar Inst. Anatomy & Biol. WO 01/16158
Bridging integrator-2 gene
Bridging integrator-2 gene sequences, encoded protein; for developing liver carcinoma therapeutics.
Yeda Res. & Develop. WO 01/16314
TRAF binding protein
IREN, a TRAF binding protein, encoding gene sequences; for treating diseases associated with NF-kappaB induction.
Yeda Res. & Develop. WO 01/16366
Template-dependent nucleic acid polymerization using oligonucleotide triphosphate building blocks.