February 21 (GB), February 21 & 28 (EP), February 15 & 22 (WO)
Abbott Labs WO 01/11033
Abbott Park, Ill.
Genome scanning of the Haemophilus influenzae genome to identify essential genes; for developing therapeutics.
Academia Sinica EP 1 078 988
Fusion polypeptide with Pseudomonas binding and antigenic moieties and a translocation domain; for vaccines.
Affymetrix WO 01/11082
Gene expression profiling
Santa Clara, Calif.
Methods for gene expression monitoring using probe arrays; for expression profiling.
Agrivax WO 01/11960
Mucosal therapeutic delivery
Mucosal nucleic acid delivery system based on purified recombinant bacterial exotoxin protein variants.
Alabama, Univ. of WO 01/11013
Smad6-Hox gene interaction in nuclear transcriptional regulation after BMP signal transduction; for osteoporosis.
Alabama, Univ. of WO 01/11084
IL-10 gene polymorphisms
Identification of polymorphisms in the interleukin-10 gene; for diagnosing susceptibility to autoimmune disease.
Amgen WO 01/10908
TNF receptor family gene
Thousand Oaks, Calif.
TNF receptor superfamily gene NTR3, encoded protein, antibodies; for designing therapeutics.
Amgen WO 01/11050
TNF ligand superfamily gene
Thousand Oaks, Calif.
TNF ligand superfamily gene, encoded protein, antibodies; for diagnostics and therapeutics.
Arkansas, Univ. of WO 01/11067
Dendritic cell gene therapy
Little Rock, Ark.
Dendritic cells transduced with adeno-associated virus vectors having inserted therapeutic genes.
Baxter WO 01/11021
Protein production cells
Stable cell lines grown in serum- and protein-free medium; for transfection and recombinant protein production.
Bayer WO 01/11047
Colon cancer genes
E. Walpole, Mass.
Colon epithelial cells growth control genes differentially regulated in cancer; for diagnostics and modulator screens.
Bilatec WO 01/10554
Automated DNA isolation
Laboratory robot and related methods for isolating nucleic acids from samples.
Biochemie WO 01/11056 & 11057
Bacterial protein production system
Production of homogeneous heterologous proteins in bacteria using endogenous autoproteolytic cleavage.
Boehringer Ingelheim WO 01/11040
Tumor-associated antigens, immunogenic peptides, encoding gene sequences; for cancer therapeutics.
British Defense Dept. WO 01/11078
Target DNA detection
Amplification methods for detecting target nucleic acids involving fluorescence energy transfer.
Catholic Univ. WO 01/11038
Vascular disease therapeutics
Modulators of the cholesterol-caveolin 1-nitric oxide synthase pathway; for vascular disease therapeutics.
Celltech Chiroscience WO 01/11069
Gene delivery complexes
Freeze-thawed lipid complexes containing nucleic acids; for cell transfection.
Chugai Res. Inst. Molec. Med. EP 1 077 219
Testicular transcriptional regulators
Bromodomain proteins from testicular cDNA libraries for use as transcriptional regulatory factors.
Chugai Res. Inst. Molec. Med. WO 01/10905
Vascular smooth muscle protein
LKB1 protein that is highly expressed in vascular smooth muscle cells, encoded protein; for modulating muscle.
Cleveland Clinic Fdn. WO 01/11074
Zinc metalloproteases with thrombospondin type I moieties, encoding gene sequences, antisense; for therapeutics.
Compugen WO 01/11079
Nucleic acid analysis
Tel Aviv, Israel
Method and system for nucleic acid analysis in which at least one probe can hybridize to multiple targets.
CuraGen WO 01/10902
New Haven, Conn.
PROX protein, encoding gene sequences, antibodies, variants, mutants, fragments; for diagnostics and therapeutics.
Digital Biotech WO 01/11045
Lactoferrin production system
Seoul, S. Korea
Human lactoferrin made in an insect cell production system; for bacterial infection diagnostics.
Exact Labs WO 01/11083
Polynucleotide repeat deletions
Detecting deletions in regions of polynucleotide repeats using primer extension methods.
Fuji Photo Film EP 1 077 264
DNA and protein-nucleic acid chips having hydrophilic spacer molecules separating nucleic acid probes.
Furcht, L.T., et al. WO 01/11011
Adult stem cells
Isolated multipotent non-embryonic stem cells that can form cells of multiple tissue types.
Genaissance Pharma WO 01/10884
New Haven, Conn.
Polymorphisms in the 5-hydroxytryptamine receptor 1A gene; for genotyping and designing neural system therapeutics.
Genaissance Pharma WO 01/11010
IgE receptor subunit SNPs
New Haven, Conn.
Polymorphisms in the immunoglobulin E receptor Ia subunit gene; for genotyping and designing immunotherapeutics.
Genoplex WO 01/11088
Evolutionarily significant gene changes
Methods for identifying evolutionarily significant changes in polynucleotide and polypeptide sequences.
GenVec WO 01/11087
Gene transfer vector interactions
Evaluation of gene transfer vector interactions with binding proteins by charged fragment detection.
Glaxo Wellcome WO 01/11027
Tres Cantos, Spain
Human lambda interaction proteins that activate NF-KappaB, encoding genes, antibodies; for modulating transcription.
Harvard WO 01/12126
Cardiac helix-loop-helix factor polypeptide, encoding gene sequences; for cardiomyocyte proliferation.
Hepavec WO 01/11030
Liver cell lines
Inducing cell replication without genomic changes in non-dividing cells; for making liver cells with prolonged lives.
Hepavec WO 01/11063
Cancer gene therapy
Combination vectors containing several expressible therapeutic genes; for cancer gene therapy.
Hepavec WO 01/11066
Non-human adenoviral vectors
Non-human adenoviral vectors suited for gene transfer into muscle cells; for vaccines.
Hoffmann-La Roche EP 1 077 262 & 263
Naturally folded proteins
Production of naturally folded and secreted proteins by co-secretion of molecular chaperones [in German].
Hoffmann-La Roche GB 2 353 281
Polyethylene glycol conjugates of erythropoietin and derivatives with additional glycosylation sites.
Human Genome Sciences WO 01/11046
Dendritic-enriched secreted lymphocyte activation protein, encoding gene, antibodies; for developing therapeutics.
Hygene WO 01/11041
TGF-_ family proteins made monomeric by cysteine deletion or substitution, encoding gene sequences; for therapeutics.
Hyseq WO 01/10205
CD39-like genes found in cDNA libraries from fetal tissue, encoded proteins, antibodies.
Idexx Labs WO 01/11049
Dog interleukin-5, encoding gene sequences, conservative variants, production methods; for developing therapeutics.
Incyte Genomics WO 01/10903
Palo Alto, Calif.
Human proteases and protease inhibitors, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 01/11032
Palo Alto, Calif.
Secretory protein genes, encoded proteins, fragments; for isolating antibodies and modulators.
Intl. School Advanced Studies WO 01/10203
Transgenics expressing an anti-NGF antibody; for studying neurodegenerative syndromes.
Itoh, K., et al. WO 01/11044
Tumor cytotoxic T cells
Tumor antigen peptide that induces HLA-A24/A2 cytotoxic T cells, encoding gene, antibodies; for modulator screens.
Ivigene WO 01/11081
Essential microbe genes
Identification of genes expressed by microbes in vivo; for finding genes associated with infection.
Jackson Fdn. Military Med. WO 01/10199
Tumor suppressor modulator screen
Transgenic knockout mice with a non-functional allele of the tumor suppressor gene annexin VII; for modulator screens.
Kirin WO 01/11951
Transgenic mice having a human cytochrome P450 transgene; for studying toxin metabolism.
Krebs Res. Ctr. EP 1 077 260 & WO 01/12666
Parvovirus NS1 variants having greater cytotoxic than replication activity, antibodies to encoded protein.
Krebs Res. Ctr. WO 01/11059
CD16 receptor-binding antibody
Fv antibody construct that has binding sites for the CD16 receptor and the CD30 surface protein, encoding gene.
Lausanne, Univ. of WO 01/11037
Regulated transgene expression
Controlling transgene transcription using chimeric activators and repressors; for regulated expression.
Lexigen Pharma WO 01/10912
Protein complexes and fusions having two cytokine molecules and an antibody targeting moiety; for therapeutics.
LION Bioscience WO 01/11051
Nucleic acid synthesis chimera
Recombinant chimeric protein having nucleic acid synthesis and interaction mediating domains.
Maryland, Univ. of WO 01/11012
Human melanoma-associated gene H11, encoded protein; for cancer diagnostics and therapeutics.
Maryland, Univ. of, Biotech. Inst. WO 01/10907 & 11048
Pregnancy urine proteins
Synthetic versions of proteins isolated from early human pregnancy urine; for developing therapeutics.
Mass. Inst. Technol. WO 01/10883
Cell death gene
Cell death gene that is downstream of p53 in the p53-dependent apoptosis pathway; for developing therapeutics.
Max Delbruck Ctr. Molec. Med. WO 01/11039
Heart disease SNPs
Sequence variants of the human _1-adrenoreceptor genes; for heart disease diagnostics.
MRC (Med. Res. Counc.) WO 01/11042
Phosphorylated protein interactors
Polypeptide with PH/H2 domains that interact with tyrosine-phosphorylated proteins; for developing therapeutics.
Merck WO 01/11035
Monoclonal antibodies to human cytochromes P450 3A4 and 2C9; for assessing cytochrome influence on metabolism.
Merlin EP 1 077 265
Use of probes for bacterial gyrA, B, and C genes for diagnostic genotyping [in German].
Miyahara, T., et al. WO 01/11351
Gene SNP detection
Electrochemically based methods for detecting point mutations and single nucleotide polymorphisms in genes.
Mochida Pharma EP 1 077 069
Fas antagonists for cirrhosis
Use of Fas antagonists to treat hepatic cirrhosis and bile duct disappearance syndrome.
NIH (Natl. Inst. Hlth.) WO 01/11065
Hepatitis A vaccines
Hepatitis virus A clones adapted for growth in African green monkey cells; for making vaccines.
Navarra Inst. Sci. & Technol. EP 1 077 068
IFN-a5 for hepatitis C
Utilization of interferon-a5 in the treatment of hepatitis C virus-induced liver pathology.
North Carolina State Univ. WO 01/11019
Bird embryonic stem cells
Collecting primordial germ cells from birds after primitive streak formation; for embryonic stem cell culture.
Novozymes WO 01/11969
Enzymatic microbe killing
Enzymatic method for killing microbes at high pH using a haloperoxidase and hydrogen peroxide and halogen sources.
Ono Pharma EP 1 077 259
Proteins with hematopoiesis-regulating activity, encoding gene sequences; for developing therapeutics.
Paris North, Univ. of WO 01/11068
Gene delivery complexes
Cationic lipid complexes useful for delivering genes into cells; for cancer therapy.
Pasteur Inst. WO 01/11064
Stimulating heart gene transcription
Polynucleotide sequence that stimulates transcription in heart cells; for gene expression activation.
Pennsylvania, Univ. of WO 01/12207
Elongated neural cells
Mechanically elongated neural cells, methods of production; for treating spinal cord and other nerve injuries.
Pharmacia & Upjohn WO 01/10906
Structure determination of Staphylococcus aureus elongation factor P crystals; for designing antibacterials.
Pharmacia & Upjohn WO 01/11053
Monoamine oxidase B
Soluble, active recombinant mitochondrial monoamine oxidase B; for modulator screens.
Pharmacia & Upjohn WO 01/11054
Staphyloccus antibacterial design
Staphylococcus aureus MurB crystals; for structure determination and inhibitor design.
Pittsburgh, Univ. of WO 01/11031
Pancreatic _ cell transplants
Transfection of genes encoding IL-1_ signal transduction inhibitors into pancreatic _ cells; for transplantation.
Res. Develop. Fdn. WO 01/11028
Cryptococcus infection therapeutics
Carson City, Nev.
Cryptococcus neoformans glucuronoxylomannan acetylhydrolase, encoding gene; for developing infection therapeutics.
Santa Coloma, T.A. EP 1 078 992
Buenos Aires, Argentina
Synthetic oligonucleotide-based antibody-like reagents that have activities like polyclonal and monoclonal antibodies.
Searle WO 01/11026
Cyclooxygenase-1 and -2 from dogs, encoding gene sequences, homologs, fragments; for designing human therapeutics.
SmithKline Beecham WO 01/10904 & 11970
Bacterial map and yloV polypeptides, encoding genes, production methods; for antibacterial screens.
SmithKline Beecham WO 01/11022
G protein-coupled receptor EDG3
Mouse G protein-coupled receptor EDG3, encoding gene; for screening modulators for human disease therapeutics.
Spectral Diagnostics WO 01/11043
Troponin antibody production
Single-chain polypeptides derived from troponin I N-terminal fragments and troponin C; for making antibodies.
Stem Cell Therapeutics WO 01/12127
TGF-a functional fragments
TGF-a polypeptide functional fragments, mimetics; for stimulating stem cell proliferation and differentiation.
Sumitomo Electric EP 1 077 258
Hepatic cancer-expressed gene
Human HRP1 gene expressed in hepatic cancer, encoded protein, antibodies; for regulating cell division.
Takeda Chemical WO 01/11533
Recording gene analysis data
Optical methods for recording gene analysis data; for comparing sequences to find variations.
Tanabe EP 1 078 987
CNS disease therapeutic screen
Assay for modulators of expression of a splicing variant of the presenilin-2 gene; for developing CNS therapeutics.
Targeted Genetics WO 01/11034
Increased gene expression
Adenoviral vectors with heterologous genes in which intrastrand base pairing occurs; for increased expression.
Tosk WO 01/10204
Metastatic tumor transgenics
Santa Cruz, Calif.
Transgenics that spontaneously produce metastatic tumors; for cancer therapeutic screens.
Tosoh EP 1 078 986
Recombinant soluble thyroid stimulating hormone receptor; for measuring autoantibodies.
U.S. Transgenics WO 01/11952
Transgenic mammals that express prothrombin in their milk; for production of hemostasis therapeutics.
Wisconsin, Univ. of WO 01/11018
Making bird transgenics
Primordial germ and blastodermal cells from birds, culture methods; for making transgenics.
Zen Bio EP 1 077 253
Stromal cells for cartilage
Research Triangle Park, N.C.
Adipose tissue-derived stromal cells for differentiation into chondrocytes to repair cartilage.
Zen Bio EP 1 077 254
Stromal cells for myocytes
Research Triangle Park, N.C.
Adipose tissue-derived stromal cells for differentiation into hematopoietic supporting cells and myocytes.