February 21 (GB), February 21 & 28 (EP), February 15 & 22 (WO)

Abbott Labs WO 01/11033

Antibacterial development

Abbott Park, Ill.

Genome scanning of the Haemophilus influenzae genome to identify essential genes; for developing therapeutics.

Academia Sinica EP 1 078 988

Pseudomonas vaccines

Taipei, Taiwan

Fusion polypeptide with Pseudomonas binding and antigenic moieties and a translocation domain; for vaccines.

Affymetrix WO 01/11082

Gene expression profiling

Santa Clara, Calif.

Methods for gene expression monitoring using probe arrays; for expression profiling.

Agrivax WO 01/11960

Mucosal therapeutic delivery

Los Angeles

Mucosal nucleic acid delivery system based on purified recombinant bacterial exotoxin protein variants.

Alabama, Univ. of WO 01/11013

Osteoporosis control

Birmingham, Ala.

Smad6-Hox gene interaction in nuclear transcriptional regulation after BMP signal transduction; for osteoporosis.

Alabama, Univ. of WO 01/11084

IL-10 gene polymorphisms

Birmingham, Ala.

Identification of polymorphisms in the interleukin-10 gene; for diagnosing susceptibility to autoimmune disease.

Amgen WO 01/10908

TNF receptor family gene

Thousand Oaks, Calif.

TNF receptor superfamily gene NTR3, encoded protein, antibodies; for designing therapeutics.

Amgen WO 01/11050

TNF ligand superfamily gene

Thousand Oaks, Calif.

TNF ligand superfamily gene, encoded protein, antibodies; for diagnostics and therapeutics.

Arkansas, Univ. of WO 01/11067

Dendritic cell gene therapy

Little Rock, Ark.

Dendritic cells transduced with adeno-associated virus vectors having inserted therapeutic genes.

Baxter WO 01/11021

Protein production cells

Vienna, Austria

Stable cell lines grown in serum- and protein-free medium; for transfection and recombinant protein production.

Bayer WO 01/11047

Colon cancer genes

E. Walpole, Mass.

Colon epithelial cells growth control genes differentially regulated in cancer; for diagnostics and modulator screens.

Bilatec WO 01/10554

Automated DNA isolation

Rudolstadt, Germany

Laboratory robot and related methods for isolating nucleic acids from samples.

Biochemie WO 01/11056 & 11057

Bacterial protein production system

Kundl, Austria

Production of homogeneous heterologous proteins in bacteria using endogenous autoproteolytic cleavage.

Boehringer Ingelheim WO 01/11040

Tumor-associated antigens

Ingelheim, Germany

Tumor-associated antigens, immunogenic peptides, encoding gene sequences; for cancer therapeutics.

British Defense Dept. WO 01/11078

Target DNA detection

Farnborough, UK

Amplification methods for detecting target nucleic acids involving fluorescence energy transfer.

Catholic Univ. WO 01/11038

Vascular disease therapeutics

Louvain, Belgium

Modulators of the cholesterol-caveolin 1-nitric oxide synthase pathway; for vascular disease therapeutics.

Celltech Chiroscience WO 01/11069

Gene delivery complexes

Slough, UK

Freeze-thawed lipid complexes containing nucleic acids; for cell transfection.

Chugai Res. Inst. Molec. Med. EP 1 077 219

Testicular transcriptional regulators

Nihari, Japan

Bromodomain proteins from testicular cDNA libraries for use as transcriptional regulatory factors.

Chugai Res. Inst. Molec. Med. WO 01/10905

Vascular smooth muscle protein

Nihari, Japan

LKB1 protein that is highly expressed in vascular smooth muscle cells, encoded protein; for modulating muscle.

Cleveland Clinic Fdn. WO 01/11074

Zinc metalloproteases

Cleveland

Zinc metalloproteases with thrombospondin type I moieties, encoding gene sequences, antisense; for therapeutics.

Compugen WO 01/11079

Nucleic acid analysis

Tel Aviv, Israel

Method and system for nucleic acid analysis in which at least one probe can hybridize to multiple targets.

CuraGen WO 01/10902

PROX protein

New Haven, Conn.

PROX protein, encoding gene sequences, antibodies, variants, mutants, fragments; for diagnostics and therapeutics.

Digital Biotech WO 01/11045

Lactoferrin production system

Seoul, S. Korea

Human lactoferrin made in an insect cell production system; for bacterial infection diagnostics.

Exact Labs WO 01/11083

Polynucleotide repeat deletions

Maynard, Mass.

Detecting deletions in regions of polynucleotide repeats using primer extension methods.

Fuji Photo Film EP 1 077 264

DNA chips

Kanagawa, Japan

DNA and protein-nucleic acid chips having hydrophilic spacer molecules separating nucleic acid probes.

Furcht, L.T., et al. WO 01/11011

Adult stem cells

Minneapolis, Minn.

Isolated multipotent non-embryonic stem cells that can form cells of multiple tissue types.

Genaissance Pharma WO 01/10884

5-HT SNPs

New Haven, Conn.

Polymorphisms in the 5-hydroxytryptamine receptor 1A gene; for genotyping and designing neural system therapeutics.

Genaissance Pharma WO 01/11010

IgE receptor subunit SNPs

New Haven, Conn.

Polymorphisms in the immunoglobulin E receptor Ia subunit gene; for genotyping and designing immunotherapeutics.

Genoplex WO 01/11088

Evolutionarily significant gene changes

Denver

Methods for identifying evolutionarily significant changes in polynucleotide and polypeptide sequences.

GenVec WO 01/11087

Gene transfer vector interactions

Gaithersburg, Md.

Evaluation of gene transfer vector interactions with binding proteins by charged fragment detection.

Glaxo Wellcome WO 01/11027

Transcription modulation

Tres Cantos, Spain

Human lambda interaction proteins that activate NF-KappaB, encoding genes, antibodies; for modulating transcription.

Harvard WO 01/12126

Cardiomyocyte regeneration

Cambridge, Mass.

Cardiac helix-loop-helix factor polypeptide, encoding gene sequences; for cardiomyocyte proliferation.

Hepavec WO 01/11030

Liver cell lines

Berlin

Inducing cell replication without genomic changes in non-dividing cells; for making liver cells with prolonged lives.

Hepavec WO 01/11063

Cancer gene therapy

Berlin

Combination vectors containing several expressible therapeutic genes; for cancer gene therapy.

Hepavec WO 01/11066

Non-human adenoviral vectors

Berlin

Non-human adenoviral vectors suited for gene transfer into muscle cells; for vaccines.

Hoffmann-La Roche EP 1 077 262 & 263

Naturally folded proteins

Basel, Switzerland

Production of naturally folded and secreted proteins by co-secretion of molecular chaperones [in German].

Hoffmann-La Roche GB 2 353 281

PEG-conjugated EPO

Basel, Switzerland

Polyethylene glycol conjugates of erythropoietin and derivatives with additional glycosylation sites.

Human Genome Sciences WO 01/11046

Lymphocyte activator

Rockville, Md.

Dendritic-enriched secreted lymphocyte activation protein, encoding gene, antibodies; for developing therapeutics.

Hygene WO 01/11041

Monomeric TGF-_

Rheinfall, Germany

TGF-_ family proteins made monomeric by cysteine deletion or substitution, encoding gene sequences; for therapeutics.

Hyseq WO 01/10205

CD39-like genes

Sunnyvale, Calif.

CD39-like genes found in cDNA libraries from fetal tissue, encoded proteins, antibodies.

Idexx Labs WO 01/11049

Dog IL-5

Westbrook, Maine

Dog interleukin-5, encoding gene sequences, conservative variants, production methods; for developing therapeutics.

Incyte Genomics WO 01/10903

Proteases

Palo Alto, Calif.

Human proteases and protease inhibitors, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 01/11032

Secretory proteins

Palo Alto, Calif.

Secretory protein genes, encoded proteins, fragments; for isolating antibodies and modulators.

Intl. School Advanced Studies WO 01/10203

Neurodegeneration transgenics

Trieste, Italy

Transgenics expressing an anti-NGF antibody; for studying neurodegenerative syndromes.

Itoh, K., et al. WO 01/11044

Tumor cytotoxic T cells

Saga, Japan

Tumor antigen peptide that induces HLA-A24/A2 cytotoxic T cells, encoding gene, antibodies; for modulator screens.

Ivigene WO 01/11081

Essential microbe genes

Alachua, Fla.

Identification of genes expressed by microbes in vivo; for finding genes associated with infection.

Jackson Fdn. Military Med. WO 01/10199

Tumor suppressor modulator screen

Rockville, Md.

Transgenic knockout mice with a non-functional allele of the tumor suppressor gene annexin VII; for modulator screens.

Kirin WO 01/11951

Cytochrome transgenics

Tokyo

Transgenic mice having a human cytochrome P450 transgene; for studying toxin metabolism.

Krebs Res. Ctr. EP 1 077 260 & WO 01/12666

Parvovirus variants

Heidelberg, Germany

Parvovirus NS1 variants having greater cytotoxic than replication activity, antibodies to encoded protein.

Krebs Res. Ctr. WO 01/11059

CD16 receptor-binding antibody

Heidelberg, Germany

Fv antibody construct that has binding sites for the CD16 receptor and the CD30 surface protein, encoding gene.

Lausanne, Univ. of WO 01/11037

Regulated transgene expression

Lausanne, Switzerland

Controlling transgene transcription using chimeric activators and repressors; for regulated expression.

Lexigen Pharma WO 01/10912

Cytokine-antibody complexes

Lexington, Mass.

Protein complexes and fusions having two cytokine molecules and an antibody targeting moiety; for therapeutics.

LION Bioscience WO 01/11051

Nucleic acid synthesis chimera

Heidelberg, Germany

Recombinant chimeric protein having nucleic acid synthesis and interaction mediating domains.

Maryland, Univ. of WO 01/11012

Melanoma-associated gene

Baltimore

Human melanoma-associated gene H11, encoded protein; for cancer diagnostics and therapeutics.

Maryland, Univ. of, Biotech. Inst. WO 01/10907 & 11048

Pregnancy urine proteins

Baltimore

Synthetic versions of proteins isolated from early human pregnancy urine; for developing therapeutics.

Mass. Inst. Technol. WO 01/10883

Cell death gene

Cambridge, Mass.

Cell death gene that is downstream of p53 in the p53-dependent apoptosis pathway; for developing therapeutics.

Max Delbruck Ctr. Molec. Med. WO 01/11039

Heart disease SNPs

Berlin

Sequence variants of the human _1-adrenoreceptor genes; for heart disease diagnostics.

MRC (Med. Res. Counc.) WO 01/11042

Phosphorylated protein interactors

London

Polypeptide with PH/H2 domains that interact with tyrosine-phosphorylated proteins; for developing therapeutics.

Merck WO 01/11035

Cytochrome antibodies

Rahway, N.J.

Monoclonal antibodies to human cytochromes P450 3A4 and 2C9; for assessing cytochrome influence on metabolism.

Merlin EP 1 077 265

Bacterial genotyping

Bornheim, Germany

Use of probes for bacterial gyrA, B, and C genes for diagnostic genotyping [in German].

Miyahara, T., et al. WO 01/11351

Gene SNP detection

Chiba, Japan

Electrochemically based methods for detecting point mutations and single nucleotide polymorphisms in genes.

Mochida Pharma EP 1 077 069

Fas antagonists for cirrhosis

Tokyo

Use of Fas antagonists to treat hepatic cirrhosis and bile duct disappearance syndrome.

NIH (Natl. Inst. Hlth.) WO 01/11065

Hepatitis A vaccines

Bethesda, Md.

Hepatitis virus A clones adapted for growth in African green monkey cells; for making vaccines.

Navarra Inst. Sci. & Technol. EP 1 077 068

IFN-a5 for hepatitis C

Pamplona, Spain

Utilization of interferon-a5 in the treatment of hepatitis C virus-induced liver pathology.

North Carolina State Univ. WO 01/11019

Bird embryonic stem cells

Raleigh, N.C.

Collecting primordial germ cells from birds after primitive streak formation; for embryonic stem cell culture.

Novozymes WO 01/11969

Enzymatic microbe killing

Bagsvaerd, Denmark

Enzymatic method for killing microbes at high pH using a haloperoxidase and hydrogen peroxide and halogen sources.

Ono Pharma EP 1 077 259

Hematopoiesis regulation

Osaka, Japan

Proteins with hematopoiesis-regulating activity, encoding gene sequences; for developing therapeutics.

Paris North, Univ. of WO 01/11068

Gene delivery complexes

Villetaneuse, France

Cationic lipid complexes useful for delivering genes into cells; for cancer therapy.

Pasteur Inst. WO 01/11064

Stimulating heart gene transcription

Paris

Polynucleotide sequence that stimulates transcription in heart cells; for gene expression activation.

Pennsylvania, Univ. of WO 01/12207

Elongated neural cells

Philadelphia

Mechanically elongated neural cells, methods of production; for treating spinal cord and other nerve injuries.

Pharmacia & Upjohn WO 01/10906

Staphylococcus antibacterials

Kalamazoo, Mich.

Structure determination of Staphylococcus aureus elongation factor P crystals; for designing antibacterials.

Pharmacia & Upjohn WO 01/11053

Monoamine oxidase B

Kalamazoo, Mich.

Soluble, active recombinant mitochondrial monoamine oxidase B; for modulator screens.

Pharmacia & Upjohn WO 01/11054

Staphyloccus antibacterial design

Kalamazoo, Mich.

Staphylococcus aureus MurB crystals; for structure determination and inhibitor design.

Pittsburgh, Univ. of WO 01/11031

Pancreatic _ cell transplants

Pittsburgh

Transfection of genes encoding IL-1_ signal transduction inhibitors into pancreatic _ cells; for transplantation.

Res. Develop. Fdn. WO 01/11028

Cryptococcus infection therapeutics

Carson City, Nev.

Cryptococcus neoformans glucuronoxylomannan acetylhydrolase, encoding gene; for developing infection therapeutics.

Santa Coloma, T.A. EP 1 078 992

Oligobodies

Buenos Aires, Argentina

Synthetic oligonucleotide-based antibody-like reagents that have activities like polyclonal and monoclonal antibodies.

Searle WO 01/11026

Dog COX-1/2

Chicago

Cyclooxygenase-1 and -2 from dogs, encoding gene sequences, homologs, fragments; for designing human therapeutics.

SmithKline Beecham WO 01/10904 & 11970

Antibacterial screen

Philadelphia

Bacterial map and yloV polypeptides, encoding genes, production methods; for antibacterial screens.

SmithKline Beecham WO 01/11022

G protein-coupled receptor EDG3

Philadelphia

Mouse G protein-coupled receptor EDG3, encoding gene; for screening modulators for human disease therapeutics.

Spectral Diagnostics WO 01/11043

Troponin antibody production

Toronto

Single-chain polypeptides derived from troponin I N-terminal fragments and troponin C; for making antibodies.

Stem Cell Therapeutics WO 01/12127

TGF-a functional fragments

Seattle

TGF-a polypeptide functional fragments, mimetics; for stimulating stem cell proliferation and differentiation.

Sumitomo Electric EP 1 077 258

Hepatic cancer-expressed gene

Osaka, Japan

Human HRP1 gene expressed in hepatic cancer, encoded protein, antibodies; for regulating cell division.

Takeda Chemical WO 01/11533

Recording gene analysis data

Osaka, Japan

Optical methods for recording gene analysis data; for comparing sequences to find variations.

Tanabe EP 1 078 987

CNS disease therapeutic screen

Osaka, Japan

Assay for modulators of expression of a splicing variant of the presenilin-2 gene; for developing CNS therapeutics.

Targeted Genetics WO 01/11034

Increased gene expression

Seattle

Adenoviral vectors with heterologous genes in which intrastrand base pairing occurs; for increased expression.

Tosk WO 01/10204

Metastatic tumor transgenics

Santa Cruz, Calif.

Transgenics that spontaneously produce metastatic tumors; for cancer therapeutic screens.

Tosoh EP 1 078 986

TSH receptor

Shinnanyo, Japan

Recombinant soluble thyroid stimulating hormone receptor; for measuring autoantibodies.

U.S. Transgenics WO 01/11952

Prothrombin transgenics

Washington

Transgenic mammals that express prothrombin in their milk; for production of hemostasis therapeutics.

Wisconsin, Univ. of WO 01/11018

Making bird transgenics

Madison, Wis.

Primordial germ and blastodermal cells from birds, culture methods; for making transgenics.

Zen Bio EP 1 077 253

Stromal cells for cartilage

Research Triangle Park, N.C.

Adipose tissue-derived stromal cells for differentiation into chondrocytes to repair cartilage.

Zen Bio EP 1 077 254

Stromal cells for myocytes

Research Triangle Park, N.C.

Adipose tissue-derived stromal cells for differentiation into hematopoietic supporting cells and myocytes.