Anemia associated with chronic liver failure (9/01)
Amgen Inc.
Kineret
Amgen Inc.
Rheumatoid arthritis (11/01)
Celgene Corp.
Focalin
Novartis Pharmaceuticals Corp.
Attention deficit/hyperactivity disorder (11/01)
Celltech Pharmaceuticals Inc.
Metadate CD
Celltech Pharmaceuticals Inc.
Attention deficit hyperactivity disorder (4/01)
Centocor Inc.
Remicade
ND
For use in conjunction with methotrexate to inhibit the progression of damage in patients with moderately to severely active rheumatoid arthritis (1/01)
CollaGenex Pharmaceuticals Inc.
Periostat
ND
For the treatment of adult periodontitis in a new tablet formulation (2/01)
Curis Inc.
OP-1
Stryker Corp.
To repair and regenerate tissue (10/01)
Debiopharm SA (Switzerland)
Trelstar LA
Debiopharm SA
Advanced-stage prostate cancer (7/01)
Eli Lilly & Co.
Xigris
Eli Lilly & Co.
Sepsis (11/01)
Enzon Inc.
Peg-Intron
Schering-Plough Corp.
Chronic hepatitis C (1/01)
Enzon Inc.
Rebetol
Schering-Plough Corp.
To be used in combination with Intron A injection for chronic hepatitis C (7/01)
Gilead Sciences Inc.
Viread
Gilead Sciences Inc.
HIV (10/01)
Genentech Inc.
Cathflo Activase
Genentech Inc.
For use in breaking down clots in central venous catheters (9/01)
Genentech Inc. and IDEC Pharmaceuticals Corp.
Rituxan
Genentech Inc. and IDEC Pharmaceuticals Corp.
For retreatment after a prior course of Rituxan therapy, doubling of infusions and treatment of bulky disease, or tumors greater than 10 centimeters, for patients with relapsed or refractory, low-grade or follicular, CD20-positive B-cell non-Hodgkin's lymphoma (5/01)
ILEX Oncology Inc. and Millennium Pharmaceuticals Inc.
Campath
Berlex Laboratories Inc.
Leukemia (5/01)
Nycomed Amersham plc (UK)
EchoSeed
Nycomed Amersham plc
Prostate cancer (6/01)
OraPharma Inc.
Arestin
ND
Adjunct treatment for periodontitis following scaling and root planing (2/01)
Ortec International Inc.
Composite cultured skin
ND
For use in patients with recessive dystrophic epidermolysis bullosa undergoing hand reconstruction surgery; also for covering donor sites (2/01)
Ortec International Inc.
OrCel
Ortec International Inc.
For healing donor site wounds in burn victims (9/01)
Protherics plc (UK)
DigiFab
Protherics plc
Digoxin toxicity (9/01)
QLT Inc.
Visudyne
Novartis Ophthalmics
The form of class subfoveal choroidal neovascularization that occurs in people 30 and older (8/01)
Serono SA (Switzerland)
Gonal-F
ND
Multi-dose for infertility (3/01)
Scios Inc.
Natrecor
Scios Inc.
Acute congestive heart failure (8/01)
SuperGen Inc.
Daunorubicin
SuperGen Inc.
Acute leukemia (11/01)
Vernalis Group plc
Frovatriptan
Elan Corp. plc
For the acute treatment of migraine (11/01)
Visible Genetics Inc.
TruGene HIV-1 Genotyping Kit and OpenGene DNA Sequencing System
Visible Genetics Inc.
To analyze genetic information of AIDS patients so doctors can prescribe individual drug therapies (9/01)
Vysis Inc.
UroVysion
Vysis Inc.
Monitoring recurrence of bladder cancer (8/01)
BIOTECH PRODUCTS 1982-2000 A-Z
Company
Product
Marketer
Indication (U.S. Approval Date)
Abbott Laboratories
HIVAG-1 monoclonal antibody
Abbott Laboratories
Diagnostic for use in blood banks and plasma centers, and for prognostic use in HIV patients (4/96)
Agouron Pharmaceuticals Inc.
Viracept
Glaxo Wellcome plc; Hoffmann-La Roche Ltd.
HIV protease inhibitor (3/97); twice-daily dosing for HIV(12/99)
Alpha Therapeutic Corp.
AlphaNine SD
Alpha Therapeutic Corp.
To prevent and control bleeding due to Factor IX deficiency associated with hemophilia B (7/96)
Second-line therapy for Kaposi's sarcoma in AIDS patients (11/95); refractory ovarian cancer (6/99)
Amgen Inc.
Neupogen
Hoffmann-La Roche Ltd.; Amgen; Kirin Brewery Co. Ltd. (Japan)
Chemotherapy-induced neutropenia (2/91); bone marrow transplant (6/94); severe chronic neutropenia (12/94); support peripheralblood progenitor cell transplantation(12/95); acute myelogenous leukemia (4/98)
Amgen Inc.
Epogen
Amgen Inc.
Treatment of anemia associated with chronic renal failure and anemia in Retrovir-treated HIV-infected patients (6/89); anemia caused by chemotherapy in patients with nonmyeloid malignancies (4/93)
Amgen Inc.
Procrit (EPO)
Ortho Biotech
Treatment of anemia in AZT-treated HIV-infected patients (12/90); anemia in cancer patients on chemotherapy (4/93); for use in anemic patients scheduled to undergo elective noncardiac, nonvascular surgery (12/96); anemia in children with chronic renal failure who are undergoing dialysis (11/99)
Amgen Inc.
Infergen
Amgen Inc.; Yamanouchi Pharmaceutical Co. Ltd.
Consensus alpha interferon for hepatitis C (10/97)
Athena Neurosciences Inc.
Zanaflex
Athena Neurosciences Inc.
Spasticity associated with spinal cord injuries and multiple sclerosis (12/96)
Atrix Laboratories Inc.
Atrisorb Barrier
Block Drug Co.
Periodontal disease (3/96); periodontal surgery (9/00)
Aventis Pharmaceuticals
Lantus
Aventis
Long-acting, once-daily form of insulin glargine (rDNA origin) injection for adults with Type II diabetes and children with Type I (4/00)
Bayer Corp.
Kogenate FS Antihemophilic Factor
Bayer
Recombinant Factor VIII for the treatment of hemophilia A (6/00)
Berlex Laboratories Inc.
BLU-U
Berlex Laboratories Inc.
Non-hyperkeratonic actinic keratoses of the face or scalp (9/00)
BioChem Pharma Inc.
3TC (Epivir)
Glaxo Wellcome plc
In combination with AZT for HIV infection and AIDS (11/95)
BioChem Pharma Inc.
Combivir
Glaxo Wellcome plc
Single-tablet formulation of 3TC and AZT for HIV (9/97)
BioChem Pharma Inc.
Trizivir
ND
HIV (11/00)
Biogen Inc.
Avonex
Biogen Inc.
Multiple sclerosis (5/96)
Biogen Inc.
Engerix-B
SmithKline Beecham plc
Hepatitis B vaccine (9/89); adults with chronic hepatitis C infection (8/98)
Biogen Inc.
Recombivax HB
Merck & Co. Inc.
Hepatitis B vaccine (7/86)
Biogen Inc.
Intron-A
Schering-Plough Corp.
Hairy cell leukemia (6/86); genital warts (6/88); AIDS-related Kaposi's sarcoma (11/88); hepatitis C (2/91); hepatitis B (7/92); adjuvant with surgery in those with high risk of malignant melanoma recurrence (12/95); low-grade non-Hodgkin's lymphoma (11/97); hepatitis B in pediatric patients (8/98)
Biomatrix Inc.
Synvisc
Wyeth-Ayerst Laboratories
Viscosupplementation treatment for arthritis of the knee (8/97)
Biota Holdings Ltd. (Australia)
Relenza
Glaxo Wellcome plc
Zanamivir for inhalation for treatment of influenza A and B (7/99)
Bio-Technology General Corp.
BioTropin
Cannot sell in U.S. due to court injunction
Human growth hormone deficiency in children (5/95)
Boehringer Ingelheim Pharmaceuticals Inc.
Viramune
Boehringer Ingelheim Pharmaceuticals Inc.
For use in combination with nucleoside analogues for treating HIV-infected adults (6/96)
Boehringer Mannheim Corp.
Retavase
Centocor Inc. (acquired marketing rights from Boehringer Mannheim Corp. and Dupont Merck Pharmaceuticals Corp. in 1998)
Thrombolytic agent for acute myocardial infarction (10/96)
CellPro Inc.
Ceprate SC System
CellPro Inc.
Separated cells returned to patient after chemotherapy or marrow-destroying procedures to restore bone marrow (12/96)
Celltech Group plc
Mylotarg
American Home Products Corp.; Wyeth-Ayerst Laboratories
Targeted chemotherapy agent to treat patients 60 years and older in first relapse with CD33-positive acute myeloid leukemia who are not considered candidates for cytotoxic chemotherapy (5/00)
Cell Therapeutics Inc.
Trisenox
Cell Therapeutics Inc.
Acute promyelocytic leukemia (9/00)
Centeon LLC
Bioclate
Centeon LLC
Treatment of hemophilia A for the prevention and control of hemorrhagic episodes; perioperative management of patients with hemophilia A (12/93)
Centeon LLC
Helixate
Centeon LLC
Treatment of hemophilia in which there is a deficiency of activity of Factor VIII (2/94)
Centeon LLC
Humate-P
Centeon LLC
Treatment of bleeding due to von Willebrand disease and treatment and prevention of bleeding episodes in hemophilia A patients (4/99)
Centocor Inc.
ReoPro
Eli Lilly & Co.
To inhibit platelet aggregation in high-risk angioplasty (12/94); prevention of blood flow stoppages to the heart in patients undergoing percutaneous coronary intervention and refractory unstable angina (11/97)
Treatment of metastatic bone disease in patients with breast cancer (8/96)
Chiron Vision
Vitrasert
Chiron Corp.
Cytomegalovirus retinitis infection in AIDS patients (3/96)
Connaught Laboratories Inc.
Tripedia
Connaught Laboratories Inc.
Vaccination of infants 2, 4 and 6 months of age and first booster at 15-20 months; primarily for whooping cough (7/96)
Connetics Corp.
Luxiq
Connetics Corp.
Relief of inflammatory and pruritic manifestations of corticoid-responsive dermatoses of the scalp (3/99)
Connetics Corp.
Olux
Connetics
Short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticoid-responsive dermatoses of the scalp (5/00)
COR Therapeutics Inc.
Integrilin
Schering-Plough Corp./ COR Therapeutics
Acute coronary syndrome and angioplasty (5/98)
Cypress Bioscience Inc. and Fresenius Hematology Inc.
Prosorba Column
Cypress Bioscience Inc.
Moderate to severe rheumatoid arthritis (3/99)
Cytogen Corp.
OncoScint CR/OV
CIB bio-International
Detection, staging and follow-up of colorectal and ovarian cancers (12/92)
Cytogen Corp.
ProstaScint
Cytogen Corp.
Diagnostic imaging of prostate cancer in newly diagnosed patients; also for use in post-prostatectomy patients suspected of having occult metastatic disease (10/96)
Cytogen Corp.
Quadramet
Cytogen Corp.
Radiopharmaceutical for pain associated with bone cancer (3/97)
Dendreon Corp.
DACS SC
Dendreon Corp.
Used to isolate cells for transplantation in cancer patients following chemotherapy or radiation (8/99)
DepoTech Corp. and Chiron Corp.
DepoCyt
Chiron Corp.
Lymphomatous meningitis (4/99)
Eli Lilly & Co.
Humalog
Eli Lilly & Co.
Diabetes (6/96)
Eli Lilly & Co.
Humatrope
Eli Lilly & Co.
Human growth hormone deficiency in children (3/87); somatotropin deficiency syndrome in adults (8/96)
Enzon Inc.
Adagen
Enzon Inc.
Treatment of infants and children with severe combined immunodeficiency (3/90)
Enzon Inc.
Oncaspar
Rhone-Poulenc Rorer Inc.
Acute lymphoblastic leukemia (2/94)
GelTex Pharmaceuticals Inc.
Renagel
Genzyme General
Reduction of serum phosphorus in patients with end-stage renal disease (11/98); reduction of serum phosphorus in hemodialysis patients with end-stage renal disease (7/00)
GelTex Pharmaceuticals Inc.
Welchol
Sankyo Parke Davis
Adjunctive therapy to diet and exercise for the reduction of low-density lipoprotein (LDL) cholesterol in patients with primary hypercholesterolemia (5/00)
Genentech Inc.
Roferon-A
F. Hoffmann-La Roche Ltd. (Switzerland)
Hairy cell leukemia (6/86); AIDS-related Kaposi's sarcoma, Philadelphia chromosome positive chronic myelogenous leukemia (11/88); chronic myelogenous leukemia and hepatitis C (10/95)
Genentech Inc.
Pulmozyme
Genentech Inc.
Cystic fibrosis (12/93); treatment of cystic fibrosis in severely ill patients (less than 40% lung function) (12/96); treatment of cystic fibrosis in infants and young children (3/98)
Genentech Inc.
Kogenate
Bayer Corp.
Hemophilia A (2/93)
Genentech Inc.
Nutropin AQ
Genentech Inc.
Growth failure associated with chronic renal insufficiency (11/93); growth hormone inadequacy (1/94); for treating children whose short stature is caused by growth hormone inadequacy or by chronic renal insufficiency (1/96); expanded label to include treatment of short stature in females with Turner's syndrome (12/96); growth hormone replacement therapy on spine bone mineral density in young adults with childhood-onset growth hormone deficiency (12/99)
Genentech Inc. and Alkermes Inc.
Nutropin Depot
Genentech Inc. and Alkermes Inc.
Human growth hormone for pediatric deficiencies (12/99)
Genentech Inc.
Protropin
Genentech Inc.
Growth hormone inadequacy; growth failure associated with chronic renal insufficiency in children (10/85)
Genentech Inc.
Humulin
Eli Lilly & Co.
Diabetes (10/82)
Genentech Inc.
Activase
Genentech Inc.
Acute myocardial infarction (11/87); acute pulmonary embolism(6/90); accelerated infusion (4/95); acute ischemic stroke within 3 hours of symptom onset (subset of adults whose strokes are caused by bleeding are not included in treatment group) (6/96)
Genentech Inc.
Herceptin
Genentech Inc.
Metastatic breast cancer in combination with paclitaxel as afirst-line agent and as single agent in women who have failed other therapies (9/98)
Genentech Inc.
TNKase (tenecteplase)
Genentech Inc.
Single-bolus thrombolytic for the treatment of acute myocardial infarction; can be administered over five seconds in a single dose (6/00)
Genentech Inc. and InterMune Pharmaceuticals Inc.
Actimmune
InterMune Pharmaceuticals Inc.
Chronic granulomatous disease (12/90); treatment for severe malignant osteopetrosis (2/00)
Genetics Institute Inc.
BeneFix
Genetics Institute Inc.
Treatment of hemophilia B (6/97)
Genetics Institute Inc.
Recombinate
Baxter International Inc.
Blood clotting Factor VIII for hemophilia A (12/92)
Genetics Institute Inc.
Neumega
Genetics Institute Inc.
Blood platelet booster (11/97)
Gensia Laboratories Ltd.
Etoposide Injection
Gensia Laboratories Ltd.
Treatment of small-cell lung cancer and refractory testicular tumors (7/96)
Genzyme Corp.
Ceredase
Genzyme Corp.
Type I Gaucher's disease (4/91)
Genzyme Corp.
Cerezyme
Genzyme Corp.
Type I Gaucher's disease (5/94)
Genzyme Corp.
Seprafilm
Genzyme Corp.
To reduce postsurgical adhesions following open abdominal or pelvic surgery (8/96)
Genzyme Corp.
Carticel
Genzyme Corp.
Autologous cultured chonddrocytes to repair knee cartilage damage (8/97)
Genzyme Corp.
Thyrogen
Knoll Pharmaceutical Co.
Follow-up diagnostic for patients who have been treated for thyroid cancer (12/98)
Gilead Sciences Inc.
AmBisome
Fujisawa Healthcare Inc. (Japan)
Label expansion for injectable liposomal formulation of aphotericin B for treatment of cryptococcal meningitis in HIV-infected patients (7/00)
Gilead Sciences Inc.
Vistide
Pharmacia & Upjohn Inc.
To delay progression of cytomegalovirus retinitis in AIDS patients (6/96)
Gilead Sciences Inc.
Tamiflu
F. Hoffmann-La Roche Ltd. (Switzerland)
Influenza A and B (10/99); flu prevention (11/00); influenza for children ages 1 to 12 (12/00)
Guilford Pharmaceuticals Inc.
Gliadel
Rhone-Poulenc Rorer Inc.
For use as adjunct to surgery to prolong survival of patients with recurrent glioblastoma multiforme (2nd-line therapy) (9/96)
Hoechst Marion Roussel
Refludan
Hoechst Marion Roussel
For anticoagulation in patients with heparin-induced thrombocytopenia and associated thromboembolic disease in order to prevent further complications (3/98)
ICN Pharmaceutical Inc. and Schering-Plough Corp.
Rebetron
ICN Pharmaceutical Inc. and Schering-Plough Corp.
Treatment of chronic hepatitis C in patients with compensated liver disease who have relapsed following alpha interferon therapy (6/98); treatment of chronic hepatitis C in patients with compensated liver disease previously untreated with alpha interferon therapy (12/98)
Idec Pharmaceuticals Corp.
Rituxan
Idec Pharmaceuticals Corp. and Genentech Inc.
Monoclonal antibody for low-grade non-Hodgkin's lymphoma recurrences (11/97)
Immunex Corp.
Etoposide Injection
SuperGen Inc.
Treatment of refractory testicular tumors and small-cell lung cancer (3/96)
Immunex Corp.
Leukine
Immunex Corp.
Treatment of autologous bone marrow transplantation (3/91); neutropenia resulting from chemotherapy in acute myelogenous leukemia (9/95); bone marrow transplant engraftment or failure (11/95); peripheral blood stem cell mobilization (12/95); to stimulate production of white blood cells in patients undergoing bone marrow and peripheral blood progenitor cell transplants, and for treating chemotherapy-induced neutropenia (11/96)
Immunex Corp.
Novantrone
Immunex Corp.
Treatment of hormone-refractory prostate cancer (in combination with steroids) (11/96); secondary progressive, progressive relapsing-remitting multiple sclerosis (10/00)
Immunex Corp.
Enbrel
Wyeth-Ayerst Laboratories
Rheumatoid arthritis (10/98); severely active polyarticular-course juvenile rheumatoid arthritis (5/99)
Immunomedics Inc.
CEA-Scan
Mallinckrodt Inc.
In vivo diagnostic imaging agent to determine site and extent of colorectal cancer (for use in conjunction with standard diagnostic tests) (7/96)
InKine Pharmaceutical Co. Inc.
Visicol
Innovex Inc.
For cleansing the bowel prior to colonoscopy (9/00)
Integra LifeSciences Corp.
Artificial Skin Dermal Regeneration Template
Integra LifeSciences Corp.
Treatment of full-thickness or deep partial-thickness burns where conventional autograft is not available or desirable (to regenerate body's own dermis) (3/96)
Integra LifeSciences Corp.
DuraGen DuralGraft Matrix
Integra LifeSciences Corp.
Dural closure in neurological procedures (7/99)
Interferon Sciences Inc.
Alferon N Injection
The Purdue Frederick Co.
Genital warts (10/89)
Interneuron Pharmaceuticals Inc.
Sarafem
Eli Lilly and Co.
Fluoxetine hydrochloride (the same active ingredient found in Prozac) for the treatment of premenstrual dysphoric disorder (7/00)
Isis Pharmaceuticals Inc.
Vitravene
CIBA Vision Corp.
Treatment of cytomegalovirus retinitis in AIDS patients (8/98)
Ligand Pharmaceuticals Inc.
Simulect
Novartis AG
Acute rejection episodes in renal transplants (5/98)
Ligand Pharmaceuticals Inc.
Ontak
Ligand
Persistent or recurrent cutaneous T-cell lymphoma whose cells express the CD25 component of the IL-2 receptor (2/99)
Ligand Pharmaceuticals Inc.
Panretin Gel
Integrated Commercialization Solutions
Dermal lesions in AIDS-related Kaposi's sarcoma (2/99)
Ligand Pharmaceuticals Inc.
Targretin
Ligand
Refractory cutaneous T-cell lymphoma (12/99); cutaneous lesions in patients with early-stage cutaneous T cell lymphoma who have refractory or persistent disease after other therapies or who have not tolerated other therapies (6/00)
MedImmune Inc.
CytoGam
Connaught Laboratories Inc.
Prevention of cytomegalovirus in kidney transplant patients (11/91); prophylaxis against CMV disease associated with kidney, lung, liver, pancreas and heart transplants (12/98)
MedImmune Inc.
RespiGam
American Home Products Corp.
Prevention of respiratory syncytial virus in children under 24 months of age with bronchopulmonary dysplasia or a history of premature birth (1/96)
MedImmune Inc.
Synagis
MedImmune/Abbott Laboratories
Prevention of respiratory syncytial virus in children and infants (6/98)
Nabi
WinRho SDF
Nabi
Prevention of Rh isoimmunization in pregnant women and the treatment of thrombocytopenic purpura (3/95)
Nabi and Cangene Corp.
Nabi-HB
Hepatitis B (3/99)
Nexell Therapeutics Inc.
Isolex 300 Isolex 300i
Nexell Therapeutics Inc.
Ex vivo stem cell selection for patients undergoing high-dose chemotherapy and bone marrow transplants (7/99)
NeXstar Pharmaceuticals Inc.
DaunoXome
Swedish Orphan AB
1st-line therapy for Kaposi's sarcoma in AIDS patients (4/96)
NeXstar Pharmaceuticals Inc.
AmBisome
Fujisawa USA Inc.
Treatment for fungal infections in patients with fever of unknown origin and as a therapy for visceral leishmaniasis (8/97)
North American Vaccine
Certiva
Abbott Laboratories Inc.
Combined diphtheria, tetanus and acellular pertussis vaccine (8/98)
Novo Nordisk A/S
Glucagen
Novo Nordisk A/S
Treatment of hypoglycemia and for use as a diagnostic (6/98)
Novo Nordisk A/S
Norditropin
Novo Nordisk A/S
Human growth hormone deficiency in children (5/95); recombinant somatropin (human growth hormone) for long-term treatment of children who have growth failure due to inadequate secretion of endogenous growth hormone (6/00)
Novo Nordisk A/S
Novolin
Novo Nordisk A/S
Insulin-dependent diabetes mellitus (7/91)
Novo Nordisk A/S
NovoSeven
Novo Nordisk A/S
Bleeding episodes in hemophiliacs (3/99)
Organogenesis Inc.
Apligraf
Novartis AG
Venous leg ulcers (5/98); living, bi-layered skin substitute for use in the treatment of diabetic foot ulcers (6/00)
Organon Inc.
Follistim
Organon Inc.
Recombinant follicle-stimulating hormone to treat infertility (9/97)
Ortho Biotech Inc.
Orthoclone OKT3
Ortho Biotech Inc.
Reversal of acute kidney rejection (6/86); reversal of heart and liver transplant rejection (6/93)
Pharmacia & Upjohn Inc.
Genotropin
Pharmacia & Upjohn
Growth hormone deficiency in children (8/95); growth hormone deficiency in adults (11/97)
Protein Design Labs Inc.
Zenapax
F. Hoffmann-La Roche Ltd. (Switzerland)
For the prevention of kidney transplant rejection (12/97)
Treatment of growth hormone deficiency in children (10/97)
Serono Laboratories Inc.
Gonal-F
Serono Laboratories Inc.
Treatment of functional infertility not due to primary ovarian failure (9/97)
Serono Laboratories Inc.
Serostim
Serono Laboratories Inc.
Treatment for AIDS wasting (8/96)
SkyePharma plc
Solaraze
SkyePharma plc, seeking partner
Actinic keratosis (10/00)
SmithKline Beecham plc
Lymerix
SmithKline Beecham plc
Lyme disease (12/98)
Teva Pharmaceutical Industries Ltd.
Copaxone
Teva Pharmaceutical Industries Ltd.
To reduce flare-ups in relapsing multiple sclerosis (12/96)
Texas Biotechnology Corp.
Argatroban (formerly Novastan)
SmithKline Beecham plc
Anticoagulant for prevention or treatment of thrombosis associated with heparin-induced thrombocytopenia (6/00)
The Liposome Co. Inc.
Abelcet
The Liposome Co. (now part of Elan Corp.)
Aspergillosis in those unable to take conventional drug (11/95); treatment of all types of confirmed or suspected invasive fungal infections (especially candidiasis) as 2nd-line therapy (10/96); severe systemic fungal infections (9/99)
The Medicines Co.
Angiomax
Innovex Inc.
Unstable angina (12/00)
U.S. Bioscience Inc.
Ethyol
Alza Corp.; Southern Research Institute
To reduce kidney toxicity after chemotherapy for advanced ovarian cancer (12/95); to reduce the cumulative kidney toxicity of cisplatin in patients undergoing chemotherapy for non-small-cell lung cancer (3/96); moderate to severe post-operative, radiation-induced xerostomia in patients undergoing radiation treatment for head and neck cancer (6/99)
Vertex Pharmaceuticals Inc.
Agenerase
Glaxo Wellcome plc
HIV infection in children ages 4 and older, and in twice-daily dosage with other antiretrovirals for HIV infection (4/99)