BIOTECH PRODUCTS 2001

Company

Product

Marketer

Indication (U.S. Approval Date)

Actelion Ltd.

Tracleer

Actelion Ltd.

Pulmonary arterial hypertension (11/01)

Advanced Tissue Sciences Inc.

Dermagraft

Smith & Nephew plc

Chronic foot ulcers in diabetic patients (10/01)

Amgen Inc.

Aranesp

Amgen Inc.

Anemia associated with chronic liver failure (9/01)

Amgen Inc.

Kineret

Amgen Inc.

Rheumatoid arthritis (11/01)

Celgene Corp.

Focalin

Novartis Pharmaceuticals Corp.

Attention deficit/hyperactivity disorder (11/01)

Celltech Pharmaceuticals Inc.

Metadate CD

Celltech Pharmaceuticals Inc.

Attention deficit hyperactivity disorder (4/01)

Centocor Inc.

Remicade

ND

For use in conjunction with methotrexate to inhibit the progression of damage in patients with moderately to severely active rheumatoid arthritis (1/01)

CollaGenex Pharmaceuticals Inc.

Periostat

ND

For the treatment of adult periodontitis in a new tablet formulation (2/01)

Curis Inc.

OP-1

Stryker Corp.

To repair and regenerate tissue (10/01)

Debiopharm SA (Switzerland)

Trelstar LA

Debiopharm SA

Advanced-stage prostate cancer (7/01)

Eli Lilly & Co.

Xigris

Eli Lilly & Co.

Sepsis (11/01)

Enzon Inc.

Peg-Intron

Schering-Plough Corp.

Chronic hepatitis C (1/01)

Enzon Inc.

Rebetol

Schering-Plough Corp.

To be used in combination with Intron A injection for chronic hepatitis C (7/01)

Gilead Sciences Inc.

Viread

Gilead Sciences Inc.

HIV (10/01)

Genentech Inc.

Cathflo Activase

Genentech Inc.

For use in breaking down clots in central venous catheters (9/01)

Genentech Inc. and IDEC Pharmaceuticals Corp.

Rituxan

Genentech Inc. and IDEC Pharmaceuticals Corp.

For retreatment after a prior course of Rituxan therapy, doubling of infusions and treatment of bulky disease, or tumors greater than 10 centimeters, for patients with relapsed or refractory, low-grade or follicular, CD20-positive B-cell non-Hodgkin's lymphoma (5/01)

ILEX Oncology Inc. and Millennium Pharmaceuticals Inc.

Campath

Berlex Laboratories Inc.

Leukemia (5/01)

Nycomed Amersham plc (UK)

EchoSeed

Nycomed Amersham plc

Prostate cancer (6/01)

OraPharma Inc.

Arestin

ND

Adjunct treatment for periodontitis following scaling and root planing (2/01)

Ortec International Inc.

Composite cultured skin

ND

For use in patients with recessive dystrophic epidermolysis bullosa undergoing hand reconstruction surgery; also for covering donor sites (2/01)

Ortec International Inc.

OrCel

Ortec International Inc.

For healing donor site wounds in burn victims (9/01)

Protherics plc (UK)

DigiFab

Protherics plc

Digoxin toxicity (9/01)

QLT Inc.

Visudyne

Novartis Ophthalmics

The form of class subfoveal choroidal neovascularization that occurs in people 30 and older (8/01)

Serono SA (Switzerland)

Gonal-F

ND

Multi-dose for infertility (3/01)

Scios Inc.

Natrecor

Scios Inc.

Acute congestive heart failure (8/01)

SuperGen Inc.

Daunorubicin

SuperGen Inc.

Acute leukemia (11/01)

Vernalis Group plc

Frovatriptan

Elan Corp. plc

For the acute treatment of migraine (11/01)

Visible Genetics Inc.

TruGene HIV-1 Genotyping Kit and OpenGene DNA Sequencing System

Visible Genetics Inc.

To analyze genetic information of AIDS patients so doctors can prescribe individual drug therapies (9/01)

Vysis Inc.

UroVysion

Vysis Inc.

Monitoring recurrence of bladder cancer (8/01)

BIOTECH PRODUCTS 1982-2000 A-Z

Company

Product

Marketer

Indication (U.S. Approval Date)

Abbott Laboratories

HIVAG-1 monoclonal antibody

Abbott Laboratories

Diagnostic for use in blood banks and plasma centers, and for prognostic use in HIV patients (4/96)

Agouron Pharmaceuticals Inc.

Viracept

Glaxo Wellcome plc; Hoffmann-La Roche Ltd.

HIV protease inhibitor (3/97); twice-daily dosing for HIV(12/99)

Alpha Therapeutic Corp.

AlphaNine SD

Alpha Therapeutic Corp.

To prevent and control bleeding due to Factor IX deficiency associated with hemophilia B (7/96)

Alpha Therapeutic Corp.

Venoglobulin-S

Alpha Therapeutic Corp.

Treatment of primary immunodeficiencies (11/91); idiopathic thrombocytopenia purpura; kawasaki disease (1/95)

Alza Corp. and Sequus Pharmaceuticals Inc.

Doxil

Alza Corp.

Second-line therapy for Kaposi's sarcoma in AIDS patients (11/95); refractory ovarian cancer (6/99)

Amgen Inc.

Neupogen

Hoffmann-La Roche Ltd.; Amgen; Kirin Brewery Co. Ltd. (Japan)

Chemotherapy-induced neutropenia (2/91); bone marrow transplant (6/94); severe chronic neutropenia (12/94); support peripheralblood progenitor cell transplantation(12/95); acute myelogenous leukemia (4/98)

Amgen Inc.

Epogen

Amgen Inc.

Treatment of anemia associated with chronic renal failure and anemia in Retrovir-treated HIV-infected patients (6/89); anemia caused by chemotherapy in patients with nonmyeloid malignancies (4/93)

Amgen Inc.

Procrit (EPO)

Ortho Biotech

Treatment of anemia in AZT-treated HIV-infected patients (12/90); anemia in cancer patients on chemotherapy (4/93); for use in anemic patients scheduled to undergo elective noncardiac, nonvascular surgery (12/96); anemia in children with chronic renal failure who are undergoing dialysis (11/99)

Amgen Inc.

Infergen

Amgen Inc.; Yamanouchi Pharmaceutical Co. Ltd.

Consensus alpha interferon for hepatitis C (10/97)

Athena Neurosciences Inc.

Zanaflex

Athena Neurosciences Inc.

Spasticity associated with spinal cord injuries and multiple sclerosis (12/96)

Atrix Laboratories Inc.

Atrisorb Barrier

Block Drug Co.

Periodontal disease (3/96); periodontal surgery (9/00)

Aventis Pharmaceuticals

Lantus

Aventis

Long-acting, once-daily form of insulin glargine (rDNA origin) injection for adults with Type II diabetes and children with Type I (4/00)

Bayer Corp.

Kogenate FS Antihemophilic Factor

Bayer

Recombinant Factor VIII for the treatment of hemophilia A (6/00)

Berlex Laboratories Inc.

BLU-U

Berlex Laboratories Inc.

Non-hyperkeratonic actinic keratoses of the face or scalp (9/00)

BioChem Pharma Inc.

3TC (Epivir)

Glaxo Wellcome plc

In combination with AZT for HIV infection and AIDS (11/95)

BioChem Pharma Inc.

Combivir

Glaxo Wellcome plc

Single-tablet formulation of 3TC and AZT for HIV (9/97)

BioChem Pharma Inc.

Trizivir

ND

HIV (11/00)

Biogen Inc.

Avonex

Biogen Inc.

Multiple sclerosis (5/96)

Biogen Inc.

Engerix-B

SmithKline Beecham plc

Hepatitis B vaccine (9/89); adults with chronic hepatitis C infection (8/98)

Biogen Inc.

Recombivax HB

Merck & Co. Inc.

Hepatitis B vaccine (7/86)

Biogen Inc.

Intron-A

Schering-Plough Corp.

Hairy cell leukemia (6/86); genital warts (6/88); AIDS-related Kaposi's sarcoma (11/88); hepatitis C (2/91); hepatitis B (7/92); adjuvant with surgery in those with high risk of malignant melanoma recurrence (12/95); low-grade non-Hodgkin's lymphoma (11/97); hepatitis B in pediatric patients (8/98)

Biomatrix Inc.

Synvisc

Wyeth-Ayerst Laboratories

Viscosupplementation treatment for arthritis of the knee (8/97)

Biota Holdings Ltd. (Australia)

Relenza

Glaxo Wellcome plc

Zanamivir for inhalation for treatment of influenza A and B (7/99)

Bio-Technology General Corp.

BioTropin

Cannot sell in U.S. due to court injunction

Human growth hormone deficiency in children (5/95)

Boehringer Ingelheim Pharmaceuticals Inc.

Viramune

Boehringer Ingelheim Pharmaceuticals Inc.

For use in combination with nucleoside analogues for treating HIV-infected adults (6/96)

Boehringer Mannheim Corp.

Retavase

Centocor Inc. (acquired marketing rights from Boehringer Mannheim Corp. and Dupont Merck Pharmaceuticals Corp. in 1998)

Thrombolytic agent for acute myocardial infarction (10/96)

CellPro Inc.

Ceprate SC System

CellPro Inc.

Separated cells returned to patient after chemotherapy or marrow-destroying procedures to restore bone marrow (12/96)

Celltech Group plc

Mylotarg

American Home Products Corp.; Wyeth-Ayerst Laboratories

Targeted chemotherapy agent to treat patients 60 years and older in first relapse with CD33-positive acute myeloid leukemia who are not considered candidates for cytotoxic chemotherapy (5/00)

Cell Therapeutics Inc.

Trisenox

Cell Therapeutics Inc.

Acute promyelocytic leukemia (9/00)

Centeon LLC

Bioclate

Centeon LLC

Treatment of hemophilia A for the prevention and control of hemorrhagic episodes; perioperative management of patients with hemophilia A (12/93)

Centeon LLC

Helixate

Centeon LLC

Treatment of hemophilia in which there is a deficiency of activity of Factor VIII (2/94)

Centeon LLC

Humate-P

Centeon LLC

Treatment of bleeding due to von Willebrand disease and treatment and prevention of bleeding episodes in hemophilia A patients (4/99)

Centocor Inc.

ReoPro

Eli Lilly & Co.

To inhibit platelet aggregation in high-risk angioplasty (12/94); prevention of blood flow stoppages to the heart in patients undergoing percutaneous coronary intervention and refractory unstable angina (11/97)

Centocor Inc.

Remicade

Centocor Inc.

Crohn's disease (8/98); rheumatoid arthritis (11/99)

Cephalon Inc.

Provigil

Cephalon Inc.

Treatment for excessive daytime sleepiness associated with narcolepsy (12/98)

Chiron Corp.

Betaseron

Berlex Laboratories Inc.

Relapsing, remitting multiple sclerosis (7/93)

Chiron Corp.

Proleukin

Chiron Corp.

Renal cell carcinoma (5/92); metastatic melanoma (1/98)

Chiron Corp.

Regranex Gel

Ortho-McNeil Pharmaceutical

Treatment of diabetic foot ulcers (12/97)

Chiron Therapeutics and Ciba Pharmaceuticals

Aredia

Chiron Corp.

Treatment of metastatic bone disease in patients with breast cancer (8/96)

Chiron Vision

Vitrasert

Chiron Corp.

Cytomegalovirus retinitis infection in AIDS patients (3/96)

Connaught Laboratories Inc.

Tripedia

Connaught Laboratories Inc.

Vaccination of infants 2, 4 and 6 months of age and first booster at 15-20 months; primarily for whooping cough (7/96)

Connetics Corp.

Luxiq

Connetics Corp.

Relief of inflammatory and pruritic manifestations of corticoid-responsive dermatoses of the scalp (3/99)

Connetics Corp.

Olux

Connetics

Short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticoid-responsive dermatoses of the scalp (5/00)

COR Therapeutics Inc.

Integrilin

Schering-Plough Corp./ COR Therapeutics

Acute coronary syndrome and angioplasty (5/98)

Cypress Bioscience Inc. and Fresenius Hematology Inc.

Prosorba Column

Cypress Bioscience Inc.

Moderate to severe rheumatoid arthritis (3/99)

Cytogen Corp.

OncoScint CR/OV

CIB bio-International

Detection, staging and follow-up of colorectal and ovarian cancers (12/92)

Cytogen Corp.

ProstaScint

Cytogen Corp.

Diagnostic imaging of prostate cancer in newly diagnosed patients; also for use in post-prostatectomy patients suspected of having occult metastatic disease (10/96)

Cytogen Corp.

Quadramet

Cytogen Corp.

Radiopharmaceutical for pain associated with bone cancer (3/97)

Dendreon Corp.

DACS SC

Dendreon Corp.

Used to isolate cells for transplantation in cancer patients following chemotherapy or radiation (8/99)

DepoTech Corp. and Chiron Corp.

DepoCyt

Chiron Corp.

Lymphomatous meningitis (4/99)

Eli Lilly & Co.

Humalog

Eli Lilly & Co.

Diabetes (6/96)

Eli Lilly & Co.

Humatrope

Eli Lilly & Co.

Human growth hormone deficiency in children (3/87); somatotropin deficiency syndrome in adults (8/96)

Enzon Inc.

Adagen

Enzon Inc.

Treatment of infants and children with severe combined immunodeficiency (3/90)

Enzon Inc.

Oncaspar

Rhone-Poulenc Rorer Inc.

Acute lymphoblastic leukemia (2/94)

GelTex Pharmaceuticals Inc.

Renagel

Genzyme General

Reduction of serum phosphorus in patients with end-stage renal disease (11/98); reduction of serum phosphorus in hemodialysis patients with end-stage renal disease (7/00)

GelTex Pharmaceuticals Inc.

Welchol

Sankyo Parke Davis

Adjunctive therapy to diet and exercise for the reduction of low-density lipoprotein (LDL) cholesterol in patients with primary hypercholesterolemia (5/00)

Genentech Inc.

Roferon-A

F. Hoffmann-La Roche Ltd. (Switzerland)

Hairy cell leukemia (6/86); AIDS-related Kaposi's sarcoma, Philadelphia chromosome positive chronic myelogenous leukemia (11/88); chronic myelogenous leukemia and hepatitis C (10/95)

Genentech Inc.

Pulmozyme

Genentech Inc.

Cystic fibrosis (12/93); treatment of cystic fibrosis in severely ill patients (less than 40% lung function) (12/96); treatment of cystic fibrosis in infants and young children (3/98)

Genentech Inc.

Kogenate

Bayer Corp.

Hemophilia A (2/93)

Genentech Inc.

Nutropin AQ

Genentech Inc.

Growth failure associated with chronic renal insufficiency (11/93); growth hormone inadequacy (1/94); for treating children whose short stature is caused by growth hormone inadequacy or by chronic renal insufficiency (1/96); expanded label to include treatment of short stature in females with Turner's syndrome (12/96); growth hormone replacement therapy on spine bone mineral density in young adults with childhood-onset growth hormone deficiency (12/99)

Genentech Inc. and Alkermes Inc.

Nutropin Depot

Genentech Inc. and Alkermes Inc.

Human growth hormone for pediatric deficiencies (12/99)

Genentech Inc.

Protropin

Genentech Inc.

Growth hormone inadequacy; growth failure associated with chronic renal insufficiency in children (10/85)

Genentech Inc.

Humulin

Eli Lilly & Co.

Diabetes (10/82)

Genentech Inc.

Activase

Genentech Inc.

Acute myocardial infarction (11/87); acute pulmonary embolism(6/90); accelerated infusion (4/95); acute ischemic stroke within 3 hours of symptom onset (subset of adults whose strokes are caused by bleeding are not included in treatment group) (6/96)

Genentech Inc.

Herceptin

Genentech Inc.

Metastatic breast cancer in combination with paclitaxel as afirst-line agent and as single agent in women who have failed other therapies (9/98)

Genentech Inc.

TNKase (tenecteplase)

Genentech Inc.

Single-bolus thrombolytic for the treatment of acute myocardial infarction; can be administered over five seconds in a single dose (6/00)

Genentech Inc. and InterMune Pharmaceuticals Inc.

Actimmune

InterMune Pharmaceuticals Inc.

Chronic granulomatous disease (12/90); treatment for severe malignant osteopetrosis (2/00)

Genetics Institute Inc.

BeneFix

Genetics Institute Inc.

Treatment of hemophilia B (6/97)

Genetics Institute Inc.

Recombinate

Baxter International Inc.

Blood clotting Factor VIII for hemophilia A (12/92)

Genetics Institute Inc.

Neumega

Genetics Institute Inc.

Blood platelet booster (11/97)

Gensia Laboratories Ltd.

Etoposide Injection

Gensia Laboratories Ltd.

Treatment of small-cell lung cancer and refractory testicular tumors (7/96)

Genzyme Corp.

Ceredase

Genzyme Corp.

Type I Gaucher's disease (4/91)

Genzyme Corp.

Cerezyme

Genzyme Corp.

Type I Gaucher's disease (5/94)

Genzyme Corp.

Seprafilm

Genzyme Corp.

To reduce postsurgical adhesions following open abdominal or pelvic surgery (8/96)

Genzyme Corp.

Carticel

Genzyme Corp.

Autologous cultured chonddrocytes to repair knee cartilage damage (8/97)

Genzyme Corp.

Thyrogen

Knoll Pharmaceutical Co.

Follow-up diagnostic for patients who have been treated for thyroid cancer (12/98)

Gilead Sciences Inc.

AmBisome

Fujisawa Healthcare Inc. (Japan)

Label expansion for injectable liposomal formulation of aphotericin B for treatment of cryptococcal meningitis in HIV-infected patients (7/00)

Gilead Sciences Inc.

Vistide

Pharmacia & Upjohn Inc.

To delay progression of cytomegalovirus retinitis in AIDS patients (6/96)

Gilead Sciences Inc.

Tamiflu

F. Hoffmann-La Roche Ltd. (Switzerland)

Influenza A and B (10/99); flu prevention (11/00); influenza for children ages 1 to 12 (12/00)

Guilford Pharmaceuticals Inc.

Gliadel

Rhone-Poulenc Rorer Inc.

For use as adjunct to surgery to prolong survival of patients with recurrent glioblastoma multiforme (2nd-line therapy) (9/96)

Hoechst Marion Roussel

Refludan

Hoechst Marion Roussel

For anticoagulation in patients with heparin-induced thrombocytopenia and associated thromboembolic disease in order to prevent further complications (3/98)

ICN Pharmaceutical Inc. and Schering-Plough Corp.

Rebetron

ICN Pharmaceutical Inc. and Schering-Plough Corp.

Treatment of chronic hepatitis C in patients with compensated liver disease who have relapsed following alpha interferon therapy (6/98); treatment of chronic hepatitis C in patients with compensated liver disease previously untreated with alpha interferon therapy (12/98)

Idec Pharmaceuticals Corp.

Rituxan

Idec Pharmaceuticals Corp. and Genentech Inc.

Monoclonal antibody for low-grade non-Hodgkin's lymphoma recurrences (11/97)

Immunex Corp.

Etoposide Injection

SuperGen Inc.

Treatment of refractory testicular tumors and small-cell lung cancer (3/96)

Immunex Corp.

Leukine

Immunex Corp.

Treatment of autologous bone marrow transplantation (3/91); neutropenia resulting from chemotherapy in acute myelogenous leukemia (9/95); bone marrow transplant engraftment or failure (11/95); peripheral blood stem cell mobilization (12/95); to stimulate production of white blood cells in patients undergoing bone marrow and peripheral blood progenitor cell transplants, and for treating chemotherapy-induced neutropenia (11/96)

Immunex Corp.

Novantrone

Immunex Corp.

Treatment of hormone-refractory prostate cancer (in combination with steroids) (11/96); secondary progressive, progressive relapsing-remitting multiple sclerosis (10/00)

Immunex Corp.

Enbrel

Wyeth-Ayerst Laboratories

Rheumatoid arthritis (10/98); severely active polyarticular-course juvenile rheumatoid arthritis (5/99)

Immunomedics Inc.

CEA-Scan

Mallinckrodt Inc.

In vivo diagnostic imaging agent to determine site and extent of colorectal cancer (for use in conjunction with standard diagnostic tests) (7/96)

InKine Pharmaceutical Co. Inc.

Visicol

Innovex Inc.

For cleansing the bowel prior to colonoscopy (9/00)

Integra LifeSciences Corp.

Artificial Skin Dermal Regeneration Template

Integra LifeSciences Corp.

Treatment of full-thickness or deep partial-thickness burns where conventional autograft is not available or desirable (to regenerate body's own dermis) (3/96)

Integra LifeSciences Corp.

DuraGen DuralGraft Matrix

Integra LifeSciences Corp.

Dural closure in neurological procedures (7/99)

Interferon Sciences Inc.

Alferon N Injection

The Purdue Frederick Co.

Genital warts (10/89)

Interneuron Pharmaceuticals Inc.

Sarafem

Eli Lilly and Co.

Fluoxetine hydrochloride (the same active ingredient found in Prozac) for the treatment of premenstrual dysphoric disorder (7/00)

Isis Pharmaceuticals Inc.

Vitravene

CIBA Vision Corp.

Treatment of cytomegalovirus retinitis in AIDS patients (8/98)

Ligand Pharmaceuticals Inc.

Simulect

Novartis AG

Acute rejection episodes in renal transplants (5/98)

Ligand Pharmaceuticals Inc.

Ontak

Ligand

Persistent or recurrent cutaneous T-cell lymphoma whose cells express the CD25 component of the IL-2 receptor (2/99)

Ligand Pharmaceuticals Inc.

Panretin Gel

Integrated Commercialization Solutions

Dermal lesions in AIDS-related Kaposi's sarcoma (2/99)

Ligand Pharmaceuticals Inc.

Targretin

Ligand

Refractory cutaneous T-cell lymphoma (12/99); cutaneous lesions in patients with early-stage cutaneous T cell lymphoma who have refractory or persistent disease after other therapies or who have not tolerated other therapies (6/00)

MedImmune Inc.

CytoGam

Connaught Laboratories Inc.

Prevention of cytomegalovirus in kidney transplant patients (11/91); prophylaxis against CMV disease associated with kidney, lung, liver, pancreas and heart transplants (12/98)

MedImmune Inc.

RespiGam

American Home Products Corp.

Prevention of respiratory syncytial virus in children under 24 months of age with bronchopulmonary dysplasia or a history of premature birth (1/96)

MedImmune Inc.

Synagis

MedImmune/Abbott Laboratories

Prevention of respiratory syncytial virus in children and infants (6/98)

Nabi

WinRho SDF

Nabi

Prevention of Rh isoimmunization in pregnant women and the treatment of thrombocytopenic purpura (3/95)

Nabi and Cangene Corp.

Nabi-HB

Hepatitis B (3/99)

Nexell Therapeutics Inc.

Isolex 300 Isolex 300i

Nexell Therapeutics Inc.

Ex vivo stem cell selection for patients undergoing high-dose chemotherapy and bone marrow transplants (7/99)

NeXstar Pharmaceuticals Inc.

DaunoXome

Swedish Orphan AB

1st-line therapy for Kaposi's sarcoma in AIDS patients (4/96)

NeXstar Pharmaceuticals Inc.

AmBisome

Fujisawa USA Inc.

Treatment for fungal infections in patients with fever of unknown origin and as a therapy for visceral leishmaniasis (8/97)

North American Vaccine

Certiva

Abbott Laboratories Inc.

Combined diphtheria, tetanus and acellular pertussis vaccine (8/98)

Novo Nordisk A/S

Glucagen

Novo Nordisk A/S

Treatment of hypoglycemia and for use as a diagnostic (6/98)

Novo Nordisk A/S

Norditropin

Novo Nordisk A/S

Human growth hormone deficiency in children (5/95); recombinant somatropin (human growth hormone) for long-term treatment of children who have growth failure due to inadequate secretion of endogenous growth hormone (6/00)

Novo Nordisk A/S

Novolin

Novo Nordisk A/S

Insulin-dependent diabetes mellitus (7/91)

Novo Nordisk A/S

NovoSeven

Novo Nordisk A/S

Bleeding episodes in hemophiliacs (3/99)

Organogenesis Inc.

Apligraf

Novartis AG

Venous leg ulcers (5/98); living, bi-layered skin substitute for use in the treatment of diabetic foot ulcers (6/00)

Organon Inc.

Follistim

Organon Inc.

Recombinant follicle-stimulating hormone to treat infertility (9/97)

Ortho Biotech Inc.

Orthoclone OKT3

Ortho Biotech Inc.

Reversal of acute kidney rejection (6/86); reversal of heart and liver transplant rejection (6/93)

Pharmacia & Upjohn Inc.

Genotropin

Pharmacia & Upjohn

Growth hormone deficiency in children (8/95); growth hormone deficiency in adults (11/97)

Protein Design Labs Inc.

Zenapax

F. Hoffmann-La Roche Ltd. (Switzerland)

For the prevention of kidney transplant rejection (12/97)

QLT Phototherapeutics Inc.

Photofrin

Sanofi Winthrop Inc.

Advanced throat cancer (12/95)

QLT Phototherapeutics Inc.

Visudyne

CIBA Vision Corp.

Wet age-related macular degeneration (4/00)

SangStat Medical Corp.

Thymoglobulin

SangStat Medical Corp.

Prevention of kidney transplant rejection (12/98)

Sequus Pharmaceuticals Inc.

Amphotec (aka Amphocil)

Sequus Pharmaceuticals Inc.

Invasive aspergillosis infections (2nd-line therapy) (11/96)

Serono Inc.

Gonal-F

Serono Inc.

Recombinant follicle-stimulating hormone for treatment of infertility in men and women (6/00)

Serono Inc.

Ovidrel

Serono Inc.

Infertility due to anovulation and promote final egg maturation in ovaries of women undergoing assisted reproductive technologies (10/00)

Serono Laboratories Inc.

Saizen

Serono Laboratories Inc.

Growth hormone deficiency in children (10/96)

Serono Laboratories Inc.

Fertinex

Serono Laboratories Inc.

Infertility treatment (8/96); hormone deficiency (10/96)

Serono Laboratories Inc.

Geref

Serono Laboratories Inc.

Treatment of growth hormone deficiency in children (10/97)

Serono Laboratories Inc.

Gonal-F

Serono Laboratories Inc.

Treatment of functional infertility not due to primary ovarian failure (9/97)

Serono Laboratories Inc.

Serostim

Serono Laboratories Inc.

Treatment for AIDS wasting (8/96)

SkyePharma plc

Solaraze

SkyePharma plc, seeking partner

Actinic keratosis (10/00)

SmithKline Beecham plc

Lymerix

SmithKline Beecham plc

Lyme disease (12/98)

Teva Pharmaceutical Industries Ltd.

Copaxone

Teva Pharmaceutical Industries Ltd.

To reduce flare-ups in relapsing multiple sclerosis (12/96)

Texas Biotechnology Corp.

Argatroban (formerly Novastan)

SmithKline Beecham plc

Anticoagulant for prevention or treatment of thrombosis associated with heparin-induced thrombocytopenia (6/00)

The Liposome Co. Inc.

Abelcet

The Liposome Co. (now part of Elan Corp.)

Aspergillosis in those unable to take conventional drug (11/95); treatment of all types of confirmed or suspected invasive fungal infections (especially candidiasis) as 2nd-line therapy (10/96); severe systemic fungal infections (9/99)

The Medicines Co.

Angiomax

Innovex Inc.

Unstable angina (12/00)

U.S. Bioscience Inc.

Ethyol

Alza Corp.; Southern Research Institute

To reduce kidney toxicity after chemotherapy for advanced ovarian cancer (12/95); to reduce the cumulative kidney toxicity of cisplatin in patients undergoing chemotherapy for non-small-cell lung cancer (3/96); moderate to severe post-operative, radiation-induced xerostomia in patients undergoing radiation treatment for head and neck cancer (6/99)

Vertex Pharmaceuticals Inc.

Agenerase

Glaxo Wellcome plc

HIV infection in children ages 4 and older, and in twice-daily dosage with other antiretrovirals for HIV infection (4/99)