November 8 (EP), November 2 (WO)
Akzo Nobel EP 1 050 541
Babesia divergens genes encoding the 37 kD protein family, encoded proteins; for vaccine development.
Albert Einstein Coll. Med. WO 00/65094
Differential gene expression assay
Assay of differential gene expression patterns using multi-fluor detection methods.
Amersham Pharmacia Biotech WO 00/65088
Primers for identifying, typing, or classifying known nucleic acid sequences that have polymorphisms.
Amsterdam, Univ. of WO 00/65345
Signal transduction assay
Identification of proteins expressed by cells that cause signal transduction.
Autogen WO 00/64931
Beacon protein ligand, encoding gene sequences, homologs; for developing obesity and diabetes therapeutics.
Aventis Pharma WO 00/65043
Hypertension gene therapy
Recombinant defective adenoviruses with a gene encoding an angiogenic factor; for treating pulmonary hypertension.
Azwell EP 1 050 584
Lipid metabolism therapeutics
Recombinant lysophosphatidic acid phosphatase; for developing therapeutics to affect lipid metabolism.
Beth Israel Deaconess Hosp. WO 00/65056
Calcium transport modulation
Gene sequences encoding a MutT domain-containing protein; for modulating calcium transport.
Beth Israel Deaconess Hosp. WO 00/65358
Protein sequence comparison
Comparison of protein sequences using computer-based methods and a protein database library.
Bio-Tech Imaging WO 00/65355
HIV viral load assay
Depleting cells actively infected with HIV from samples; for determining latent viral load.
Bio-Tech Imaging WO 00/65356
HIV-1 infectivity assay
Cells having increased susceptibility to HIV infection; for HIV-1 infectivity assay.
Biocept WO 00/65097
Methods for making hydrogel biochips; for gene sequence characterization.
Biotech Res. Inst. WO 00/65074
High-level gene expression
Promoter-transactivator system for inducible high-level mammalian gene expression and cell growth control.
Boehringer Ingelheim WO 00/65357
Diagnosing spongiform encephalopathies
Measurement of altered expression of prion proteins; for diagnosing transmissible spongiform encephalopathies.
Cedars-Sinai Med. Ctr. WO 00/65078
Cancer gene therapy
Herpes simplex 1-derived vector for selective inhibition of malignant cells.
CNRS (Natl. Ctr. Sci. Res.) WO 00/65062
Bacterial infection therapeutics
Genome sequences and encoded proteins from Pyrococcus abissy; for diagnostics and therapeutics.
Ctr. Translational Res. in Cancer WO 00/65034
Cancer gene therapy
Retroviral vectors pseudotyped with vesicular stomatitis virus G protein; for suicide cancer gene therapy.
Ceptyr WO 00/65068 & 65069
MAP kinase phosphatases
Dual-specificity MAP kinase phosphatases, encoding genes; for modulating cell proliferation and differentiation.
Chicago, Univ. of WO 00/65098
Extension on microarrays
Nucleotide extension of primers that are gel-immobilized on microarrays; for gene sequence characterization.
Chugai Res. Inst. Molec. Med. WO 00/65047
Tumor suppressor genes
Tumor suppressor genes, encoded proteins, antisense; for regulating cell proliferation.
Cobra Therapeutics WO 00/64929
Cell delivery agent
Membrane disruptive peptides that are modified by covalent oligomerization; for use as cell delivery vehicles.
Corixa WO 00/65053
Lung carcinoma therapy
Proteins from head and neck tumors, encoding genes; for lung squamous cell carcinoma diagnostics and therapeutics.
CuraGen WO 00/64941
PPAR gamma ligands
New Haven, Conn.
Methods of identifying ligands for and genes regulated by the peroxisome proliferator activated receptor gamma.
CuraGen WO 00/65091
G-protein coupled receptor therapeutics
New Haven, Conn.
G-protein coupled receptors differentially expressed in diseased fibroblasts; for developing therapeutics.
Dalhousie Univ. WO 00/64457
Orally delivered vaccines
Live oral commensal bacterial strains transduced to express heterologous immunogenic proteins; for mucosal immunity.
Eberhard Karls Univ. WO 00/65075
Enhanced cell transfection
Non-infectious peptides from coxsackie viruses that enhance cell transfection via endosomolytic action.
Florida, Univ. of WO 00/65063
Rickettsial disease vaccines
Nucleic acid sequences encoding proteins useful for inducing rickettsial disease immunity; for vaccines.
Genentech WO 00/65070
S. San Francisco
Enhanced glycosylation of recombinant proteins using cell culture media having cell cycle inhibitors.
Genetics Inst. WO 00/65027
Human protein having a high degree of homology with interleukin-10, encoding gene sequences; for therapeutics.
Genox Res. WO 00/65045, 65046 & 65048-65051
Pollen allergy genes
Pollinosis-associated genes differentially expressed in patients with high cedar pollen-specific IgE levels.
Guelph, Univ. of WO 00/64247
Transgenics having integrated genes whose expression is directed by gastrointestinal tract specific promoters.
Habener, J.F., et al. WO 00/65052
Gene sequences encoding Bridge-1, encoded protein, fragments, antibodies; for screening binding ligands.
Hisamitsu Pharma EP 1 050 583
HIV infection inhibition
Antisense oligos to chromosomal DNA encoding CXCR4; for inhibiting HIV infection.
Human Genome Sciences WO 00/64465
Death domain containing receptor proteins, encoding genes, production methods; for modulator screens.
Incyte Genomics WO 00/65054
Palo Alto, Calif.
Human membrane-associated proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/64469
Arthritis modulator screens
Use of glucose-6-phosphate isomerase and antibodies to it for arthritis diagnosis and therapy and modulator screens.
Japan Tobacco EP 1 050 580
Heterologous gene expression
Nucleic acid fragments that promote expression of downstream structural genes; for heterologous gene expression.
Karolinska Innovations WO 00/64482
Nerve cell growth modulators
Fusions of nerve cell binding moieties that neutralize growth inhibition to stimulatory moieties.
Kyowa Hakko Kogyo WO 00/64933
Transcription activation inhibition
_-catenin binding protein that inhibits the binding to a TCF/Lef family protein; for inhibiting transcription.
Leuven Res. & Develop. WO 00/65076
HIV enzyme expression
Synthetic genes having modified codons; for enhanced expression of active HIV enzymes in eukaryotes.
Lexicon Genetics WO 00/65055
Human transporter proteins
The Woodlands, Texas
Human transporter proteins, encoding genes, antibodies, antisense, modulators; for diagnostics and therapeutics.
M&E Biotech WO 00/65058
Chronic allergy therapy
Method for down-regulating interleukin-5 levels using antibodies; for lowering eosinophil levels.
Mass. Gen. Hosp. WO 00/65077
Triple viral hybrid amplicon vector systems for generating retroviral packaging cell lines.
Mass. Inst. Technol. WO 00/64935
Anion channel modulators
Serotonin-gated anion channel that is permeable to chloride ions; for screening modulators.
Max Planck Inst. WO 00/65085
Angiopoietin receptor modulation
Use of vertebrate vascular endothelial protein-tyrosine phosphatase to modulate angiopoietin receptor Tie-2.
McGill Univ. WO 00/65030
Microencapsulated E. coli; for removal of undesirable electrolytes and metabolites in patients.
Med. & Biol. Labs EP 1 050 581
Methods for detecting acetyltransferase and deacetylase activity in proteins; for screening modulators.
Merck WO 00/65025
Endothelin converting enzyme 3
Human endothelin converting enzyme 3, encoding gene; for identifying modulators.
Merck WO 00/65060
Gene sequence for a grass pollen allergen, encoded protein, production methods; for allergy therapy.
Mirus WO 00/65350
Antigen display assay
Selection of surface-expressed epitopes for identification of antibodies that bind to these epitopes.
Montreal, Univ. of WO 00/65035
Nuclear transfer methods
Telophase enucleated oocytes for nuclear transfer; for mammalian cloning and transgenic production.
Myriad Genetics WO 00/65340
Protein-protein interaction assay
Salt Lake City
Identification of protein-protein interactions in various disease states, including diabetes and Alzheimer's.
Neovacs WO 00/64937
Carboxymethylated interferon-a and its fragments, viral regulatory protein fragments; for immunotherapy.
North Carolina, Univ. of WO 00/64262
Chapel Hill, N.C.
Antisense oligonucleotides to human fucosyltransferase; for cancer treatment.
North Carolina, Univ. of WO 00/65099
Binding pair assay
Chapel Hill, N.C.
Monolayer and electrode for detecting a label-bearing target in an assay for binding pairs.
Northwestern Univ. WO 00/64466
Major peptide autoimmune epitopes from nucleosomal histones; for treating systemic lupus erythematosus.
Pacific Northwest Cancer Fdn. WO 00/64464
Rat ganglioside GM1-specific a1-2 fucosyltransferase, encoding gene; for cancer immunotherapeutics.
Pennsylvania, Univ. of WO 00/64919
TZD inducible gene, encoded protein whose expression is induced by antidiabetic thiazolidinediones.
Pennsylvania, Univ. of WO 00/64920
Mammalian resistin gene, encoded protein whose expression is suppressed by antidiabetic thiazolidinediones.
Physiome Sciences WO 00/65523
Finding drug targets
Database and system for modeling genetic and biochemical information; for identifying new drug targets.
R.E.D. Labs WO 00/65086
Multiple sclerosis diagnosis
Measurement of high and low molecular weight RNase L activity proteins; for diagnosing multiple sclerosis.
Res. Corp. Technol. WO 00/64475
Inhibition of the expression and functioning of mts-1 protein and its binding to p53; for cancer therapy.
Res. Corp. Technol. WO 00/64934
Metastatic cancer therapy
Inhibition of the mts-1 protein using antibody-conjugated toxins or antisense; for metastatic cancer therapy.
Rhein Biotech WO 00/65065
Hepatitis B antigen production
Recombinant methylotrophic yeast strains that express hepatitis B antigens, purification methods.
Sankyo WO 00/65044
Apoptosis-associated proteins, encoding gene sequences; for identifying cell death modulators.
Sci. & Technol. Corp. WO 00/65092 & 65093
Enhanced microorganism detection
Blocking of non-specific binding of nucleic acid sequences to granulocytes; for enhancing detection of microorganisms.
SmithKline Beecham WO 00/64928
R35 proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/64942
G-protein coupled receptor
G-protein coupled receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/64943
Mouse protein, encoding gene, recombinant production methods; for cancer diagnostics and therapeutics.
SmithKline Beecham WO 00/65026
Bacterial YycG protein, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/65089
Bacterial tktA protein, encoding gene sequences, recombinant production methods; for antibacterial screens.
Stanford Univ. WO 00/65042
P element-derived vector
Palo Alto, Calif.
P element-derived vector; for inserting heterologous genes into cellular genomes.
Stem Cell Pharma WO 00/65028
Functional fragments of TGF-a; for stimulating hematopoiesis in patients undergoing chemotherapy.
Surromed WO 00/65472
Palo Alto, Calif.
Phenotype assay and biological marker identification using cell populations and cell-associated molecules.
Takara Shuzo EP 1 050 586
Germ line gene therapy
Transfecting the testes using recombinant viral vectors having therapeutic genes; for germ line gene transmission.
Takeda Chemical WO 00/65031
Human stem cell line having stable expression of cytochrome P450; for analyzing the metabolism of toxins.
Targeted Genetics WO 00/65038
AAV-based gene therapy vectors
Methods and cells for encapsidating recombinant vectors in adeno-associated virus particles; for gene therapy.
Tufts Univ. WO 00/65082
Transcription modulator screens
Identification of modulators of MarR family proteins binding to DNA sequences; for affecting transcription.
Tulane Univ. WO 00/65064
Lyme disease vaccine
Antigenically conserved peptide from B. burgdorferi strains; for Lyme disease vaccine.
Unilever WO 00/65057
Viral infection inhibition
Inhibition of viral infection using monovalent antigen-binding proteins.
Washington, Univ. of WO 00/65067
Prostate cancer therapy
Prostate-specific androgen-regulated proteins, encoding gene sequences; for cancer diagnostics and therapeutics.
Wieser, R.J. WO 00/64936
Interferon peptide dimers
Peptide homodimers and heterodimers derived from interferon-a2, variants; for modulating immune responses.
Weiser, R.J. WO 00/64938
IL-12 peptide dimers
Peptide homodimers and heterodimers derived from interleukin-12, variants; for modulating immune responses.
Yamanouchi EP 1 050 542
Potassium channel expressed in brain, encoding gene sequences; for developing modulators.
Zanetti, M. WO 00/64488
Somatic transgene immunization
La Jolla, Calif.
Transfection of lymphoid cells with hematopoietic-specific promoters linked to immunoglobulin genes; for vaccination.
ZymoGenetics WO 00/65090
Insulin receptor-related receptor gene sequence; for detecting polymorphisms and diagnosing type II diabetes.