August 16 (EP), August 10 (WO), August 16 (GB)

Abbott Labs WO 00/46407

Xenotransplant viruses

Abbott Park, Ill.

Nucleic acid oligomer probes and primers useful for detecting TT virus prior to xenotransplantation.

Alabama, Univ. of WO 00/46364

Modified adenoviral fibers

Birmingham, Ala.

Modification of adenoviral fibers with a C-terminal tag encoding an artificial receptor; for changing tropism.

AlphaGene WO 00/46406

Protein-protein interactions

Woburn, Mass.

High-throughput microarray assay systems that identify protein-protein interactions; for constructing networks.

American Cyanamid WO 00/46242

Ulcer vaccines

Madison, N.J.

19 kilodalton protein from Helicobacter pylori, encoding gene sequences; for ulcer vaccines.

Amersham Pharmacia Biotech WO 00/46402

Polymorphism detection

Little Chalfont, UK

Comparing genomic DNA from two individuals having the same phenotype to detect polymorphisms.

Biotechnol. Res. Ctr. WO 00/46378

Energy metabolism modification

Braunschweig, Germany

Transfection of mammalian cell lines with a yeast pyruvate carboxylase gene; for improving primary energy metabolism.

Bulow, J.-U. WO 00/46251

Human polyclonal antibodies

Karlsruhe, Germany

Transgenics with functional human heavy and light chain immunoglobulin loci; for making human polyclonal antibodies.

Cambridge Molec. Technol. GB 2 346 615

Isolating plasmid DNA

Cambridge, UK

Extraction and isolation of plasmid DNA from mixtures of plasmid and genomic DNA.

Canadian Natl. Res. Counc. WO 00/46379

Ganglioside biosynthesis

Ottawa, Ont.

Campylobacter glycosyltransferases, encoding gene sequences; for biosynthesis of ganglioside and ganglioside mimics.

CDC (Ctr. Disease Control) WO 00/46403

HIV-1 strain detection

Atlanta, Ga.

Nucleic acid primers for detecting HIV-1 groups M, N, and O; for monitoring treatment regimens and drug resistance.

Children's Hosp. WO 00/46385 & 46386

Gene repair

Boston

Gene repair involving excision of targeting DNA through SCE1-induced recombination; for treating genetic disease.

Chiron WO 00/46369

Pancreatic disease genes

Emeryville, Calif.

Genes differentially expressed in pancreatic diseases, encoded proteins; for diagnostics and therapeutics.

Chiron WO 00/46372

Glucose-regulated genes

Emeryville, Calif.

Genes expressed in pancreatic islet cells that are regulated by serum glucose concentrations.

Chiron WO 00/46380

Angiogenesis inhibition

Emeryville, Calif.

Fibroblast growth factor-immunoglobulin fusion; for inhibiting cell proliferation and angiogenesis.

Chugai Res. Inst. Molec. Med. WO 00/46368

Organic cation transporter

Ibaraki, Japan

Organic cation transporter homolog gene isolated from a testes-origin cDNA library, encoded protein.

Cycluosl GB 2 346 616

Transmembrane carrier

Dundee, UK

Modified and truncated forms of penetratin peptides; for use as a transmembrane carrier.

Diversa WO 00/46344

Directed evolution of genes

San Diego, Calif.

Non-stochastic methods of directed evolution of genes; for making vaccines and enzymes with desirable properties.

European Molec. Biol. Lab WO 00/46367

Cell proliferation protein

Heidelberg, Germany

Protein that induces oocyte maturation and modulates cell proliferation and differentiation, encoding gene sequences.

Geron WO 00/46355

Telomerase regulatory sequences

Menlo Park, Calif.

Telomerase reverse transcriptase transcriptional regulatory sequences; oncolytic viral genes linked to these sequences.

Helix Res. Inst. WO 00/46348

Mesenchymal stem cell differentiation

Chiba, Japan

Inducing the differentiation of multipotential mesenchymal stem cells into adipocytes using prolactin.

Hildt, E. WO 00/46376

Gene therapy particles

Berlin

Nucleic acid-containing particles that include cell targeting viral proteins; for gene therapy.

Illinois, Univ. of WO 00/46370

p37 tumor promoter gene

Urbana, Ill.

Promoter expressing a longer mRNA from the p37ING1 gene which coincides with the transformation of cells.

Leiden State Univ. WO 00/46383

Metabolite biosynthesis modulation

Leiden, Netherlands

Modulating metabolite biosynthesis by transfecting DNA encoding transcription factors.

LGC WO 00/46401

DNA amplification references

Teddington, UK

Reference nucleic acid sequences of differing lengths for use in amplification reactions.

Life Technol. WO 00/46366

Vector isolation

Rockville, Md.

Isolating single- and double-stranded vectors using oligonucleotide probes that bind their functional sequences.

Maryland, Univ. of WO 00/46384

Nucleic acid delivery

Baltimore, Md.

Cell targeting receptor bound to influenza hemagglutinin endosmolytic peptide; for delivering nucleic acid sequences.

Mass. Gen. Hosp. WO 00/46246

2-macroglobulin gene mutations

Boston

2-macroglobulin gene deletion mutations; for diagnosis for predisposition to Alzheimer's disease.

Max Planck Inst. WO 00/46400

Nucleic acid detection

Munich, Germany

Detection of specific nucleic acid sequences using RNA replicons and their amplification.

Merck WO 00/46247

TNF receptor-related protein

Rahway, N.J.

Tumor necrosis factor (TNF) receptor-related protein, encoding gene sequences; for identifying modulators.

Merck WO 00/46360

Adenoviral gene therapy vector

Rahway, N.J.

Helper-dependent adenoviral vector system for gene therapy applications.

Multigene WO 00/46244

Fanconi anemia protein ligand

Wurzburg, Germany

Protein that interacts with a Fanconi anemia protein, encoding gene, antibodies; for diagnostic screens.

Netherlands Org. Technol. Develop. EP 1 028 117

Protein prenylation inhibitors

Delft, Netherlands

Peptide analogs for use as inhibitors of prenyl transferases that prenylate proteins.

Neutec Pharma WO 00/46359

Chlamydia disease therapies

Manchester, UK

Diagnosis and treatment of atherosclerosis caused by Chlamydia pneumoniae infection.

Novo Nordisk Biotech WO 00/46375

Recombinant proteins from fungi

Davis, Calif.

Fungal pacC pH signal transduction pathway gene linked to a foreign gene; for fungal expression of recombinant proteins.

Olympus Optical WO 00/46363

Nucleic acid sequencing

Tokyo

Determination of nucleic acid sequence by analyzing smaller fragments of the whole sequence.

Oregon Hlth. Sci. Univ. WO 00/46361

Treating transplant rejection

Portland, Ore.

MHC II pathway blockage with human cytomegalovirus protein; for treating transplant rejection and autoimmune diseases.

Palsson, B. WO 00/46405

Antibacterial drug targets

La Jolla, Calif.

Computational methods for finding potential antibacterial drug targets based on genomic DNA sequences.

Schering WO 00/46245

Human antibacterial proteins

Berlin

Human antibacterial proteins SAP-2 and -3, cells transfected with cDNAs; for production of antimicrobials.

Scriptgen Pharma WO 00/46374

Yeast RNA polymerase II gene

Waltham, Mass.

Candida albicans yeast SRB-7 gene that encoded a protein that is part of the RNA polymerase II holoenzyme complex.

Sloan-Kettering Inst. WO 00/46408

Replicating DNA in large amounts

New York

Process for replicating large segments of DNA by assembling a replisome at the D-loop; for detecting genetic variation.

Suntory WO 00/45633

Blood pressure regulation study

Osaka, Japan

Transgenics with vascular-specific expression of angiotensin II2 receptor; for studying blood pressure regulation.

Sydney, Univ. of WO 00/46233

Fluorescent pigment protein

Sydney, Australia

Pigment protein from coral tissue for use as a tissue or general fluorescent marker.

Texas, Univ. of WO 00/46347

Drug resistance modulation

Austin, Texas

Manipulation of ABC transporters to alter cellular ATP gradients; for modulating drug resistance.

Thomas Jefferson Univ. WO 00/46350

Recombinant proteins from plants

Philadelphia

Use of transcomplementation systems to systemically transfect plants; for producing recombinant proteins.

Thomas Jefferson Univ. WO 00/46377

Non-dividing cell infection

Philadelphia

Retroviral vector particles having matrix protein gene mutations; for infecting non-dividing cells.

Utah, Univ. of WO 00/46371

Tau-conotoxins

Salt Lake City, Utah

Short peptides known as tau-conotoxins from cone snail venom, peptide analogs.

Virginia Comm. Univ. WO 00/46365

Enhancing immune responses

Richmond, Va.

Particles for presenting haptens, including nucleic acids and proteins; for enhancing immune responses.

Walter Reed Army Res. Inst. WO 00/46404

Toxin-exposure gene expression

Washington, D.C.

Comparison of differential protein and/or gene expression patterns in normal and toxin-exposed individuals.

Western Australia, Univ. of WO 00/46398

Methylated DNA detection

Nedlands, Australia

Use of fluorescent molecular beacons in detecting methylated nucleic acids.

Zetatronics GB 2 346 694

Detecting single-stranded DNA

Hatfield, UK

Detecting single-stranded nucleic acids in a hybridization reaction in which excess probe is destroyed.

Zouboulis, C. WO 00/46353

Sebaceous gland cells

Berlin

Sebaceous gland cells that can be subcultured over several generations.

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