August 16 (EP), August 10 (WO), August 16 (GB)
Abbott Labs WO 00/46407
Abbott Park, Ill.
Nucleic acid oligomer probes and primers useful for detecting TT virus prior to xenotransplantation.
Alabama, Univ. of WO 00/46364
Modified adenoviral fibers
Modification of adenoviral fibers with a C-terminal tag encoding an artificial receptor; for changing tropism.
AlphaGene WO 00/46406
High-throughput microarray assay systems that identify protein-protein interactions; for constructing networks.
American Cyanamid WO 00/46242
19 kilodalton protein from Helicobacter pylori, encoding gene sequences; for ulcer vaccines.
Amersham Pharmacia Biotech WO 00/46402
Little Chalfont, UK
Comparing genomic DNA from two individuals having the same phenotype to detect polymorphisms.
Biotechnol. Res. Ctr. WO 00/46378
Energy metabolism modification
Transfection of mammalian cell lines with a yeast pyruvate carboxylase gene; for improving primary energy metabolism.
Bulow, J.-U. WO 00/46251
Human polyclonal antibodies
Transgenics with functional human heavy and light chain immunoglobulin loci; for making human polyclonal antibodies.
Cambridge Molec. Technol. GB 2 346 615
Isolating plasmid DNA
Extraction and isolation of plasmid DNA from mixtures of plasmid and genomic DNA.
Canadian Natl. Res. Counc. WO 00/46379
Campylobacter glycosyltransferases, encoding gene sequences; for biosynthesis of ganglioside and ganglioside mimics.
CDC (Ctr. Disease Control) WO 00/46403
HIV-1 strain detection
Nucleic acid primers for detecting HIV-1 groups M, N, and O; for monitoring treatment regimens and drug resistance.
Children's Hosp. WO 00/46385 & 46386
Gene repair involving excision of targeting DNA through SCE1-induced recombination; for treating genetic disease.
Chiron WO 00/46369
Pancreatic disease genes
Genes differentially expressed in pancreatic diseases, encoded proteins; for diagnostics and therapeutics.
Chiron WO 00/46372
Genes expressed in pancreatic islet cells that are regulated by serum glucose concentrations.
Chiron WO 00/46380
Fibroblast growth factor-immunoglobulin fusion; for inhibiting cell proliferation and angiogenesis.
Chugai Res. Inst. Molec. Med. WO 00/46368
Organic cation transporter
Organic cation transporter homolog gene isolated from a testes-origin cDNA library, encoded protein.
Cycluosl GB 2 346 616
Modified and truncated forms of penetratin peptides; for use as a transmembrane carrier.
Diversa WO 00/46344
Directed evolution of genes
San Diego, Calif.
Non-stochastic methods of directed evolution of genes; for making vaccines and enzymes with desirable properties.
European Molec. Biol. Lab WO 00/46367
Cell proliferation protein
Protein that induces oocyte maturation and modulates cell proliferation and differentiation, encoding gene sequences.
Geron WO 00/46355
Telomerase regulatory sequences
Menlo Park, Calif.
Telomerase reverse transcriptase transcriptional regulatory sequences; oncolytic viral genes linked to these sequences.
Helix Res. Inst. WO 00/46348
Mesenchymal stem cell differentiation
Inducing the differentiation of multipotential mesenchymal stem cells into adipocytes using prolactin.
Hildt, E. WO 00/46376
Gene therapy particles
Nucleic acid-containing particles that include cell targeting viral proteins; for gene therapy.
Illinois, Univ. of WO 00/46370
p37 tumor promoter gene
Promoter expressing a longer mRNA from the p37ING1 gene which coincides with the transformation of cells.
Leiden State Univ. WO 00/46383
Metabolite biosynthesis modulation
Modulating metabolite biosynthesis by transfecting DNA encoding transcription factors.
LGC WO 00/46401
DNA amplification references
Reference nucleic acid sequences of differing lengths for use in amplification reactions.
Life Technol. WO 00/46366
Isolating single- and double-stranded vectors using oligonucleotide probes that bind their functional sequences.
Maryland, Univ. of WO 00/46384
Nucleic acid delivery
Cell targeting receptor bound to influenza hemagglutinin endosmolytic peptide; for delivering nucleic acid sequences.
Mass. Gen. Hosp. WO 00/46246
2-macroglobulin gene mutations
2-macroglobulin gene deletion mutations; for diagnosis for predisposition to Alzheimer's disease.
Max Planck Inst. WO 00/46400
Nucleic acid detection
Detection of specific nucleic acid sequences using RNA replicons and their amplification.
Merck WO 00/46247
TNF receptor-related protein
Tumor necrosis factor (TNF) receptor-related protein, encoding gene sequences; for identifying modulators.
Merck WO 00/46360
Adenoviral gene therapy vector
Helper-dependent adenoviral vector system for gene therapy applications.
Multigene WO 00/46244
Fanconi anemia protein ligand
Protein that interacts with a Fanconi anemia protein, encoding gene, antibodies; for diagnostic screens.
Netherlands Org. Technol. Develop. EP 1 028 117
Protein prenylation inhibitors
Peptide analogs for use as inhibitors of prenyl transferases that prenylate proteins.
Neutec Pharma WO 00/46359
Chlamydia disease therapies
Diagnosis and treatment of atherosclerosis caused by Chlamydia pneumoniae infection.
Novo Nordisk Biotech WO 00/46375
Recombinant proteins from fungi
Fungal pacC pH signal transduction pathway gene linked to a foreign gene; for fungal expression of recombinant proteins.
Olympus Optical WO 00/46363
Nucleic acid sequencing
Determination of nucleic acid sequence by analyzing smaller fragments of the whole sequence.
Oregon Hlth. Sci. Univ. WO 00/46361
Treating transplant rejection
MHC II pathway blockage with human cytomegalovirus protein; for treating transplant rejection and autoimmune diseases.
Palsson, B. WO 00/46405
Antibacterial drug targets
La Jolla, Calif.
Computational methods for finding potential antibacterial drug targets based on genomic DNA sequences.
Schering WO 00/46245
Human antibacterial proteins
Human antibacterial proteins SAP-2 and -3, cells transfected with cDNAs; for production of antimicrobials.
Scriptgen Pharma WO 00/46374
Yeast RNA polymerase II gene
Candida albicans yeast SRB-7 gene that encoded a protein that is part of the RNA polymerase II holoenzyme complex.
Sloan-Kettering Inst. WO 00/46408
Replicating DNA in large amounts
Process for replicating large segments of DNA by assembling a replisome at the D-loop; for detecting genetic variation.
Suntory WO 00/45633
Blood pressure regulation study
Transgenics with vascular-specific expression of angiotensin II2 receptor; for studying blood pressure regulation.
Sydney, Univ. of WO 00/46233
Fluorescent pigment protein
Pigment protein from coral tissue for use as a tissue or general fluorescent marker.
Texas, Univ. of WO 00/46347
Drug resistance modulation
Manipulation of ABC transporters to alter cellular ATP gradients; for modulating drug resistance.
Thomas Jefferson Univ. WO 00/46350
Recombinant proteins from plants
Use of transcomplementation systems to systemically transfect plants; for producing recombinant proteins.
Thomas Jefferson Univ. WO 00/46377
Non-dividing cell infection
Retroviral vector particles having matrix protein gene mutations; for infecting non-dividing cells.
Utah, Univ. of WO 00/46371
Salt Lake City, Utah
Short peptides known as tau-conotoxins from cone snail venom, peptide analogs.
Virginia Comm. Univ. WO 00/46365
Enhancing immune responses
Particles for presenting haptens, including nucleic acids and proteins; for enhancing immune responses.
Walter Reed Army Res. Inst. WO 00/46404
Toxin-exposure gene expression
Comparison of differential protein and/or gene expression patterns in normal and toxin-exposed individuals.
Western Australia, Univ. of WO 00/46398
Methylated DNA detection
Use of fluorescent molecular beacons in detecting methylated nucleic acids.
Zetatronics GB 2 346 694
Detecting single-stranded DNA
Detecting single-stranded nucleic acids in a hybridization reaction in which excess probe is destroyed.
Zouboulis, C. WO 00/46353
Sebaceous gland cells
Sebaceous gland cells that can be subcultured over several generations.