August 3 (WO)
Abbott Labs WO 00/44930
Biosensor
Abbott Park, Ill.
Diagnostic test and biosensor apparatus for the measurement of analytes in biological fluids.
American Home Products WO 00/44901
_3-adrenergic receptor gene regulation
Madison, N.J.
Regulatory sequences of the human _3-adrenergic receptor gene; for control of gene transcription.
Amgen WO 00/44397
Stimulating inner ear sensation
Thousand Oaks, Calif.
Non-natural peptide based on EGF-like domains of heregulin protein isoforms; for stimulating inner ear sensory cells.
Amgen WO 00/44898
Modulating melanocortin receptors
Thousand Oaks, Calif.
Agouti signaling protein and related proteins, encoding genes; for modulating melanocortin 3/4 receptors.
Amgen Canada WO 00/44407
Hodgkin's disease treatment
Mississauga, Ont.
Inhibition of interleukin (IL)-13 action and associated signal transduction pathways; for treating Hodgkin's.
Anticancer WO 00/44932
Cardiovascular disease risk
San Diego
Fluorescence-based assay for pyridoxal 5'-phosphate; for assessing cardiovascular disease risk.
AP Cells WO 00/44389
Membrane vesicle preparation
Menlo Park, Calif.
Preparing membrane vesicles from tumor or antigen-presenting cells by column chromatography.
Australian Natl. Univ. WO 00/44230
Fungal pathogen control
Acton, Australia
Controlling fungal pathogens by using Pseudomonas strains that produce sugar acids.
Australian Red Cross WO 00/44780
Mannose binding protein
Brisbane, Australia
Protein that binds mannose moieties on surface glycoproteins of neutrophils and neutrophil precursor cells.
Avi Biopharma WO 00/44897
Restenosis antisense
Corvallis, Ore.
Morpholino moiety-containing antisense targeted to the c-myc gene; for treating restenosis.
Bavarian Nordic Res. Inst. WO 00/44935
Nucleic acid sequence variants
Copenhagen, Denmark
Multiplex real-time PCR for detecting nucleic acid sequence variants differing at the probe binding site.
Beth Israel Deaconess Hosp. WO 00/44908
Angiogenesis inhibition
Boston
Fusions of thrombospondins and cartilage oligomeric matrix protein; for inhibiting angiogenesis.
Bion WO 00/44931
Na+-K+-ATPase modulators
Cambridge, Mass.
High-throughput screening assays for modulators of Na+-K+-ATPase; for regulating fluid balance and cell volume.
California, Univ. of WO 00/44879
Prostate cancer cell lines
Oakland, Calif.
Aggressive prostate cancer sublines selected by androgen deprivation; for diagnostics and therapeutics.
California, Univ. of WO 00/44929 & 45179
Sensory cell modulation
Oakland, Calif.
Gene sequences for sensory cell specific G-protein otein and _ subunits; for screening modulators.
California, Univ. of WO 00/45322
Protein function determination
Oakland, Calif.
Computational methods and computer programs for inferring functional links from genomic sequences.
Children's Hosp. WO 00/44391
Angiogenesis inhibition
Boston
Plasminogen kringle 4 fragments; for inhibiting endothelial cell proliferation and consequent angiogenesis.
Chiron Behring WO 00/44392
Mycobacteria diagnostics
Marburg, Germany
Antigens differentially expressed in virulent and non-virulent strains of mycobacteria; for diagnostics.
Compugen WO 00/44784
Chemokine homolog
Tel Aviv, Israel
Gene sequences having a homology to a chemokine, encoded protein; for diagnostics and therapeutics.
Corixa WO 00/44899
Cancer vaccine
Seattle, Wash.
HER-2/neu fusion proteins, encoding genes; for making a vaccine that elicits an immunoresponse against cancer.
Cytovia WO 00/45165
Antineoplastic agent assay
San Diego
Identifying antineoplastic agents that activate the caspase cascade in cultured cells having a cancer phenotype.
Delta Biotech WO 00/44772
Albumin purification
Nottingham, UK
Purification of albumin expressed in yeast using chromatographic techniques.
Elitra Pharma WO 00/44906
E coli antibacterials
San Diego
Genes encoding proteins required for E coli proliferation, encoded proteins; for antibacterial screens.
Epigenomics WO 00/44934
Gene silencing assay
Berlin
Mass spectrometry assay for cytosine methylation patterns in genomic DNA samples; for assaying gene silencing.
Epimmune WO 00/44775
HLA-restricted T cell epitopes
San Diego
Identifying broadly active HLA-restricted T cell epitopes; for screening disease-related targets and vaccines.
French Atomic Energy Comm. WO 00/44887
Bee venom allergy therapy
Paris
Antigenic fragments of the major bee venom allergen; for desensitization to allergic reactions to bee stings.
French Atomic Energy Comm. WO 00/44936
Gene expression patterns
Paris
Microassay for serial analysis of gene expression patterns using thermal PCR methods.
Gen-Probe WO 00/44940
Prostate cancer diagnostics
San Diego
Human prostate cancer-associated genetic markers; for PCR-based diagnostic assay for this disease.
Genotech WO 00/44891
DNA-labeled manufactured goods
Taejon, S. Korea
Multiple copies of amplified DNA sequences incorporated into ink; for identifying manufactured goods.
Georgia, Med. Coll. of WO 00/44914
Gene expression attenuation
Augusta, Ga.
Attenuation of gene expression in vivo and in vitro by using double-stranded RNA.
Halaka, F.G. WO 00/44928
DNA purification
North Chicago, Ill.
Compounds having pKa values between 5 and 7; for electrophoretic purification of nucleic acids and proteins.
Hoffmann-La Roche WO 00/44785
PEG conjugates of GCSF
Nutley, N.J.
Physiologically active polyethylene (PEG) conjugates of granulocyte colony stimulating factor (GCSF).
ICN Pharma WO 00/44388
Ribavirin immunoresponse
Costa Mesa, Calif.
Modulating immune responses by using Ribavirin and its analogs to affect the B7 marker.
IDEC Pharma WO 00/44788
Tetravalent antibodies
San Diego
Production of tetravalent antibodies using linked antibody molecules; for crosslinking membrane antigens.
Imclone Systems WO 00/44777
Angiogenesis inhibition
New York
Antibodies that bind to KDR with an affinity comparable to human VEGF; for inhibiting angiogenesis.
Imperial Coll. Innovations WO 00/45173
Intimin inhibitors
London
Tir binding domain peptides as inhibitors of intimin adhesion; for treating bacterial diarrhoea.
Incyte Genomics WO 00/44900
Nucleic acid binding proteins
Palo Alto, Calif.
Nucleic acid binding proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/44880
Immunogenic leukemia cells
Paris
Treatment of acute myeloid leukemia cells with cytokines; for increasing immunogenicity.
Japan Sci. & Technol. WO 00/44881
Transplant organs
Kanagawa, Japan
Inducing embryonic development in vitro using TGF-_ family proteins; for making organs for transplantation.
Keygene WO 00/44937
Restriction enzymes for sequencing
Wageningen, Netherlands
Determination of appropriate restriction enzymes for use in analyzing specific nucleic acid sequences.
Kreutzer, R., et al. WO 00/44895
Gene expression inhibition
Weldenberg, Germany
Double-stranded oligoribonucleotide complementary to a target gene; for inhibiting gene expression.
Kyowa Hakko Kogyo WO 00/44886
Producing HMG CoA-reductase inhibitors
Tokyo
Bacillus hydroxylating enzymes; for derivatizing bacterial lactones that act as HMG CoA-reductase inhibitors.
Leukosite WO 00/44789 & 44790
CCR1 antibodies
Cambridge, Mass.
CC-chemokine receptor 1 (CCR1) antibodies; for blocking cell interactions involving CCR1.
Lubitz, W. WO 00/44878
Compartmental protein production
Vienna, Austria
Compartmentalization of recombinant polypeptides in host cells; for use in therapeutic protein production.
Ludwig Inst. Cancer Res. WO 00/44903
PDGF/VEGF-like growth factors
New York
PDGF/VEGF-like growth factors, encoding genes, antibodies, other modulators; for diagnostics and therapeutics.
Maryland, Univ. of WO 00/44405
Foreign proteins for vaccines
Baltimore, Md.
Bacterial vector based on the dmsA promoter; for expressing foreign proteins in live, attenuated vaccines.
Max Planck Inst. WO 00/44894
Apoptosis-inducing genes
Munich, Germany
Detection of apoptosis-inducing DNA sequences using secreted enzymes as a reporter system.
Mice & More WO 00/44889
Mammary cancer therapy
Hamburg, Germany
Transgenics with a prolactin-activated oncogene causing mammary ductal carcinoma; for diagnostics and therapeutics.
Millennium Pharma WO 00/44910
Lysyl oxidase-related protein
Cambridge, Mass.
Lysyl oxidase-related protein, encoding genes, antibodies, transgenics; for diagnostics and therapeutics.
Miyata, T., et al. WO 00/44783
Mesangial cell-expressed gene
Kanagawa, Japan
Gene highly expressed in mesangial cells, encoded protein; for diagnosing and treating mesangial cell diseases.
Neurosearch WO 00/44786
Potassium channel
Ballerup, Denmark
KCNQ4 potassium channel, encoding gene sequences, transgenics; for screening modulators.
Onyx Pharma WO 00/44922
Recombinant adenovirus vectors
Richmond, Calif.
Recombinant adenovirus vectors with E1B region mutations for easy insertion of foreign genes; for gene therapy.
Oregon Hlth. Sci. Univ. WO 00/44403
HER-2 binding antagonists
Portland, Ore.
HER-2 binding antagonists and antibodies; for treating cancers that overexpress HER-2.
Otsuka Pharma WO 00/44905
Pathogenic bacteria vaccines
Tokyo
Protein that has immunogenicity against pathogenic acid-fast bacteria, encoding gene; for vaccines.
Palmetto Richland Mem. Hosp. WO 00/44893
Preventing leukemia relapse
Columbia, S.C.
In vitro expansion of activated gamma delta lymphocytes; for preventing leukemia relapse after bone marrow transplant.
Pharmacia & Upjohn WO 00/45177
Ribosomal activity modulators
Kalamazoo, Mich.
Assays for modulators of the activity of elongation factor P and related constituents of ribosomal complexes.
Prolifix WO 00/44771
Cell growth inhibitor
Abingdon, UK
Transcription factor E2F DNA-binding domain inhibitors; for preventing uncontrolled cell proliferation.
Res. Develop. Fdn. WO 00/44766
NO level reduction
Carson City, Nev.
Inhibition of cationic transporter activity using antisense and antibodies; for lowering nitric oxide (NO) levels.
Roche Diagnostics WO 00/44759
Endotoxin-free DNA
Mannheim, Germany
Methods for producing endotoxin-free nucleic acids; for purifying gene therapy vectors.
Roche Diagnostics WO 00/45176
Detecting N-terminal proBNP
Mannheim, Germany
Methods for detecting N-terminal proBNF using at least two antibodies that detect two different epitopes.
RTP Pharma WO 00/44400
Diabetes therapy
Nun's Island, Que.
Use of gastrin/CCK receptor ligands to cause pancreatic islet cell differentiation; for treating diabetes.
Schering-Plough WO 00/44883
Virus production
Lucerne, Switzerland
Propagation of bovine coronavirus in Chinese hamster ovary cells; for virus production.
Schneider, E.M. WO 00/44782
Ewing's tumor antigen
Ulm, Germany
Ewing's tumor antigen, encoding gene sequences, diagnostic detection by antibodies.
Scripps Res. Inst. WO 00/45334
Tertiary protein structures
La Jolla, Calif.
Assembly of protein tertiary structure information from known, loosely encoded secondary structure constraints.
Searle WO 00/44902
Carcinogenesis biomarkers
Chicago
Carcinogenesis biomarkers produced by phenobarbital-treated rat liver cells, encoding genes; for diagnostics.
Signature Bioscience WO 00/45160 & 45170
Molecular binding detection
Burlingame, Calif.
Detection of molecular binding events using the unique dielectric properties of the bound structure.
SmithKline Beecham WO 00/44764
Antibacterial screens
Philadelphia
Bacterial mvd polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/44765 & 44778
Antibacterial screens
Philadelphia
Bacterial mvk polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/44773
Staphylococcus antibacterials
Philadelphia
Staphylococcus fabG polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/44779
Antibacterial screens
Philadelphia
Bacterial MurA polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/44787
Calcitonin receptor modulators
Philadelphia
Gene sequences encoding bovine calcitonin receptor-like receptor, encoded protein; for modulator screens.
SmithKline Beecham WO 00/44885
Streptococcus antibacterials
Philadelphia
Streptococcus fabG polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/44890 & 44904
Meningitis therapeutics
Rixensart, Belgium
Neisseria meningitidis proteins, encoding genes, production methods; for meningitis diagnostics and therapeutics.
SmithKline Beecham WO 00/44913
Metalloproteases
Brentford, UK
Metalloproteases, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/44927
Staphylococcus antibacterials
Philadelphia
Staphylococcus pskG polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/44933
Cytochrome P450 activity
Brentford, UK
Resorufin derivatives as substrates for cytochrome P450; for assaying enzyme activity.
SmithKline Beecham WO 00/44941
Immune disease-associated proteins
Philadelphia
Immune disease-associated proteins, encoding genes, production methods; for diagnostics and therapeutics.
South Florida, Univ. of WO 00/44774
Cancer therapeutic
Tampa, Fla.
Disruption of the STAT signal transduction pathway; for treating human cancers.
Stichting Biomed. Primate Res. Ctr. WO 00/44410
Less immunogenic vectors
Rijswijk, Netherlands
Less immunogenic recombinant viral and bacterial vectors for expressing antigens; for vaccines.
Stratagene WO 00/44926
Rare codon usage
La Jolla, Calif.
Modified host cells for the high level expression of heterologous proteins using rare tRNA codons.
3M Innovative Properties WO 00/45174
Whole cell selection
St. Paul, Minn.
Whole cell selection and purification using appropriately derivatized azlactone functional supports.
Tranxenogen WO 00/44892
Proteins from milk
Shrewsbury, Mass.
Use of human lactoferrin promoter sequences to express heterologous proteins in mammary glands in transgenics.
U.S. Med. Res. Inst. WO 00/44406
Hantavirus DNA vaccines
Frederick, Md.
Gene sequences encoding the G1 and G2 glycoproteins from hantaviruses; for DNA vaccines.
Univ. College WO 00/44409
Connexin antisense
London
Formulations of antisense nucleotides to connexin; for reducing neuronal cell death.
Univ. College WO 00/44888
Modulating nitric oxide levels
London
Two human dimethylarginine dimethylaminohydrolases; for screening inhibitors to modulate nitric oxide levels.
Utah, Univ. of WO 00/44769 & 44776
-conotoxin peptides
Salt Lake City
-conotoxin peptides with 10 to 30 amino acid residues and two disulfide bonds; for pain treatment and prevention.
Virginia, Univ. of WO 00/44395
Modulating fertility
Charlottesville, Va.
FSP95 genes, encoded proteins, derivatives, antibodies; for modulating fertility.
Vlaams Inst. Biotech WO 00/44896
Cell cycle-regulated vectors
Zwijnaarde, Netherlands
Internal ribosome entry site in a gene encoding two protein kinase isoforms; for making cell cycle-regulated vectors.
Zen-Bio WO 00/44882
Adipocyte differentiation
Res. Triangle Park, N.C.
Methods for differentiating human preadipocytes into adipocytes that are then grown in biomatrices.