August 3 (WO)

Abbott Labs WO 00/44930


Abbott Park, Ill.

Diagnostic test and biosensor apparatus for the measurement of analytes in biological fluids.

American Home Products WO 00/44901

_3-adrenergic receptor gene regulation

Madison, N.J.

Regulatory sequences of the human _3-adrenergic receptor gene; for control of gene transcription.

Amgen WO 00/44397

Stimulating inner ear sensation

Thousand Oaks, Calif.

Non-natural peptide based on EGF-like domains of heregulin protein isoforms; for stimulating inner ear sensory cells.

Amgen WO 00/44898

Modulating melanocortin receptors

Thousand Oaks, Calif.

Agouti signaling protein and related proteins, encoding genes; for modulating melanocortin 3/4 receptors.

Amgen Canada WO 00/44407

Hodgkin's disease treatment

Mississauga, Ont.

Inhibition of interleukin (IL)-13 action and associated signal transduction pathways; for treating Hodgkin's.

Anticancer WO 00/44932

Cardiovascular disease risk

San Diego

Fluorescence-based assay for pyridoxal 5'-phosphate; for assessing cardiovascular disease risk.

AP Cells WO 00/44389

Membrane vesicle preparation

Menlo Park, Calif.

Preparing membrane vesicles from tumor or antigen-presenting cells by column chromatography.

Australian Natl. Univ. WO 00/44230

Fungal pathogen control

Acton, Australia

Controlling fungal pathogens by using Pseudomonas strains that produce sugar acids.

Australian Red Cross WO 00/44780

Mannose binding protein

Brisbane, Australia

Protein that binds mannose moieties on surface glycoproteins of neutrophils and neutrophil precursor cells.

Avi Biopharma WO 00/44897

Restenosis antisense

Corvallis, Ore.

Morpholino moiety-containing antisense targeted to the c-myc gene; for treating restenosis.

Bavarian Nordic Res. Inst. WO 00/44935

Nucleic acid sequence variants

Copenhagen, Denmark

Multiplex real-time PCR for detecting nucleic acid sequence variants differing at the probe binding site.

Beth Israel Deaconess Hosp. WO 00/44908

Angiogenesis inhibition


Fusions of thrombospondins and cartilage oligomeric matrix protein; for inhibiting angiogenesis.

Bion WO 00/44931

Na+-K+-ATPase modulators

Cambridge, Mass.

High-throughput screening assays for modulators of Na+-K+-ATPase; for regulating fluid balance and cell volume.

California, Univ. of WO 00/44879

Prostate cancer cell lines

Oakland, Calif.

Aggressive prostate cancer sublines selected by androgen deprivation; for diagnostics and therapeutics.

California, Univ. of WO 00/44929 & 45179

Sensory cell modulation

Oakland, Calif.

Gene sequences for sensory cell specific G-protein otein and _ subunits; for screening modulators.

California, Univ. of WO 00/45322

Protein function determination

Oakland, Calif.

Computational methods and computer programs for inferring functional links from genomic sequences.

Children's Hosp. WO 00/44391

Angiogenesis inhibition


Plasminogen kringle 4 fragments; for inhibiting endothelial cell proliferation and consequent angiogenesis.

Chiron Behring WO 00/44392

Mycobacteria diagnostics

Marburg, Germany

Antigens differentially expressed in virulent and non-virulent strains of mycobacteria; for diagnostics.

Compugen WO 00/44784

Chemokine homolog

Tel Aviv, Israel

Gene sequences having a homology to a chemokine, encoded protein; for diagnostics and therapeutics.

Corixa WO 00/44899

Cancer vaccine

Seattle, Wash.

HER-2/neu fusion proteins, encoding genes; for making a vaccine that elicits an immunoresponse against cancer.

Cytovia WO 00/45165

Antineoplastic agent assay

San Diego

Identifying antineoplastic agents that activate the caspase cascade in cultured cells having a cancer phenotype.

Delta Biotech WO 00/44772

Albumin purification

Nottingham, UK

Purification of albumin expressed in yeast using chromatographic techniques.

Elitra Pharma WO 00/44906

E coli antibacterials

San Diego

Genes encoding proteins required for E coli proliferation, encoded proteins; for antibacterial screens.

Epigenomics WO 00/44934

Gene silencing assay


Mass spectrometry assay for cytosine methylation patterns in genomic DNA samples; for assaying gene silencing.

Epimmune WO 00/44775

HLA-restricted T cell epitopes

San Diego

Identifying broadly active HLA-restricted T cell epitopes; for screening disease-related targets and vaccines.

French Atomic Energy Comm. WO 00/44887

Bee venom allergy therapy


Antigenic fragments of the major bee venom allergen; for desensitization to allergic reactions to bee stings.

French Atomic Energy Comm. WO 00/44936

Gene expression patterns


Microassay for serial analysis of gene expression patterns using thermal PCR methods.

Gen-Probe WO 00/44940

Prostate cancer diagnostics

San Diego

Human prostate cancer-associated genetic markers; for PCR-based diagnostic assay for this disease.

Genotech WO 00/44891

DNA-labeled manufactured goods

Taejon, S. Korea

Multiple copies of amplified DNA sequences incorporated into ink; for identifying manufactured goods.

Georgia, Med. Coll. of WO 00/44914

Gene expression attenuation

Augusta, Ga.

Attenuation of gene expression in vivo and in vitro by using double-stranded RNA.

Halaka, F.G. WO 00/44928

DNA purification

North Chicago, Ill.

Compounds having pKa values between 5 and 7; for electrophoretic purification of nucleic acids and proteins.

Hoffmann-La Roche WO 00/44785

PEG conjugates of GCSF

Nutley, N.J.

Physiologically active polyethylene (PEG) conjugates of granulocyte colony stimulating factor (GCSF).

ICN Pharma WO 00/44388

Ribavirin immunoresponse

Costa Mesa, Calif.

Modulating immune responses by using Ribavirin and its analogs to affect the B7 marker.

IDEC Pharma WO 00/44788

Tetravalent antibodies

San Diego

Production of tetravalent antibodies using linked antibody molecules; for crosslinking membrane antigens.

Imclone Systems WO 00/44777

Angiogenesis inhibition

New York

Antibodies that bind to KDR with an affinity comparable to human VEGF; for inhibiting angiogenesis.

Imperial Coll. Innovations WO 00/45173

Intimin inhibitors


Tir binding domain peptides as inhibitors of intimin adhesion; for treating bacterial diarrhoea.

Incyte Genomics WO 00/44900

Nucleic acid binding proteins

Palo Alto, Calif.

Nucleic acid binding proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/44880

Immunogenic leukemia cells


Treatment of acute myeloid leukemia cells with cytokines; for increasing immunogenicity.

Japan Sci. & Technol. WO 00/44881

Transplant organs

Kanagawa, Japan

Inducing embryonic development in vitro using TGF-_ family proteins; for making organs for transplantation.

Keygene WO 00/44937

Restriction enzymes for sequencing

Wageningen, Netherlands

Determination of appropriate restriction enzymes for use in analyzing specific nucleic acid sequences.

Kreutzer, R., et al. WO 00/44895

Gene expression inhibition

Weldenberg, Germany

Double-stranded oligoribonucleotide complementary to a target gene; for inhibiting gene expression.

Kyowa Hakko Kogyo WO 00/44886

Producing HMG CoA-reductase inhibitors


Bacillus hydroxylating enzymes; for derivatizing bacterial lactones that act as HMG CoA-reductase inhibitors.

Leukosite WO 00/44789 & 44790

CCR1 antibodies

Cambridge, Mass.

CC-chemokine receptor 1 (CCR1) antibodies; for blocking cell interactions involving CCR1.

Lubitz, W. WO 00/44878

Compartmental protein production

Vienna, Austria

Compartmentalization of recombinant polypeptides in host cells; for use in therapeutic protein production.

Ludwig Inst. Cancer Res. WO 00/44903

PDGF/VEGF-like growth factors

New York

PDGF/VEGF-like growth factors, encoding genes, antibodies, other modulators; for diagnostics and therapeutics.

Maryland, Univ. of WO 00/44405

Foreign proteins for vaccines

Baltimore, Md.

Bacterial vector based on the dmsA promoter; for expressing foreign proteins in live, attenuated vaccines.

Max Planck Inst. WO 00/44894

Apoptosis-inducing genes

Munich, Germany

Detection of apoptosis-inducing DNA sequences using secreted enzymes as a reporter system.

Mice & More WO 00/44889

Mammary cancer therapy

Hamburg, Germany

Transgenics with a prolactin-activated oncogene causing mammary ductal carcinoma; for diagnostics and therapeutics.

Millennium Pharma WO 00/44910

Lysyl oxidase-related protein

Cambridge, Mass.

Lysyl oxidase-related protein, encoding genes, antibodies, transgenics; for diagnostics and therapeutics.

Miyata, T., et al. WO 00/44783

Mesangial cell-expressed gene

Kanagawa, Japan

Gene highly expressed in mesangial cells, encoded protein; for diagnosing and treating mesangial cell diseases.

Neurosearch WO 00/44786

Potassium channel

Ballerup, Denmark

KCNQ4 potassium channel, encoding gene sequences, transgenics; for screening modulators.

Onyx Pharma WO 00/44922

Recombinant adenovirus vectors

Richmond, Calif.

Recombinant adenovirus vectors with E1B region mutations for easy insertion of foreign genes; for gene therapy.

Oregon Hlth. Sci. Univ. WO 00/44403

HER-2 binding antagonists

Portland, Ore.

HER-2 binding antagonists and antibodies; for treating cancers that overexpress HER-2.

Otsuka Pharma WO 00/44905

Pathogenic bacteria vaccines


Protein that has immunogenicity against pathogenic acid-fast bacteria, encoding gene; for vaccines.

Palmetto Richland Mem. Hosp. WO 00/44893

Preventing leukemia relapse

Columbia, S.C.

In vitro expansion of activated gamma delta lymphocytes; for preventing leukemia relapse after bone marrow transplant.

Pharmacia & Upjohn WO 00/45177

Ribosomal activity modulators

Kalamazoo, Mich.

Assays for modulators of the activity of elongation factor P and related constituents of ribosomal complexes.

Prolifix WO 00/44771

Cell growth inhibitor

Abingdon, UK

Transcription factor E2F DNA-binding domain inhibitors; for preventing uncontrolled cell proliferation.

Res. Develop. Fdn. WO 00/44766

NO level reduction

Carson City, Nev.

Inhibition of cationic transporter activity using antisense and antibodies; for lowering nitric oxide (NO) levels.

Roche Diagnostics WO 00/44759

Endotoxin-free DNA

Mannheim, Germany

Methods for producing endotoxin-free nucleic acids; for purifying gene therapy vectors.

Roche Diagnostics WO 00/45176

Detecting N-terminal proBNP

Mannheim, Germany

Methods for detecting N-terminal proBNF using at least two antibodies that detect two different epitopes.

RTP Pharma WO 00/44400

Diabetes therapy

Nun's Island, Que.

Use of gastrin/CCK receptor ligands to cause pancreatic islet cell differentiation; for treating diabetes.

Schering-Plough WO 00/44883

Virus production

Lucerne, Switzerland

Propagation of bovine coronavirus in Chinese hamster ovary cells; for virus production.

Schneider, E.M. WO 00/44782

Ewing's tumor antigen

Ulm, Germany

Ewing's tumor antigen, encoding gene sequences, diagnostic detection by antibodies.

Scripps Res. Inst. WO 00/45334

Tertiary protein structures

La Jolla, Calif.

Assembly of protein tertiary structure information from known, loosely encoded secondary structure constraints.

Searle WO 00/44902

Carcinogenesis biomarkers


Carcinogenesis biomarkers produced by phenobarbital-treated rat liver cells, encoding genes; for diagnostics.

Signature Bioscience WO 00/45160 & 45170

Molecular binding detection

Burlingame, Calif.

Detection of molecular binding events using the unique dielectric properties of the bound structure.

SmithKline Beecham WO 00/44764

Antibacterial screens


Bacterial mvd polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/44765 & 44778

Antibacterial screens


Bacterial mvk polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/44773

Staphylococcus antibacterials


Staphylococcus fabG polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/44779

Antibacterial screens


Bacterial MurA polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/44787

Calcitonin receptor modulators


Gene sequences encoding bovine calcitonin receptor-like receptor, encoded protein; for modulator screens.

SmithKline Beecham WO 00/44885

Streptococcus antibacterials


Streptococcus fabG polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/44890 & 44904

Meningitis therapeutics

Rixensart, Belgium

Neisseria meningitidis proteins, encoding genes, production methods; for meningitis diagnostics and therapeutics.

SmithKline Beecham WO 00/44913


Brentford, UK

Metalloproteases, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/44927

Staphylococcus antibacterials


Staphylococcus pskG polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/44933

Cytochrome P450 activity

Brentford, UK

Resorufin derivatives as substrates for cytochrome P450; for assaying enzyme activity.

SmithKline Beecham WO 00/44941

Immune disease-associated proteins


Immune disease-associated proteins, encoding genes, production methods; for diagnostics and therapeutics.

South Florida, Univ. of WO 00/44774

Cancer therapeutic

Tampa, Fla.

Disruption of the STAT signal transduction pathway; for treating human cancers.

Stichting Biomed. Primate Res. Ctr. WO 00/44410

Less immunogenic vectors

Rijswijk, Netherlands

Less immunogenic recombinant viral and bacterial vectors for expressing antigens; for vaccines.

Stratagene WO 00/44926

Rare codon usage

La Jolla, Calif.

Modified host cells for the high level expression of heterologous proteins using rare tRNA codons.

3M Innovative Properties WO 00/45174

Whole cell selection

St. Paul, Minn.

Whole cell selection and purification using appropriately derivatized azlactone functional supports.

Tranxenogen WO 00/44892

Proteins from milk

Shrewsbury, Mass.

Use of human lactoferrin promoter sequences to express heterologous proteins in mammary glands in transgenics.

U.S. Med. Res. Inst. WO 00/44406

Hantavirus DNA vaccines

Frederick, Md.

Gene sequences encoding the G1 and G2 glycoproteins from hantaviruses; for DNA vaccines.

Univ. College WO 00/44409

Connexin antisense


Formulations of antisense nucleotides to connexin; for reducing neuronal cell death.

Univ. College WO 00/44888

Modulating nitric oxide levels


Two human dimethylarginine dimethylaminohydrolases; for screening inhibitors to modulate nitric oxide levels.

Utah, Univ. of WO 00/44769 & 44776

-conotoxin peptides

Salt Lake City

-conotoxin peptides with 10 to 30 amino acid residues and two disulfide bonds; for pain treatment and prevention.

Virginia, Univ. of WO 00/44395

Modulating fertility

Charlottesville, Va.

FSP95 genes, encoded proteins, derivatives, antibodies; for modulating fertility.

Vlaams Inst. Biotech WO 00/44896

Cell cycle-regulated vectors

Zwijnaarde, Netherlands

Internal ribosome entry site in a gene encoding two protein kinase isoforms; for making cell cycle-regulated vectors.

Zen-Bio WO 00/44882

Adipocyte differentiation

Res. Triangle Park, N.C.

Methods for differentiating human preadipocytes into adipocytes that are then grown in biomatrices.

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