Published August 2 & 9 (EPO); July 27 (WO); August 2 & 9 (GB)

Abbott Labs WO 00/43420 & 43421

Breast cancer diagnosis

Abbott Park, Ill.

Contiguous and partially overlapping genes transcribed in breast tissue; for breast cancer diagnosis and therapy.

Affymetrix EP 1 024 200

Genotyping probes

Santa Clara, Calif.

Polymorphic site- and allele-specific primers and probes; for genotype analysis.

Affymetrix EP 1 026 258

Multiplex genotyping

Santa Clara, Calif.

Multiplex genotyping of individuals by generating polymorphic profiles.

Agene Res. Inst. WO 00/43522

RecQ4 helicase

Kanagawa, Japan

RecQ4 helicase gene that causes Rothmund-Thomson syndrome, encoded protein; for disease diagnostics and therapeutics.

Aventis Behring EP 1 026 250

Coagulation deficiency therapy

Marburg, Germany

DNA constructs encoding a fusion of Factor IX and P-selectin; for treating blood coagulation deficiencies.

Aventis Pharma WO 00/43524

Cell cycle regulation

Antony, France

Polypeptides derived from JNK3 protein, encoding gene sequences; for regulating the cell cycle.

Beth Israel Hosp. EP 1 024 197

Mesothelial gene therapy

Boston

Delivery of nucleic acid sequences to body cavities; for mesothelial cell gene therapy.

Biochip Technol. WO 00/43539

Surface immobilization

Freiburg, Germany

Immobilization of molecules on surfaces using polyfunctional polymer monolayers.

Bio Merieux WO 00/43521

Integrated retroviral genes

Marcy l'Etoile, France

Endogenetic nucleic acid fragments encoding the gag protein from retroviruses that are integrated in the human genome.

California, Univ. of EP 1 026 238

Autoimmune disease enzyme

Oakland, Calif.

Glutamic acid decarboxylase, encoding gene sequences; for autoimmune disease diagnostics and therapeutics.

Cambridge Molecular Technol. GB 2 346 370

Genomic DNA isolation

Cambridge, UK

Methods using filters for retaining cells to be lysed in order to isolate genomic DNA.

Chugai EP 1 024 193

Transcription factor conversion

Tokyo

Screening genes that encode polypeptides that convert inactive transcription factors to active ones.

Cobra Therapeutics WO 00/43541

Prodrug activation

Keele, UK

Methods for selecting genes encoding enzymes that convert a prodrug into its active form.

Compugen WO 00/43506

Serotonin receptor homologs

Tel Aviv, Israel

Nucleic acid sequences with homology to the serotonin receptor gene, encoded proteins.

Cornell Univ. WO 00/43551

HIV viral loads

Ithaca, N.Y.

Determining viral loads in CD4-CD- T cells in HIV-infected patients where viral loads are not detectable in plasma.

Dade Behring WO 00/43543-43546

Finding drug-resistant organisms

Deerfield, Ill.

Detecting polynucleotide sequence differences using double-stranded complexes; for finding drug-resistant organisms.

Dana-Farber Cancer Inst. EP 1 025 856

Cancer therapy

Boston

Modulating antigen-specific T-cell unresponsiveness by stimulation of CD2 receptors; for anti-cancer responses.

Dyax EP 1 026 240

Proteins binding selected targets

Cambridge, Mass.

Generation and selection of recombinant proteins that bind chosen targets using a DNA library.

European Molec. Biol. Lab EP 1 026 244

Cell cycle regulators

Heidelberg, Germany

Proteins that trigger the G2/M mitotic transition and that bind CDC2 and cyclin B, encoding gene sequences.

French Atomic Energy Comm. EP 1 024 201

Gene expression analysis

Paris

Microassay methods for analyzing gene expression using a library of tags.

Fuji EP 1 026 259

DNA chip

Kanagawa, Japan

DNA chip composed of a solid carrier with polynucleotides fixed to the carrier using a hydrophilic polymer.

Fujisawa Pharma EP 1 024 194

Plasmid vector

Osaka, Japan

Plasmid vectors that control autonomous replication in bacteria and can incorporate other structural genes.

Fujita, J. EP 1 024 190

Gankyrin

Kyoto, Japan

Gankyrin, derivatives retaining biological activity, encoding gene sequences.

Gamidagen WO 00/43531

GC-rich DNA assay

Rehovot, Israel

Amplification methods for characterizing GC-rich nucleic acid sequences in samples.

Genzyme EP 1 024 198

Hemophilia gene therapy

Cambridge, Mass.

Pseudo-adenoviral vectors having inverted terminal repeats that encode Factor VIII or IX; for treating hemophilia.

Helix Res. Inst. EP 1 026 242

Full-length cDNA clones

Chiba, Japan

Screening full-length cDNA clones to obtain a library with a high ratio of these clones.

Hosp. Sick Children WO 00/43510

Cell signaling therapeutics

Toronto, Ont.

Ras activator nucleic acid sequences, encoded proteins; for screening drugs involved in cell signaling.

Human Genome Sciences WO 00/43493

Metalloproteinase

Rockville, Md.

Metalloproteinase ADAM 22, encoding gene sequences; for identifying modulators for use in cancer therapy.

Human Genome Sciences WO 00/43495

33 secreted proteins

Rockville, Md.

33 human secreted proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.

Humboldt Univ. WO 00/43501

Telomerase ribozymes

Berlin

Ribozymes directed against the catalytic subunit of human telomerase; for limiting tumor proliferation.

Immunex WO 00/43525

Metalloproteinase family proteins

Seattle, Wash.

Metalloproteinase-disintegrin family proteins, encoding gene sequences, recombinant production methods.

Incyte Genomics WO 00/43508

Cancer-associated proteins

Palo Alto, Calif.

Cancer-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Indian Counc. Sci. & Ind. Res. EP 1 024 192

Streptokinase proteins

New Delhi, India

Clot-specific streptokinase proteins possessing altered plasminogen activation characteristics; for therapeutics.

Isis Innovation WO 00/43542

Male genealogy assay

Oxford, UK

Databases that correlate Y chromosome haplotypes with surnames; for detecting male genealogical relationships.

Japan Sci. & Technol. EP 1 026 243

Ras protein binding nucleic acid

Kawaguchi, Japan

Nucleic acid that specifically binds the Ras target protein, screens for other binding nucleic acids; for therapeutics.

Johns Hopkins Univ. WO 00/43526

NMDA receptor overstimulation

Baltimore, Md.

Mammalian serine racemase, encoding gene; for treating conditions involving overstimulation of NMDA receptors.

Lockheed Martin Energy Res. WO 00/43552

Biochips

Oak Ridge, Tenn.

Multifunctional and multispectral biochip devices for quantifying multiple biomolecules per chip.

Ludwig Inst. Cancer Res. EP 1 025 849

Abnormal leukocyte assay

New York

Finding complexes of human leukocyte antigens and tyrosinase on abnormal cells; for diagnostics and therapeutics.

Mass. Inst. Technol. EP 1 026 237

Alzheimer's diagnostic immunoassay

Cambridge, Mass.

Tau/neurofilament protein kinases, encoding gene sequences; for immunoassays in Alzheimer's diagnosis.

Med. Molec. Res. WO 00/43505

Protease

Cologne, Germany

Protease having aspartate residues in the transmembrane region of the protein.

MRC (Med. Res. Counc.) EP 1 024 191

Chimeric antibody production

London

Production of chimeric antibodies from an antibody segment repertoire displayed on phage.

Metamorphix WO 00/43781

GDF-8/11 inhibitors

Baltimore

Inhibitors of growth differentiation factor (GDF)-8 and -11; for generating transgenics and finding therapeutics.

Millennium Pharma WO 00/43513

G-protein coupled receptor

Cambridge, Mass.

G-protein coupled receptor, encoding gene sequences; for diagnostics and therapeutics and modulator screens.

Millennium Pharma WO 00/43514

Acid sensing ion channel

Cambridge, Mass.

Acid sensing ion channel, encoding gene, antibodies, transgenics; for diagnostics and therapeutics.

Miyata, T., et al. WO 00/43528

MEGSIN gene regulatory elements

Kanagawa, Japan

Genomic DNA containing upstream and downstream regulatory sequences of the MEGSIN gene.

Montreal, Univ. of WO 00/43538

Oligo genomic libraries

Montreal, Que.

Generation of oligonucleotide libraries representative of various genomes.

Nebraska, Univ. of WO 00/43548

Prostate cancer diagnostics

Lincoln, Neb.

Prostate cancer-specific acid phosphatase; for diagnostics and therapeutics and making transgenics.

Nippon Zeon EP 1 026 246

Recombinant protein production

Tokyo

Insertion of foreign genes into turkey herpesvirus vectors; for expressing recombinant proteins.

North Carolina, Univ. of WO 00/43498

Liver cell progenitors

Chapel Hill, N.C.

Methods of isolating and cryopreserving human liver cell progenitor cells; for making artificial organs.

Northwestern Univ. WO 00/43547

Altering DNA electrophoretic mobility

Evanston, Ill.

Polyamides for binding to polynucleotides to alter their electrophoretic mobility.

Novo Nordisk WO 00/43502

Recovering solubilized enzymes

Bagsvaerd, Denmark

Methods for recovering glycosidases and peptidases by solubilizing them using high pH.

Ortho-Clinical Diagnostics EP 1 026 241

Serum DNA isolation

Rochester, N.Y.

Methods for isolating DNA from alkalinized serum and plasma that has been heated.

Ortho-Clinical Diagnostics EP 1 026 261

Enhancing amplification specificity

Rochester, N.Y.

Enhancing the specificity of nucleic acid amplification by using carrier nucleic acid.

Ortho-Clinical Diagnostics EP 1 026 262

Hepatitis C detection

Rochester, N.Y.

Oligonucleotide primers for the efficient detection of hepatitis C virus in biological samples.

Ortho-Clinical Diagnostics EP 1 026 263

HIV-1/2 detection

Rochester, N.Y.

Oligonucleotide primers for the efficient detection of HIV-1 and -2 in biological samples.

Pfizer EP 1 026 251

Alzheimer's tau activation

Groton, Conn.

Transgenic animal expressing the protein kinase activator of cdk involved in tau protein phosphorylation in Alzheimer's.

Pro-Duct Hlth. WO 00/43553

Hormone-responsive breast cancer

Menlo Park, Calif.

Screening women for a breast cancer-associated estrogen-related marker; for diagnosing hormone-responsive cancer.

Pyrosequencing WO 00/43540

Identifying single nucleotides

London

Identification of specific nucleotide bases in a given DNA sequence using targeted primers.

Ramot Univ. EP 1 026 248

Antibiotic TA production

Tel Aviv, Israel

Gene sequences encoding enzymes required for antibiotic TA production, encoded proteins; for production.

Rigel Pharma WO 00/43419

Exocytosis pathway proteins

S. San Francisco

Exocytosis pathway proteins, encoding gene sequences, fusion proteins; for identifying other pathway-related proteins.

Scripps Res. Inst. EP 1 026 239

Specific receptor isolation

La Jolla, Calif.

Isolation of genes encoding receptors having the ability to bind preselected ligands from the immunological repertoire.

Scripps Res. Inst. WO 00/43494

Viral infection control

La Jolla, Calif.

Controlling viral infection by using replication-associated proteins.

Seattle Biomedical Res. Inst. WO 00/43499

Hematopoietic reconstruction

Seattle, Wash.

Stem cells treated with TGF-_ antibodies; for in vivo hematopoietic reconstruction.

SmithKline Beecham WO 00/43418

Antibacterial screens

Philadelphia

Bacterial birA gene sequences, encoded proteins, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/43491

Antibacterial screens

Philadelphia

Bacterial yhxB gene sequences, encoded proteins, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/43492

Site-specific protein labeling

Philadelphia

Methods for site-specific labeling of proteins at glutamine residues using glutaminase; for high-throughput screens.

SmithKline Beecham WO 00/43509 & 43511

Proteins for cancer therapy

Rixensart, Belgium

Proteins that can be used to diagnose and treat cancer and immune diseases, encoding gene sequences.

SmithKline Beecham WO 00/43517 & 43518

Meningitis therapeutics

Rixensart, Belgium

Neisseria meningitidis peptides, encoding gene, production methods; for meningitis diagnostics and therapeutics.

SmithKline Beecham WO 00/43519

Proteins

Rixensart, Belgium

Proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/43527

Varicella virus vaccines

Rixensart, Belgium

Varicella Zoster virus gE protein, immunologically active fragments; for vaccines.

Somalogic WO 00/43534

DNA ligand generation

Boulder, Colo.

Robotic and computer-assisted methods and apparatus for automated generation of nucleic acid ligands.

South Carolina, Med. Univ. of WO 00/43515

HIV drug resistance assay

Charleston, S.C.

Methods for detecting HIV presence in samples using cells expressing CD4 receptors; for monitoring drug resistance.

Taiho Pharma EP 1 026 173

Thymidylate synthase antibodies

Tokyo

Human thymidylate synthase monoclonal antibodies; for immunoassays.

Takara Shuzo EP 1 026 245

Yeast infection resistance

Kyoto, Japan

Candida yeast antigenic proteins, encoding gene sequences; for inducing infection resistance.

Unilever WO 00/43507

Producing antibody fragments

London

Expression library of antibody heavy chain variable domain genes from non-immunized sources; for antibody fragments.

Utrecht Univ. WO 00/43530

Stabilized stored DNA

Utrecht, Netherlands

Nucleic acid compositions that are stabilized for storage by using cationic polymers; for gene therapy

V.I. Technol. WO 00/43549

Quenching viral inactivators

Cambridge, Mass.

Lipophilic quenching of aziridino moiety-containing viral inactivating agents.

Vitro Diagnostics WO 00/43500

Immortalizing cells

Littleton, Colo.

Immortalizing primary cells using vectors containing gene sequences of oncogenes.

Vysis EP 1 026 260

Genomic abnormality assay

Downers Grove, Ill.

Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays.

Wayne State Univ. WO 00/43550

Mammary disease diagnosis

Detroit

Methods and apparatus for non-invasively obtaining mammary fluid; for measuring factors associated with disease.

Wisconsin, Univ. of EP 1 026 253

DNA delivery intracellularly

Madison, Wis.

Methods of delivering exogenous polynucleotides to the interior of cells; for gene therapy.

Yeda Res. & Develop. WO 00/43490

Rhamnosyl-transferase

Rehovot, Israel

Rhamnosyl-transferase gene, encoded protein; for modulating oligosaccharides.

Zetatronics GB 2 346 145

Amplified product detection

Hertfordshire, UK

Detection of amplified products in nucleic acid assays using light-based assay systems.

ZymoGenetics WO 00/43512

EGF-like domain protein

Seattle

Human protein with multiple epidermal growth factor (EGF)-like domains, encoding gene; for regulating differentiation.

ZymoGenetics WO 00/43516

Secretin family protein

Seattle

Human secretin family protein, encoding gene sequences; for diagnostics and therapeutics

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