Published August 2 & 9 (EPO); July 27 (WO); August 2 & 9 (GB)
Abbott Labs WO 00/43420 & 43421
Breast cancer diagnosis
Abbott Park, Ill.
Contiguous and partially overlapping genes transcribed in breast tissue; for breast cancer diagnosis and therapy.
Affymetrix EP 1 024 200
Santa Clara, Calif.
Polymorphic site- and allele-specific primers and probes; for genotype analysis.
Affymetrix EP 1 026 258
Santa Clara, Calif.
Multiplex genotyping of individuals by generating polymorphic profiles.
Agene Res. Inst. WO 00/43522
RecQ4 helicase gene that causes Rothmund-Thomson syndrome, encoded protein; for disease diagnostics and therapeutics.
Aventis Behring EP 1 026 250
Coagulation deficiency therapy
DNA constructs encoding a fusion of Factor IX and P-selectin; for treating blood coagulation deficiencies.
Aventis Pharma WO 00/43524
Cell cycle regulation
Polypeptides derived from JNK3 protein, encoding gene sequences; for regulating the cell cycle.
Beth Israel Hosp. EP 1 024 197
Mesothelial gene therapy
Delivery of nucleic acid sequences to body cavities; for mesothelial cell gene therapy.
Biochip Technol. WO 00/43539
Immobilization of molecules on surfaces using polyfunctional polymer monolayers.
Bio Merieux WO 00/43521
Integrated retroviral genes
Marcy l'Etoile, France
Endogenetic nucleic acid fragments encoding the gag protein from retroviruses that are integrated in the human genome.
California, Univ. of EP 1 026 238
Autoimmune disease enzyme
Glutamic acid decarboxylase, encoding gene sequences; for autoimmune disease diagnostics and therapeutics.
Cambridge Molecular Technol. GB 2 346 370
Genomic DNA isolation
Methods using filters for retaining cells to be lysed in order to isolate genomic DNA.
Chugai EP 1 024 193
Transcription factor conversion
Screening genes that encode polypeptides that convert inactive transcription factors to active ones.
Cobra Therapeutics WO 00/43541
Methods for selecting genes encoding enzymes that convert a prodrug into its active form.
Compugen WO 00/43506
Serotonin receptor homologs
Tel Aviv, Israel
Nucleic acid sequences with homology to the serotonin receptor gene, encoded proteins.
Cornell Univ. WO 00/43551
HIV viral loads
Determining viral loads in CD4-CD- T cells in HIV-infected patients where viral loads are not detectable in plasma.
Dade Behring WO 00/43543-43546
Finding drug-resistant organisms
Detecting polynucleotide sequence differences using double-stranded complexes; for finding drug-resistant organisms.
Dana-Farber Cancer Inst. EP 1 025 856
Modulating antigen-specific T-cell unresponsiveness by stimulation of CD2 receptors; for anti-cancer responses.
Dyax EP 1 026 240
Proteins binding selected targets
Generation and selection of recombinant proteins that bind chosen targets using a DNA library.
European Molec. Biol. Lab EP 1 026 244
Cell cycle regulators
Proteins that trigger the G2/M mitotic transition and that bind CDC2 and cyclin B, encoding gene sequences.
French Atomic Energy Comm. EP 1 024 201
Gene expression analysis
Microassay methods for analyzing gene expression using a library of tags.
Fuji EP 1 026 259
DNA chip composed of a solid carrier with polynucleotides fixed to the carrier using a hydrophilic polymer.
Fujisawa Pharma EP 1 024 194
Plasmid vectors that control autonomous replication in bacteria and can incorporate other structural genes.
Fujita, J. EP 1 024 190
Gankyrin, derivatives retaining biological activity, encoding gene sequences.
Gamidagen WO 00/43531
GC-rich DNA assay
Amplification methods for characterizing GC-rich nucleic acid sequences in samples.
Genzyme EP 1 024 198
Hemophilia gene therapy
Pseudo-adenoviral vectors having inverted terminal repeats that encode Factor VIII or IX; for treating hemophilia.
Helix Res. Inst. EP 1 026 242
Full-length cDNA clones
Screening full-length cDNA clones to obtain a library with a high ratio of these clones.
Hosp. Sick Children WO 00/43510
Cell signaling therapeutics
Ras activator nucleic acid sequences, encoded proteins; for screening drugs involved in cell signaling.
Human Genome Sciences WO 00/43493
Metalloproteinase ADAM 22, encoding gene sequences; for identifying modulators for use in cancer therapy.
Human Genome Sciences WO 00/43495
33 secreted proteins
33 human secreted proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.
Humboldt Univ. WO 00/43501
Ribozymes directed against the catalytic subunit of human telomerase; for limiting tumor proliferation.
Immunex WO 00/43525
Metalloproteinase family proteins
Metalloproteinase-disintegrin family proteins, encoding gene sequences, recombinant production methods.
Incyte Genomics WO 00/43508
Palo Alto, Calif.
Cancer-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Indian Counc. Sci. & Ind. Res. EP 1 024 192
New Delhi, India
Clot-specific streptokinase proteins possessing altered plasminogen activation characteristics; for therapeutics.
Isis Innovation WO 00/43542
Male genealogy assay
Databases that correlate Y chromosome haplotypes with surnames; for detecting male genealogical relationships.
Japan Sci. & Technol. EP 1 026 243
Ras protein binding nucleic acid
Nucleic acid that specifically binds the Ras target protein, screens for other binding nucleic acids; for therapeutics.
Johns Hopkins Univ. WO 00/43526
NMDA receptor overstimulation
Mammalian serine racemase, encoding gene; for treating conditions involving overstimulation of NMDA receptors.
Lockheed Martin Energy Res. WO 00/43552
Oak Ridge, Tenn.
Multifunctional and multispectral biochip devices for quantifying multiple biomolecules per chip.
Ludwig Inst. Cancer Res. EP 1 025 849
Abnormal leukocyte assay
Finding complexes of human leukocyte antigens and tyrosinase on abnormal cells; for diagnostics and therapeutics.
Mass. Inst. Technol. EP 1 026 237
Alzheimer's diagnostic immunoassay
Tau/neurofilament protein kinases, encoding gene sequences; for immunoassays in Alzheimer's diagnosis.
Med. Molec. Res. WO 00/43505
Protease having aspartate residues in the transmembrane region of the protein.
MRC (Med. Res. Counc.) EP 1 024 191
Chimeric antibody production
Production of chimeric antibodies from an antibody segment repertoire displayed on phage.
Metamorphix WO 00/43781
Inhibitors of growth differentiation factor (GDF)-8 and -11; for generating transgenics and finding therapeutics.
Millennium Pharma WO 00/43513
G-protein coupled receptor
G-protein coupled receptor, encoding gene sequences; for diagnostics and therapeutics and modulator screens.
Millennium Pharma WO 00/43514
Acid sensing ion channel
Acid sensing ion channel, encoding gene, antibodies, transgenics; for diagnostics and therapeutics.
Miyata, T., et al. WO 00/43528
MEGSIN gene regulatory elements
Genomic DNA containing upstream and downstream regulatory sequences of the MEGSIN gene.
Montreal, Univ. of WO 00/43538
Oligo genomic libraries
Generation of oligonucleotide libraries representative of various genomes.
Nebraska, Univ. of WO 00/43548
Prostate cancer diagnostics
Prostate cancer-specific acid phosphatase; for diagnostics and therapeutics and making transgenics.
Nippon Zeon EP 1 026 246
Recombinant protein production
Insertion of foreign genes into turkey herpesvirus vectors; for expressing recombinant proteins.
North Carolina, Univ. of WO 00/43498
Liver cell progenitors
Chapel Hill, N.C.
Methods of isolating and cryopreserving human liver cell progenitor cells; for making artificial organs.
Northwestern Univ. WO 00/43547
Altering DNA electrophoretic mobility
Polyamides for binding to polynucleotides to alter their electrophoretic mobility.
Novo Nordisk WO 00/43502
Recovering solubilized enzymes
Methods for recovering glycosidases and peptidases by solubilizing them using high pH.
Ortho-Clinical Diagnostics EP 1 026 241
Serum DNA isolation
Methods for isolating DNA from alkalinized serum and plasma that has been heated.
Ortho-Clinical Diagnostics EP 1 026 261
Enhancing amplification specificity
Enhancing the specificity of nucleic acid amplification by using carrier nucleic acid.
Ortho-Clinical Diagnostics EP 1 026 262
Hepatitis C detection
Oligonucleotide primers for the efficient detection of hepatitis C virus in biological samples.
Ortho-Clinical Diagnostics EP 1 026 263
Oligonucleotide primers for the efficient detection of HIV-1 and -2 in biological samples.
Pfizer EP 1 026 251
Alzheimer's tau activation
Transgenic animal expressing the protein kinase activator of cdk involved in tau protein phosphorylation in Alzheimer's.
Pro-Duct Hlth. WO 00/43553
Hormone-responsive breast cancer
Menlo Park, Calif.
Screening women for a breast cancer-associated estrogen-related marker; for diagnosing hormone-responsive cancer.
Pyrosequencing WO 00/43540
Identifying single nucleotides
Identification of specific nucleotide bases in a given DNA sequence using targeted primers.
Ramot Univ. EP 1 026 248
Antibiotic TA production
Tel Aviv, Israel
Gene sequences encoding enzymes required for antibiotic TA production, encoded proteins; for production.
Rigel Pharma WO 00/43419
Exocytosis pathway proteins
S. San Francisco
Exocytosis pathway proteins, encoding gene sequences, fusion proteins; for identifying other pathway-related proteins.
Scripps Res. Inst. EP 1 026 239
Specific receptor isolation
La Jolla, Calif.
Isolation of genes encoding receptors having the ability to bind preselected ligands from the immunological repertoire.
Scripps Res. Inst. WO 00/43494
Viral infection control
La Jolla, Calif.
Controlling viral infection by using replication-associated proteins.
Seattle Biomedical Res. Inst. WO 00/43499
Stem cells treated with TGF-_ antibodies; for in vivo hematopoietic reconstruction.
SmithKline Beecham WO 00/43418
Bacterial birA gene sequences, encoded proteins, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/43491
Bacterial yhxB gene sequences, encoded proteins, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/43492
Site-specific protein labeling
Methods for site-specific labeling of proteins at glutamine residues using glutaminase; for high-throughput screens.
SmithKline Beecham WO 00/43509 & 43511
Proteins for cancer therapy
Proteins that can be used to diagnose and treat cancer and immune diseases, encoding gene sequences.
SmithKline Beecham WO 00/43517 & 43518
Neisseria meningitidis peptides, encoding gene, production methods; for meningitis diagnostics and therapeutics.
SmithKline Beecham WO 00/43519
Proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/43527
Varicella virus vaccines
Varicella Zoster virus gE protein, immunologically active fragments; for vaccines.
Somalogic WO 00/43534
DNA ligand generation
Robotic and computer-assisted methods and apparatus for automated generation of nucleic acid ligands.
South Carolina, Med. Univ. of WO 00/43515
HIV drug resistance assay
Methods for detecting HIV presence in samples using cells expressing CD4 receptors; for monitoring drug resistance.
Taiho Pharma EP 1 026 173
Thymidylate synthase antibodies
Human thymidylate synthase monoclonal antibodies; for immunoassays.
Takara Shuzo EP 1 026 245
Yeast infection resistance
Candida yeast antigenic proteins, encoding gene sequences; for inducing infection resistance.
Unilever WO 00/43507
Producing antibody fragments
Expression library of antibody heavy chain variable domain genes from non-immunized sources; for antibody fragments.
Utrecht Univ. WO 00/43530
Stabilized stored DNA
Nucleic acid compositions that are stabilized for storage by using cationic polymers; for gene therapy
V.I. Technol. WO 00/43549
Quenching viral inactivators
Lipophilic quenching of aziridino moiety-containing viral inactivating agents.
Vitro Diagnostics WO 00/43500
Immortalizing primary cells using vectors containing gene sequences of oncogenes.
Vysis EP 1 026 260
Genomic abnormality assay
Downers Grove, Ill.
Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays.
Wayne State Univ. WO 00/43550
Mammary disease diagnosis
Methods and apparatus for non-invasively obtaining mammary fluid; for measuring factors associated with disease.
Wisconsin, Univ. of EP 1 026 253
DNA delivery intracellularly
Methods of delivering exogenous polynucleotides to the interior of cells; for gene therapy.
Yeda Res. & Develop. WO 00/43490
Rhamnosyl-transferase gene, encoded protein; for modulating oligosaccharides.
Zetatronics GB 2 346 145
Amplified product detection
Detection of amplified products in nucleic acid assays using light-based assay systems.
ZymoGenetics WO 00/43512
EGF-like domain protein
Human protein with multiple epidermal growth factor (EGF)-like domains, encoding gene; for regulating differentiation.
ZymoGenetics WO 00/43516
Secretin family protein
Human secretin family protein, encoding gene sequences; for diagnostics and therapeutics