Published July 26 (EPO); July 20 (WO); July 26 (GB)

A+ Science Invest WO 00/42202

Stem cell gene therapy

Goteborg, Sweden

Introduction of gene sequences into neural stem cells using inherent cell transport mechanisms.

Abbott Labs WO 00/41516

Breast tissue-expressed genes

Abbott Park, Ill.

Gene sequences that are transcribed in breast tissue, encoded proteins; for breast cancer diagnosis.

Aventis Pharma WO 00/42179

Protein complexes

Frankfurt, Germany

Protein complexes having targeting and mutated dimerization domains, encoding gene sequences.

Avi Biopharma WO 00/41717

hCG immunotherapy

Corvallis, Ore.

Immunotherapy using gene sequences encoding human chorionic gonadotropin (hCG) or immunogenic epitopes.

Bayer EP 1 022 337 & 339

IL-4 manufacture

Leverkusen, Germany

Construction and use of expression plasmids in manufacturing interleukin (IL-4) and IL-4 muteins.

Biocrystal WO 00/42431

Pro-tumor immune response

Westerville, Ohio

Pro-tumor immune response detection by measurement of mononuclear cell phenotypes in patient samples.

Biopolo WO 00/41477

Recombinant protein production

Milan, Italy

Production of recombinant proteins in Zygosaccharomyces yeast strains.

Bolder Biotech WO 00/42175

PEG-conjugated free cysteines

Louisville, Colo.

Methods for making soluble proteins having free cysteines that can be attached to polyethylene glycol (PEG).

British Defense Ministry GB 2 345 913

Mutant luciferase

Farnborough, UK

Mutant luciferase having a modified amino acid sequence that confers increased thermostability.

CA*TX WO 00/42436

Protein truncation immunoassays

Gladwyne, Penn.

Immunoassays for diagnosing disease susceptibility associated with gene mutations causing protein truncation.

California, Univ. of WO 00/42220

Glaucoma diagnosis

Oakland, Calif.

Analysis of upstream sequences of the TIGR protein gene; for diagnosing glaucoma and related disorders.

Cedars-Sinai Med. Ctr. EP 1 022 330 & 331

Neural progenitor cells

Los Angeles

Transdifferentiation of epidermal basal cells into neural progenitor cells, neuronal cells, or glial cells.

Children's Hosp. WO 00/41731

Reverse gene therapy

Philadelphia

Reverse gene therapy in which a gene encoding a protein expressed in abnormal tissue is used to treat the disease.

Children's Hosp. WO 00/41732

Viral vector delivery

Philadelphia

Hydrogel compositions for the controlled delivery of viral vectors.

Dae Sang WO 00/42197

Cephalosporin C conversion

Seoul, S. Korea

Recombinant bacterial enzyme having D-amino acid oxidase activity; for converting cephalosporin C.

Du Pont Pharma WO 00/42166

Alzheimer's drug screens

Wilmington, Del.

Methods for monitoring cellular processing of epitope-tagged ß-amyloid precursor protein; for Alzheimer's drug screens.

Du Pont Pharma WO 00/42178

CRF-2 receptor antisense

Wilmington, Del.

Antisense oligos to corticotropin releasing factor (CRF)-2 receptor mRNA; for treating psychiatric disorders.

Glasgow, Univ. of WO 00/42194

Hepatitis B diagnostics

Glasgow, UK

Mutant hepatitis B surface antigen; for making antibodies reactive with a wide variety of hepatitis B variants.

Gene Logic WO 00/42222

Detecting DNA hybridization

Gaithersburg, Md.

Immobilized fluorescently labelled nucleic acid sequences with hairpin structures; for detecting hybridization events.

Genentech WO 00/42072

Variant Fc region peptides

S. San Francisco, Calif.

Variant Fc region-containing peptides with altered effector function resulting from amino acid substitutions.

Glaxo WO 00/42211

Protease inhibitor screen

Greenford, UK

Methods for screening protease inhibitors that affect symptoms of dyslipidemia and related disorders.

Hartwich, G. WO 00/42217

Electrochemical hybridization detection

Munich, Germany

Electrochemical detection of DNA hybridization using conductive surfaces and redox active moieties.

Harvard Univ. WO 00/41524

Isothermal DNA amplification

Cambridge, Mass.

Isothermal amplification of DNA that does not require adding exogenous oligonucleotide primers.

Human Genome Sciences WO 00/42165

Bone marrow-specific protein

Rockville, Md.

Bone marrow-specific protein, encoding gene, antibodies, production methods; for diagnostics and therapeutics.

Human Genome Sciences WO 00/42189

IL-20

Rockville, Md.

Interleukin (IL)-20, encoding gene sequences; for finding modulators and treating immune system diseases.

Incyte Genomics WO 00/42172

Circadian rhythm proteins

Palo Alto, Calif.

Proteins associated with circadian rhythms, encoding gene sequences, antibodies, modulators.

Incyte Genomics WO 00/42201

Human peptidases

Palo Alto, Calif.

Human peptidases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Introgene EP 1 022 335

Gene function screen

Leiden, Netherlands

High-throughput screening of gene function libraries that allow measurement of altered phenotypes.

Introgene WO 00/42181

Lymphoblastic leukemia therapy

Leiden, Netherlands

Tumor-specific minor histocompatibility antigens; for treating B-cell acute lymphoblastic leukemia.

Isis Innovation WO 00/42204

Antifungal assay

Oxford, UK

Identification of trans-acting factors associated with transcription termination in yeast; for antifungals.

Japan Sci. & Technol. WO 00/41561

Bacterial peptidoglycan knockout mice

Saitama, Japan

Knockout mice strains that are unresponsive to bacterial peptidoglycans and lipoproteins.

JCR Pharma EP 1 022 333

Tumor suppressor

Ashiya, Japan

Human tumor suppressor whose expression is inhibited by human growth hormone, encoding gene sequence.

Johns Hopkins Univ. WO 00/41679

Genetic immunization

Baltimore, Md.

Co-delivery of antigen-encoding genes and encapsulated cytokines; for genetic immunization.

Johnson & Johnson WO 00/42167

Gene modulator identification

Eveleigh, Australia

Nucleic acid fusions having reporter sequences that can be expressed in yeast strains; for finding gene modulators.

Kao EP 1 022 334

Thermostable amylases

Tokyo

Amylases that retain activity at alkaline pH and high temperature and are resistant to chelator action.

Krebs Res. Ctr. WO 00/42063

Hepatitis infection therapy

Heidelberg, Germany

Peptides that inhibit hepatitis B virus protein function, encoding genes; for infection therapeutics.

Krebs Res. Ctr. WO 00/42064

Papillomavirus infection therapy

Heidelberg, Germany

Peptides that inhibit human papillomavirus E6 protein function, encoding genes; for disease therapeutics.

Krebs Res. Ctr. WO 00/42176

Antibody selection method

Heidelberg, Germany

Methods for selecting antibodies displayed on hybridomas using an antibody-binding protein.

Kyowa Hakko Kogyo WO 00/42180

Cancer-related protein

Tokyo

Protein involved in cancer and inflammation, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Leadd WO 00/41497

Apoptosis-inducing proteins

Leiden, Netherlands

Apoptosis-inducing proteins, encoding gene sequences; for treating autoimmune diseases.

Leiden Univ. WO 00/42200

Terpenoid indole drugs

Leiden, Netherlands

In vitro plant culture system for the production of terpenoid indole alcohol pharmaceuticals.

Lexicon Genetics WO 00/42182

Cortexin-like proteins

The Woodlands, Texas

Mammalian cortexin-like proteins, encoding gene sequences; for diagnostics and therapeutics.

LJL Biosystems WO 00/42209

DNA hybridization assay

Sunnyvale, Calif.

Detection of nucleic acid hybridization in luminescence-based assays.

Max Planck Inst. WO 00/42177

DNA isolation from samples

Munich, Germany

Methods for isolating DNA from biological samples containing impurities and interfering substances.

Maxygen WO 00/42560

In silico recombination

Redwood City, Calif.

Making character strings, polynucleotides, and polypeptides with desired characteristics using in silico recombination.

Maxygen WO 00/42561

Gene shuffling oligos

Redwood City, Calif.

Oligonucleotide-mediated nucleic acid recombination using families of gene shuffling oligos.

McGill Univ. WO 00/42196

Neural tube defect diagnosis

Montreal, Que.

Human methionine synthase reductase, encoding gene; for diagnosing neural tube defects and Down's Syndrome.

Meiji EP 1 022 332

ß-fructofuranosidase

Tokyo

ß-fructofuranosidase, encoding gene sequence; for producing oligosaccharides.

Merial EP 1 022 338

Marek's disease vaccines

Lyon, France

Attenuated vaccines against Marek's disease virus that use antigenic viral proteins.

Millennium Biotherapeutics WO 00/42170

LRSG proteins

Cambridge, Mass.

LRSG proteins, encoding genes, antibodies, transgenics; for diagnostics and therapeutics.

Millennium Pharma WO 00/42074

CCR4 antibodies

Cambridge, Mass.

Antibodies to CC-chemokine receptor 4 (CCR4), functional fragments; for diagnostics and therapeutics.

Mindset Biopharma WO 00/42185

Stabilized single chain antibodies

New York

Intracellular production of single chain antibodies with residues that stabilize them against in vivo proteolysis.

Molec. Biol. Resources WO 00/42199

Modified reverse transcriptases

Milwaukee, Wis.

Modified reverse transcriptases having improved stability and solubility, encoding gene sequences; for PCR assays.

Myriad Genetics WO 00/42223

Reading more DNA sequence

Salt Lake City, Utah

DNA sequencing that allows more even distribution of strand length in synthesized DNA; for reading more sequence.

NIH (Natl. Inst. Hlth.) WO 00/42068

HIV infection survival

Bethesda, Md.

Specific HIV peptide epitopes and antibodies associated with long-term survival of HIV-1 infected individuals.

New York, State Univ. of WO 00/42213

Protein kinase inhibitors

Amherst, N.Y.

Methods for finding protein kinase inhibitors, identified inhibitors; for modulating immune system activity.

Novartis WO 00/41474

Transplant rejection immunotoxins

Basel, Switzerland

Recombinant immunotoxins having CD3-binding and Pseudomonas exotoxin mutant domains; for transplant rejection therapy.

Novartis WO 00/42208

Adenoviral gene therapy vectors

Basel, Switzerland

Adenovirus vectors and packaging cell lines for high-capacity, targeted gene therapy vectors.

Novo Nordisk Biotech WO 00/41509

Acid phosphatase-like proteins

Davis, Calif.

Proteins with acid phosphatase activity, encoding gene sequences, production methods.

Novo Nordisk Biotech WO 00/42203

Recombinant protein production

Davis, Calif.

Heterologous protein production in cyclohexadepsipeptide-deficient fungal cells.

OctoPlus EP 1 022 340

Nucleic acid transfection

Leiden, Netherlands

Methods for making storage-stable nucleic acid complexes with cationic polymers; for gene therapy.

Ono Pharma EP 1 022 286

Human protein

Osaka, Japan

Human protein, encoding gene sequences, antibodies; for therapeutics.

Ono Pharma EP 1 022 336

Mouse ES cell protein

Osaka, Japan

Mouse embryonic stem (ES) cell protein, encoding gene sequence, antibodies; for therapeutics.

Osteometer Biotech WO 00/42216

Bone growth promotion

Herlev, Denmark

Polypeptides that increase or promote bone growth, encoding gene sequences, antibodies.

Osteopharm WO 00/42069

Osteoporosis predisposition

Mississauga, Ont.

Assessing predisposition to osteoporosis by determining the genotype of bone-expressed gene promoters.

Perkin-Elmer WO 00/41549

Target hybridization detection

Foster City, Calif.

Methods for target hybridization detection using PCR along with labels and nucleic acid analogs.

PPL Therapeutics WO 00/42174

Double nuclear transfer

Roslin, UK

Nuclear transfer in which the genetic material transferred to an oocyte is subsequently transferred to another oocyte.

Queensland, Univ. of WO 00/42215

Codon translation efficiency

St. Lucia, Australia

Determining the translational efficiency of codons in specific cells by fusing the codon to a reporter sequence.

Sanagamo Biosciences WO 00/41566

Gene expression regulation

Richmond, Calif.

Regulation of endogenous gene expression in cells using recombinant zinc finger proteins.

Sanagamo Biosciences WO 00/42219

Zinc finger protein sites

Richmond, Calif.

Selection of sites for targeting by zinc finger proteins and designing such proteins that bind at preselected sites.

Schering WO 00/42187 & 42188

IL-17 related cytokine

Kenilworth, N.J.

Interleukin (IL)-17 related mammalian cytokine, encoding gene sequences, antibodies; for therapeutics.

Signal Pharma WO 00/42221

Isolating new RNA

San Diego, Calif.

Methods for affinity isolation of newly synthesized RNA by incorporating biotinylated analogs into cellular mRNA.

SmithKline Beecham WO 00/42191

Polypeptides

Rixensart, Belgium

Polypeptides, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/42192 & 42193

Meningitis therapeutics

Rixensart, Belgium

Neisseria meningitidis antigens, encoding genes, recombinant production methods; for diagnostics and therapeutics.

Sumitomo Pharma WO 00/42186

IFN-a subtype

Osaka, Japan

Interferon (IFN)-a subtype, encoding gene sequences, production methods; for therapeutics.

Unisearch WO 00/42173

EGR-1 DNAzymes

Sydney, Australia

DNAzymes targeted against mRNA encoding EGR-1; for therapeutics.

Wisconsin, Univ. of EP 1 022 285

Mutant ribonuclease inhibitors

Madison, Wis.

Mutant ribonuclease inhibitors that retain ribonuclease and angiogenin affinity while being more resistant to oxidation.

Yissum Res. & Develop. WO 00/42198

Tyrosine phosphorylation

Jerusalem

E. coli protein tyrosine kinase, encoding gene sequences; for phosphorylating tyrosines in target proteins.

Yissum Res. & Develop. WO 00/42206

Gene expression silencing

Jerusalem

Gene expression silencing system using T7 polymerase gene sequences attached to a targeting sequence.

Yung Shin Pharma EP 1 022 287

ADP-ribosylation factor-like proteins

Taipei, Taiwan

ADP-ribosylation factor-like proteins, antibodies, transgenic knockout yeast strains.

ZymoGenetics WO 00/41539

Glycoprotein synthesis modification

Seattle, Wash.

ß-1,3-galactosyltransferase homolog, encoding gene, antibodies; for modulating glycoprotein synthesis.

ZymoGenetics WO 00/42070

Immune function modulation

Seattle, Wash.

Mammalian a helix-12 protein, encoding gene, antibodies; for modulating immune function.

ZymoGenetics WO 00/42183

Tumor suppressor genes

Seattle, Wash.

Tumor suppressor genes located on chromosome 16, encoded proteins; for prostate and breast cancer diagnostics.

ZymoGenetics WO 00/42184

Leucine-rich repeat protein

Seattle, Wash.

Human leucine-rich repeat protein, encoding gene sequences; for modulating neural differentiation and development.

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