Published July 26 (EPO); July 20 (WO); July 26 (GB)
A+ Science Invest WO 00/42202
Stem cell gene therapy
Goteborg, Sweden
Introduction of gene sequences into neural stem cells using inherent cell transport mechanisms.
Abbott Labs WO 00/41516
Breast tissue-expressed genes
Abbott Park, Ill.
Gene sequences that are transcribed in breast tissue, encoded proteins; for breast cancer diagnosis.
Aventis Pharma WO 00/42179
Protein complexes
Frankfurt, Germany
Protein complexes having targeting and mutated dimerization domains, encoding gene sequences.
Avi Biopharma WO 00/41717
hCG immunotherapy
Corvallis, Ore.
Immunotherapy using gene sequences encoding human chorionic gonadotropin (hCG) or immunogenic epitopes.
Bayer EP 1 022 337 & 339
IL-4 manufacture
Leverkusen, Germany
Construction and use of expression plasmids in manufacturing interleukin (IL-4) and IL-4 muteins.
Biocrystal WO 00/42431
Pro-tumor immune response
Westerville, Ohio
Pro-tumor immune response detection by measurement of mononuclear cell phenotypes in patient samples.
Biopolo WO 00/41477
Recombinant protein production
Milan, Italy
Production of recombinant proteins in Zygosaccharomyces yeast strains.
Bolder Biotech WO 00/42175
PEG-conjugated free cysteines
Louisville, Colo.
Methods for making soluble proteins having free cysteines that can be attached to polyethylene glycol (PEG).
British Defense Ministry GB 2 345 913
Mutant luciferase
Farnborough, UK
Mutant luciferase having a modified amino acid sequence that confers increased thermostability.
CA*TX WO 00/42436
Protein truncation immunoassays
Gladwyne, Penn.
Immunoassays for diagnosing disease susceptibility associated with gene mutations causing protein truncation.
California, Univ. of WO 00/42220
Glaucoma diagnosis
Oakland, Calif.
Analysis of upstream sequences of the TIGR protein gene; for diagnosing glaucoma and related disorders.
Cedars-Sinai Med. Ctr. EP 1 022 330 & 331
Neural progenitor cells
Los Angeles
Transdifferentiation of epidermal basal cells into neural progenitor cells, neuronal cells, or glial cells.
Children's Hosp. WO 00/41731
Reverse gene therapy
Philadelphia
Reverse gene therapy in which a gene encoding a protein expressed in abnormal tissue is used to treat the disease.
Children's Hosp. WO 00/41732
Viral vector delivery
Philadelphia
Hydrogel compositions for the controlled delivery of viral vectors.
Dae Sang WO 00/42197
Cephalosporin C conversion
Seoul, S. Korea
Recombinant bacterial enzyme having D-amino acid oxidase activity; for converting cephalosporin C.
Du Pont Pharma WO 00/42166
Alzheimer's drug screens
Wilmington, Del.
Methods for monitoring cellular processing of epitope-tagged ß-amyloid precursor protein; for Alzheimer's drug screens.
Du Pont Pharma WO 00/42178
CRF-2 receptor antisense
Wilmington, Del.
Antisense oligos to corticotropin releasing factor (CRF)-2 receptor mRNA; for treating psychiatric disorders.
Glasgow, Univ. of WO 00/42194
Hepatitis B diagnostics
Glasgow, UK
Mutant hepatitis B surface antigen; for making antibodies reactive with a wide variety of hepatitis B variants.
Gene Logic WO 00/42222
Detecting DNA hybridization
Gaithersburg, Md.
Immobilized fluorescently labelled nucleic acid sequences with hairpin structures; for detecting hybridization events.
Genentech WO 00/42072
Variant Fc region peptides
S. San Francisco, Calif.
Variant Fc region-containing peptides with altered effector function resulting from amino acid substitutions.
Glaxo WO 00/42211
Protease inhibitor screen
Greenford, UK
Methods for screening protease inhibitors that affect symptoms of dyslipidemia and related disorders.
Hartwich, G. WO 00/42217
Electrochemical hybridization detection
Munich, Germany
Electrochemical detection of DNA hybridization using conductive surfaces and redox active moieties.
Harvard Univ. WO 00/41524
Isothermal DNA amplification
Cambridge, Mass.
Isothermal amplification of DNA that does not require adding exogenous oligonucleotide primers.
Human Genome Sciences WO 00/42165
Bone marrow-specific protein
Rockville, Md.
Bone marrow-specific protein, encoding gene, antibodies, production methods; for diagnostics and therapeutics.
Human Genome Sciences WO 00/42189
IL-20
Rockville, Md.
Interleukin (IL)-20, encoding gene sequences; for finding modulators and treating immune system diseases.
Incyte Genomics WO 00/42172
Circadian rhythm proteins
Palo Alto, Calif.
Proteins associated with circadian rhythms, encoding gene sequences, antibodies, modulators.
Incyte Genomics WO 00/42201
Human peptidases
Palo Alto, Calif.
Human peptidases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Introgene EP 1 022 335
Gene function screen
Leiden, Netherlands
High-throughput screening of gene function libraries that allow measurement of altered phenotypes.
Introgene WO 00/42181
Lymphoblastic leukemia therapy
Leiden, Netherlands
Tumor-specific minor histocompatibility antigens; for treating B-cell acute lymphoblastic leukemia.
Isis Innovation WO 00/42204
Antifungal assay
Oxford, UK
Identification of trans-acting factors associated with transcription termination in yeast; for antifungals.
Japan Sci. & Technol. WO 00/41561
Bacterial peptidoglycan knockout mice
Saitama, Japan
Knockout mice strains that are unresponsive to bacterial peptidoglycans and lipoproteins.
JCR Pharma EP 1 022 333
Tumor suppressor
Ashiya, Japan
Human tumor suppressor whose expression is inhibited by human growth hormone, encoding gene sequence.
Johns Hopkins Univ. WO 00/41679
Genetic immunization
Baltimore, Md.
Co-delivery of antigen-encoding genes and encapsulated cytokines; for genetic immunization.
Johnson & Johnson WO 00/42167
Gene modulator identification
Eveleigh, Australia
Nucleic acid fusions having reporter sequences that can be expressed in yeast strains; for finding gene modulators.
Kao EP 1 022 334
Thermostable amylases
Tokyo
Amylases that retain activity at alkaline pH and high temperature and are resistant to chelator action.
Krebs Res. Ctr. WO 00/42063
Hepatitis infection therapy
Heidelberg, Germany
Peptides that inhibit hepatitis B virus protein function, encoding genes; for infection therapeutics.
Krebs Res. Ctr. WO 00/42064
Papillomavirus infection therapy
Heidelberg, Germany
Peptides that inhibit human papillomavirus E6 protein function, encoding genes; for disease therapeutics.
Krebs Res. Ctr. WO 00/42176
Antibody selection method
Heidelberg, Germany
Methods for selecting antibodies displayed on hybridomas using an antibody-binding protein.
Kyowa Hakko Kogyo WO 00/42180
Cancer-related protein
Tokyo
Protein involved in cancer and inflammation, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Leadd WO 00/41497
Apoptosis-inducing proteins
Leiden, Netherlands
Apoptosis-inducing proteins, encoding gene sequences; for treating autoimmune diseases.
Leiden Univ. WO 00/42200
Terpenoid indole drugs
Leiden, Netherlands
In vitro plant culture system for the production of terpenoid indole alcohol pharmaceuticals.
Lexicon Genetics WO 00/42182
Cortexin-like proteins
The Woodlands, Texas
Mammalian cortexin-like proteins, encoding gene sequences; for diagnostics and therapeutics.
LJL Biosystems WO 00/42209
DNA hybridization assay
Sunnyvale, Calif.
Detection of nucleic acid hybridization in luminescence-based assays.
Max Planck Inst. WO 00/42177
DNA isolation from samples
Munich, Germany
Methods for isolating DNA from biological samples containing impurities and interfering substances.
Maxygen WO 00/42560
In silico recombination
Redwood City, Calif.
Making character strings, polynucleotides, and polypeptides with desired characteristics using in silico recombination.
Maxygen WO 00/42561
Gene shuffling oligos
Redwood City, Calif.
Oligonucleotide-mediated nucleic acid recombination using families of gene shuffling oligos.
McGill Univ. WO 00/42196
Neural tube defect diagnosis
Montreal, Que.
Human methionine synthase reductase, encoding gene; for diagnosing neural tube defects and Down's Syndrome.
Meiji EP 1 022 332
ß-fructofuranosidase
Tokyo
ß-fructofuranosidase, encoding gene sequence; for producing oligosaccharides.
Merial EP 1 022 338
Marek's disease vaccines
Lyon, France
Attenuated vaccines against Marek's disease virus that use antigenic viral proteins.
Millennium Biotherapeutics WO 00/42170
LRSG proteins
Cambridge, Mass.
LRSG proteins, encoding genes, antibodies, transgenics; for diagnostics and therapeutics.
Millennium Pharma WO 00/42074
CCR4 antibodies
Cambridge, Mass.
Antibodies to CC-chemokine receptor 4 (CCR4), functional fragments; for diagnostics and therapeutics.
Mindset Biopharma WO 00/42185
Stabilized single chain antibodies
New York
Intracellular production of single chain antibodies with residues that stabilize them against in vivo proteolysis.
Molec. Biol. Resources WO 00/42199
Modified reverse transcriptases
Milwaukee, Wis.
Modified reverse transcriptases having improved stability and solubility, encoding gene sequences; for PCR assays.
Myriad Genetics WO 00/42223
Reading more DNA sequence
Salt Lake City, Utah
DNA sequencing that allows more even distribution of strand length in synthesized DNA; for reading more sequence.
NIH (Natl. Inst. Hlth.) WO 00/42068
HIV infection survival
Bethesda, Md.
Specific HIV peptide epitopes and antibodies associated with long-term survival of HIV-1 infected individuals.
New York, State Univ. of WO 00/42213
Protein kinase inhibitors
Amherst, N.Y.
Methods for finding protein kinase inhibitors, identified inhibitors; for modulating immune system activity.
Novartis WO 00/41474
Transplant rejection immunotoxins
Basel, Switzerland
Recombinant immunotoxins having CD3-binding and Pseudomonas exotoxin mutant domains; for transplant rejection therapy.
Novartis WO 00/42208
Adenoviral gene therapy vectors
Basel, Switzerland
Adenovirus vectors and packaging cell lines for high-capacity, targeted gene therapy vectors.
Novo Nordisk Biotech WO 00/41509
Acid phosphatase-like proteins
Davis, Calif.
Proteins with acid phosphatase activity, encoding gene sequences, production methods.
Novo Nordisk Biotech WO 00/42203
Recombinant protein production
Davis, Calif.
Heterologous protein production in cyclohexadepsipeptide-deficient fungal cells.
OctoPlus EP 1 022 340
Nucleic acid transfection
Leiden, Netherlands
Methods for making storage-stable nucleic acid complexes with cationic polymers; for gene therapy.
Ono Pharma EP 1 022 286
Human protein
Osaka, Japan
Human protein, encoding gene sequences, antibodies; for therapeutics.
Ono Pharma EP 1 022 336
Mouse ES cell protein
Osaka, Japan
Mouse embryonic stem (ES) cell protein, encoding gene sequence, antibodies; for therapeutics.
Osteometer Biotech WO 00/42216
Bone growth promotion
Herlev, Denmark
Polypeptides that increase or promote bone growth, encoding gene sequences, antibodies.
Osteopharm WO 00/42069
Osteoporosis predisposition
Mississauga, Ont.
Assessing predisposition to osteoporosis by determining the genotype of bone-expressed gene promoters.
Perkin-Elmer WO 00/41549
Target hybridization detection
Foster City, Calif.
Methods for target hybridization detection using PCR along with labels and nucleic acid analogs.
PPL Therapeutics WO 00/42174
Double nuclear transfer
Roslin, UK
Nuclear transfer in which the genetic material transferred to an oocyte is subsequently transferred to another oocyte.
Queensland, Univ. of WO 00/42215
Codon translation efficiency
St. Lucia, Australia
Determining the translational efficiency of codons in specific cells by fusing the codon to a reporter sequence.
Sanagamo Biosciences WO 00/41566
Gene expression regulation
Richmond, Calif.
Regulation of endogenous gene expression in cells using recombinant zinc finger proteins.
Sanagamo Biosciences WO 00/42219
Zinc finger protein sites
Richmond, Calif.
Selection of sites for targeting by zinc finger proteins and designing such proteins that bind at preselected sites.
Schering WO 00/42187 & 42188
IL-17 related cytokine
Kenilworth, N.J.
Interleukin (IL)-17 related mammalian cytokine, encoding gene sequences, antibodies; for therapeutics.
Signal Pharma WO 00/42221
Isolating new RNA
San Diego, Calif.
Methods for affinity isolation of newly synthesized RNA by incorporating biotinylated analogs into cellular mRNA.
SmithKline Beecham WO 00/42191
Polypeptides
Rixensart, Belgium
Polypeptides, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/42192 & 42193
Meningitis therapeutics
Rixensart, Belgium
Neisseria meningitidis antigens, encoding genes, recombinant production methods; for diagnostics and therapeutics.
Sumitomo Pharma WO 00/42186
IFN-a subtype
Osaka, Japan
Interferon (IFN)-a subtype, encoding gene sequences, production methods; for therapeutics.
Unisearch WO 00/42173
EGR-1 DNAzymes
Sydney, Australia
DNAzymes targeted against mRNA encoding EGR-1; for therapeutics.
Wisconsin, Univ. of EP 1 022 285
Mutant ribonuclease inhibitors
Madison, Wis.
Mutant ribonuclease inhibitors that retain ribonuclease and angiogenin affinity while being more resistant to oxidation.
Yissum Res. & Develop. WO 00/42198
Tyrosine phosphorylation
Jerusalem
E. coli protein tyrosine kinase, encoding gene sequences; for phosphorylating tyrosines in target proteins.
Yissum Res. & Develop. WO 00/42206
Gene expression silencing
Jerusalem
Gene expression silencing system using T7 polymerase gene sequences attached to a targeting sequence.
Yung Shin Pharma EP 1 022 287
ADP-ribosylation factor-like proteins
Taipei, Taiwan
ADP-ribosylation factor-like proteins, antibodies, transgenic knockout yeast strains.
ZymoGenetics WO 00/41539
Glycoprotein synthesis modification
Seattle, Wash.
ß-1,3-galactosyltransferase homolog, encoding gene, antibodies; for modulating glycoprotein synthesis.
ZymoGenetics WO 00/42070
Immune function modulation
Seattle, Wash.
Mammalian a helix-12 protein, encoding gene, antibodies; for modulating immune function.
ZymoGenetics WO 00/42183
Tumor suppressor genes
Seattle, Wash.
Tumor suppressor genes located on chromosome 16, encoded proteins; for prostate and breast cancer diagnostics.
ZymoGenetics WO 00/42184
Leucine-rich repeat protein
Seattle, Wash.
Human leucine-rich repeat protein, encoding gene sequences; for modulating neural differentiation and development.