Published July 12 (EP); July 6 (WO); July 12 (GB)

Aclara Biosciences WO 00/39335

Biopolymer presence determinations

Mountain View, Calif.

Solid surfaces addressable by individual or combination dyes; for multiplexed determinations of biopolymer presence.

Adv. Res. & Technol. Inst. WO 00/39311

Gene therapy methods

Indianapolis

Human fibroblast growth factor 1 used as a cofactor for successful infection by adeno-associated virus vectors.

Advanced Technol. WO 00/39300

Chemically induced expression

London

Chimeric gene having a promoter that is inducible by chemicals; for expression in eukaryotes.

AstraZeneca WO 00/39331

Pyruvate kinase SNPs

London

Single nucleotide polymorphisms (SNPs) in a pyruvate kinase isoenzyme 2; for identifying allelic variation in diabetes.

Auckland Uniservices WO 00/39159

Superantigens

Auckland, New Zealand

Superantigens, encoding gene sequences; for diagnostics and therapeutics.

Banyu Pharma WO 00/39164

Signal transduction ligands

Tokyo

GTP-binding protein-coupled receptor from human hippocampus, encoding gene; for signal transduction ligand screening.

BioChem Pharma WO 00/39299

Streptococcus vaccines

Laval, Que.

Streptococcus antigens, encoding gene sequences, recombinant production methods; for diagnostics and vaccines.

Bionative WO 00/39163

Interferon-a production

Umea, Sweden

Production of interferon-a using virus-induced human leukocytes and organic solvents.

Bristol-Myers Squibb WO 00/39276

Epithilone synthesis

Princeton, N.J.

Transformation of microbes with the genes for the biosynthesis of epithilones.

C.B.F. Leti WO 00/39298

Leishmaniasis vaccines

Tres Cantos, Spain

Chimeric gene encoding antigenic determinants of Leishmania infantum proteins, encoded protein; for vaccines.

Calydon WO 00/39319

Cancer gene therapy

Sunnyvale, Calif.

Adenoviral vectors with target cell-specific transcriptional response elements; for improved cancer cytotoxicity.

Chicago, Univ. of WO 00/38518

Cardiomyocyte gene transfection

Chicago

Stable in vivo gene transfer into cardiomyocytes using recombinant adeno-associated virus vectors.

Chiron WO 00/39302

Stimulating HIV immunoresponse

Emeryville, Calif.

HIV protein production using expression cassettes encoding HIV gag proteins; for stimulating immune responses.

Chiron WO 00/39303

Modified HIV envelope proteins

Emeryville, Calif.

Modified HIV envelope polypeptides having exposed CD4 binding regions; for diagnostics and therapeutics.

Chiron WO 00/39304

Antigenic HIV polypeptides

Emeryville, Calif.

Genes encoding antigenic HIV type C gag- and env-containing polypeptides; for diagnostics and therapeutics.

Chiron WO 00/39318

Alphavirus vectors

Emeryville, Calif.

Compositions and methods for packaging alphavirus vectors having therapeutic genes; for gene therapy.

City of Hope WO 00/39343

Mutation detection

Duarte, Calif.

Denaturing fingerprinting methods for detecting mutations in nucleic acid sequences.

Connaught Labs WO 00/39157 & 39158

Chlamydia vaccines

Toronto

Chlamydia antigens, encoding gene sequences; for diagnostics, vaccines, and infection prevention.

Corixa WO 00/39301

Mycobacterial protein adjuvants

Seattle, Wash.

Mycobacterium proteins that stimulate interleukin-12 and interferon gamma production; for immunological adjuvants.

Dana-Farber Cancer Inst. WO 00/39345

Mutation scanning array

Boston

Mutation scanning array having immobilized oligonucleotides; for identifying mismatches or polymorphisms.

Danisco WO 00/39289

Xylanase inhibitors

Copenhagen, Denmark

Endo-_-1,4-xylanases, encoding gene sequences; for identifying inhibitors.

DNAVec Res. EP 1 018 560

Target gene expression

Ibaraki, Japan

Transcription of recombinase genes in cells having specific transcription factors; for target gene expression.

Florence Medical WO 00/39275

Angiogenesis disorder vectors

Kfar-Saba, Israel

Expression vectors with therapeutic genes linked to shear stress responsive elements; for angiogenesis disorders.

Gardella, T.J., et al. WO 00/39278

PTH peptide conjugates

Cambridge, Mass.

Parathyroid hormone (PTH) peptides, analogs, fragments, conjugate peptides, derivatives; for modulator screens.

Gene Logic WO 00/39344

Mixed probe assay device

Gaithersburg, Md.

Multiple binding reagents as affixed to substrates; for mixed probe detection elements.

Genelabs Technol. EP 1 018 558

Hepatitis C diagnostics

Redwood City, Calif.

Hepatitis C virus immunogenic protein epitopes, encoding genes; for diagnostics.

Genencor Intl. WO 00/39323

Recombinant proteins from bacteria

Rochester, N.Y.

Recombinant protein production in Gram-positive bacteria having mutations in the opp operon gene cluster.

Genentech WO 00/39297

IL-1 related proteins

S. San Francisco

Interleukin- (IL)-1 related proteins, encoding gene sequences, peptides, chimeras, fusions, antibodies.

Genentech WO 00/39320

Transfection complexes

S. San Francisco

Transfection complexes of nucleic acid and calcium phosphate; for inserting gene sequences.

Georgia, Univ. of WO 00/39310

Rubredoxin fusions

Athens, Ga.

Rubredoxin fusion proteins having a linkage subject to proteolysis; for affinity purification for vaccines.

Gladstone Inst. WO 00/39316

HIV receptor transgenics

San Francisco

Transgenic rodents and rodent cell lines expressing HIV co-CD4 receptors; for studying HIV infection mechanisms.

Glaxo WO 00/39295

TNF ligand family member

Greenford, UK

A member of the tumor necrosis factor (TNF) ligand superfamily, variants.

Glaxo Wellcome WO 00/39308

Inflammation modulators

Tokyo

IKK kinase, IKK3, encoding genes; for screening modulators and treating inflammation.

Human Genome Sciences WO 00/39136

Human brainiac-5

Rockville, Md.

Human brainiac-5 gene, encoded protein, production methods; for diagnostics, therapeutics, and screening modulators.

Human Genome Sciences WO 00/39166

Hyaluronan-binding proteins

Rockville, Md.

Hyaluronan-binding proteins, encoding genes; for screening modulators and cancer diagnostics and therapeutics.

Human Genome Sciences WO 00/39327

Peptidoglycan recognition proteins

Rockville, Md.

Peptidoglycan recognition binding proteins expressed in keratinocytes, encoding genes; for therapeutics.

Iconix Pharma WO 00/39346

Pathway reporter system

Mountain View, Calif.

Methods and nucleic acid constructs for testing and validating a pathway reporter system.

Immunex WO 00/39296

Lectin

Seattle, Wash.

Lectin protein, encoding gene sequences, peptides, fragments, antibodies; for therapeutics.

Inst. Child Hlth. Develop. EP 1 018 550

Dust mite allergens

Sublaco, Australia

Allergenic proteins and peptides from the house dust mite, encoding genes; for allergy diagnostics and therapeutics.

Inst. Phys. & Chem. Res. EP 1 018 549

DNA purification

Wako, Japan

Methods of purifying DNA from complex biological samples using DNA-binding carrier on membranes.

Janssen Pharma WO 00/39332

Cytochrome polymorphisms

Beerse, Belgium

Genotyping polymorphisms in cytochromes; for determining drug metabolizing capabilities.

Kirin-Amgen EP 1 018 552

Pluripotent G-CSF

Thousand Oaks, Calif.

Pluripotent granulocyte colony-stimulating factor (G-CSF), encoding gene, biological and chemical production methods.

Krebs Res. Ctr. WO 00/39292

Adhesion molecule antisense

Heidelberg, Germany

Antisense oligos to the a4-chain of VLA-4 adhesion molecule; for cancer and immune system therapeutics.

Kurokawa, K. EP 1 018 551

Mesangial cell expressed gene

Tokyo

Gene expressed in mesangial cells, encoded protein, antibodies; for diagnostics and therapeutics.

Lexow, P. WO 00/39333

Sequencing using magnifying tags

Bergen, Norway

Nucleic acid sequencing methods that use base magnifying tags.

Maryland, Univ. of WO 00/39152

Stable subtilin

College Park, Md.

Stable preparations of subtilin made using hydrophobic interaction chromatography.

Max Delbruck Ctr. Molec. Med. WO 00/39293

Tissue regeneration inhibition

Berlin

Vector with a gene encoding a c-myb DNA-binding domain fusion; for inhibiting tissue regeneration in restenosis.

Max Delbruck Ctr. Molec. Med. WO 00/39317

Tumor-specific promoter

Berlin

Tumor-specific YB-1 promoter; for linkage to transgenes to diagnose and treat cancer.

Merck WO 00/39147

Melanocortin 1 receptor modulators

Rahway, N.J.

DNA molecules encoding splice variants of human melanocortin 1 receptor protein; for identifying modulators.

Merck WO 00/39151

Papillomavirus neutralizing antibodies

Rahway, N.J.

Papillomavirus-like particles having reporter gene constructs; for detecting neutralizing antibodies.

Millennium Pharma WO 00/39149

High temperature requirement proteins

Cambridge, Mass.

Secreted high temperature requirement proteins, encoding genes, antibodies; for diagnostics and therapeutics.

Millennium Pharma WO 00/39150 & 39284

Secreted proteins

Cambridge, Mass.

Secreted and membrane-associated proteins, encoding genes, antibodies, transgenics; for diagnostics and therapeutics.

Millennium Pharma WO 00/39161

Cytokine receptor-like proteins

Cambridge, Mass.

Class II cytokine receptor-like proteins, encoding genes, antibodies, transgenics; for use as modulators.

Millennium Pharma WO 00/39277

Prostate cancer diagnostics

Cambridge, Mass.

NDSP genes, encoded proteins, antibodies, modulators; for androgen-independent prostate cancer diagnosis.

Millennium Pharma WO 00/39287

Identifying antifungals

Cambridge, Mass.

Aspergillus fumigatus coenzyme-A carboxylase genes, encoded proteins; for identifying antifungal agents.

Millennium Pharma WO 00/39342

Identifying antifungals

Cambridge, Mass.

Saccharomyces yeast genes essential for survival; for use in identifying antifungal agents.

Natl. Inst. Agron. Res. WO 00/39309

Bacterial protein production system

Paris

Gram-positive bacteria lacking functional a HtrA surface protease; for expressing exported proteins.

NIH (Natl. Inst. Hlth.) EP 1 018 555

Papillomavirus vaccines

Bethesda, Md.

Chimeric papillomavirus-like particles; for gene delivery and vaccines.

NIH (Natl. Inst. Hlth.) EP 1 018 556

Flavivirus vaccines

Bethesda, Md.

Chimeric and growth-restricted flaviviruses including mutated virulence genes; for vaccines.

Nebraska, Univ. of WO 00/39326

Peptide synthesis measurement

Lincoln, Neb.

Quantifying heavy hydrogen levels at specific peptide amide linkages; for studying peptide synthesis.

New Zealand Res. Inst. WO 00/39165

Serine protease inhibitor

Palmerston North, New Zealand

Serine protease inhibitor from mussels that has anti-thrombin and metal-chelating activity.

Norpharma WO 00/39307

Nucleoside production

Valleambrosia di Rozzano, Italy

Recombinant bacterial strains modified to produce natural nucleosides and their analogs.

Novartis WO 00/39294

Xenograft acceptance

Basel, Switzerland

Pig cells that do not express the CD40 antigen; for preventing rejection of xenografts.

Novation Pharma WO 00/39314

mRNA degradation induction

Coquitlam, B.C.

Methods for the identification of compounds that induce mRNA degradation.

Novo Nordisk WO 00/39322

Recombinant proteins in fungi

Bagsvaerd, Denmark

Methods for producing recombinant proteins in mutant Aspergillus fungal cells; for making toxins.

Pfizer EP 1 018 557

PRRS vaccines

Groton, Conn.

Infectious cDNA clone of pig reproductive and respiratory syndrome (PRRS) virus, encoded proteins, for vaccines.

Pfizer EP 1 018 559

Phosphodiesterase enzymes

Sandwich, UK

Phosphodiesterase enzymes, encoding gene sequences; for diagnostics and therapeutics.

Rosetta Inpharmatics WO 00/39336

Consensus response patterns

Kirkland, Wash.

Consensus biological response pattern profiles to drugs determined using expression profiles.

Rosetta Inpharmatics WO 00/39337

Response pattern discrimination

Kirkland, Wash.

Robust discrimination of subtle effects of disease states on biological response pattern profiles.

Rosetta Inpharmatics WO 00/39338

Biological response analysis

Kirkland, Wash.

Methods and systems for analyzing biological response signal data using computer-based imaging of databases.

Rosetta Inpharmatics WO 00/39339

Combining expression profiles

Kirkland, Wash.

Statistical combining of cell expression profiles from fluorophore measurement of microarray system data.

Rosetta Inpharmatics WO 00/39340

Drug interaction prediction

Kirkland, Wash.

Detection and prediction of drug interactions using biological response profiles.

Rosetta Inpharmatics WO 00/39341

Therapeutic index measurement

Kirkland, Wash.

Methods for determining therapeutic index from gene expression profile data.

St. Jude Children's Hosp. WO 00/39347

Tumor suppressor death signal

Memphis, Tenn.

Caspase-8 as a tumor suppressor involved in cell death signaling; for cancer diagnostics and therapeutics.

SKW Biosystems WO 00/39312

Conjugation DNA sequences

Boulogne Billancourt, France

DNA sequences capable of being transferred by conjugation; for inserting coding gene sequences.

SmithKline Beecham GB 2 345 487

Multidrug-resistance modulators

Philadelphia

Rat mdr1a gene, encoded protein, recombinant production methods; for screening multidrug resistance modulators.

SmithKline Beecham WO 00/39162

Human Wnt-7a proteins

Brentford, UK

Human Wnt-7a proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/39286

Antibacterial screens

Philadelphia

Microbial DnaE proteins, encoding genes, recombinant production methods; for antibacterial screens.

Synaptic Pharma WO 00/39279

Melanin concentrating hormone receptor

Paramus, N.J.

Human melanin concentrating hormone receptor gene, encoded protein, antisense; for diagnostics and therapeutics.

Takara Shuzo WO 00/39288

Cellobiohydrolase

Kyoto, Japan

Cellobiohydrolase-like proteins, variants made by deletions, additions, insertions, and substitutions.

Takeda Chemical WO 00/39315

Finding diabetes therapeutics

Osaka, Japan

Regulator sequence of uncoupling protein-2; for identifying diabetes and hypertension therapeutics.

Univ. College WO 00/39285

Insulin resistance therapy

London

Glycosyl phosphatidyl linositol-specific phospholipase D; for treating insulin resistance and liver dysfunction.

Yeda Res. & Develop WO 00/39160

Caspase-8 interacting protein

Rehovot, Israel

Caspase-8 interacting proteins, production methods; for modulating apoptosis.

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