Published July 12 (EP); July 6 (WO); July 12 (GB)
Aclara Biosciences WO 00/39335
Biopolymer presence determinations
Mountain View, Calif.
Solid surfaces addressable by individual or combination dyes; for multiplexed determinations of biopolymer presence.
Adv. Res. & Technol. Inst. WO 00/39311
Gene therapy methods
Indianapolis
Human fibroblast growth factor 1 used as a cofactor for successful infection by adeno-associated virus vectors.
Advanced Technol. WO 00/39300
Chemically induced expression
London
Chimeric gene having a promoter that is inducible by chemicals; for expression in eukaryotes.
AstraZeneca WO 00/39331
Pyruvate kinase SNPs
London
Single nucleotide polymorphisms (SNPs) in a pyruvate kinase isoenzyme 2; for identifying allelic variation in diabetes.
Auckland Uniservices WO 00/39159
Superantigens
Auckland, New Zealand
Superantigens, encoding gene sequences; for diagnostics and therapeutics.
Banyu Pharma WO 00/39164
Signal transduction ligands
Tokyo
GTP-binding protein-coupled receptor from human hippocampus, encoding gene; for signal transduction ligand screening.
BioChem Pharma WO 00/39299
Streptococcus vaccines
Laval, Que.
Streptococcus antigens, encoding gene sequences, recombinant production methods; for diagnostics and vaccines.
Bionative WO 00/39163
Interferon-a production
Umea, Sweden
Production of interferon-a using virus-induced human leukocytes and organic solvents.
Bristol-Myers Squibb WO 00/39276
Epithilone synthesis
Princeton, N.J.
Transformation of microbes with the genes for the biosynthesis of epithilones.
C.B.F. Leti WO 00/39298
Leishmaniasis vaccines
Tres Cantos, Spain
Chimeric gene encoding antigenic determinants of Leishmania infantum proteins, encoded protein; for vaccines.
Calydon WO 00/39319
Cancer gene therapy
Sunnyvale, Calif.
Adenoviral vectors with target cell-specific transcriptional response elements; for improved cancer cytotoxicity.
Chicago, Univ. of WO 00/38518
Cardiomyocyte gene transfection
Chicago
Stable in vivo gene transfer into cardiomyocytes using recombinant adeno-associated virus vectors.
Chiron WO 00/39302
Stimulating HIV immunoresponse
Emeryville, Calif.
HIV protein production using expression cassettes encoding HIV gag proteins; for stimulating immune responses.
Chiron WO 00/39303
Modified HIV envelope proteins
Emeryville, Calif.
Modified HIV envelope polypeptides having exposed CD4 binding regions; for diagnostics and therapeutics.
Chiron WO 00/39304
Antigenic HIV polypeptides
Emeryville, Calif.
Genes encoding antigenic HIV type C gag- and env-containing polypeptides; for diagnostics and therapeutics.
Chiron WO 00/39318
Alphavirus vectors
Emeryville, Calif.
Compositions and methods for packaging alphavirus vectors having therapeutic genes; for gene therapy.
City of Hope WO 00/39343
Mutation detection
Duarte, Calif.
Denaturing fingerprinting methods for detecting mutations in nucleic acid sequences.
Connaught Labs WO 00/39157 & 39158
Chlamydia vaccines
Toronto
Chlamydia antigens, encoding gene sequences; for diagnostics, vaccines, and infection prevention.
Corixa WO 00/39301
Mycobacterial protein adjuvants
Seattle, Wash.
Mycobacterium proteins that stimulate interleukin-12 and interferon gamma production; for immunological adjuvants.
Dana-Farber Cancer Inst. WO 00/39345
Mutation scanning array
Boston
Mutation scanning array having immobilized oligonucleotides; for identifying mismatches or polymorphisms.
Danisco WO 00/39289
Xylanase inhibitors
Copenhagen, Denmark
Endo-_-1,4-xylanases, encoding gene sequences; for identifying inhibitors.
DNAVec Res. EP 1 018 560
Target gene expression
Ibaraki, Japan
Transcription of recombinase genes in cells having specific transcription factors; for target gene expression.
Florence Medical WO 00/39275
Angiogenesis disorder vectors
Kfar-Saba, Israel
Expression vectors with therapeutic genes linked to shear stress responsive elements; for angiogenesis disorders.
Gardella, T.J., et al. WO 00/39278
PTH peptide conjugates
Cambridge, Mass.
Parathyroid hormone (PTH) peptides, analogs, fragments, conjugate peptides, derivatives; for modulator screens.
Gene Logic WO 00/39344
Mixed probe assay device
Gaithersburg, Md.
Multiple binding reagents as affixed to substrates; for mixed probe detection elements.
Genelabs Technol. EP 1 018 558
Hepatitis C diagnostics
Redwood City, Calif.
Hepatitis C virus immunogenic protein epitopes, encoding genes; for diagnostics.
Genencor Intl. WO 00/39323
Recombinant proteins from bacteria
Rochester, N.Y.
Recombinant protein production in Gram-positive bacteria having mutations in the opp operon gene cluster.
Genentech WO 00/39297
IL-1 related proteins
S. San Francisco
Interleukin- (IL)-1 related proteins, encoding gene sequences, peptides, chimeras, fusions, antibodies.
Genentech WO 00/39320
Transfection complexes
S. San Francisco
Transfection complexes of nucleic acid and calcium phosphate; for inserting gene sequences.
Georgia, Univ. of WO 00/39310
Rubredoxin fusions
Athens, Ga.
Rubredoxin fusion proteins having a linkage subject to proteolysis; for affinity purification for vaccines.
Gladstone Inst. WO 00/39316
HIV receptor transgenics
San Francisco
Transgenic rodents and rodent cell lines expressing HIV co-CD4 receptors; for studying HIV infection mechanisms.
Glaxo WO 00/39295
TNF ligand family member
Greenford, UK
A member of the tumor necrosis factor (TNF) ligand superfamily, variants.
Glaxo Wellcome WO 00/39308
Inflammation modulators
Tokyo
IKK kinase, IKK3, encoding genes; for screening modulators and treating inflammation.
Human Genome Sciences WO 00/39136
Human brainiac-5
Rockville, Md.
Human brainiac-5 gene, encoded protein, production methods; for diagnostics, therapeutics, and screening modulators.
Human Genome Sciences WO 00/39166
Hyaluronan-binding proteins
Rockville, Md.
Hyaluronan-binding proteins, encoding genes; for screening modulators and cancer diagnostics and therapeutics.
Human Genome Sciences WO 00/39327
Peptidoglycan recognition proteins
Rockville, Md.
Peptidoglycan recognition binding proteins expressed in keratinocytes, encoding genes; for therapeutics.
Iconix Pharma WO 00/39346
Pathway reporter system
Mountain View, Calif.
Methods and nucleic acid constructs for testing and validating a pathway reporter system.
Immunex WO 00/39296
Lectin
Seattle, Wash.
Lectin protein, encoding gene sequences, peptides, fragments, antibodies; for therapeutics.
Inst. Child Hlth. Develop. EP 1 018 550
Dust mite allergens
Sublaco, Australia
Allergenic proteins and peptides from the house dust mite, encoding genes; for allergy diagnostics and therapeutics.
Inst. Phys. & Chem. Res. EP 1 018 549
DNA purification
Wako, Japan
Methods of purifying DNA from complex biological samples using DNA-binding carrier on membranes.
Janssen Pharma WO 00/39332
Cytochrome polymorphisms
Beerse, Belgium
Genotyping polymorphisms in cytochromes; for determining drug metabolizing capabilities.
Kirin-Amgen EP 1 018 552
Pluripotent G-CSF
Thousand Oaks, Calif.
Pluripotent granulocyte colony-stimulating factor (G-CSF), encoding gene, biological and chemical production methods.
Krebs Res. Ctr. WO 00/39292
Adhesion molecule antisense
Heidelberg, Germany
Antisense oligos to the a4-chain of VLA-4 adhesion molecule; for cancer and immune system therapeutics.
Kurokawa, K. EP 1 018 551
Mesangial cell expressed gene
Tokyo
Gene expressed in mesangial cells, encoded protein, antibodies; for diagnostics and therapeutics.
Lexow, P. WO 00/39333
Sequencing using magnifying tags
Bergen, Norway
Nucleic acid sequencing methods that use base magnifying tags.
Maryland, Univ. of WO 00/39152
Stable subtilin
College Park, Md.
Stable preparations of subtilin made using hydrophobic interaction chromatography.
Max Delbruck Ctr. Molec. Med. WO 00/39293
Tissue regeneration inhibition
Berlin
Vector with a gene encoding a c-myb DNA-binding domain fusion; for inhibiting tissue regeneration in restenosis.
Max Delbruck Ctr. Molec. Med. WO 00/39317
Tumor-specific promoter
Berlin
Tumor-specific YB-1 promoter; for linkage to transgenes to diagnose and treat cancer.
Merck WO 00/39147
Melanocortin 1 receptor modulators
Rahway, N.J.
DNA molecules encoding splice variants of human melanocortin 1 receptor protein; for identifying modulators.
Merck WO 00/39151
Papillomavirus neutralizing antibodies
Rahway, N.J.
Papillomavirus-like particles having reporter gene constructs; for detecting neutralizing antibodies.
Millennium Pharma WO 00/39149
High temperature requirement proteins
Cambridge, Mass.
Secreted high temperature requirement proteins, encoding genes, antibodies; for diagnostics and therapeutics.
Millennium Pharma WO 00/39150 & 39284
Secreted proteins
Cambridge, Mass.
Secreted and membrane-associated proteins, encoding genes, antibodies, transgenics; for diagnostics and therapeutics.
Millennium Pharma WO 00/39161
Cytokine receptor-like proteins
Cambridge, Mass.
Class II cytokine receptor-like proteins, encoding genes, antibodies, transgenics; for use as modulators.
Millennium Pharma WO 00/39277
Prostate cancer diagnostics
Cambridge, Mass.
NDSP genes, encoded proteins, antibodies, modulators; for androgen-independent prostate cancer diagnosis.
Millennium Pharma WO 00/39287
Identifying antifungals
Cambridge, Mass.
Aspergillus fumigatus coenzyme-A carboxylase genes, encoded proteins; for identifying antifungal agents.
Millennium Pharma WO 00/39342
Identifying antifungals
Cambridge, Mass.
Saccharomyces yeast genes essential for survival; for use in identifying antifungal agents.
Natl. Inst. Agron. Res. WO 00/39309
Bacterial protein production system
Paris
Gram-positive bacteria lacking functional a HtrA surface protease; for expressing exported proteins.
NIH (Natl. Inst. Hlth.) EP 1 018 555
Papillomavirus vaccines
Bethesda, Md.
Chimeric papillomavirus-like particles; for gene delivery and vaccines.
NIH (Natl. Inst. Hlth.) EP 1 018 556
Flavivirus vaccines
Bethesda, Md.
Chimeric and growth-restricted flaviviruses including mutated virulence genes; for vaccines.
Nebraska, Univ. of WO 00/39326
Peptide synthesis measurement
Lincoln, Neb.
Quantifying heavy hydrogen levels at specific peptide amide linkages; for studying peptide synthesis.
New Zealand Res. Inst. WO 00/39165
Serine protease inhibitor
Palmerston North, New Zealand
Serine protease inhibitor from mussels that has anti-thrombin and metal-chelating activity.
Norpharma WO 00/39307
Nucleoside production
Valleambrosia di Rozzano, Italy
Recombinant bacterial strains modified to produce natural nucleosides and their analogs.
Novartis WO 00/39294
Xenograft acceptance
Basel, Switzerland
Pig cells that do not express the CD40 antigen; for preventing rejection of xenografts.
Novation Pharma WO 00/39314
mRNA degradation induction
Coquitlam, B.C.
Methods for the identification of compounds that induce mRNA degradation.
Novo Nordisk WO 00/39322
Recombinant proteins in fungi
Bagsvaerd, Denmark
Methods for producing recombinant proteins in mutant Aspergillus fungal cells; for making toxins.
Pfizer EP 1 018 557
PRRS vaccines
Groton, Conn.
Infectious cDNA clone of pig reproductive and respiratory syndrome (PRRS) virus, encoded proteins, for vaccines.
Pfizer EP 1 018 559
Phosphodiesterase enzymes
Sandwich, UK
Phosphodiesterase enzymes, encoding gene sequences; for diagnostics and therapeutics.
Rosetta Inpharmatics WO 00/39336
Consensus response patterns
Kirkland, Wash.
Consensus biological response pattern profiles to drugs determined using expression profiles.
Rosetta Inpharmatics WO 00/39337
Response pattern discrimination
Kirkland, Wash.
Robust discrimination of subtle effects of disease states on biological response pattern profiles.
Rosetta Inpharmatics WO 00/39338
Biological response analysis
Kirkland, Wash.
Methods and systems for analyzing biological response signal data using computer-based imaging of databases.
Rosetta Inpharmatics WO 00/39339
Combining expression profiles
Kirkland, Wash.
Statistical combining of cell expression profiles from fluorophore measurement of microarray system data.
Rosetta Inpharmatics WO 00/39340
Drug interaction prediction
Kirkland, Wash.
Detection and prediction of drug interactions using biological response profiles.
Rosetta Inpharmatics WO 00/39341
Therapeutic index measurement
Kirkland, Wash.
Methods for determining therapeutic index from gene expression profile data.
St. Jude Children's Hosp. WO 00/39347
Tumor suppressor death signal
Memphis, Tenn.
Caspase-8 as a tumor suppressor involved in cell death signaling; for cancer diagnostics and therapeutics.
SKW Biosystems WO 00/39312
Conjugation DNA sequences
Boulogne Billancourt, France
DNA sequences capable of being transferred by conjugation; for inserting coding gene sequences.
SmithKline Beecham GB 2 345 487
Multidrug-resistance modulators
Philadelphia
Rat mdr1a gene, encoded protein, recombinant production methods; for screening multidrug resistance modulators.
SmithKline Beecham WO 00/39162
Human Wnt-7a proteins
Brentford, UK
Human Wnt-7a proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/39286
Antibacterial screens
Philadelphia
Microbial DnaE proteins, encoding genes, recombinant production methods; for antibacterial screens.
Synaptic Pharma WO 00/39279
Melanin concentrating hormone receptor
Paramus, N.J.
Human melanin concentrating hormone receptor gene, encoded protein, antisense; for diagnostics and therapeutics.
Takara Shuzo WO 00/39288
Cellobiohydrolase
Kyoto, Japan
Cellobiohydrolase-like proteins, variants made by deletions, additions, insertions, and substitutions.
Takeda Chemical WO 00/39315
Finding diabetes therapeutics
Osaka, Japan
Regulator sequence of uncoupling protein-2; for identifying diabetes and hypertension therapeutics.
Univ. College WO 00/39285
Insulin resistance therapy
London
Glycosyl phosphatidyl linositol-specific phospholipase D; for treating insulin resistance and liver dysfunction.
Yeda Res. & Develop WO 00/39160
Caspase-8 interacting protein
Rehovot, Israel
Caspase-8 interacting proteins, production methods; for modulating apoptosis.