Published June 7 (EP); June 2 (WO); June 7 (GB)
Affymetrix EP 1 006 181
BRCA1 affected expression
Santa Clara, Calif.
Analyzing expression patterns of genes whose expression is affected by BRCA1; for finding potential anticancer agents.
Akzo Nobel WO 00/31112
Estrogen receptor modulators
Arnhem, the Netherlands
Estradiol derivatives having an 11_ substitution; for use as modulators of estrogen receptor signalling.
American Home Products WO 00/31262
Neurotensin receptor modulators
Human neurotensin subtype 2 receptor, encoding gene sequences; for high-throughput modulator screens.
Amgen WO 00/31254
Thousand Oaks, Calif.
Apoptosis-inducing factor, encoding gene sequences; for diagnostics and therapeutics.
Arena Pharma WO 00/31258
G protein-coupled receptors
Human orphan G protein-coupled receptors, encoding gene sequences; for diagnostics and therapeutics.
Azwell WO 00/31275
Lysophosphatidic acid phosphatase
Recombinant lysophosphatidic acid phosphatase, encoding gene; for LPA disease diagnostics and therapeutics.
Babraham Inst. GB 2 344 344
Transgenic humanized antibodies
Transgenic mice containing the human immunoglobulin gamma light chain locus; for making humanized antibodies.
Barcelona Free Univ. WO 00/31267
Cellular diabetes therapy
Transfection of muscle cells with the insulin gene; for implantation to treat diabetes.
Bayer WO 00/31121
Factor VIII binding peptides
Recombinant Factor VIII binding peptides isolated from a combinatorial library; for use in purification.
Boehringer Ingelheim Pharma WO 00/31240
Immortalized brain endothelium
Immortalized brain endothelial cells having a papovirus middle-T antigen gene; for studying the blood-brain barrier.
Bresagen WO 00/30441
Oocyte and embryo preservation after centrifugation of cellular contents; for producing animals.
Bristol-Myers Squibb WO 00/31113
Targeted intracellular delivery
Intracellular targeted delivery of compounds using the 70 kD heat shock protein or fragments.
Bristol-Myers Squibb WO 00/31244
Treating angiogenesis disorders
Angiostatin and the kringle 5 region of plasminogen; for treating angiogenic-associated disorders.
Cadus Pharma WO 00/31261
Receptor/ion channel modulators
Rapid, effective assays for screening cell receptor or ion channel modulators; for affecting bioactivity.
California, Univ. of WO 00/31109
Inhibitors of core 2 N-acetyl glucose transferase; for treating inflammation.
CDC (Ctr. Disease Cont.) WO 00/31270
Bartonella infection therapy
Bartonella proteins, encoding gene sequences, antibodies; for infection diagnostics and therapeutics.
Chemo-Serotherapeutic Res. Inst. WO 00/31131
Cell death modulation
Selenoprotein P fragments having cell death inhibitory activity, antibodies; for modulator screens.
Chiron EP 1 006 182
Factor VIIIC fragments
Factor VIIIC polypeptide fragments, encoding gene sequences; for treating coagulation defects.
Chugai Res. Inst. Molec. Med. WO 00/31255
Ubiquitin-like protein isolated from the brain by a 2-hybrid screen, encoding gene; for diagnostics and therapeutics.
Chugai Res. Inst. Molec. Med. WO 00/31256
Brain-specific protein containing a PDZ domain, encoding gene sequences; for diagnostics and therapeutics.
City of Hope WO 00/31301
Androgen receptor polymorphisms
Association of trinucleotide repeat polymorphisms of the androgen receptor gene with disruptive disorders.
CSIRO (Comm. Sci. & Ind. Res. Org.) WO 00/31115
Mycoplasma antigen genes
Identification of mycoplasma antigen gene sequences using polyhistidine tags; for vaccine development.
Curie, Univ. Pierre & Marie EP 1 006 123
Chimeric viral envelopes
Chimeric viral envelope proteins, encoding gene sequences; for virus production [in French].
Epigenomics WO 00/31294
Gene methylation patterns
Methods for identifying cytosine methylation patterns in genomic DNA; for determining gene silencing occurrence.
Exact Labs WO 00/31298
Lower frequency molecules
Methods for detecting molecules of lower frequency against a background of higher frequency molecules.
Fuso Pharma WO 00/31243
Serine protease BSSP5
Serine protease BSSP5 gene, encoded proteins, modified versions, antibodies, transgenics; for detection assays.
Fuso Pharma WO 00/31257
Serine protease BSSP6
Serine protease BSSP6 gene, encoded proteins, modified versions, antibodies, transgenics; for detection assays.
Fuso Pharma WO 00/31272
Serine protease BSSP2
Serine protease BSSP2 gene, encoded proteins, modified versions, antibodies, transgenics; for detection assays.
Fuso Pharma WO 00/31277
Serine protease BSSP4
Serine protease BSSP4 gene, encoded proteins, modified versions, antibodies, transgenics; for detection assays.
Fuso Pharma WO 00/31284
Protein expression vector
Protein expression vector having a secretory signal nucleic acid sequence and a cloning site.
Genetica WO 00/31238
Preventing cellular senescence
Cold Spr. Harbor, N.Y.
Methods for activating telomerase activity and inhibition of the Rb/p16 or p53 pathway; for preventing senescence.
Guerriero, V., et al. WO 00/31114
Hsp 70 function inhibition
Genes encoding proteins that inhibit heat shock protein (Hsp) 70 function, encoded proteins; for disease treatment.
Hartwich, G. WO 00/31101
Electrochemical hybridization detection
Electrochemical detection of sequence-specific nucleic acid hybridization using a redox moiety attached to a probe.
Heinrich Pette Inst. EP 1 006 196
Retroviral hybrid vectors pseudotyped with LCMV glycoprotein during infection; for diagnostics [in German].
Helix Res. Inst. EP 1 006 179
Transfection expression patterns
Gene transfection and measurement of changes in gene expression patterns; for finding transferred gene effects.
Hisamitsu Pharma WO 00/31271
HIV infection inhibitors
Antisense oligonucleotides to the CXCR4 receptor; for inhibiting HIV infection.
Hoffmann-La Roche EP 1 006 184
IGF receptor interacting proteins
Insulin growth factor-1 receptor interacting proteins, encoding genes; for diagnostics and therapeutics.
Human Genome Sciences EP 1 006 188
Human chemokine _4 and _10, encoding genes, recombinant production methods, modulators; for therapeutics.
Idec Pharma WO 00/30680
Tumor antigen antibodies
Tumor antigen-specific antibody GP39, chimeric proteins with CD40 ligand domains; for inducing cancer immune responses.
Incyte Genomics WO 00/31263
Palo Alto, Calif.
GTPase-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/31265
Urotensin II, encoding gene sequences; for treating neurodegeneration and spinal chord trauma.
Intl. Superior Sch. Adv. Studies WO 00/31246
Nucleic acid library preparation
Preparation of large, highly diverse nucleic acid libraries using recombinase-induced recombination.
Introgene WO 00/31285
Smooth muscle vectors
Gene delivery vectors having sequences allowing them to be expressed in smooth muscle and/or endothelial cells.
Isis Pharma WO 00/31103
Antisense modulation of MEK2 expression; for treating diseases associated with MEK2 expression.
Isis Pharma WO 00/31105
Inhibitor-kappa B kinase-_ antisense
Antisense modulation of Inhibitor-kappa B kinase-_ expression; for disease treatment.
Isis Pharma WO 00/31106
Antisense modulation of MEK1 expression; for treating diseases associated with MEK1 expression.
Isis Pharma WO 00/31110
Disease predictive mRNAs
Comparative analysis of mRNAs produced from a common gene; for identifying disease predictive mRNAs.
Isis Pharma WO 00/31111
NF-kappa-B P65 subunit antisense
Antisense modulation of NF-kappa-B P65 subunit expression; for treating associated diseases.
Isis Pharma WO 00/31296
Antisense modulation of interleukin-15 expression; for treating associated diseases.
Isis Pharma WO 00/31302
In situ binary synthesis of biologically effective molecules made of functionalized oligonucleotides.
Japan Tobacco WO 00/31250
Gene expression enhancer
Nucleic acid sequences that promote the expression of structural genes located downstream.
Johns Hopkins Univ. WO 00/31300
Genotyping by mass spectrometric analysis of short DNA fragments; for detecting single nucleotide polymorphisms.
Kikkoman WO 00/31245
Creatine amidinohydrolase, bacterial production methods; for creatinine assays that are not affected by bilirubin.
Korea Inst. Sci. & Technol. WO 00/31141
Humanized hepatitis antibodies
Seoul, S. Korea
Humanized antibody against hepatitis B virus pre-S1 surface antigen; for less immunogenic treatment of infections.
Kosan Biosciences WO 00/31247
Epithilone cancer therapeutics
Recombinant epithilone polyketide synthase gene; for producing epithilone cancer therapeutics.
Kramer, M.D. WO 00/31125
Keratinocyte regulatory protein
Regulatory protein from activated human keratinocytes, encoding gene sequences; for diagnostics and therapeutics.
Kreatech Biotech EP 1 006 199 & 1 006 200
Gene probe construction
Generation of interstrand cross-links in nucleic acids at specific locations; for probe construction.
Kyowa Hakko Kogyo WO 00/31132
JNK3 binding protein
JNK3 binding protein, encoding gene; for diagnostics and therapeutics for diseases associated with the JNK3 cascade.
Lexicon Genetics WO 00/31236
Gene trap vectors
The Woodlands, Texas
3' gene trap cassettes that do not encode an antibiotic resistance marker; for producing mutated cells and animals.
Link Technol. WO 00/31102
Conjugation of oligonucleotides to peptides; for making hybrid molecules for therapeutics.
Loyola Univ. WO 00/31128
Delivering biotinylated substances
Chimeric protein having papillomavirus L1/L2 protein and biotin-binding domains; for cellular delivery.
Ludwig Inst. Cancer Res. WO 00/31299
Finding orphan genes
Methods for determining nucleotide sequences using arbitrary primers and low stringency; for finding orphan genes.
Maryland, Univ. of WO 00/31297
Diabetes status markers
College Park, Md.
Genetic markers that identify individuals who improve their diabetes status with exercise.
Mass. Gen. Hosp. WO 00/31266
Modified human PTH
Modified human parathyroid hormone (PTH), encoding gene sequences; for therapeutics.
Max Planck Inst. EP 1 006 183
Recombinant soluble Fc receptors, encoding genes, microbial production methods; for isolating antibodies.
Max Planck Inst. WO 00/31252
Neural regeneration gene
Human semaphorin 6A-1 gene that is useful in neuronal development and regeneration mechanisms during apoptosis.
MRC (Med. Res. Counc.) WO 00/31127
Hepatitis C protein targeting
Hepatitis C core protein or fragments used as a targeting sequence and linked to lipids; for protein targeting.
Merck WO 00/31108
G-protein coupled receptor
Human G-protein coupled receptor, encoding gene sequences; for identifying modulators.
Micrologix Biotech WO 00/31279
Antimicrobial cationic peptides
Efficient production of antimicrobial cationic peptides in host cells, anion exchange chromatography purification.
Millennium Pharma EP 1 006 187
Cancer gene expression
Genes that are differentially expressed in benign and malignant tumors; for cancer diagnostics and therapeutics.
Millennium Pharma WO 00/31133
Potassium channel interactors
Potassium channel interactors, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.
Novo Nordisk Biotech WO 00/31241
Choline oxidase-like proteins
Choline oxidase-like proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.
Otsuka Pharma EP 1 006 186
p53 regulated genes
Genes that are transcriptionally regulated by tumor suppressor gene p53; for diagnostics and therapeutics.
Oxford Biomedica WO 00/31280
Nitrous oxide inhibitor
Recombinant retroviral vector for delivering nitrous oxide inhibitor; for blood pressure therapeutics.
Queensland, Univ. of WO 00/31540
Methods for identifying immunostimulatory DNA, modulators; for immune system modulation
Rhone-Poulenc Rorer WO 00/31253
Parkinson gene mutations
Gene sequences coding for mutated or truncated parkin forms, encoded proteins, antibodies; for Parkinson's therapeutics.
RIKEN EP 1 006 180
Production of double-stranded DNA with its terminal homopolymer part eliminated; for gene sequencing.
Schwab, M.E., et al. WO 00/31235
Nogo genes, encoded proteins, derivatives, analogs, antibodies; for diagnostics and therapeutics.
Shionogi WO 00/31295
HLA class I allele types
Distinguishing HLA class I allele types using PCR amplification techniques.
SmithKline Beecham WO 00/31104 & 31107
G-protein coupled receptors
G-protein coupled 7 transmembrane receptors, encoding genes, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/31248
Integrin receptor antibodies
Humanized antibodies to heterodimeric integrin receptors, encoding genes; for cancer therapeutics.
Stanford Univ. WO 00/30687
Adenoviral gene therapy vectors
Palo Alto, Calif.
Recombinant adenoviral vectors having E region deletions; for gene therapy.
Sydney, Univ. of WO 00/31293
TNF receptor polymorphisms
Tumor necrosis factor receptor 2 complex polymorphisms; for diagnosing polygenic disease susceptibility.
Transgene EP 1 006 197
Immune complex with an antibody and a polynucleotide; for transfecting micropinocyte target cells.
Triton Biosciences EP 1 006 194
c-erbB-2 cancer vaccines
c-erb-2 external domain gp75 glycoprotein, antibodies; for cancer diagnostics, vaccines, and therapeutics.
Valentis WO 00/31286
Modified steroid hormone receptors
The Woodlands, Texas
Adenoviral-mediated delivery of modified steroid hormone receptors using vectors lacking viral sequences.
Vanderbilt Univ. WO 00/30444
Gene transfer using lipids
Cationic lipids and liposome formulations; for introducing functional bioactive agents into cells.
Vlaams Inst. Biotech EP 1 006 185
Uterine cancer genes
Splice variants of RAD51B involved in formation of uterine leiomyomas, encoded proteins; for therapeutics.
Wisconsin, Univ. of WO 00/30437
Microinjection of infectious retroviruses into perivitelline spaces of oocytes; for efficient production of transgenics.
Wisconsin, Univ. of WO 00/31242
Engineered cytotoxic ribonuclease
RNase superfamily ribonucleases modified to enhance its cytotoxicity toward tumor cells.
Xerion Pharma WO 00/31544
Protein functional sites
Identifying functional sites in proteins using tagged binding partners that form free radicals when irradiated.
Yeda Res. & Develop. WO 00/31239
Immune cell response
Immune cells transfected with antigen-specific MHC-restricted T cell receptor genes; for immune responses.
ZymoGenetics WO 00/31259
Human membrane-associated secretory protein, encoding gene sequences; for diagnostics and therapeutics.
ZymoGenetics WO 00/31260
Testis-specific glycoprotein, encoding gene sequences, antibodies; for modulating egg-sperm interactions.
ZymoGenetics WO 00/31264
Testis-specific cystatin-like protein, encoding gene, antibodies; for modulating spermatogenesis.
ZymoGenetics WO 00/31278
Human zinc metalloenzyme of the angiotensin-converting enzyme family, encoding gene sequences.