Published June 7 (EP); June 2 (WO); June 7 (GB)

Affymetrix EP 1 006 181

BRCA1 affected expression

Santa Clara, Calif.

Analyzing expression patterns of genes whose expression is affected by BRCA1; for finding potential anticancer agents.

Akzo Nobel WO 00/31112

Estrogen receptor modulators

Arnhem, the Netherlands

Estradiol derivatives having an 11_ substitution; for use as modulators of estrogen receptor signalling.

American Home Products WO 00/31262

Neurotensin receptor modulators

Madison, N.J.

Human neurotensin subtype 2 receptor, encoding gene sequences; for high-throughput modulator screens.

Amgen WO 00/31254

Apoptosis-inducing factor

Thousand Oaks, Calif.

Apoptosis-inducing factor, encoding gene sequences; for diagnostics and therapeutics.

Arena Pharma WO 00/31258

G protein-coupled receptors

San Diego

Human orphan G protein-coupled receptors, encoding gene sequences; for diagnostics and therapeutics.

Azwell WO 00/31275

Lysophosphatidic acid phosphatase

Osaka, Japan

Recombinant lysophosphatidic acid phosphatase, encoding gene; for LPA disease diagnostics and therapeutics.

Babraham Inst. GB 2 344 344

Transgenic humanized antibodies

Babraham, UK

Transgenic mice containing the human immunoglobulin gamma light chain locus; for making humanized antibodies.

Barcelona Free Univ. WO 00/31267

Cellular diabetes therapy

Barcelona, Spain

Transfection of muscle cells with the insulin gene; for implantation to treat diabetes.

Bayer WO 00/31121

Factor VIII binding peptides

Berkeley, Calif.

Recombinant Factor VIII binding peptides isolated from a combinatorial library; for use in purification.

Boehringer Ingelheim Pharma WO 00/31240

Immortalized brain endothelium

Ridgefield, Conn.

Immortalized brain endothelial cells having a papovirus middle-T antigen gene; for studying the blood-brain barrier.

Bresagen WO 00/30441

Oocyte cryopreservation

Thebarton, Australia

Oocyte and embryo preservation after centrifugation of cellular contents; for producing animals.

Bristol-Myers Squibb WO 00/31113

Targeted intracellular delivery

Princeton, N.J.

Intracellular targeted delivery of compounds using the 70 kD heat shock protein or fragments.

Bristol-Myers Squibb WO 00/31244

Treating angiogenesis disorders

Princeton, N.J.

Angiostatin and the kringle 5 region of plasminogen; for treating angiogenic-associated disorders.

Cadus Pharma WO 00/31261

Receptor/ion channel modulators

Tarrytown, N.Y.

Rapid, effective assays for screening cell receptor or ion channel modulators; for affecting bioactivity.

California, Univ. of WO 00/31109

Inflammation inhibitors

Oakland, Calif.

Inhibitors of core 2 N-acetyl glucose transferase; for treating inflammation.

CDC (Ctr. Disease Cont.) WO 00/31270

Bartonella infection therapy

Atlanta

Bartonella proteins, encoding gene sequences, antibodies; for infection diagnostics and therapeutics.

Chemo-Serotherapeutic Res. Inst. WO 00/31131

Cell death modulation

Kumamoto, Japan

Selenoprotein P fragments having cell death inhibitory activity, antibodies; for modulator screens.

Chiron EP 1 006 182

Factor VIIIC fragments

Emeryville, Calif.

Factor VIIIC polypeptide fragments, encoding gene sequences; for treating coagulation defects.

Chugai Res. Inst. Molec. Med. WO 00/31255

Ubiquitin-like protein

Ibaraki, Japan

Ubiquitin-like protein isolated from the brain by a 2-hybrid screen, encoding gene; for diagnostics and therapeutics.

Chugai Res. Inst. Molec. Med. WO 00/31256

Brain-specific protein

Ibaraki, Japan

Brain-specific protein containing a PDZ domain, encoding gene sequences; for diagnostics and therapeutics.

City of Hope WO 00/31301

Androgen receptor polymorphisms

Duarte, Calif.

Association of trinucleotide repeat polymorphisms of the androgen receptor gene with disruptive disorders.

CSIRO (Comm. Sci. & Ind. Res. Org.) WO 00/31115

Mycoplasma antigen genes

Campbell, Australia

Identification of mycoplasma antigen gene sequences using polyhistidine tags; for vaccine development.

Curie, Univ. Pierre & Marie EP 1 006 123

Chimeric viral envelopes

Paris

Chimeric viral envelope proteins, encoding gene sequences; for virus production [in French].

Epigenomics WO 00/31294

Gene methylation patterns

Berlin

Methods for identifying cytosine methylation patterns in genomic DNA; for determining gene silencing occurrence.

Exact Labs WO 00/31298

Lower frequency molecules

Maynard, Mass.

Methods for detecting molecules of lower frequency against a background of higher frequency molecules.

Fuso Pharma WO 00/31243

Serine protease BSSP5

Osaka, Japan

Serine protease BSSP5 gene, encoded proteins, modified versions, antibodies, transgenics; for detection assays.

Fuso Pharma WO 00/31257

Serine protease BSSP6

Osaka, Japan

Serine protease BSSP6 gene, encoded proteins, modified versions, antibodies, transgenics; for detection assays.

Fuso Pharma WO 00/31272

Serine protease BSSP2

Osaka, Japan

Serine protease BSSP2 gene, encoded proteins, modified versions, antibodies, transgenics; for detection assays.

Fuso Pharma WO 00/31277

Serine protease BSSP4

Osaka, Japan

Serine protease BSSP4 gene, encoded proteins, modified versions, antibodies, transgenics; for detection assays.

Fuso Pharma WO 00/31284

Protein expression vector

Osaka, Japan

Protein expression vector having a secretory signal nucleic acid sequence and a cloning site.

Genetica WO 00/31238

Preventing cellular senescence

Cold Spr. Harbor, N.Y.

Methods for activating telomerase activity and inhibition of the Rb/p16 or p53 pathway; for preventing senescence.

Guerriero, V., et al. WO 00/31114

Hsp 70 function inhibition

Tucson, Ariz.

Genes encoding proteins that inhibit heat shock protein (Hsp) 70 function, encoded proteins; for disease treatment.

Hartwich, G. WO 00/31101

Electrochemical hybridization detection

Munich, Germany

Electrochemical detection of sequence-specific nucleic acid hybridization using a redox moiety attached to a probe.

Heinrich Pette Inst. EP 1 006 196

Pseudotyped vectors

Hamburg, Germany

Retroviral hybrid vectors pseudotyped with LCMV glycoprotein during infection; for diagnostics [in German].

Helix Res. Inst. EP 1 006 179

Transfection expression patterns

Chiba, Japan

Gene transfection and measurement of changes in gene expression patterns; for finding transferred gene effects.

Hisamitsu Pharma WO 00/31271

HIV infection inhibitors

Saga, Japan

Antisense oligonucleotides to the CXCR4 receptor; for inhibiting HIV infection.

Hoffmann-La Roche EP 1 006 184

IGF receptor interacting proteins

Basel, Switzerland

Insulin growth factor-1 receptor interacting proteins, encoding genes; for diagnostics and therapeutics.

Human Genome Sciences EP 1 006 188

Chemokine _4/_10

Rockville, Md.

Human chemokine _4 and _10, encoding genes, recombinant production methods, modulators; for therapeutics.

Idec Pharma WO 00/30680

Tumor antigen antibodies

San Diego

Tumor antigen-specific antibody GP39, chimeric proteins with CD40 ligand domains; for inducing cancer immune responses.

Incyte Genomics WO 00/31263

GTPase-associated proteins

Palo Alto, Calif.

GTPase-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/31265

Urotensin II

Paris

Urotensin II, encoding gene sequences; for treating neurodegeneration and spinal chord trauma.

Intl. Superior Sch. Adv. Studies WO 00/31246

Nucleic acid library preparation

Trieste, Italy

Preparation of large, highly diverse nucleic acid libraries using recombinase-induced recombination.

Introgene WO 00/31285

Smooth muscle vectors

Leiden, Netherlands

Gene delivery vectors having sequences allowing them to be expressed in smooth muscle and/or endothelial cells.

Isis Pharma WO 00/31103

MEK2 antisense

Carlsbad, Calif.

Antisense modulation of MEK2 expression; for treating diseases associated with MEK2 expression.

Isis Pharma WO 00/31105

Inhibitor-kappa B kinase-_ antisense

Carlsbad, Calif.

Antisense modulation of Inhibitor-kappa B kinase-_ expression; for disease treatment.

Isis Pharma WO 00/31106

MEK1 antisense

Carlsbad, Calif.

Antisense modulation of MEK1 expression; for treating diseases associated with MEK1 expression.

Isis Pharma WO 00/31110

Disease predictive mRNAs

Carlsbad, Calif.

Comparative analysis of mRNAs produced from a common gene; for identifying disease predictive mRNAs.

Isis Pharma WO 00/31111

NF-kappa-B P65 subunit antisense

Carlsbad, Calif.

Antisense modulation of NF-kappa-B P65 subunit expression; for treating associated diseases.

Isis Pharma WO 00/31296

IL-15 antisense

Carlsbad, Calif.

Antisense modulation of interleukin-15 expression; for treating associated diseases.

Isis Pharma WO 00/31302

Functionalized oligos

Carlsbad, Calif.

In situ binary synthesis of biologically effective molecules made of functionalized oligonucleotides.

Japan Tobacco WO 00/31250

Gene expression enhancer

Tokyo

Nucleic acid sequences that promote the expression of structural genes located downstream.

Johns Hopkins Univ. WO 00/31300

Detecting SNPs

Baltimore, Md.

Genotyping by mass spectrometric analysis of short DNA fragments; for detecting single nucleotide polymorphisms.

Kikkoman WO 00/31245

Bilirubin assays

Chiba, Japan

Creatine amidinohydrolase, bacterial production methods; for creatinine assays that are not affected by bilirubin.

Korea Inst. Sci. & Technol. WO 00/31141

Humanized hepatitis antibodies

Seoul, S. Korea

Humanized antibody against hepatitis B virus pre-S1 surface antigen; for less immunogenic treatment of infections.

Kosan Biosciences WO 00/31247

Epithilone cancer therapeutics

Hayward, Calif.

Recombinant epithilone polyketide synthase gene; for producing epithilone cancer therapeutics.

Kramer, M.D. WO 00/31125

Keratinocyte regulatory protein

Pfungstadt, Germany

Regulatory protein from activated human keratinocytes, encoding gene sequences; for diagnostics and therapeutics.

Kreatech Biotech EP 1 006 199 & 1 006 200

Gene probe construction

Amsterdam

Generation of interstrand cross-links in nucleic acids at specific locations; for probe construction.

Kyowa Hakko Kogyo WO 00/31132

JNK3 binding protein

Tokyo

JNK3 binding protein, encoding gene; for diagnostics and therapeutics for diseases associated with the JNK3 cascade.

Lexicon Genetics WO 00/31236

Gene trap vectors

The Woodlands, Texas

3' gene trap cassettes that do not encode an antibiotic resistance marker; for producing mutated cells and animals.

Link Technol. WO 00/31102

Oligonucleotide conjugation

Cumbernauld, UK

Conjugation of oligonucleotides to peptides; for making hybrid molecules for therapeutics.

Loyola Univ. WO 00/31128

Delivering biotinylated substances

Chicago

Chimeric protein having papillomavirus L1/L2 protein and biotin-binding domains; for cellular delivery.

Ludwig Inst. Cancer Res. WO 00/31299

Finding orphan genes

New York

Methods for determining nucleotide sequences using arbitrary primers and low stringency; for finding orphan genes.

Maryland, Univ. of WO 00/31297

Diabetes status markers

College Park, Md.

Genetic markers that identify individuals who improve their diabetes status with exercise.

Mass. Gen. Hosp. WO 00/31266

Modified human PTH

Boston

Modified human parathyroid hormone (PTH), encoding gene sequences; for therapeutics.

Max Planck Inst. EP 1 006 183

Antibody isolation

Munich, Germany

Recombinant soluble Fc receptors, encoding genes, microbial production methods; for isolating antibodies.

Max Planck Inst. WO 00/31252

Neural regeneration gene

Munich, Germany

Human semaphorin 6A-1 gene that is useful in neuronal development and regeneration mechanisms during apoptosis.

MRC (Med. Res. Counc.) WO 00/31127

Hepatitis C protein targeting

London

Hepatitis C core protein or fragments used as a targeting sequence and linked to lipids; for protein targeting.

Merck WO 00/31108

G-protein coupled receptor

Rahway, N.J.

Human G-protein coupled receptor, encoding gene sequences; for identifying modulators.

Micrologix Biotech WO 00/31279

Antimicrobial cationic peptides

Vancouver, B.C.

Efficient production of antimicrobial cationic peptides in host cells, anion exchange chromatography purification.

Millennium Pharma EP 1 006 187

Cancer gene expression

Cambridge, Mass.

Genes that are differentially expressed in benign and malignant tumors; for cancer diagnostics and therapeutics.

Millennium Pharma WO 00/31133

Potassium channel interactors

Cambridge, Mass.

Potassium channel interactors, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.

Novo Nordisk Biotech WO 00/31241

Choline oxidase-like proteins

Davis, Calif.

Choline oxidase-like proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.

Otsuka Pharma EP 1 006 186

p53 regulated genes

Tokyo

Genes that are transcriptionally regulated by tumor suppressor gene p53; for diagnostics and therapeutics.

Oxford Biomedica WO 00/31280

Nitrous oxide inhibitor

Oxford, UK

Recombinant retroviral vector for delivering nitrous oxide inhibitor; for blood pressure therapeutics.

Queensland, Univ. of WO 00/31540

Immunostimulatory DNA

Brisbane, Australia

Methods for identifying immunostimulatory DNA, modulators; for immune system modulation

Rhone-Poulenc Rorer WO 00/31253

Parkinson gene mutations

Antony, France

Gene sequences coding for mutated or truncated parkin forms, encoded proteins, antibodies; for Parkinson's therapeutics.

RIKEN EP 1 006 180

Gene sequencing

Wako, Japan

Production of double-stranded DNA with its terminal homopolymer part eliminated; for gene sequencing.

Schwab, M.E., et al. WO 00/31235

Nogo genes

Zurich, Switzerland

Nogo genes, encoded proteins, derivatives, analogs, antibodies; for diagnostics and therapeutics.

Shionogi WO 00/31295

HLA class I allele types

Osaka, Japan

Distinguishing HLA class I allele types using PCR amplification techniques.

SmithKline Beecham WO 00/31104 & 31107

G-protein coupled receptors

Philadelphia

G-protein coupled 7 transmembrane receptors, encoding genes, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/31248

Integrin receptor antibodies

Philadelphia

Humanized antibodies to heterodimeric integrin receptors, encoding genes; for cancer therapeutics.

Stanford Univ. WO 00/30687

Adenoviral gene therapy vectors

Palo Alto, Calif.

Recombinant adenoviral vectors having E region deletions; for gene therapy.

Sydney, Univ. of WO 00/31293

TNF receptor polymorphisms

Sydney, Australia

Tumor necrosis factor receptor 2 complex polymorphisms; for diagnosing polygenic disease susceptibility.

Transgene EP 1 006 197

Transfecting micropinocytes

Strasbourg, France

Immune complex with an antibody and a polynucleotide; for transfecting micropinocyte target cells.

Triton Biosciences EP 1 006 194

c-erbB-2 cancer vaccines

Alameda, Calif.

c-erb-2 external domain gp75 glycoprotein, antibodies; for cancer diagnostics, vaccines, and therapeutics.

Valentis WO 00/31286

Modified steroid hormone receptors

The Woodlands, Texas

Adenoviral-mediated delivery of modified steroid hormone receptors using vectors lacking viral sequences.

Vanderbilt Univ. WO 00/30444

Gene transfer using lipids

Nashville, Tenn.

Cationic lipids and liposome formulations; for introducing functional bioactive agents into cells.

Vlaams Inst. Biotech EP 1 006 185

Uterine cancer genes

Zwijnaarde, Belgium

Splice variants of RAD51B involved in formation of uterine leiomyomas, encoded proteins; for therapeutics.

Wisconsin, Univ. of WO 00/30437

Producing transgenics

Madison, Wis.

Microinjection of infectious retroviruses into perivitelline spaces of oocytes; for efficient production of transgenics.

Wisconsin, Univ. of WO 00/31242

Engineered cytotoxic ribonuclease

Madison, Wis.

RNase superfamily ribonucleases modified to enhance its cytotoxicity toward tumor cells.

Xerion Pharma WO 00/31544

Protein functional sites

Martinsreid, Germany

Identifying functional sites in proteins using tagged binding partners that form free radicals when irradiated.

Yeda Res. & Develop. WO 00/31239

Immune cell response

Rehovot, Israel

Immune cells transfected with antigen-specific MHC-restricted T cell receptor genes; for immune responses.

ZymoGenetics WO 00/31259

Membrane-associated protein

Seattle

Human membrane-associated secretory protein, encoding gene sequences; for diagnostics and therapeutics.

ZymoGenetics WO 00/31260

Testis-specific glycoprotein

Seattle

Testis-specific glycoprotein, encoding gene sequences, antibodies; for modulating egg-sperm interactions.

ZymoGenetics WO 00/31264

Cystatin-like protein

Seattle

Testis-specific cystatin-like protein, encoding gene, antibodies; for modulating spermatogenesis.

ZymoGenetics WO 00/31278

Zinc metalloenzyme

Seattle

Human zinc metalloenzyme of the angiotensin-converting enzyme family, encoding gene sequences.

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