Published May 24 (EP); May 18 (WO); May 24 (GB)
Aberdeen, Univ. of GB 2 343 895
Immortalized insulin-producing human _-cell that can be rendered glucose responsive; for cell transplants.
Abraham, N.G., et al. WO 00/27198
Retroviral vectors encoding interferon-a, cells transduced with these vectors; for interferon therapy.
Adv. Biotech. Ctr. Consortium WO 00/27996
Chondrocyte culture medium
Serum-free medium for the growth and proliferation of chondrocytes and mesenchymal cells in culture.
Ajinomoto EP 1 002 866
Controlling bacterial growth
Genes encoding corynebacteria surfactant temperature sensitivity, encoded protein; for controlling growth.
Alcon Labs WO 00/28042
Lowering intraocular pressure
Ft. Worth, Texas
Administration of an inducible gene for cyclooxygenase to eye tissue; for lowering intraocular pressure.
Aventis Pharma WO 00/28010
Ex vivo gene therapy
Removing cells for transfection with a growth and/or differentiation factor gene; for therapeutic reintroduction.
Aventis Pharma WO 00/28062
Neuronal gene therapy vector
Vector having a tetracycline (tet) transactivator controlled by a tet-dependent promoter; for neuronal gene therapy.
Aventis Pharma WO 00/28064
Production of vancoresmycin from microorganisms; for use as an antibiotic.
Barth, S. WO 00/28050
Recombinant protein expression
Recovery of recombinant proteins from transformed organisms in which expression is triggered by stress.
BASF WO 00/27884
Vitamin E antibodies
Antibodies, mini-antibodies, and antibody fragments that bind vitamin E, antibody selection methods.
BASF WO 00/28063
Catalytic antibodies and fragments; for producing chromanes by cyclization.
Baxter WO 00/28021
Factor VIII polypeptide
Factor VIII polypeptide having Factor VIII:C activity, production method; for influencing LDL binding affinity.
Bayer WO 00/27881
Human interleukin (IL)-2 mutant proteins, encoding gene sequences; for therapeutics.
Ben Gurion Univ. WO 00/28019
Beer Sheva, Israel
Antisense oligomers capable of inhibiting interleukin (IL)-15 production; for therapeutics.
Beth Israel Deaconess Hosp. WO 00/27416
Stimulation of angiogenesis via the syndecan-4 cytoplasmic domain signalling pathway.
Biocrystal WO 00/28088 & 28089
Nanocrystals with attached polynucleotide strands that form dendrimers when hybridized to targets; for sequencing.
Biogen WO 00/27422
Peripheral neuropathy therapy
Treating or preventing peripheral neuropathies using hedgehog gene products.
Bionebraska WO 00/28067
Enzymatic amidation of proteins so that the C-terminal arginine has an a-carboxamide group.
Bologne, Univ. of EP 1 002 864
Herpes infection therapeutic
Monoclonal antibodies to herpes simplex proteins; for preventing and treating infections.
Brigham & Women's Hosp. WO 00/27865
Gene sequences encoding cbl-SL protein, fragments, functional variants; for diagnostics and therapeutics.
Cedars-Sinai Med. Ctr. WO 00/27874
Transferrin receptor-like proteins
Transferrin receptor-like proteins, fragments, encoding gene sequences, antisense; for diagnostics and therapeutics.
CNRS (Natl. Ctr. Sci. Res.) WO 00/27871
Potassium channel family
Potassium channel family regulated by external pH, encoding genes; for screening modulators for therapeutics.
Cytomatrix WO 00/27999
Lymphoid cell production
Production of lymphoid tissue-specific cells from hematopoietic progenitor cells in three-dimensional devices.
Diasorin WO 00/28039
Viral gene probes
Viral genome genes, probes for identification; for infection diagnostics and therapeutics.
Digital Gene Technol. WO 00/28013
Macrophage activation modulated genes
La Jolla, Calif.
Gene sequences and encoded proteins whose expression is modulated by microglia and macrophage activation.
Digital Gene Technol. WO 00/28026
La Jolla, Calif.
Gene sequences and encoded proteins whose expression is modulated by opiate administration and withdrawal.
Digital Gene Technol. WO 00/28033
La Jolla, Calif.
Novel polypeptides, encoding gene sequences, fragments, antibodies, production methods.
Du Pont WO 00/28036
Disease resistance factors
NPR1 gene, encoded disease resistance factors, chimeric genes; for therapeutics.
Eiken Kagaku WO 00/28082
Nucleic acid synthesis
Process for synthesizing nucleic acids using an isothermal reaction and specific primers.
Emory Univ. WO 00/27998
Cell division control
Proteins that generate reactive oxygen intermediates that affect cell division, encoding genes; for therapeutics.
Emory Univ. WO 00/28031
Hematopoietic cell transplants
Improving allogeneic hematopoietic cell transplantation using cell preparations with reduced dendritic cell number.
Eurona Medical WO 00/28079
Aplastic anemia gene
Gene that is inactivated in aplastic anemia, mutations, oligo probes; for diagnostics and therapeutics.
Fibrogen WO 00/27868
Connective tissue growth factor
S. San Francisco
Connective tissue growth factor, encoding gene sequences, production methods; for therapeutics.
Gendaq WO 00/27878
Zinc finger protein screen
Screening system for finding zinc finger nucleic acid binding proteins using polysome display.
Genecare WO 00/28048
Gene therapy plasmids
Plasmid having the ability to maintain low or high copy number depending on defined conditions, for gene therapy.
Genencor Intl. WO 00/28007
Mutant serine hydrolases
Palo Alto, Calif.
Chemically modified mutant serine hydrolases having improved catalytic activity and chiral selectivity.
Genset WO 00/28080
Methods, software, and instrumentation for finding genomic regions having a gene associated with a detectable trait.
Hadasit Med. Res. Serv. & Develop. WO 00/27870
Newly identified proteins
Newly identified proteins, biologically functional homologs, encoding gene sequences, antibodies.
Harvard Univ. WO 00/28011
Engineered cell regulation
FK506-based regulation of target gene transcription, growth, proliferation, and differentiation of engineered cells.
Hoechst Marion Roussel WO 00/28024
Human transcription factor
Human transcription factor htfIIIA, encoded protein; for diagnostics and therapeutics.
Hoechst Marion Roussel WO 00/28037
Candida yeast transcription factor, encoding gene sequences, analogs, production methods; for finding antifungal agents.
Human Genome Sciences WO 00/28035
Chemokine _-7, encoding gene sequences, mutants, production methods; for immune system therapeutics.
Identigene WO 00/28085
Methods for identification and tracking newborns using genotyping methods.
Incyte Genomics WO 00/28027
Corticosteroid synthesis-associated genes
Palo Alto, Calif.
Corticosteroid synthesis-associated genes, encoded proteins, antisense, antibodies; for diagnostics and therapeutics.
Incyte Genomics WO 00/28029
Cell surface glycoproteins
Palo Alto, Calif.
Cell surface glycoproteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/28032
Cell surface receptor proteins
Palo Alto, Calif.
Human cell surface receptor proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/28034
Cytokine signal regulators
Palo Alto, Calif.
Cytokine signal regulators, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/28045
Palo Alto, Calif.
Human hydrolases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Indian Counc. Sci. & Indus. Res. EP 1 002 869
New Delhi, India
Chemically synthesized artificial promoter designed using database sequences.
Indian Counc. Sci. & Indus. Res. EP 1 002 872
New Delhi, India
Identification of mutations and associated phenotypes in non-dividing cells using mutagens.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/28001
Exosome vesicles that contain major histocompatibility (MHC) molecules; for inducing immune responses.
Isis Innovation WO 00/28000
Dendritic cell production
Producing mature dendritic cells by co-culture of embryonic stem cells and immature dendritic cells.
Isis Innovation WO 00/28075
Bacillus strains having genes replaced by heterologous and reporter genes; for antibiotic screens.
Isotis EP 1 002 859
Seeding cells onto scaffolds
Methods for seeding cells onto porous or fibrous scaffolds; for tissue engineering.
IVS Technol. WO 00/28086
DNA-based diagnostic methods using two differentially-labeled primers and amplification reactions.
Japan Sci. & Technol. WO 00/27186
Animals lacking T cell function into which human T cell leukemia virus-1 infected cells have been transplanted.
Japan Sci. & Technol. WO 00/28015
Introducing more point mutations into one strand of double-stranded genomic DNA; for mutation analysis.
Karolinska Innovations WO 00/28022
Prostaglandin E (PGE) synthase, encoding gene sequences, production methods; for finding modulators.
Kerckhoff Clinic WO 00/28023
Bad Nauheim, Germany
Gene sequences whose expression is induced by ischemia and reperfusion; for therapeutic preconditioning.
Kirkpatrick, S.A. WO 00/27409
Transfected Sertoli cells
Sertoli cells transfected with vectors coding therapeutics; for producing immunologically privileged sites.
Kyowa Hakko Kogyo WO 00/27885
klotho protein-Ig chimera
klotho protein-immunoglobulin (Ig) chimera, encoding gene sequences; for diagnostics and therapeutics.
Leuven Res. & Develop. WO 00/27876
Methods for isolating lectins from the albumin fraction, purified lectins; for use as therapeutics.
Ludwig Inst. WO 00/27879
Platelet-derived growth factor (PDGF) D, encoding gene sequences, antibodies; for diagnostics and therapeutics.
MacFarlane Burnet Ctr. Med. Res. WO 00/28003
Fowl pox vectors encoding HIV gag or pol antigens and a cytokine; for HIV therapy.
McGill Univ. WO 00/28324
Neuronal growth modulators
Controlling neuronal growth by affecting the p75NTR or MEK/MAPK pathways, methods for identifying modulators.
Medigene WO 00/28059
Brain tumor gene therapy
Adenoviral vectors having functional thymidine kinase genes; for brain tumor gene therapy.
Melbourne, Univ. of WO 00/27877
Major facilitator proteins
Major facilitator superfamily proteins having laminin homology, encoding gene sequences, antibodies.
Merck WO 00/27862
Melanocortin 3 receptor
Gene sequences encoding the melanocortin 3 receptor from rhesus monkeys, encoded protein; for finding modulators.
Merck WO 00/27863
Melanocortin 4 receptor
Gene sequences encoding the melanocortin 4 receptor from rhesus monkeys, encoded protein; for finding modulators.
Merck WO 00/28002
Melanocortin 5 receptor
Gene sequences encoding the melanocortin 5 receptor from rhesus monkeys, encoded protein; for finding modulators.
Methexis WO 00/28081
Genotyping of polymorphisms using variation in endonuclease sites in the polymorphic region.
Microbilogical Res. Auth. WO 00/28041
Neuronal SOD targeting
Delivery of superoxide dismutase (SOD) to neuronal cells using targeting domains; for treating oxidative damage.
Microscience WO 00/28038
Virulence genes from E. coli K1, encoded proteins; for treating infection of pathogenic E. coli.
Millennium Pharma WO 00/28028
Epstein Barr-induced receptors
G protein-coupled receptors homologous to those induced by Epstein Barr virus, encoding genes; for therapeutics.
Mira Diagnostics EP 1 002 875
Oligo polymerase inhibitor
Oligonucleotide inhibitor of the 5'-3' exonuclease activity of a thermostable polymerase.
Mitokor WO 00/28458
DNA sequence patterns
Methods and systems for analyzing patterns in DNA sequence files; for finding gene families.
Mitsubishi Chemical WO 00/27872
Sensor protein made up of a binding protein linked to a reporter protein; for monitoring biological function.
Molec. Biol. Res. Inst. WO 00/28060
Adenoviral vector production
Cells for the production of helper-dependent adenoviral vectors, methods of preparation and use in gene therapy.
Molec. Biol. Resources WO 00/28084
Isothermal DNA amplification
Isothermal nucleic acid amplification methods using serial generation of double-stranded DNA with terminal nick sites.
Monash Univ. WO 00/27995
Human embryonic stem cells
Undifferentiated human embryonic stem cells, methods of cultivation and propagation.
Myriad Genetics WO 00/27864
Prostate cancer gene
Salt Lake City
Chromosome 17p-linked prostate cancer susceptibility gene, encoded protein; for diagnostics and therapeutics.
NIH (Natl. Inst. Hlth.) WO 00/27875
Activity dependent neurotrophic factor III, encoding gene sequences, antibodies; for treating neural disease.
NIH (Natl. Inst. Hlth.) WO 00/28049
High-stability vector derived from the large virulence plasmid of Shigella flexneri; for improved cell stability.
Nitsch, R.M. EP 1 002 862
Brain-derived gene sequence, encoded protein; for diagnosing and treating neurological disease.
North Carolina, Univ. of WO 00/28004
Chapel Hill, N.C.
Genetically engineered parvovirus vectors having inserted heterologous genes; for less antigenic gene therapy.
North Western Hlth. Care Network WO 00/28009
Hepatitis B variant
Hepatitis B virus variant strain having an altered immunological profile; for therapeutics.
Novo Nordisk WO 00/28065
Factor VII production
Enhancing the expression of Factor VII by co-expressing kex2 endoprotease in mammalian cells.
Novo Nordisk Biotech WO 00/28043
Preventing microbial biofilms
Lactonohydrolase, encoding gene sequences, production methods; for preventing microbial biofilm development.
Novo Nordisk Biotech WO 00/28044
Lysophospholipase, encoding gene sequences, production methods.
Nyxis WO 00/28090
Gene expression patterns characteristic of brain cancers such as glioblastomas; for diagnostics.
Oregon Hlth. Sci. Univ. WO 00/28040
Kaposi's sarcoma model
Cloning of rhadinovirus which causes Kaposi's sarcoma-like symptoms in immune compromised primates; for Kaposi's model.
Ortho-McNeil Pharma WO 00/28092
Gene expression profiling
Methods for generating gene expression profiles from selected cells; for differential expression assays.
Pennsylvania, Univ. of WO 00/28061
AAV gene therapy vectors
Adeno-associated virus (AAV) serotype 1 nucleic acid sequences, vectors, functional fragments; for gene therapy.
Res. Corp. Technol. WO 00/27873
IL-2 binding protein
Interleukin (IL)-2 binding protein from arthropods, antibodies, modulators; for affecting immunoresponses.
Rochester, Univ. of WO 00/28016
Tumor-killing T cells
Induction and isolation of cytotoxic T cells that specifically attack tumor cells.
Rogosin Inst. WO 00/27207
Suppressing cell growth
Growth restricted cells; for producing proliferation suppressive materials.
San Raffaele del Monte Tabor Fdn. WO 00/27880
RANTES-derived peptides having anti-HIV activity; for therapeutics.
Sanko Junyaku EP 1 002 877
Gene amplification methods that do not use enzymes or branched DNA but do use overlapping probes.
Sanofi-Synthelabo EP 1 002 863
Potassium channel from the erg protein family, encoding gene; for neurological diagnostics and therapeutics.
Sanofi-Synthelabo EP 1 002 865
Adipose-specific protein, encoding gene, recombinant production methods; for treating obesity.
Schering EP 1 002 870
DNA binding steroid receptor
Androgen and progesterone receptor binding hormone response DNA sequence elements [in German].
Scios WO 00/28091
Gene expression analysis
Integrated computer software systems for analyzing gene expression data from microarrays and gene chips.
Sequetech WO 00/28087
Nucleic acid sequencing
Mountain View, Calif.
Library of modified primers for nucleic acid sequencing using polymerase-catalyzed primer-extension reactions.
SmithKline Beecham WO 00/27427
Bacterial trmD proteins, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/27882
HNOVILR peptides, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/28083
Mouse 7-transmembrane receptor
Mouse 7-transmembrane receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.
South Carolina, Med. Univ. of WO 00/27883
Tumor cell apoptosis
Transfecting tumor cells with Fas ligand gene; for causing apoptosis in Fas positive tumor cells.
Stanford Univ. WO 00/27861
Palo Alto, Calif.
Phosphodiesterase (PDE)-interacting proteins, encoding genes; for inflammation diagnostics and therapeutics.
Sterrenbeld Biotech WO 00/27869, 27997 & 28066
Purifying recombinant erythropoietin (EPO) from supernatants from large-scale cell culture, host cells, purified EPO.
Temple Univ. WO 00/27866
Inhibition of angiogenesis by high molecular weight kininogen and its peptide analogs.
Texas, Univ. of WO 00/28020
Inhibiting cardiac hypertrophy
Inhibition of calcium stimulation of cardiac hypertrophic response through the MEF2 transcription factor.
Thomas Jefferson Univ. WO 00/28047
Apoptotic protease caspase-14, encoding gene sequences, functional fragments, antibodies; for modulating apoptosis.
Tosoh EP 1 002 878
Hepatitis C therapeutic
Hepatitis C virus RNA-binding oligonucleotide, preparation method; for treating hepatitis C infections.
Unilever EP 1 002 861
Heavy chain variable domains of immunoglobulins attached with linkers having restricted conformational flexibility.
U.S. Navy WO 00/27205
E. coli-Campylobacter coli fusion protein; for vaccines against campylobacter-induced diarrhea.
Wales, Univ. Coll. Med. WO 00/28025
Pholasin, a bioluminescent oxidative indicator, variants with modified emission characteristics; for reporter use.
Zeneca WO 00/28323
TGF-_ modulator modulators
Methods for identifying modulators of BS69, a modulator of transforming growth factor (TGF)-_; for therapeutics.
Zymogenetics WO 00/28030
Placenta regulating protein
Human secretory protein 61, encoding gene sequences, antibodies; for regulating placental development.