Published May 17 (EP); May 11 (WO); May 17 (GB)

Actinova WO 00/26240

Streptococcal vaccines

Cambridge, UK

Protein that binds a2-macroglobulin, encoding gene; for generating immunoresponses to Group A Streptococcus.

Adherex Technol. WO 00/26360

Cell adhesion modulators

Ottawa, Ont.

Modulators of claudin-mediated cell adhesion; for linkage to targeting agents and drugs.

Affymetrix WO 00/26413

Signal transduction networks

Santa Clara, Calif.

Reconstruction of signal transduction networks using gene expression profiles.

Alabama, Univ. of WO 00/26416

HIV therapeutics

Birmingham, Ala.

Reference clones and sequences for non-subtype B isolates of HIV type 1, encoded proteins; for diagnostics/therapeutics.

Alberta, Univ. of WO 00/26383

Cancer-related oligosaccharides

Edmonton, Alberta

Helicobacter pylori a 1,2-fucosyltransferase gene, encoded protein; for producing cancer-related oligosaccharides.

Angstrom Pharma WO 00/26353

Metastasis therapeutics

San Diego

Cyclic peptide ligands that target urokinase plasminogen activator receptor; for treating cancer cell metastasis.

Athena Neurosciences EP 1 001 019

APP mutation transgenics

S. San Francisco

Transgenic animals having a transgene encoding amyloid precursor protein (APP) having the Swedish mutation.

Babraham Inst. WO 00/26373

Humanized mice antibodies

Cambridge, UK

Transgenic mice having most of the human immunoglobulin lambda light chain locus inserted into their genomes.

Baylor College Med. WO 00/25800

Steroid receptor RNA activator

Houston, Texas

Steroid receptor RNA activator; for steroid-dependent cancer diagnostics and therapeutics.

Beattie, K.L., et al. WO 00/26412

Gene expression analysis

Crossville, Tenn.

Genomic nucleic acid analysis using sequence-targeted tandem hybridization; for gene expression pattern determination.

Biogen WO 00/25725

Hedgehog protein antagonists

Cambridge, Mass.

Variants of hedgehog protein with N-terminal modifications; for use as functional antagonists.

Boehringer Ingelheim Intl. EP 1 001 022

Cancer immunotherapeutic

Ingelheim, Germany

CAMEL, an alternative translation product of tumor antigen LAGE-1, encoding gene sequences; for cancer immunotherapy.

Boehringer Ingelheim Pharma WO 00/26670

TRAF-receptor interaction antagonists

Ridgefield, Conn.

High-throughput compatible assay for identifying antagonists of TRAF-receptor interactions.

Brigham & Women's Hosp. WO 00/26415

Subtractive hybridization

Boston

Genomic subtractive hybridization using a library of probes substantially free of repetitive sequences.

British Columbia, Univ. of WO 00/26236

Invasiveness modifying agents

Vancouver, B.C.

Agents that affect cadherin-11 expression; for modulating cellular invasiveness.

Case Western Res. Univ. WO 00/26343

Screening cancer therapeutics

Cleveland

Promoters for targeting gene expression to stratifying squamous epithelium; for screening cancer therapeutics.

Cellomics WO 00/26408

Cell state analysis

Pittsburgh

Optical system for rapidly determining the biological state of cells having fluorescently labeled reporter molecules.

Centocor WO 00/26256

Integrin receptor antibodies

Malvern, Penn.

Modified antibodies to human integrin receptors, fragments; for treating abnormal platelet aggregation.

Children's Hosp. WO 00/26368

Antiangiogenic endostatins

Boston

Endostatins that inhibit endothelial cell proliferation, inhibit angiogenesis, and cause tumor regression.

Children's Hosp. WO 00/26380

Rotavirus vaccines

Cincinnati

Generation and use of recombinant rotavirus fusion proteins to create vaccines.

Chiron EP 1 001 032

Immunoresponse activation

Emeryville, Calif.

Replication-defective retrovirus vectors that infect cells and deliver MHC proteins; for activating immunoresponses.

Chiron WO 00/26369

Seven transmembrane receptor

Emeryville, Calif.

Seven transmembrane receptor, encoding gene sequences, mutants, fragments, fusions; for finding modulators.

Chugai Res. Inst. Molec. Med. WO 00/26352

Sperm serine proteases

Ibaraki, Japan

Trypsin family serine proteases participating in sperm function, encoding genes; for developing contraceptives.

Clontech Labs WO 00/26228

Cell death proteins

Palo Alto, Calif.

Polypeptides involved in regulating cell death, encoding genes, antibodies; for diagnostics and therapeutics.

Cold Spr. Harbor Labs WO 00/26242

DNA replication-regulating genes

Cold Spr. Harbor, N.Y.

DNA replication-regulating genes, encoded proteins, antibodies; for diagnostics and therapeutics.

Connaught Labs WO 00/26237, 26239, & 26376

Chlamydia vaccines

Toronto

Chlamydia antigens from the outer membrane protein, encoding gene sequences; for vaccines.

Connex WO 00/26671

Microorganism detection

Martinsreid, Germany

Detection of acid-resistant microorganisms in stool samples using monoclonal antibodies.

Cornell Univ. WO 00/26381

Thermostable ligase

Ithaca, N.Y.

Thermostable ligase with substantially higher fidelity than either T4 or Thermus thermophilus ligases, encoding gene.

Dana-Farber Cancer Inst. WO 00/26231

Lymphoma expressed genes

Boston

Genes differentially expressed in non-Hodgkin's lymphoma, encoded proteins, antibodies, transgenics; for therapeutics.

Davies, A.M. GB 2 343 679

Autologous transplantation

Porthcawl, UK

Autologous T cell transplantation for cancer using cells obtained at a time before disease onset.

Digital Gene Technol. WO 00/26406

Identifying mRNAs

La Jolla, Calif.

Simultaneous sequence-specific identification of mRNAs using amplification reactions and gel electrophoresis separation.

Dyax WO 00/25807

Removing parvoviruses

Cambridge, Mass.

Polypeptide moieties that bind capsid-forming proteins of human parvovirus B19; for removal from biological samples.

European Molec. Biol. Lab WO 00/26364

Notch signaling regulator

Heidelberg, Germany

Regulator of Notch signaling activity, encoding gene sequences; for treating cancer and neurodegeneration.

Genset WO 00/26363

Adipocyte APM1

Paris

Human adipocyte-specific APM1, encoding genes, biallelic markers, antibodies; for genotyping.

Genzyme Transgenics WO 00/26357

Cloning animals

Framingham, Mass.

Introducing transgenic somatic cell genomes into enucleated oocytes; for cloning animals.

Georgia, Univ. of WO 00/26386

Cell transformation vector

Athens, Ga.

Shuttle vector for assembling coding DNA sequences into a single docking vector; for cell transformation.

Hemosol WO 00/26347

T cell production

Etobicoke, Ont.

Production of TCR gamma delta T cells using a culture medium containing a T cell mitogen and two cytokines.

Heska WO 00/26246

Modeling antibody receptors

Ft. Collins, Colo.

Three-dimensional models of antibody receptor proteins, muteins having increased stability and antibody binding.

Hildt, E. WO 00/26379

Mediating cell permeability

Munich, Germany

Cell permeability mediating peptide, encoding gene sequences, antibodies, production methods.

Hoffman, S. WO 00/25728

Malaria vaccines

Rockville, Md.

Human malaria parasite Plasmodium falciparum chromosome 2 sequence, encoded proteins; for diagnostics and vaccines.

Holtzman, J.L. WO 00/26251

Alzheimer's diagnostic

Minneapolis

Measuring chaperone protein Q2 complexed to _-amyloid; for diagnosing Alzheimer's disease.

Illinois, Univ. of WO 00/26232

Estrogen receptor activity repressor

Champaign, Ill.

Isolation of a repressor of estrogen receptor activity; for therapeutics in estrogen target cells.

Imperial College Innovations WO 00/26238

Prion disease therapy

London

Making _-form of prion proteins; for producing antibodies and finding agents that affect prion protein conversion.

Imperial College Innovations WO 00/26249

Cancer immunotherapy

London

Human WT-1 polypeptide, encoding gene sequences; for cancer immunotherapy.

Incyte Genomics WO 00/26243

Transmembrane 4 proteins

Palo Alto, Calif.

Transmembrane 4 proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/26245

Membrane transport proteins

Palo Alto, Calif.

Membrane transport proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/26350

Coenzyme A-utilizing enzymes

Palo Alto, Calif.

Coenzyme A-utilizing enzymes, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/26372

Myosin heavy chain homolog

Palo Alto, Calif.

Myosin heavy chain homolog, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Insight Strategy & Marketing WO 00/25817

Heparanase antibodies

Rehovot, Israel

Monoclonal antibodies to heparanase; for inhibiting the activity of the enzyme.

Iowa, Univ. of WO 00/26367

Ocular disease therapeutics

Iowa City, Iowa

Diagnostics and therapeutics for ocular disorders such as retinal detachment and macular degeneration.

Isis Innovation WO 00/26248

Tuberculosis diagnostics

Oxford, UK

Assay that measures T cell recognition of mycobacterial protein peptides; for tuberculosis diagnosis.

Japan Sci. & Technol. WO 00/26250

Cell proliferation regulators

Saitama, Japan

Human H37 proteins, encoding genes, gene fragments, antibodies; for regulating cell proliferation.

Johns Hopkins Univ. WO 00/26401

Methylated CpG

Baltimore

Identifying and amplifying methylated CpG nucleic acid sequences; for diagnosing age-associated disorders.

Janssen Pharma WO 00/26397

Yeast retrotransposon

Beerse, Belgium

Retrotransposon from the pathogenic yeast Candida albicans; for introducing random mutations into genomes.

Kazusa DNA Res. Inst. WO 00/26365

Brain-derived protein

Chiba, Japan

Human brain-derived protein, encoding gene sequences; for developing therapeutics.

Kosan Biosciences WO 00/26349

Antibiotic production

Hayward, Calif.

Recombinant oleandolide polyketide synthase; for production of antibiotics.

Krebs Res. Ctr. EP 1 001 031

Parvovirus vectors

Heidelberg, Germany

Parvovirus vectors having a minimal origin of replication; for inserting heterologous genes as therapeutics.

Krebs Res. Ctr. WO 00/26254

AAV capsid antibodies

Heidelberg, Germany

Antibodies to adeno-associated virus (AAV) capsids; for preventing virus binding and modifying cytotropism.

Ludwig Inst. Cancer Res. WO 00/25805

VEGF function modulation

New York

Viral-derived vascular endothelial growth factor (VEGF)-like protein that binds VEGF receptor-2; for therapeutics.

Ludwig Inst. Cancer Res. WO 00/26407

Determining cancer presence

New York

Determining cancer presence by measuring the expression of tumor rejection antigen precursor MAGE-10.

Mass. Inst. Technol. WO 00/26634

Apoptosis modulators

Cambridge, Mass.

Mutant forms of the Drosophila hid gene, encoded proteins; for finding modulators of the MAPK phosphorylation site.

Max Delbruck Ctr. Molec. Med. WO 00/26362

Stomatin for pain

Berlin

Stomatin and related proteins, encoding gene sequences; for treating pain.

Max Zeller WO 00/26255

Petasin antibodies

Romanshorn, Switzerland

Antibodies to petasin; for detecting serum petasin and its conjugates.

Med. & Biol. Labs WO 00/26358

Expressing selenoproteins

Aichi, Japan

Selenocysteine sequence for insertion into a translational region; for expressing selenoproteins.

Med. & Biol. Labs WO 00/26382

Thioreductase II

Aichi, Japan

Thioreductase II, encoding gene sequences, alternatively spliced isozymes.

Menarini Res. WO 00/25827

Cancer immunotherapy

Pomezia, Italy

Gene sequences encoding fragments of proteins over-expressed in tumor cells; for anti-tumor immune responses.

Mesosystems Technol. WO 00/26405

Bacterial spore identification

Richland, Wash.

Lysing bacterial spores using ionizing discharges; for identification by nucleic acid hybridization.

Millennium Pharma WO 00/26227

LDL receptor-like protein

Cambridge, Mass.

LDL receptor family protein, encoding gene sequences, antisense, antibodies, transgenics; for diagnostics.

Miller, J.L. WO 00/26667

Inhibiting platelet aggregation

Syracuse, N.Y.

Variable heavy and light chain human platelet glycoprotein Iba antibody regions; for inhibiting platelet aggregation.

Mitokor WO 00/26370

Adenine nucleotide translocator

San Diego

Producing adenine nucleotide translocator and its fusion proteins; for identifying modulators.

Montreal Inst. Clinical Res. WO 00/26348

Subtilisin/kexin isozyme

Montreal

Mammalian subtilisin/kexin isozyme having a unique cleavage specificity, encoding gene sequences; for therapeutics.

Murdoch Inst. WO 00/26396

Recombination methods

Parkville, Australia

Recombining circular and linear nucleic acid sequences in cells expressing RecBCD nuclease; for modifying chromosomes.

NIH (Natl. Inst. Hlth.) WO 00/26233

Toxic modified RNase A peptides

Bethesda, Md.

RNase A superfamily peptides with modified amino terminals; for selectively killing Kaposi's sarcoma cells.

NIH (Natl. Inst. Hlth.) WO 00/26244

TNF family member

Bethesda, Md.

Tumor necrosis factor (TNF) family member, encoding genes, antibodies to inhibit apoptosis and autoimmune responses.

NIH (Natl. Inst. Hlth.) WO 00/26394

Humanized carcinoma antibodies

Bethesda, Md.

Variants of humanized anti-carcinoma monoclonal antibody CC49, production methods; for therapeutics.

Netherlands Ministry of Health WO 00/26384

Reduced toxicity LPS

Rijswijk, the Netherlands

Recombinant lipopolysaccharide (LPS) from Gram negative bacteria that has reduced toxicity.

New Jersey, Med. & Dent. Univ. of WO 00/26393

Myeloid stem cells

Newark, N.J.

Long-lived myeloid-committed stem cell population; for retroviral gene therapy for congenital myeloid defects.

New York, State Univ. of WO 00/25583

Keratinocytes for wounds

Albany, N.Y.

Recombinant keratinocytes transfected with the human _3 integrin subunit gene; for adhering to fibrin in wounds.

Northwestern Univ. WO 00/26342

Cell proliferation modifiers

Evanston, Ill.

Methods of interfering with cell proliferation by using inhibitors of laminin and integrin function.

Novo Nordisk WO 00/26230 & 26354

Less allergenic proteins

Bagsvaerd, Denmark

Selection of less allergenic protein variants using a phage library, identified glycosylated proteins, encoding genes.

Pasteur Inst. WO 00/26392

Acetylcholine receptor knockouts

Paris

Knockout mice having a mutation in the endogenous a4 subunit of the nicotinic acetylcholine receptor.

Pasteur Merieux WO 00/26375

Neisseria infection therapeutics

Lyon, France

Genes from Neisseria genus pathogenic strains, encoded proteins; for infection diagnostics and therapeutics.

Penn. State Univ. WO 00/26340

Opioid growth factor receptors

University Park, Penn.

Opioid growth factor receptor genes, encoded proteins, antisense, antibodies; for modulating cell growth.

Pharmadigm WO 00/25820

Elderly immunization

Salt Lake City, Utah

Screening potential antigens for their ability to elicit immune responses in the elderly; for genetic immunization.

Powderject Vaccines WO 00/26385

Eliciting immunoresponses

Madison, Wis.

Fusion proteins having Hepatitis B core antigen and T cell epitope domains; for eliciting immunoresponses.

Prodinger, W. EP 1 001 021

CD21 antibodies

Innsbruck, Austria

Monoclonal antibodies to human complement receptor 2 (CD21) that can remove receptor-bound C3-derived fragments.

Regeneron Pharma EP 1 001 024

trkB proto-oncogene protein

Tarrytown, N.Y.

Protein encoded by the trkB proto-oncogene; for identifying agents exhibiting neurotrophin-like activity.

Resistentia Pharma WO 00/25722

Self-antigen vaccines

Stockholm, Sweden

Immunogenic polypeptides that reduce the amount of IgE antibodies; for vaccination against self-antigens.

Rigel Pharma WO 00/26241

T-cell activators

S. San Francisco

Methods for screening for T-cell and B-cell activators, identified RasGP homolog.

Sanofi-Synthelabo WO 00/26374

Adipose specific protein

Paris

Adipose specific protein, encoding gene, production methods; for obesity and diabetes diagnostics and therapeutics.

Saskatchewan, Univ. of WO 00/26395

Adenoviral vector production

Saskatoon, Sask.

Bovine cells that express adenovirus essential functions; for propagating recombinant adenoviral vectors.

Shanghai Biorigin Gene Develop. WO 00/26361

Leptin-associated protein

Shanghai, China

Leptin-associated protein, encoding gene sequence; for obesity therapeutics.

Singapore Natl. Univ. WO 00/26366

Secreting recombinant proteins

Singapore

Isolated nucleic acids encoding a secretory signal; for expression and secretion of heterologous proteins.

SmithKline Beecham EP 1 001 023

Wnt receptor

Brentford, UK

Frizzled-4, a putative Wnt receptor, encoding gene sequences; for diagnostics and therapeutics.

SmithKline Beecham WO 00/25818

Antibacterial screens

Philadelphia

Bacterial asuE/trmM polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/26253

Potassium channel

Brentford, UK

Human potassium channel, encoding gene, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/26339

Gprotein-coupled receptor

Philadelphia

G-protein coupled receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/26359

Antibacterial screens

Philadelphia

Bacterial ftsX polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/26377

Antibacterial screens

Philadelphia

Bacterial metK polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

Snow Brand Milk Products EP 1 001 035

Fungal antibiotics

Sapporo, Japan

Antibiotics having new chemical structures isolated from Streptomyces fungus species.

Stanford Univ. WO 00/26418

Pan-HCV antibodies

Stanford, Calif.

Pan-hepatitis C virus (HCV) human monoclonal antibodies; for diagnostics and therapeutics.

Sumitomo Electric EP 1 001 020

Leukemia diagnostic antibodies

Osaka, Japan

Antibodies to human pre-B cell receptors; for acute lymphocytic leukemia diagnosis.

Takara Shuzo WO 00/26404

Endocrine disruptor effects

Kyoto, Japan

Treating cells with endocrine disruptors and hybridizing expressed mRNAs with gene arrays to find disruptor effects.

Thomas Jefferson Univ. WO 00/25574

Plant-produced therapeutics

Philadelphia

Production of biomedically useful peptides and proteins in plants using plant virus vectors.

Tufts Univ. WO 00/25578

Animal cloning

Medford, Mass.

Chemical enucleation of oocytes and activation of donor and enucleated oocytes; for obtaining a nuclear transfer embryo.

U-BiSys EP 1 001 017

Lipid-modified immune proteins

Utrecht, the Netherlands

Modifying cells or their membranes using lipid-modified proteins at least partially derived from the immune system.

Washington Univ. WO 00/26417

Detecting RNA viruses

St. Louis

Cells that express a reporter gene product when infected by negative-strand RNA viruses; for virus detection.

Wayne Hughes Inst. WO 00/26247

Lymphoid abnormality therapy

St. Paul, Minn.

Ikaros gene mutations and encoded protein isoforms; for treating lymphoid cell abnormalities.

Whitehead Inst. Biomed. Res. EP 1 001 037

Polymorphism isolation

Cambridge, Mass.

Reproducible methods for pre-selection and isolation of single nucleotide polymorphisms.

World AIDS Res. & Prevention Fdn. EP 1 000 628

HIV vaccines

Paris

Antigenic complexes of HIV envelope protein and HLA class I antigens; for use as vaccines.

Yale Univ. WO 00/26226

Receptor-linked ribozymes

New Haven, Conn.

Multidomain polynucleotide molecular sensors having linked reporter and receptor domains; for evaluating ribozymes.

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