Published May 17 (EP); May 11 (WO); May 17 (GB)
Actinova WO 00/26240
Protein that binds a2-macroglobulin, encoding gene; for generating immunoresponses to Group A Streptococcus.
Adherex Technol. WO 00/26360
Cell adhesion modulators
Modulators of claudin-mediated cell adhesion; for linkage to targeting agents and drugs.
Affymetrix WO 00/26413
Signal transduction networks
Santa Clara, Calif.
Reconstruction of signal transduction networks using gene expression profiles.
Alabama, Univ. of WO 00/26416
Reference clones and sequences for non-subtype B isolates of HIV type 1, encoded proteins; for diagnostics/therapeutics.
Alberta, Univ. of WO 00/26383
Helicobacter pylori a 1,2-fucosyltransferase gene, encoded protein; for producing cancer-related oligosaccharides.
Angstrom Pharma WO 00/26353
Cyclic peptide ligands that target urokinase plasminogen activator receptor; for treating cancer cell metastasis.
Athena Neurosciences EP 1 001 019
APP mutation transgenics
S. San Francisco
Transgenic animals having a transgene encoding amyloid precursor protein (APP) having the Swedish mutation.
Babraham Inst. WO 00/26373
Humanized mice antibodies
Transgenic mice having most of the human immunoglobulin lambda light chain locus inserted into their genomes.
Baylor College Med. WO 00/25800
Steroid receptor RNA activator
Steroid receptor RNA activator; for steroid-dependent cancer diagnostics and therapeutics.
Beattie, K.L., et al. WO 00/26412
Gene expression analysis
Genomic nucleic acid analysis using sequence-targeted tandem hybridization; for gene expression pattern determination.
Biogen WO 00/25725
Hedgehog protein antagonists
Variants of hedgehog protein with N-terminal modifications; for use as functional antagonists.
Boehringer Ingelheim Intl. EP 1 001 022
CAMEL, an alternative translation product of tumor antigen LAGE-1, encoding gene sequences; for cancer immunotherapy.
Boehringer Ingelheim Pharma WO 00/26670
TRAF-receptor interaction antagonists
High-throughput compatible assay for identifying antagonists of TRAF-receptor interactions.
Brigham & Women's Hosp. WO 00/26415
Genomic subtractive hybridization using a library of probes substantially free of repetitive sequences.
British Columbia, Univ. of WO 00/26236
Invasiveness modifying agents
Agents that affect cadherin-11 expression; for modulating cellular invasiveness.
Case Western Res. Univ. WO 00/26343
Screening cancer therapeutics
Promoters for targeting gene expression to stratifying squamous epithelium; for screening cancer therapeutics.
Cellomics WO 00/26408
Cell state analysis
Optical system for rapidly determining the biological state of cells having fluorescently labeled reporter molecules.
Centocor WO 00/26256
Integrin receptor antibodies
Modified antibodies to human integrin receptors, fragments; for treating abnormal platelet aggregation.
Children's Hosp. WO 00/26368
Endostatins that inhibit endothelial cell proliferation, inhibit angiogenesis, and cause tumor regression.
Children's Hosp. WO 00/26380
Generation and use of recombinant rotavirus fusion proteins to create vaccines.
Chiron EP 1 001 032
Replication-defective retrovirus vectors that infect cells and deliver MHC proteins; for activating immunoresponses.
Chiron WO 00/26369
Seven transmembrane receptor
Seven transmembrane receptor, encoding gene sequences, mutants, fragments, fusions; for finding modulators.
Chugai Res. Inst. Molec. Med. WO 00/26352
Sperm serine proteases
Trypsin family serine proteases participating in sperm function, encoding genes; for developing contraceptives.
Clontech Labs WO 00/26228
Cell death proteins
Palo Alto, Calif.
Polypeptides involved in regulating cell death, encoding genes, antibodies; for diagnostics and therapeutics.
Cold Spr. Harbor Labs WO 00/26242
DNA replication-regulating genes
Cold Spr. Harbor, N.Y.
DNA replication-regulating genes, encoded proteins, antibodies; for diagnostics and therapeutics.
Connaught Labs WO 00/26237, 26239, & 26376
Chlamydia antigens from the outer membrane protein, encoding gene sequences; for vaccines.
Connex WO 00/26671
Detection of acid-resistant microorganisms in stool samples using monoclonal antibodies.
Cornell Univ. WO 00/26381
Thermostable ligase with substantially higher fidelity than either T4 or Thermus thermophilus ligases, encoding gene.
Dana-Farber Cancer Inst. WO 00/26231
Lymphoma expressed genes
Genes differentially expressed in non-Hodgkin's lymphoma, encoded proteins, antibodies, transgenics; for therapeutics.
Davies, A.M. GB 2 343 679
Autologous T cell transplantation for cancer using cells obtained at a time before disease onset.
Digital Gene Technol. WO 00/26406
La Jolla, Calif.
Simultaneous sequence-specific identification of mRNAs using amplification reactions and gel electrophoresis separation.
Dyax WO 00/25807
Polypeptide moieties that bind capsid-forming proteins of human parvovirus B19; for removal from biological samples.
European Molec. Biol. Lab WO 00/26364
Notch signaling regulator
Regulator of Notch signaling activity, encoding gene sequences; for treating cancer and neurodegeneration.
Genset WO 00/26363
Human adipocyte-specific APM1, encoding genes, biallelic markers, antibodies; for genotyping.
Genzyme Transgenics WO 00/26357
Introducing transgenic somatic cell genomes into enucleated oocytes; for cloning animals.
Georgia, Univ. of WO 00/26386
Cell transformation vector
Shuttle vector for assembling coding DNA sequences into a single docking vector; for cell transformation.
Hemosol WO 00/26347
T cell production
Production of TCR gamma delta T cells using a culture medium containing a T cell mitogen and two cytokines.
Heska WO 00/26246
Modeling antibody receptors
Ft. Collins, Colo.
Three-dimensional models of antibody receptor proteins, muteins having increased stability and antibody binding.
Hildt, E. WO 00/26379
Mediating cell permeability
Cell permeability mediating peptide, encoding gene sequences, antibodies, production methods.
Hoffman, S. WO 00/25728
Human malaria parasite Plasmodium falciparum chromosome 2 sequence, encoded proteins; for diagnostics and vaccines.
Holtzman, J.L. WO 00/26251
Measuring chaperone protein Q2 complexed to _-amyloid; for diagnosing Alzheimer's disease.
Illinois, Univ. of WO 00/26232
Estrogen receptor activity repressor
Isolation of a repressor of estrogen receptor activity; for therapeutics in estrogen target cells.
Imperial College Innovations WO 00/26238
Prion disease therapy
Making _-form of prion proteins; for producing antibodies and finding agents that affect prion protein conversion.
Imperial College Innovations WO 00/26249
Human WT-1 polypeptide, encoding gene sequences; for cancer immunotherapy.
Incyte Genomics WO 00/26243
Transmembrane 4 proteins
Palo Alto, Calif.
Transmembrane 4 proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/26245
Membrane transport proteins
Palo Alto, Calif.
Membrane transport proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/26350
Coenzyme A-utilizing enzymes
Palo Alto, Calif.
Coenzyme A-utilizing enzymes, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/26372
Myosin heavy chain homolog
Palo Alto, Calif.
Myosin heavy chain homolog, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Insight Strategy & Marketing WO 00/25817
Monoclonal antibodies to heparanase; for inhibiting the activity of the enzyme.
Iowa, Univ. of WO 00/26367
Ocular disease therapeutics
Iowa City, Iowa
Diagnostics and therapeutics for ocular disorders such as retinal detachment and macular degeneration.
Isis Innovation WO 00/26248
Assay that measures T cell recognition of mycobacterial protein peptides; for tuberculosis diagnosis.
Japan Sci. & Technol. WO 00/26250
Cell proliferation regulators
Human H37 proteins, encoding genes, gene fragments, antibodies; for regulating cell proliferation.
Johns Hopkins Univ. WO 00/26401
Identifying and amplifying methylated CpG nucleic acid sequences; for diagnosing age-associated disorders.
Janssen Pharma WO 00/26397
Retrotransposon from the pathogenic yeast Candida albicans; for introducing random mutations into genomes.
Kazusa DNA Res. Inst. WO 00/26365
Human brain-derived protein, encoding gene sequences; for developing therapeutics.
Kosan Biosciences WO 00/26349
Recombinant oleandolide polyketide synthase; for production of antibiotics.
Krebs Res. Ctr. EP 1 001 031
Parvovirus vectors having a minimal origin of replication; for inserting heterologous genes as therapeutics.
Krebs Res. Ctr. WO 00/26254
AAV capsid antibodies
Antibodies to adeno-associated virus (AAV) capsids; for preventing virus binding and modifying cytotropism.
Ludwig Inst. Cancer Res. WO 00/25805
VEGF function modulation
Viral-derived vascular endothelial growth factor (VEGF)-like protein that binds VEGF receptor-2; for therapeutics.
Ludwig Inst. Cancer Res. WO 00/26407
Determining cancer presence
Determining cancer presence by measuring the expression of tumor rejection antigen precursor MAGE-10.
Mass. Inst. Technol. WO 00/26634
Mutant forms of the Drosophila hid gene, encoded proteins; for finding modulators of the MAPK phosphorylation site.
Max Delbruck Ctr. Molec. Med. WO 00/26362
Stomatin for pain
Stomatin and related proteins, encoding gene sequences; for treating pain.
Max Zeller WO 00/26255
Antibodies to petasin; for detecting serum petasin and its conjugates.
Med. & Biol. Labs WO 00/26358
Selenocysteine sequence for insertion into a translational region; for expressing selenoproteins.
Med. & Biol. Labs WO 00/26382
Thioreductase II, encoding gene sequences, alternatively spliced isozymes.
Menarini Res. WO 00/25827
Gene sequences encoding fragments of proteins over-expressed in tumor cells; for anti-tumor immune responses.
Mesosystems Technol. WO 00/26405
Bacterial spore identification
Lysing bacterial spores using ionizing discharges; for identification by nucleic acid hybridization.
Millennium Pharma WO 00/26227
LDL receptor-like protein
LDL receptor family protein, encoding gene sequences, antisense, antibodies, transgenics; for diagnostics.
Miller, J.L. WO 00/26667
Inhibiting platelet aggregation
Variable heavy and light chain human platelet glycoprotein Iba antibody regions; for inhibiting platelet aggregation.
Mitokor WO 00/26370
Adenine nucleotide translocator
Producing adenine nucleotide translocator and its fusion proteins; for identifying modulators.
Montreal Inst. Clinical Res. WO 00/26348
Mammalian subtilisin/kexin isozyme having a unique cleavage specificity, encoding gene sequences; for therapeutics.
Murdoch Inst. WO 00/26396
Recombining circular and linear nucleic acid sequences in cells expressing RecBCD nuclease; for modifying chromosomes.
NIH (Natl. Inst. Hlth.) WO 00/26233
Toxic modified RNase A peptides
RNase A superfamily peptides with modified amino terminals; for selectively killing Kaposi's sarcoma cells.
NIH (Natl. Inst. Hlth.) WO 00/26244
TNF family member
Tumor necrosis factor (TNF) family member, encoding genes, antibodies to inhibit apoptosis and autoimmune responses.
NIH (Natl. Inst. Hlth.) WO 00/26394
Humanized carcinoma antibodies
Variants of humanized anti-carcinoma monoclonal antibody CC49, production methods; for therapeutics.
Netherlands Ministry of Health WO 00/26384
Reduced toxicity LPS
Rijswijk, the Netherlands
Recombinant lipopolysaccharide (LPS) from Gram negative bacteria that has reduced toxicity.
New Jersey, Med. & Dent. Univ. of WO 00/26393
Myeloid stem cells
Long-lived myeloid-committed stem cell population; for retroviral gene therapy for congenital myeloid defects.
New York, State Univ. of WO 00/25583
Keratinocytes for wounds
Recombinant keratinocytes transfected with the human _3 integrin subunit gene; for adhering to fibrin in wounds.
Northwestern Univ. WO 00/26342
Cell proliferation modifiers
Methods of interfering with cell proliferation by using inhibitors of laminin and integrin function.
Novo Nordisk WO 00/26230 & 26354
Less allergenic proteins
Selection of less allergenic protein variants using a phage library, identified glycosylated proteins, encoding genes.
Pasteur Inst. WO 00/26392
Acetylcholine receptor knockouts
Knockout mice having a mutation in the endogenous a4 subunit of the nicotinic acetylcholine receptor.
Pasteur Merieux WO 00/26375
Neisseria infection therapeutics
Genes from Neisseria genus pathogenic strains, encoded proteins; for infection diagnostics and therapeutics.
Penn. State Univ. WO 00/26340
Opioid growth factor receptors
University Park, Penn.
Opioid growth factor receptor genes, encoded proteins, antisense, antibodies; for modulating cell growth.
Pharmadigm WO 00/25820
Salt Lake City, Utah
Screening potential antigens for their ability to elicit immune responses in the elderly; for genetic immunization.
Powderject Vaccines WO 00/26385
Fusion proteins having Hepatitis B core antigen and T cell epitope domains; for eliciting immunoresponses.
Prodinger, W. EP 1 001 021
Monoclonal antibodies to human complement receptor 2 (CD21) that can remove receptor-bound C3-derived fragments.
Regeneron Pharma EP 1 001 024
trkB proto-oncogene protein
Protein encoded by the trkB proto-oncogene; for identifying agents exhibiting neurotrophin-like activity.
Resistentia Pharma WO 00/25722
Immunogenic polypeptides that reduce the amount of IgE antibodies; for vaccination against self-antigens.
Rigel Pharma WO 00/26241
S. San Francisco
Methods for screening for T-cell and B-cell activators, identified RasGP homolog.
Sanofi-Synthelabo WO 00/26374
Adipose specific protein
Adipose specific protein, encoding gene, production methods; for obesity and diabetes diagnostics and therapeutics.
Saskatchewan, Univ. of WO 00/26395
Adenoviral vector production
Bovine cells that express adenovirus essential functions; for propagating recombinant adenoviral vectors.
Shanghai Biorigin Gene Develop. WO 00/26361
Leptin-associated protein, encoding gene sequence; for obesity therapeutics.
Singapore Natl. Univ. WO 00/26366
Secreting recombinant proteins
Isolated nucleic acids encoding a secretory signal; for expression and secretion of heterologous proteins.
SmithKline Beecham EP 1 001 023
Frizzled-4, a putative Wnt receptor, encoding gene sequences; for diagnostics and therapeutics.
SmithKline Beecham WO 00/25818
Bacterial asuE/trmM polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/26253
Human potassium channel, encoding gene, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/26339
G-protein coupled receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/26359
Bacterial ftsX polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/26377
Bacterial metK polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
Snow Brand Milk Products EP 1 001 035
Antibiotics having new chemical structures isolated from Streptomyces fungus species.
Stanford Univ. WO 00/26418
Pan-hepatitis C virus (HCV) human monoclonal antibodies; for diagnostics and therapeutics.
Sumitomo Electric EP 1 001 020
Leukemia diagnostic antibodies
Antibodies to human pre-B cell receptors; for acute lymphocytic leukemia diagnosis.
Takara Shuzo WO 00/26404
Endocrine disruptor effects
Treating cells with endocrine disruptors and hybridizing expressed mRNAs with gene arrays to find disruptor effects.
Thomas Jefferson Univ. WO 00/25574
Production of biomedically useful peptides and proteins in plants using plant virus vectors.
Tufts Univ. WO 00/25578
Chemical enucleation of oocytes and activation of donor and enucleated oocytes; for obtaining a nuclear transfer embryo.
U-BiSys EP 1 001 017
Lipid-modified immune proteins
Utrecht, the Netherlands
Modifying cells or their membranes using lipid-modified proteins at least partially derived from the immune system.
Washington Univ. WO 00/26417
Detecting RNA viruses
Cells that express a reporter gene product when infected by negative-strand RNA viruses; for virus detection.
Wayne Hughes Inst. WO 00/26247
Lymphoid abnormality therapy
St. Paul, Minn.
Ikaros gene mutations and encoded protein isoforms; for treating lymphoid cell abnormalities.
Whitehead Inst. Biomed. Res. EP 1 001 037
Reproducible methods for pre-selection and isolation of single nucleotide polymorphisms.
World AIDS Res. & Prevention Fdn. EP 1 000 628
Antigenic complexes of HIV envelope protein and HLA class I antigens; for use as vaccines.
Yale Univ. WO 00/26226
New Haven, Conn.
Multidomain polynucleotide molecular sensors having linked reporter and receptor domains; for evaluating ribozymes.