Published March 22 (EPO); March 16 (WO); March 22 (GB)

Aberdeen Univ. WO 00/14267

Light biosensor

Aberdeen, UK

Biosensor for evaluating biological effects that uses a gene that expresses a light emitting protein.

Agouron Pharma WO 00/14105

VEGF receptor ligands

La Jolla, Calif.

Catalytic kinase domain of the vascular endothelial growth factor receptor (VEGF); for identifying therapeutics.

Asahi WO 00/14229

Immunomodulation

Osaka, Japan

Seven-pass transmembrane receptor from immature dendritic cells, encoding gene; for finding immunomodulatory ligands.

Aventis Pharma WO 00/14275

Differential gene display

Frankfurt, Germany

Two different color dye marked primers; for differential display of regulated genes.

Bayer EPO 987 329

Cold therapeutic

Pittsburgh

Multimeric forms of an intercellular adhesion protein that serves as a rhinovirus receptor; for treating colds.

Beth Israel Deaconess Med. Ctr. WO 00/14103

Angiogenesis stimulation

Boston

Angiogenesis stimulation by enhanced endothelial expression of core proteins with a syndecan-4 cytoplasmic region.

Bristol, Univ. of WO 00/14114

Toxin vaccine adjuvants

Bristol, UK

Peptide fragments and variants of cholera toxin B or enterotoxin B; for use as vaccine adjuvants.

British Columbia, Univ. of WO 00/14274

Bacterial strain identification

Vancouver, B.C.

Identification of Burkholderia cepacia bacterial strains using recA gene sequences.

British Agricultural Ministry GB 2 341 606

Glycosylated immunogens

London

Glycosylation peptides, variants, fragments; for improved immunogenicity and stability of immunogenic proteins.

British Defense Ministry WO 00/14278

Reaction temperature monitor

Farnborough, UK

Methods for monitoring the temperature of amplification reactions using temperature-sensitive fluorescent probes.

British Defense Ministry WO 00/14279

DNA amplification

Farnborough, UK

Amplification of DNA using control sequences that differ in GC content.

Burnham Inst. WO 00/14106

BAG-1 related proteins

La Jolla, Calif.

BAG-1 related protein family from humans, yeast, and Caenorhabditis elegans, encoding gene sequences.

Choy, J.H. EPO 987 328

Gene delivery composition

Seoul, S. Korea

Bio-inorganic hybrid material containing metal ions and anionic biomaterial; for carrying and delivering genes.

Chugai WO 00/14203

Hematopoietic stem cells

Tokyo

Separation of cell fractions from myeloid cells enriched in hematopoietic stem cells by using a cell sorter.

Chugai Res. Inst. Molec. Med. WO 00/14210

Systemic carnitine deficiency

Ibaraki, Japan

Gene associated with systemic carnitine deficiency, encoded protein; for diagnostics and therapeutics.

Connaught Labs WO 00/14244

Cervical cancer vaccines

Toronto

Genes encoding non-toxic T cell epitopes of papillomavirus strains associated with cervical cancer; for vaccines.

Cortecs WO 00/14253

Immunostimulants

Deeside, UK

Proteins from crude pineapple stem bromelain, encoding gene sequences; for immunostimulation and cancer therapeutics.

Cortecs WO 00/14254

Anti-IL-2 proteins

Deeside, UK

Bromelain components responsible for anti-ERK-2 and anti-interleukin (IL)-2 activity.

CPG Immunopharma WO 00/14217

Infection oligos

Hilden, Germany

G-motif oligonucleotides, encoded proteins; for treating infection, septic shock, and inflammation.

Creatogen Biosciences WO 00/14240

Salmonella antigen carriers

Augsburg, Germany

Attenuated Salmonella mutated at the SP12 gene locus; for non-virulent antigen carriers.

Cummings, R.D., et al. WO 00/14199

Fucosyltransferase transgenics

Edmond, Okla.

Fucosyltransferases from Caenorhabditis elegans, encoding genes; for making developmental transgenics.

Curie Inst. WO 00/14118

OZF protein antibodies

Paris

OZF protein-specific antibodies; for modulator screens and cancer diagnostics and therapeutics.

Cytos Biotech. WO 00/14261

Human EPO production

Zurich, Switzerland

Erythropoietin (EPO) production in kidney cells transfected with a myeloproliferative sarcoma virus promoter.

Du Pont WO 00/14239

Thioredoxin H homologs

Wilmington, Del.

Thioredoxin H homologs, encoding gene sequences, chimeric gene, antisense; for regulating thioredoxin levels.

Eberhard Karls Univ. WO 00/14215

Targeting peptides

Tubingen, Germany

Phage display methods for selecting peptides for the targeted transport of drugs to tumors.

Enzecta R&D GB 2 341 605

Activating prodrugs

London

Fusions of a targeting moiety and NADPH quinone reductase 2; for activating prodrugs at specific sites during therapy.

Genolife WO 00/14277

Differential expression methods

Gerzat, France

Chip-based amplification techniques suitable for small size and damaged DNA fragments; for differential display.

Genotherapeutics WO 00/14211

Cancer gene therapy

Memphis, Tenn.

Adenovirus expression vector with the p16 tumor suppressor gene controlled by the RSV promoter; for cancer therapy.

Genotherapeutics WO 00/14256

Cancer gene therapy

Memphis, Tenn.

Replication-defective adenovirus encoding a cytochrome under the control of the RSV promoter; for cancer gene therapy.

Genzyme WO 00/14262

Less immunogenic vectors

Framingham, Mass.

Methylated plasmid DNA; for reduced immunogenicity during gene therapy.

Georgia, Univ. of WO 00/14243

Phenolic acid esterases

Athens, Ga.

Phenolic acid esterases contained as domains within xylanases; for enzyme production.

Glaxo WO 00/14222

GABAB receptor subtypes

Greenford, UK

GABAB receptor subtypes, variants, encoding gene sequences, antibodies; for screening modulators.

Hitachi Software Engin. WO 00/14197

Biochips

Kanagawa, Japan

Biochips with a storage medium added to a glass substrate spotted with DNA or protein; for measuring interactions.

IBM EPO 987 653

Self-assembled nano-devices

Armonk, N.Y.

Self-assembled nano-devices containing inorganic atoms bound to specific locations on DNA.

Incyte Genomics WO 00/14231

LIM domain protein homolog

Palo Alto, Calif.

LIM domain protein homolog, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/14248

Cyclic nucleotide-associated proteins

Palo Alto, Calif.

Human cyclic nucleotide-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/14251

Transferases

Palo Alto, Calif.

Human transferase proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Japan Sci. & Technol. WO 00/14213

Gene mutation methods

Saitama, Japan

Highly efficient mutagenesis methods using psoralen derivatives; for examining gene function.

Japan Sci. & Technol. WO 00/14228

Cancer growth inhibition

Saitama, Japan

Neutral amino acid transporter, encoding gene sequences; for inhibiting cancer cell growth.

Japan Tobacco WO 00/14242

Antibacterial protein

Tokyo

Antibacterial protein that can also inhibit pathogenic fungi growth, encoding gene sequences.

Kaneka EPO 987 332

Optically active compounds

Osaka, Japan

Process for producing optically active amino acid containing compounds using microbial enzymes.

Keio Univ. WO 00/14204

Alzheimer's therapy assay

Tokyo

Increased expression of amyloid precursor protein in transfected cells; for finding Alzheimer's therapeutics.

Kim, S.S., et al. WO 00/14209

Prothrombin fragments

Seoul, S. Korea

Endothelial cell proliferation inhibitors derived from human prothrombin, encoding gene sequences; for cancer therapy.

Kirin WO 00/14259

Heterologous protein production

Tokyo

Candida yeast strains having lowered protease activity; for expressing and producing heterologous proteins.

Krebs Res. Inst. WO 00/14112

Papillomavirus vaccines

Heidelberg, Germany

Papillomavirus major capsid protein gene, encoded protein, antibodies; for diagnostics, therapeutics, and vaccines.

KS Biomedix WO 00/14119

Bifunctional antibodies

Esher, UK

Bifunctional antibodies that bind a target site and an organic molecule linked to a toxin; for tumor targeting.

Kyowa Hakko Kogyo WO 00/14241

Lysozyme-resistant bacteria

Tokyo

Bacterial strains transfected with a gene encoding a protein causing resistance to lysozyme action.

La Jolla Cancer Res. Fdn. EPO 987 275

Targeting peptides

La Jolla, Calif.

Peptides that target specific tissues; for conjugation to therapeutic drugs.

Loma Linda Univ. WO 00/14271

Protein interaction assays

Loma Linda, Calif.

Studying protein interactions in vivo using separate proteins complexed to luciferase and a fluorophore.

Ludwig Inst. Cancer Res. WO 00/13699

Antigenic M-CSF peptides

New York

Antigenic peptides encoded by an alternate open reading frame of human macrophage colony stimulating factor (M-CSF).

Lynx Therapeutics WO 00/14282

Genetic polymorphism screen

Hayward, Calif.

Genetic polymorphism screen using amplification reactions followed by exonuclease digestion of mismatched sequences.

Max Planck Inst. WO 00/14246

Fructose polymers

Berlin

Protein having fructosyltransferase activity, encoding gene sequences; for producing fructose polymers.

Medvet Science WO 00/14272

Latent HIV assay

Adelaide, Australia

Measuring persistent latent HIV viral load using PCR amplification techniques with LTR probes.

Millennium Biotherapeutics WO 00/14230

Herpes entry modulation

Cambridge, Mass.

TANGO receptors from the herpes entry mediator protein family, encoding gene; for diagnostics and therapeutics.

Millennium Pharma WO 00/14200

Antibacterial screens

Cambridge, Mass.

Streptococcus pneumoniae genes necessary for survival of a wide range of bacteria; for antibacterial screens.

Millennium Pharma WO 00/14212

Protein kinases

Cambridge, Mass.

Protein kinases, encoding genes, fusions, fragments, antibodies, transgenics; for diagnostics and therapeutics.

Millennium Pharma WO 00/14233

G-protein coupled receptor

Cambridge, Mass.

G-protein coupled 14272 receptor from the EDG family, encoding gene; for modulator screens and therapeutics.

Myelos WO 00/14113

Prosaposin receptor activity

San Diego, Calif.

Transfection of neural stem cells with prosaposin or prosaposin receptor agonist genes; for transplantation.

NIH (Natl. Inst. Hlth.) WO 00/14219

mRNA synthesis suppression

Bethesda, Md.

Peptide nucleic acid-oligoadenylate chimeric molecules; for antisense that affects RNase L and related mRNA synthesis.

NIH (Natl. Inst. Hlth.) WO 00/14245

Dengue virus vaccines

Bethesda, Md.

Dengue viruses that are replication defective in mosquitos; for use as vaccines.

New England Biolabs WO 00/14536

Motif-specific antibodies

Beverly, Mass.

Production of motif-specific, context-independent antibodies using modified peptide libraries as antigens.

Novo Nordisk WO 00/14258

Heterologous protein production

Bagsvaerd, Denmark

Methods for the production of heterologous proteins in transformed yeast cells.

Oklahoma, Univ. of WO 00/14250

Post-translational modification

Norman, Okla.

Tyrosyl-protein sulfotransferase, encoding gene sequences; for post-translational modification of proteins.

Qiagen EPO 987 327

Closed circular DNA

Hilden, Germany

Methods for purifying closed circular DNA from bacteria that is essentially free from genomic DNA.

Res. Corp. Technol. WO 00/14198

Liver disease therapeutics

Tucson, Ariz.

Human phosphatidylethanolamine N-methyltransferase-2 gene, encoded protein; for liver disease diagnostics/therapeutics.

Schering WO 00/14220

Developing HIV therapeutics

Berlin

Cell lines expressing CD4 and the orphan seven transmembrane domain receptor APJ that is a co-receptor for HIV infection.

Signalgene WO 00/14273

Differential gene expression

Montreal

Differential gene expression display using arrays of mono-length cRNA libraries.

Sloan-Kettering Inst. Cancer Res. WO 00/14257

Prostate cancer therapy

New York

Fusion T cell receptor for promoting a cellular immunoresponse to prostate-specific membrane antigen.

SmithKline Beecham WO 00/13694

Antibacterial screens

Philadelphia

Bacterial gcp polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/14221

Glycine transporter

Brentford, UK

Glycine transporter, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/14223-14225

Calcium channel

Brentford, UK

Voltage-gated skeletal and neural muscle calcium channels, subunits, encoding genes; for diagnostics.

Sumitomo Pharma WO 00/14252

Prodrug ribozyme

Osaka, Japan

Gene encoding a prodrug ribozyme that can be converted into a functional ribozyme after splicing in the cytoplasm.

Sumitomo Pharma WO 00/14260

Receptor modulators

Osaka, Japan

Recombinant human SM-11044-binding receptor protein; for screening modulators.

Takara Shuzo EPO 987 326

Site-directed mutagenesis

Kyoto, Japan

Site-directed mutagenesis using double-stranded DNA vectors having amber codons in PCR reactions.

Takara Shuzo WO 00/14218

Faster DNA synthesis

Kyoto, Japan

Methods for faster DNA synthesis using PCR amplification methods.

Takeda Chemical WO 00/14226

Secreted protein

Osaka, Japan

Secreted protein, encoding gene sequences, antibodies; for immune disease diagnostics and therapeutics.

Takeda Chemical WO 00/14227

Extracellular matrix protease

Osaka, Japan

Extracellular matrix protease, encoding gene, antibodies; for modulator screens, diagnostics, and therapeutics.

Targeted Genetics WO 00/14205

Helper-free AAV

Seattle

Methods for generating high-titer, helper-free preparations of released adeno-associated virus (AAV) vectors.

Texas, Univ. of WO 00/14263

Hepatitis A vaccines

Austin, Texas

Recombinant hepatitis A virus, variants, production methods; for vaccines for liver disease.

Theratechnologies WO 00/14236

Growth hormone deficiency therapy

Montreal

Chimeric fat body-growth hormone releasing factor (GRF) analogs; for treating growth hormone deficiencies.

Tufts Univ. WO 00/14232

Hypertension transcription factor

N. Grafton, Mass.

Hypertension-associated transcription factor, encoding gene, antigens, antibodies; for diagnostics and therapeutics.

U.S. Surgical WO 00/14201

Proteins with modified amino acids

Norwalk, Conn.

Polypeptides containing modified, non-natural amino acids, production methods.

Urocor WO 00/14234

Prostate cancer therapeutics

Oklahoma City

Prostate specific promoter, encoding gene; for identifying transcription factors involved in prostate cancer.

Washington Univ. WO 00/14283

Chronic mucosal injury

St. Louis

Measuring expression products of the REG gene family to detect chronic mucosal injury and ulcerative colitis.

Yissum Res. Develop. WO 00/14255

mRNA splicing control

Jerusalem

Nucleotide sequences derived from the 3' untranslated region of TNF; for regulating gene expression by mRNA splicing.

ZK Pharma WO 00/14216

Virus binding inhibition

Redwood City, Calif.

Target cell receptor methods for selecting peptides that inhibit viral surface protein binding to cell surfaces.

Zymogenetics WO 00/14235

Proteinase inhibitors

Seattle

Proteinase inhibitors having Kunitz domains, encoding gene sequences; for finding inhibitors.

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