Published March 22 (EPO); March 16 (WO); March 22 (GB)
Aberdeen Univ. WO 00/14267
Light biosensor
Aberdeen, UK
Biosensor for evaluating biological effects that uses a gene that expresses a light emitting protein.
Agouron Pharma WO 00/14105
VEGF receptor ligands
La Jolla, Calif.
Catalytic kinase domain of the vascular endothelial growth factor receptor (VEGF); for identifying therapeutics.
Asahi WO 00/14229
Immunomodulation
Osaka, Japan
Seven-pass transmembrane receptor from immature dendritic cells, encoding gene; for finding immunomodulatory ligands.
Aventis Pharma WO 00/14275
Differential gene display
Frankfurt, Germany
Two different color dye marked primers; for differential display of regulated genes.
Bayer EPO 987 329
Cold therapeutic
Pittsburgh
Multimeric forms of an intercellular adhesion protein that serves as a rhinovirus receptor; for treating colds.
Beth Israel Deaconess Med. Ctr. WO 00/14103
Angiogenesis stimulation
Boston
Angiogenesis stimulation by enhanced endothelial expression of core proteins with a syndecan-4 cytoplasmic region.
Bristol, Univ. of WO 00/14114
Toxin vaccine adjuvants
Bristol, UK
Peptide fragments and variants of cholera toxin B or enterotoxin B; for use as vaccine adjuvants.
British Columbia, Univ. of WO 00/14274
Bacterial strain identification
Vancouver, B.C.
Identification of Burkholderia cepacia bacterial strains using recA gene sequences.
British Agricultural Ministry GB 2 341 606
Glycosylated immunogens
London
Glycosylation peptides, variants, fragments; for improved immunogenicity and stability of immunogenic proteins.
British Defense Ministry WO 00/14278
Reaction temperature monitor
Farnborough, UK
Methods for monitoring the temperature of amplification reactions using temperature-sensitive fluorescent probes.
British Defense Ministry WO 00/14279
DNA amplification
Farnborough, UK
Amplification of DNA using control sequences that differ in GC content.
Burnham Inst. WO 00/14106
BAG-1 related proteins
La Jolla, Calif.
BAG-1 related protein family from humans, yeast, and Caenorhabditis elegans, encoding gene sequences.
Choy, J.H. EPO 987 328
Gene delivery composition
Seoul, S. Korea
Bio-inorganic hybrid material containing metal ions and anionic biomaterial; for carrying and delivering genes.
Chugai WO 00/14203
Hematopoietic stem cells
Tokyo
Separation of cell fractions from myeloid cells enriched in hematopoietic stem cells by using a cell sorter.
Chugai Res. Inst. Molec. Med. WO 00/14210
Systemic carnitine deficiency
Ibaraki, Japan
Gene associated with systemic carnitine deficiency, encoded protein; for diagnostics and therapeutics.
Connaught Labs WO 00/14244
Cervical cancer vaccines
Toronto
Genes encoding non-toxic T cell epitopes of papillomavirus strains associated with cervical cancer; for vaccines.
Cortecs WO 00/14253
Immunostimulants
Deeside, UK
Proteins from crude pineapple stem bromelain, encoding gene sequences; for immunostimulation and cancer therapeutics.
Cortecs WO 00/14254
Anti-IL-2 proteins
Deeside, UK
Bromelain components responsible for anti-ERK-2 and anti-interleukin (IL)-2 activity.
CPG Immunopharma WO 00/14217
Infection oligos
Hilden, Germany
G-motif oligonucleotides, encoded proteins; for treating infection, septic shock, and inflammation.
Creatogen Biosciences WO 00/14240
Salmonella antigen carriers
Augsburg, Germany
Attenuated Salmonella mutated at the SP12 gene locus; for non-virulent antigen carriers.
Cummings, R.D., et al. WO 00/14199
Fucosyltransferase transgenics
Edmond, Okla.
Fucosyltransferases from Caenorhabditis elegans, encoding genes; for making developmental transgenics.
Curie Inst. WO 00/14118
OZF protein antibodies
Paris
OZF protein-specific antibodies; for modulator screens and cancer diagnostics and therapeutics.
Cytos Biotech. WO 00/14261
Human EPO production
Zurich, Switzerland
Erythropoietin (EPO) production in kidney cells transfected with a myeloproliferative sarcoma virus promoter.
Du Pont WO 00/14239
Thioredoxin H homologs
Wilmington, Del.
Thioredoxin H homologs, encoding gene sequences, chimeric gene, antisense; for regulating thioredoxin levels.
Eberhard Karls Univ. WO 00/14215
Targeting peptides
Tubingen, Germany
Phage display methods for selecting peptides for the targeted transport of drugs to tumors.
Enzecta R&D GB 2 341 605
Activating prodrugs
London
Fusions of a targeting moiety and NADPH quinone reductase 2; for activating prodrugs at specific sites during therapy.
Genolife WO 00/14277
Differential expression methods
Gerzat, France
Chip-based amplification techniques suitable for small size and damaged DNA fragments; for differential display.
Genotherapeutics WO 00/14211
Cancer gene therapy
Memphis, Tenn.
Adenovirus expression vector with the p16 tumor suppressor gene controlled by the RSV promoter; for cancer therapy.
Genotherapeutics WO 00/14256
Cancer gene therapy
Memphis, Tenn.
Replication-defective adenovirus encoding a cytochrome under the control of the RSV promoter; for cancer gene therapy.
Genzyme WO 00/14262
Less immunogenic vectors
Framingham, Mass.
Methylated plasmid DNA; for reduced immunogenicity during gene therapy.
Georgia, Univ. of WO 00/14243
Phenolic acid esterases
Athens, Ga.
Phenolic acid esterases contained as domains within xylanases; for enzyme production.
Glaxo WO 00/14222
GABAB receptor subtypes
Greenford, UK
GABAB receptor subtypes, variants, encoding gene sequences, antibodies; for screening modulators.
Hitachi Software Engin. WO 00/14197
Biochips
Kanagawa, Japan
Biochips with a storage medium added to a glass substrate spotted with DNA or protein; for measuring interactions.
IBM EPO 987 653
Self-assembled nano-devices
Armonk, N.Y.
Self-assembled nano-devices containing inorganic atoms bound to specific locations on DNA.
Incyte Genomics WO 00/14231
LIM domain protein homolog
Palo Alto, Calif.
LIM domain protein homolog, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/14248
Cyclic nucleotide-associated proteins
Palo Alto, Calif.
Human cyclic nucleotide-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/14251
Transferases
Palo Alto, Calif.
Human transferase proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Japan Sci. & Technol. WO 00/14213
Gene mutation methods
Saitama, Japan
Highly efficient mutagenesis methods using psoralen derivatives; for examining gene function.
Japan Sci. & Technol. WO 00/14228
Cancer growth inhibition
Saitama, Japan
Neutral amino acid transporter, encoding gene sequences; for inhibiting cancer cell growth.
Japan Tobacco WO 00/14242
Antibacterial protein
Tokyo
Antibacterial protein that can also inhibit pathogenic fungi growth, encoding gene sequences.
Kaneka EPO 987 332
Optically active compounds
Osaka, Japan
Process for producing optically active amino acid containing compounds using microbial enzymes.
Keio Univ. WO 00/14204
Alzheimer's therapy assay
Tokyo
Increased expression of amyloid precursor protein in transfected cells; for finding Alzheimer's therapeutics.
Kim, S.S., et al. WO 00/14209
Prothrombin fragments
Seoul, S. Korea
Endothelial cell proliferation inhibitors derived from human prothrombin, encoding gene sequences; for cancer therapy.
Kirin WO 00/14259
Heterologous protein production
Tokyo
Candida yeast strains having lowered protease activity; for expressing and producing heterologous proteins.
Krebs Res. Inst. WO 00/14112
Papillomavirus vaccines
Heidelberg, Germany
Papillomavirus major capsid protein gene, encoded protein, antibodies; for diagnostics, therapeutics, and vaccines.
KS Biomedix WO 00/14119
Bifunctional antibodies
Esher, UK
Bifunctional antibodies that bind a target site and an organic molecule linked to a toxin; for tumor targeting.
Kyowa Hakko Kogyo WO 00/14241
Lysozyme-resistant bacteria
Tokyo
Bacterial strains transfected with a gene encoding a protein causing resistance to lysozyme action.
La Jolla Cancer Res. Fdn. EPO 987 275
Targeting peptides
La Jolla, Calif.
Peptides that target specific tissues; for conjugation to therapeutic drugs.
Loma Linda Univ. WO 00/14271
Protein interaction assays
Loma Linda, Calif.
Studying protein interactions in vivo using separate proteins complexed to luciferase and a fluorophore.
Ludwig Inst. Cancer Res. WO 00/13699
Antigenic M-CSF peptides
New York
Antigenic peptides encoded by an alternate open reading frame of human macrophage colony stimulating factor (M-CSF).
Lynx Therapeutics WO 00/14282
Genetic polymorphism screen
Hayward, Calif.
Genetic polymorphism screen using amplification reactions followed by exonuclease digestion of mismatched sequences.
Max Planck Inst. WO 00/14246
Fructose polymers
Berlin
Protein having fructosyltransferase activity, encoding gene sequences; for producing fructose polymers.
Medvet Science WO 00/14272
Latent HIV assay
Adelaide, Australia
Measuring persistent latent HIV viral load using PCR amplification techniques with LTR probes.
Millennium Biotherapeutics WO 00/14230
Herpes entry modulation
Cambridge, Mass.
TANGO receptors from the herpes entry mediator protein family, encoding gene; for diagnostics and therapeutics.
Millennium Pharma WO 00/14200
Antibacterial screens
Cambridge, Mass.
Streptococcus pneumoniae genes necessary for survival of a wide range of bacteria; for antibacterial screens.
Millennium Pharma WO 00/14212
Protein kinases
Cambridge, Mass.
Protein kinases, encoding genes, fusions, fragments, antibodies, transgenics; for diagnostics and therapeutics.
Millennium Pharma WO 00/14233
G-protein coupled receptor
Cambridge, Mass.
G-protein coupled 14272 receptor from the EDG family, encoding gene; for modulator screens and therapeutics.
Myelos WO 00/14113
Prosaposin receptor activity
San Diego, Calif.
Transfection of neural stem cells with prosaposin or prosaposin receptor agonist genes; for transplantation.
NIH (Natl. Inst. Hlth.) WO 00/14219
mRNA synthesis suppression
Bethesda, Md.
Peptide nucleic acid-oligoadenylate chimeric molecules; for antisense that affects RNase L and related mRNA synthesis.
NIH (Natl. Inst. Hlth.) WO 00/14245
Dengue virus vaccines
Bethesda, Md.
Dengue viruses that are replication defective in mosquitos; for use as vaccines.
New England Biolabs WO 00/14536
Motif-specific antibodies
Beverly, Mass.
Production of motif-specific, context-independent antibodies using modified peptide libraries as antigens.
Novo Nordisk WO 00/14258
Heterologous protein production
Bagsvaerd, Denmark
Methods for the production of heterologous proteins in transformed yeast cells.
Oklahoma, Univ. of WO 00/14250
Post-translational modification
Norman, Okla.
Tyrosyl-protein sulfotransferase, encoding gene sequences; for post-translational modification of proteins.
Qiagen EPO 987 327
Closed circular DNA
Hilden, Germany
Methods for purifying closed circular DNA from bacteria that is essentially free from genomic DNA.
Res. Corp. Technol. WO 00/14198
Liver disease therapeutics
Tucson, Ariz.
Human phosphatidylethanolamine N-methyltransferase-2 gene, encoded protein; for liver disease diagnostics/therapeutics.
Schering WO 00/14220
Developing HIV therapeutics
Berlin
Cell lines expressing CD4 and the orphan seven transmembrane domain receptor APJ that is a co-receptor for HIV infection.
Signalgene WO 00/14273
Differential gene expression
Montreal
Differential gene expression display using arrays of mono-length cRNA libraries.
Sloan-Kettering Inst. Cancer Res. WO 00/14257
Prostate cancer therapy
New York
Fusion T cell receptor for promoting a cellular immunoresponse to prostate-specific membrane antigen.
SmithKline Beecham WO 00/13694
Antibacterial screens
Philadelphia
Bacterial gcp polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/14221
Glycine transporter
Brentford, UK
Glycine transporter, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/14223-14225
Calcium channel
Brentford, UK
Voltage-gated skeletal and neural muscle calcium channels, subunits, encoding genes; for diagnostics.
Sumitomo Pharma WO 00/14252
Prodrug ribozyme
Osaka, Japan
Gene encoding a prodrug ribozyme that can be converted into a functional ribozyme after splicing in the cytoplasm.
Sumitomo Pharma WO 00/14260
Receptor modulators
Osaka, Japan
Recombinant human SM-11044-binding receptor protein; for screening modulators.
Takara Shuzo EPO 987 326
Site-directed mutagenesis
Kyoto, Japan
Site-directed mutagenesis using double-stranded DNA vectors having amber codons in PCR reactions.
Takara Shuzo WO 00/14218
Faster DNA synthesis
Kyoto, Japan
Methods for faster DNA synthesis using PCR amplification methods.
Takeda Chemical WO 00/14226
Secreted protein
Osaka, Japan
Secreted protein, encoding gene sequences, antibodies; for immune disease diagnostics and therapeutics.
Takeda Chemical WO 00/14227
Extracellular matrix protease
Osaka, Japan
Extracellular matrix protease, encoding gene, antibodies; for modulator screens, diagnostics, and therapeutics.
Targeted Genetics WO 00/14205
Helper-free AAV
Seattle
Methods for generating high-titer, helper-free preparations of released adeno-associated virus (AAV) vectors.
Texas, Univ. of WO 00/14263
Hepatitis A vaccines
Austin, Texas
Recombinant hepatitis A virus, variants, production methods; for vaccines for liver disease.
Theratechnologies WO 00/14236
Growth hormone deficiency therapy
Montreal
Chimeric fat body-growth hormone releasing factor (GRF) analogs; for treating growth hormone deficiencies.
Tufts Univ. WO 00/14232
Hypertension transcription factor
N. Grafton, Mass.
Hypertension-associated transcription factor, encoding gene, antigens, antibodies; for diagnostics and therapeutics.
U.S. Surgical WO 00/14201
Proteins with modified amino acids
Norwalk, Conn.
Polypeptides containing modified, non-natural amino acids, production methods.
Urocor WO 00/14234
Prostate cancer therapeutics
Oklahoma City
Prostate specific promoter, encoding gene; for identifying transcription factors involved in prostate cancer.
Washington Univ. WO 00/14283
Chronic mucosal injury
St. Louis
Measuring expression products of the REG gene family to detect chronic mucosal injury and ulcerative colitis.
Yissum Res. Develop. WO 00/14255
mRNA splicing control
Jerusalem
Nucleotide sequences derived from the 3' untranslated region of TNF; for regulating gene expression by mRNA splicing.
ZK Pharma WO 00/14216
Virus binding inhibition
Redwood City, Calif.
Target cell receptor methods for selecting peptides that inhibit viral surface protein binding to cell surfaces.
Zymogenetics WO 00/14235
Proteinase inhibitors
Seattle
Proteinase inhibitors having Kunitz domains, encoding gene sequences; for finding inhibitors.