Published March 8 (EPO); March 2 (WO); March 8 (GB)
Abbott Labs WO 00/11167
Purinergic receptor
Abbott Park, Ill.
Human purinergic receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Abbott Labs WO 00/11890
_-casein isolation
Abbott Park, Ill.
Two-stage extraction methods for isolating recombinant _-casein from cell lysates.
Affymetrix WO 00/11218
CMV infection monitoring
Santa Clara, Calif.
Monitoring the expression of genes known to be affected by human cytomegalovirus (CMV) infection; for diagnostics.
Affymetrix WO 00/11223
Pooled probe arrays
Santa Clara, Calif.
Polynucleotide arrays with pooled probes at one position; for linkage and sequence analysis and expression monitoring.
Agrevo WO 00/11189
Fungicide screen
Cambridge, U.K.
Promoter from fungal 3-isopropylmalate dehydrogenase; for screening fungicides.
Ajinomoto EPO 984 066
Methanol dehydrogenase activator
Tokyo
Activator of methanol dehydrogenase, encoding gene sequences; for enzyme and activator production.
Ajinomoto WO 00/10601
Antithrombotic
Tokyo
Antithrombotic agent containing humanized anti-von Willebrand Factor monoclonal antibodies.
Alabama, Univ. of WO 00/10389
Diabetes transgenics
Birmingham, Ala.
Transgenics with impaired glucosamine synthesis using streptozotocin; for diabetes drug screens.
Alabama, Univ. of WO 00/11149
High titer AAV
Birmingham, Ala.
Methods for producing high titer recombinant adeno-associated virus (AAV) stocks; for gene therapy vectors.
Albany Med. Coll. WO 00/11173
Leptin-related peptides
Albany, N.Y.
Leptin-related peptides; for diagnostics and therapeutics for maintaining weight and adipose tissue mass homeostasis.
Albert Einstein Coll. Med. WO 00/10604
Regulating muscle tone
Bronx, N.Y.
Gene sequences encoding a smooth muscle tone protein; for regulating smooth muscle tone.
Alphagene WO 00/11015
Secreted proteins
Woburn, Mass.
Secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.
Auburn Univ. WO 00/11172
Antithrombin proteins
Auburn, Ala.
Antithrombin proteins isolated from horn fly salivary glands, encoding genes; for thrombosis therapeutics.
BASF WO 00/11191
Controlling inflammation
Worcester, Mass.
TPL-2 for phosphorylating p105 which causes its proteolysis; for regulating NFkappaB and inflammatory responses.
Berger, E.G., et al. WO 00/11190
Polysaccharide repeats
Zurich, Switzerland
Glycosyl transferase, encoding gene sequences; for making polysaccharides having glucosamine-galactose repeats.
Biotransplant WO 00/11187
Transplant viral assays
Charlestown, Mass.
Swine retrovirus genomic sequences, encoded proteins; for detecting pig retroviruses in transplant tissues.
Bioventures WO 00/11221
Sequence variation assay
Murfreesboro, Tenn.
Identifying sequence variations by amplification of both strands of a template followed by hybridization comparison.
Bristol-Myers Squibb WO 00/11216
Target modulator assay
Princeton, N.J.
Cell lines expressing molecular targets without knowledge of sequence information; for high-throughput modulator screens.
California, Univ. of WO 00/11037
Streptococcus diagnostics
Oakland, Calif.
Monoclonal antibodies specific for Streptococcus mutans surface lipopolysaccharides; for clinical diagnostics.
Catholic Univ. WO 00/11158
Diabetes therapeutics
Louvain-La-Neuve, Belgium
Transgenics having disrupted ONECUT family genes, ONECUT family genes; for therapeutics and diabetes models.
Cell Genesys WO 00/11154
Producing toxic proteins
Foster City, Calif.
Use of suppressor tRNAs to regulate cytotoxicity of recombinantly produced toxic proteins.
CDC (Ctr. Disease Control) WO 00/11179
Malarial vaccine
Atlanta
Recombinant protein made from peptides of various life cycle stages of Plasmodium, for multivalent malarial vaccines.
Chugai WO 00/10382
Nerve networks visualized
Tokyo
Transgenics having a trans-synaptic tracer protein gene; for nerve network visualization.
Connaught Labs WO 00/11180, 11181 & 11183
Chlamydia vaccines
Toronto
Chlamydia antigen proteins, encoding gene sequences; for nucleic acid immunization against infection.
Cultor WO 00/11142
Methyltransferases
Espoo, Finland
Methyltransferases, encoding genes, mutants, recombinant production methods; for transferring methyl groups.
Cytos Biotech EPO 984 062
EPO production
Zurich, Switzerland
Making human erythropoietin (EPO) in mammalian kidney cells using E. coli tryptophan synthetase gene for selection.
E. Heller WO 00/11224
Electrochemical PCR verification
Alameda, Calif.
Rapid electrochemical verification of DNA amplification by PCR in small samples.
Eli Lilly EPO 984 063
Angiogenesis modulators
Indianapolis
Vascular endothelial growth factor (VEGF)-related gene, encoded protein; for finding angiogenesis modulators.
Frey, F., et al. WO 00/11019
Transfection targeting agents
Bern, Switzerland
Conjugates of DNA interacting groups with steroid hormones; for use in targeting gene sequences to be transfected.
Fujitsu WO 00/11145
Gene motif extraction
Kanagawa, Japan
Extracting gene motifs using database manipulation, methods of iterative learning based on identified motifs.
Fuso Pharma WO 00/11161
Antibacterials
Osaka, Japan
Collectin-related protein, encoding gene sequences; for antibacterials and antivirals.
Genetic Assays WO 00/11222
Nucleotide variation assay
Nashville, Tenn.
Screening nucleic acids for nucleotide variations using single-stranded extension products.
Genzyme WO 00/11202
Adenovirus gene therapy
Framingham, Mass.
Cationic lipid complexes of polyalkalene polymer-modified recombinant adenovirus vectors; for gene therapy.
Georgia, Univ. of WO 00/11151
Bird transgenesis
Athens, Ga.
Transgenesis of oviducts by delivering transgenes to oviduct lumens; for secreting exogenous proteins into eggs.
Glaxo WO 00/11160
Human CD28 ligand
Greenford, UK
Human adapter protein related to the GRB2 family, encoding gene; for binding to human CD28.
Higeta Shoyu EPO 984 065
Syphilis diagnostics
Tokyo
Modified Triponema palladum-derived antigen, encoding gene sequences, antibodies; for syphilis diagnostics.
Human Genome Sciences WO 00/11014
49 secreted proteins
Rockville, Md.
49 human secreted proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.
Immtech Intl. WO 00/111207
Cell delivery methods
Evanston, Ill.
Use of modified C-reactive protein fusions to deliver materials into cells.
Immune Response WO 00/11476
Immune function assay
Carlsbad, Calif.
Peripheral blood mononuclear cells contacted by antigens and evaluated for cell division; for measuring immune function.
Immunex WO 00/11174
Human IL-1 epsilon
Seattle
Human interleukin (IL)-1 epsilon, encoding gene sequences, fragments, antibodies; for immunotherapy.
Immunobiology WO 00/10597
Cancer vaccines
Cambridge, UK
Producing and isolating immunogenic cytokine-induced heat shock proteins from cancer cells; for vaccines.
Incyte Genomics WO 00/11150
Immunomodulators
Palo Alto, Calif.
Cell surface immunomodulators, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/11164
Human angiopoietin-3
Palo Alto, Calif.
Human angiopoietin-3, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/11169
Cell signaling proteins
Palo Alto, Calif.
Human cell signaling proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/11171
RNA-associated proteins
Palo Alto, Calif.
Human RNA-associated proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/11194
Cyclophilin isomerase
Palo Alto, Calif.
Cyclophilin-type peptidyl-prolyl cis/trans isomerase, encoding gene, antibodies, modulators; for therapeutics.
Innogenetics EPO 984 067 & 984 068
Diagnosing hepatitis C
Ghent, Belgium
Hepatitis C virus genotype sequences, encoded proteins; for hepatitis diagnostics.
Japan Inst. Agrobiol. Res. WO 00/11156
Microsatellite isolation
Ibaraki, Japan
Genomic DNA libraries having elevated homogeneity using non-base dependent cleavage; for isolating microsatellites.
Japan Sci. & Technol. WO 00/11153
ATP liberation antibodies
Saitama, Japan
Monoclonal antibodies that inhibit the liberation of ATP from cells, production hybridomas.
Japan Tobacco EPO 984 023
Cell adhesion molecule
Tokyo
Cell surface molecule that mediates cell adhesion and signal transduction, encoding gene, antibodies; for autoimmunity.
Johns Hopkins Univ. WO 00/11195
Tumor suppressor regulation
Baltimore
_-catenin regulation of APC tumor suppressor protein; for colon cancer diagnostics and therapeutics.
Johns Hopkins Univ. WO 00/11201
Alphavirus gene therapy
Baltimore
Recombinant alphavirus vectors having an incorporated cell targeting gene; for gene therapy.
Johns Hopkins Univ. WO 00/11204
Calcium mobilization modulators
Baltimore
Homer interacting protein; for finding modulators of calcium mobilization and receptor clustering.
Johns Hopkins Univ. WO 00/11219
Tumor mutation assay
Baltimore
Assay for single basepair mutations in the mitochondrial genome; for detecting tumor formation.
Kirin WO 00/10383
Chromosomal transgenics
Tokyo
Modified foreign chromosomes constructed in cells with high homologous recombination efficiency; for making trangenics.
Kirin WO 00/10384
Neuraminate transgenics
Tokyo
Transgenics and derived cells having a disrupted CMP-N-acetylneuraminate hydroxylase gene.
Kleesiek, K. WO 00/11034
Thrombosis diagnostics
Bad Oeynhausen, Germany
Tissue factor pathway inhibitor mutant, encoding gene sequences; for thrombosis diagnostics and therapeutics.
Lexingen Pharma WO 00/11033
Angiogenesis inhibitor fusions
Lexington, Mass.
Fusions of angiogenesis inhibitors with immunoglobulin fragments; for treating cancer.
Maryland, Univ. of WO 00/11217
Enhanced transfection
Baltimore
Gene delivery system including nucleases; for enhanced transfection.
Mass. Gen. Hosp. WO 00/11016 & 11157
Dysferlin mutations
Boston
Dysferlin gene mutations associated with distal myopathy and limb girdle muscular dystrophy, encoded protein.
Mass. Gen. Hosp. WO 00/11147
Pig tissues for transplant
Boston
Inbred miniature swine having MHC and leukocyte antigens homozygous to humans; for transplant tolerance.
Metabolix WO 00/11188
Bioploymer production
Cambridge, Mass.
Microbial strains with polyhydroxyalkanoate synthesis genes inserted by transposons; for biopolymer production.
Millennium Pharma WO 00/11166
G-protein receptor
Cambridge, Mass.
14274, a G-protein receptor of the EDG receptor family, encoding gene; for modulator screens and diagnostics.
Millennium Pharma WO 00/11170
G-protein receptor
Cambridge, Mass.
14000, a G-protein receptor of the EDG receptor family, encoding gene; for modulator screens and diagnostics.
Miyagi Ken EPO 984 061
Ganglioside modulators
Miyagi, Japan
Plasma membrane sialidases, encoding gene, variants; for removing sialate residues from gangliosides.
Mt. Sinai Hosp. WO 00/11141
tRNA synthesis modulators
Toronto
Peptides having tRNA binding domains; for testing modulators of the interaction between tRNA and tRNA synthetase.
Nabel, G.J., et al. WO 00/11165
Cell growth control
Ann Arbor, Mich.
Human kis, a kinase that inhibits cyclin-dependent kinase inhibitor p27; for controlling cell growth.
NIH (Natl. Inst. Hlth.) WO 00/11036
Antiviral antibodies
Bethesda, Md.
Anti-cyanovirin antibody having an internal image of gp120; for treating viral infections.
NIH (Natl. Inst. Hlth.) WO 00/11186
Hepatitis C peptide vaccines
Bethesda, Md.
Modified hepatitis C core peptides, encoding gene sequences; for making vaccines.
Neovacs WO 00/11225
HIV infection monitoring
Paris
Assay for serum levels of anti-tat antibodies and p24 protein; for determining HIV infection prognosis.
New Jersey, Med. & Dent. Univ. WO 00/11148
Cold-shock response control
New Brunswick, N.J.
Cold-shock inducible gene regulatory elements, vectors; for modulating cold-shock responses.
Novartis WO 00/11027
Multiple sclerosis treatment
Vienna, Austria
Treating multiple sclerosis using peptide analogs of human myelin basic protein.
Novo Nordisk WO 00/11211 & 11212
Catalyst selection
Bagsvaerd, Denmark
In vitro selection of catalysts from libraries using an enzyme activity screen.
Oklahoma Med. Res. Fdn. WO 00/10609
Large vessel targeting
Oklahoma City
Targeting of molecules to large vessel endothelium using the endothelial protein C receptor.
Princeton Univ. WO 00/11168
Blood stem cell expansion
Princeton, N.J.
Genes regulating hematopoietic stem cell formation, encoded proteins, methods for expanding blood stem cells.
Regeneron Pharma WO 00/11163
Antagonizing BMP action
Tarrytown, N.Y.
DCR5, a bone morphogenetic protein (BMP) binding protein, encoding gene sequences; for antagonizing BMP action.
Res. Develop. Fdn. WO 00/10612
Cancer gene therapy
Carson City, Nev.
Gene therapy vectors having sequences allowing sustained or regulatable expression; for treating various cancers.
Sankyo WO 00/11193
Antiviral screens
Tokyo
Virus activation protease, encoding gene sequences, variants; for screening antivirals.
Schering WO 00/11184
Staphylococcus antibacterials
Kenilworth, N.J.
Staphylococcus aureus polypeptides, encoding gene sequences, antibodies, production methods; for antibacterials.
Scripps Res. Inst. WO 00/11206
Protein function prediction
La Jolla, Calif.
Geometric representations of protein functional sites; for predicting protein function from inexact structures.
SmithKline Beecham WO 00/10583
Histone deacetylase
Philadelphia
Human histone deacetylase gene, encoded protein, production techniques; for diagnostics and therapeutics.
SmithKline Beecham WO 00/11143
Phoaphatidylinositol kinase
Brentford, UK
Human phosphatidylinositol 3-kinase regulatory P101 subunit, encoding gene; for diagnostics and therapeutics.
SmithKline Beecham WO 00/11182
Meningitis therapeutics
Rixensart, Belgium
Outer membrane protein of Neisseria meningitidis, encoding gene, production methods; for diagnostics and therapeutics.
Stanford Univ. WO 00/11155
Gene integration
Palo Alto, Calif.
Site-specific integration of gene sequences using recombination sites and recombinases; for gene therapy.
Stanford Univ. WO 00/11214
Mycobacterial gene deletions
Palo Alto, Calif.
Specific deletions in mycobacterial isolate genes; for distinguishing pathogenic strains and improving vaccines.
Sumitomo Electric WO 00/11146
Increased protein from milk
Osaka, Japan
Epimorphine from cows and sheep which causes differentiation of milk-producing cells; for increased protein yield.
T.Breeders WO 00/11139
Hemangioblast production
Worcester, Mass.
Cell populations containing non-fetal hemangioblasts, methods of production.
Washington, Univ. of WO 00/11152
Vascular device coatings
Seattle
Streptavidin mutants having secondary functional domains with cell adhesion activity; for coating vascular devices.
Washington Univ. WO 00/11162
Apoptosis modulation
St. Louis, Mo.
p15 BID polypeptide produced by caspase cleavage of BID; for modulating apoptosis.
Washington Univ. WO 00/11220
DNA diagnostic methods
St. Louis
Gene-based diagnostic methods using template-directed primer extension and detection by fluorescence polarization.
Wieslab WO 00/11475
Goodpasture autoantibodies
Lund, Sweden
Autoantibodies to the non-collagenous domain of the a3 chain of type IV collagen; for Goodpasture disease diagnosis.
Wistar Inst. WO 00/11140
Mucosal immunity enhancement
Philadelphia
Enhancing mucosal immunity by pre-administration of a pathogene antigen gene via a non-mucosal route.
Yale Univ. WO 00/10602
Cancer therapeutics assay
New Haven, Conn.
Transgenics with disrupted a lats gene which develop a variety of tumors; for testing cancer therapeutics.
Yamanouchi GB 2 341 182
Growth control protein
Littlemore Park, UK
SH3 domain protein concentrated in cell nuclei during interphase, encoding gene, antibodies; for growth control.