Published March 8 (EPO); March 2 (WO); March 8 (GB)

Abbott Labs WO 00/11167

Purinergic receptor

Abbott Park, Ill.

Human purinergic receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Abbott Labs WO 00/11890

_-casein isolation

Abbott Park, Ill.

Two-stage extraction methods for isolating recombinant _-casein from cell lysates.

Affymetrix WO 00/11218

CMV infection monitoring

Santa Clara, Calif.

Monitoring the expression of genes known to be affected by human cytomegalovirus (CMV) infection; for diagnostics.

Affymetrix WO 00/11223

Pooled probe arrays

Santa Clara, Calif.

Polynucleotide arrays with pooled probes at one position; for linkage and sequence analysis and expression monitoring.

Agrevo WO 00/11189

Fungicide screen

Cambridge, U.K.

Promoter from fungal 3-isopropylmalate dehydrogenase; for screening fungicides.

Ajinomoto EPO 984 066

Methanol dehydrogenase activator


Activator of methanol dehydrogenase, encoding gene sequences; for enzyme and activator production.

Ajinomoto WO 00/10601



Antithrombotic agent containing humanized anti-von Willebrand Factor monoclonal antibodies.

Alabama, Univ. of WO 00/10389

Diabetes transgenics

Birmingham, Ala.

Transgenics with impaired glucosamine synthesis using streptozotocin; for diabetes drug screens.

Alabama, Univ. of WO 00/11149

High titer AAV

Birmingham, Ala.

Methods for producing high titer recombinant adeno-associated virus (AAV) stocks; for gene therapy vectors.

Albany Med. Coll. WO 00/11173

Leptin-related peptides

Albany, N.Y.

Leptin-related peptides; for diagnostics and therapeutics for maintaining weight and adipose tissue mass homeostasis.

Albert Einstein Coll. Med. WO 00/10604

Regulating muscle tone

Bronx, N.Y.

Gene sequences encoding a smooth muscle tone protein; for regulating smooth muscle tone.

Alphagene WO 00/11015

Secreted proteins

Woburn, Mass.

Secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.

Auburn Univ. WO 00/11172

Antithrombin proteins

Auburn, Ala.

Antithrombin proteins isolated from horn fly salivary glands, encoding genes; for thrombosis therapeutics.

BASF WO 00/11191

Controlling inflammation

Worcester, Mass.

TPL-2 for phosphorylating p105 which causes its proteolysis; for regulating NFkappaB and inflammatory responses.

Berger, E.G., et al. WO 00/11190

Polysaccharide repeats

Zurich, Switzerland

Glycosyl transferase, encoding gene sequences; for making polysaccharides having glucosamine-galactose repeats.

Biotransplant WO 00/11187

Transplant viral assays

Charlestown, Mass.

Swine retrovirus genomic sequences, encoded proteins; for detecting pig retroviruses in transplant tissues.

Bioventures WO 00/11221

Sequence variation assay

Murfreesboro, Tenn.

Identifying sequence variations by amplification of both strands of a template followed by hybridization comparison.

Bristol-Myers Squibb WO 00/11216

Target modulator assay

Princeton, N.J.

Cell lines expressing molecular targets without knowledge of sequence information; for high-throughput modulator screens.

California, Univ. of WO 00/11037

Streptococcus diagnostics

Oakland, Calif.

Monoclonal antibodies specific for Streptococcus mutans surface lipopolysaccharides; for clinical diagnostics.

Catholic Univ. WO 00/11158

Diabetes therapeutics

Louvain-La-Neuve, Belgium

Transgenics having disrupted ONECUT family genes, ONECUT family genes; for therapeutics and diabetes models.

Cell Genesys WO 00/11154

Producing toxic proteins

Foster City, Calif.

Use of suppressor tRNAs to regulate cytotoxicity of recombinantly produced toxic proteins.

CDC (Ctr. Disease Control) WO 00/11179

Malarial vaccine


Recombinant protein made from peptides of various life cycle stages of Plasmodium, for multivalent malarial vaccines.

Chugai WO 00/10382

Nerve networks visualized


Transgenics having a trans-synaptic tracer protein gene; for nerve network visualization.

Connaught Labs WO 00/11180, 11181 & 11183

Chlamydia vaccines


Chlamydia antigen proteins, encoding gene sequences; for nucleic acid immunization against infection.

Cultor WO 00/11142


Espoo, Finland

Methyltransferases, encoding genes, mutants, recombinant production methods; for transferring methyl groups.

Cytos Biotech EPO 984 062

EPO production

Zurich, Switzerland

Making human erythropoietin (EPO) in mammalian kidney cells using E. coli tryptophan synthetase gene for selection.

E. Heller WO 00/11224

Electrochemical PCR verification

Alameda, Calif.

Rapid electrochemical verification of DNA amplification by PCR in small samples.

Eli Lilly EPO 984 063

Angiogenesis modulators


Vascular endothelial growth factor (VEGF)-related gene, encoded protein; for finding angiogenesis modulators.

Frey, F., et al. WO 00/11019

Transfection targeting agents

Bern, Switzerland

Conjugates of DNA interacting groups with steroid hormones; for use in targeting gene sequences to be transfected.

Fujitsu WO 00/11145

Gene motif extraction

Kanagawa, Japan

Extracting gene motifs using database manipulation, methods of iterative learning based on identified motifs.

Fuso Pharma WO 00/11161


Osaka, Japan

Collectin-related protein, encoding gene sequences; for antibacterials and antivirals.

Genetic Assays WO 00/11222

Nucleotide variation assay

Nashville, Tenn.

Screening nucleic acids for nucleotide variations using single-stranded extension products.

Genzyme WO 00/11202

Adenovirus gene therapy

Framingham, Mass.

Cationic lipid complexes of polyalkalene polymer-modified recombinant adenovirus vectors; for gene therapy.

Georgia, Univ. of WO 00/11151

Bird transgenesis

Athens, Ga.

Transgenesis of oviducts by delivering transgenes to oviduct lumens; for secreting exogenous proteins into eggs.

Glaxo WO 00/11160

Human CD28 ligand

Greenford, UK

Human adapter protein related to the GRB2 family, encoding gene; for binding to human CD28.

Higeta Shoyu EPO 984 065

Syphilis diagnostics


Modified Triponema palladum-derived antigen, encoding gene sequences, antibodies; for syphilis diagnostics.

Human Genome Sciences WO 00/11014

49 secreted proteins

Rockville, Md.

49 human secreted proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.

Immtech Intl. WO 00/111207

Cell delivery methods

Evanston, Ill.

Use of modified C-reactive protein fusions to deliver materials into cells.

Immune Response WO 00/11476

Immune function assay

Carlsbad, Calif.

Peripheral blood mononuclear cells contacted by antigens and evaluated for cell division; for measuring immune function.

Immunex WO 00/11174

Human IL-1 epsilon


Human interleukin (IL)-1 epsilon, encoding gene sequences, fragments, antibodies; for immunotherapy.

Immunobiology WO 00/10597

Cancer vaccines

Cambridge, UK

Producing and isolating immunogenic cytokine-induced heat shock proteins from cancer cells; for vaccines.

Incyte Genomics WO 00/11150


Palo Alto, Calif.

Cell surface immunomodulators, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/11164

Human angiopoietin-3

Palo Alto, Calif.

Human angiopoietin-3, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/11169

Cell signaling proteins

Palo Alto, Calif.

Human cell signaling proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/11171

RNA-associated proteins

Palo Alto, Calif.

Human RNA-associated proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/11194

Cyclophilin isomerase

Palo Alto, Calif.

Cyclophilin-type peptidyl-prolyl cis/trans isomerase, encoding gene, antibodies, modulators; for therapeutics.

Innogenetics EPO 984 067 & 984 068

Diagnosing hepatitis C

Ghent, Belgium

Hepatitis C virus genotype sequences, encoded proteins; for hepatitis diagnostics.

Japan Inst. Agrobiol. Res. WO 00/11156

Microsatellite isolation

Ibaraki, Japan

Genomic DNA libraries having elevated homogeneity using non-base dependent cleavage; for isolating microsatellites.

Japan Sci. & Technol. WO 00/11153

ATP liberation antibodies

Saitama, Japan

Monoclonal antibodies that inhibit the liberation of ATP from cells, production hybridomas.

Japan Tobacco EPO 984 023

Cell adhesion molecule


Cell surface molecule that mediates cell adhesion and signal transduction, encoding gene, antibodies; for autoimmunity.

Johns Hopkins Univ. WO 00/11195

Tumor suppressor regulation


_-catenin regulation of APC tumor suppressor protein; for colon cancer diagnostics and therapeutics.

Johns Hopkins Univ. WO 00/11201

Alphavirus gene therapy


Recombinant alphavirus vectors having an incorporated cell targeting gene; for gene therapy.

Johns Hopkins Univ. WO 00/11204

Calcium mobilization modulators


Homer interacting protein; for finding modulators of calcium mobilization and receptor clustering.

Johns Hopkins Univ. WO 00/11219

Tumor mutation assay


Assay for single basepair mutations in the mitochondrial genome; for detecting tumor formation.

Kirin WO 00/10383

Chromosomal transgenics


Modified foreign chromosomes constructed in cells with high homologous recombination efficiency; for making trangenics.

Kirin WO 00/10384

Neuraminate transgenics


Transgenics and derived cells having a disrupted CMP-N-acetylneuraminate hydroxylase gene.

Kleesiek, K. WO 00/11034

Thrombosis diagnostics

Bad Oeynhausen, Germany

Tissue factor pathway inhibitor mutant, encoding gene sequences; for thrombosis diagnostics and therapeutics.

Lexingen Pharma WO 00/11033

Angiogenesis inhibitor fusions

Lexington, Mass.

Fusions of angiogenesis inhibitors with immunoglobulin fragments; for treating cancer.

Maryland, Univ. of WO 00/11217

Enhanced transfection


Gene delivery system including nucleases; for enhanced transfection.

Mass. Gen. Hosp. WO 00/11016 & 11157

Dysferlin mutations


Dysferlin gene mutations associated with distal myopathy and limb girdle muscular dystrophy, encoded protein.

Mass. Gen. Hosp. WO 00/11147

Pig tissues for transplant


Inbred miniature swine having MHC and leukocyte antigens homozygous to humans; for transplant tolerance.

Metabolix WO 00/11188

Bioploymer production

Cambridge, Mass.

Microbial strains with polyhydroxyalkanoate synthesis genes inserted by transposons; for biopolymer production.

Millennium Pharma WO 00/11166

G-protein receptor

Cambridge, Mass.

14274, a G-protein receptor of the EDG receptor family, encoding gene; for modulator screens and diagnostics.

Millennium Pharma WO 00/11170

G-protein receptor

Cambridge, Mass.

14000, a G-protein receptor of the EDG receptor family, encoding gene; for modulator screens and diagnostics.

Miyagi Ken EPO 984 061

Ganglioside modulators

Miyagi, Japan

Plasma membrane sialidases, encoding gene, variants; for removing sialate residues from gangliosides.

Mt. Sinai Hosp. WO 00/11141

tRNA synthesis modulators


Peptides having tRNA binding domains; for testing modulators of the interaction between tRNA and tRNA synthetase.

Nabel, G.J., et al. WO 00/11165

Cell growth control

Ann Arbor, Mich.

Human kis, a kinase that inhibits cyclin-dependent kinase inhibitor p27; for controlling cell growth.

NIH (Natl. Inst. Hlth.) WO 00/11036

Antiviral antibodies

Bethesda, Md.

Anti-cyanovirin antibody having an internal image of gp120; for treating viral infections.

NIH (Natl. Inst. Hlth.) WO 00/11186

Hepatitis C peptide vaccines

Bethesda, Md.

Modified hepatitis C core peptides, encoding gene sequences; for making vaccines.

Neovacs WO 00/11225

HIV infection monitoring


Assay for serum levels of anti-tat antibodies and p24 protein; for determining HIV infection prognosis.

New Jersey, Med. & Dent. Univ. WO 00/11148

Cold-shock response control

New Brunswick, N.J.

Cold-shock inducible gene regulatory elements, vectors; for modulating cold-shock responses.

Novartis WO 00/11027

Multiple sclerosis treatment

Vienna, Austria

Treating multiple sclerosis using peptide analogs of human myelin basic protein.

Novo Nordisk WO 00/11211 & 11212

Catalyst selection

Bagsvaerd, Denmark

In vitro selection of catalysts from libraries using an enzyme activity screen.

Oklahoma Med. Res. Fdn. WO 00/10609

Large vessel targeting

Oklahoma City

Targeting of molecules to large vessel endothelium using the endothelial protein C receptor.

Princeton Univ. WO 00/11168

Blood stem cell expansion

Princeton, N.J.

Genes regulating hematopoietic stem cell formation, encoded proteins, methods for expanding blood stem cells.

Regeneron Pharma WO 00/11163

Antagonizing BMP action

Tarrytown, N.Y.

DCR5, a bone morphogenetic protein (BMP) binding protein, encoding gene sequences; for antagonizing BMP action.

Res. Develop. Fdn. WO 00/10612

Cancer gene therapy

Carson City, Nev.

Gene therapy vectors having sequences allowing sustained or regulatable expression; for treating various cancers.

Sankyo WO 00/11193

Antiviral screens


Virus activation protease, encoding gene sequences, variants; for screening antivirals.

Schering WO 00/11184

Staphylococcus antibacterials

Kenilworth, N.J.

Staphylococcus aureus polypeptides, encoding gene sequences, antibodies, production methods; for antibacterials.

Scripps Res. Inst. WO 00/11206

Protein function prediction

La Jolla, Calif.

Geometric representations of protein functional sites; for predicting protein function from inexact structures.

SmithKline Beecham WO 00/10583

Histone deacetylase


Human histone deacetylase gene, encoded protein, production techniques; for diagnostics and therapeutics.

SmithKline Beecham WO 00/11143

Phoaphatidylinositol kinase

Brentford, UK

Human phosphatidylinositol 3-kinase regulatory P101 subunit, encoding gene; for diagnostics and therapeutics.

SmithKline Beecham WO 00/11182

Meningitis therapeutics

Rixensart, Belgium

Outer membrane protein of Neisseria meningitidis, encoding gene, production methods; for diagnostics and therapeutics.

Stanford Univ. WO 00/11155

Gene integration

Palo Alto, Calif.

Site-specific integration of gene sequences using recombination sites and recombinases; for gene therapy.

Stanford Univ. WO 00/11214

Mycobacterial gene deletions

Palo Alto, Calif.

Specific deletions in mycobacterial isolate genes; for distinguishing pathogenic strains and improving vaccines.

Sumitomo Electric WO 00/11146

Increased protein from milk

Osaka, Japan

Epimorphine from cows and sheep which causes differentiation of milk-producing cells; for increased protein yield.

T.Breeders WO 00/11139

Hemangioblast production

Worcester, Mass.

Cell populations containing non-fetal hemangioblasts, methods of production.

Washington, Univ. of WO 00/11152

Vascular device coatings


Streptavidin mutants having secondary functional domains with cell adhesion activity; for coating vascular devices.

Washington Univ. WO 00/11162

Apoptosis modulation

St. Louis, Mo.

p15 BID polypeptide produced by caspase cleavage of BID; for modulating apoptosis.

Washington Univ. WO 00/11220

DNA diagnostic methods

St. Louis

Gene-based diagnostic methods using template-directed primer extension and detection by fluorescence polarization.

Wieslab WO 00/11475

Goodpasture autoantibodies

Lund, Sweden

Autoantibodies to the non-collagenous domain of the a3 chain of type IV collagen; for Goodpasture disease diagnosis.

Wistar Inst. WO 00/11140

Mucosal immunity enhancement


Enhancing mucosal immunity by pre-administration of a pathogene antigen gene via a non-mucosal route.

Yale Univ. WO 00/10602

Cancer therapeutics assay

New Haven, Conn.

Transgenics with disrupted a lats gene which develop a variety of tumors; for testing cancer therapeutics.

Yamanouchi GB 2 341 182

Growth control protein

Littlemore Park, UK

SH3 domain protein concentrated in cell nuclei during interphase, encoding gene, antibodies; for growth control.