Published March 1 (EPO); February 24 (WO)

Advanced Res. & Technol. Inst. WO 00/09670

Papillomavirus vaccines

Bloomington, Ind.

Purified live, infectious human papillomavirus; for testing vaccines and antiviral agents.

Alberta, Univ. of WO 00/09710

Fatty acid oxidation modulators

Edmonton, Alberta

Mammalian malonyl CoA decarboxylase, encoding genes; for finding modulators to control fatty acid oxidation.

Amgen WO 00/09692

Heart disease modulators

Thousand Oaks, Calif.

Peptides that modulate inflammatory heart disease, encoding gene sequences, production methods; for therapeutics.

Amgen WO 00/09714

Cyclin D-mediated gene expression

Thousand Oaks, Calif.

Cyclin D-mediated overexpression of gene transfected into eukaryotic cells.

Angeletti Molec. Biol. Res. Inst. WO 00/09713

EPO anemia treatment

Pomezia, Italy

Adenoviral vectors encoding erythropoietin (EPO); for repeat administration to treat anemias and _-thalassemia.

Asahi WO 00/09683

Bacterial detection probes


Gene probes from ribosomal RNA for detecting Pectinatus bacteria.

Aventis Pharma WO 00/09675

Adenovirus vector storage

Collegeville, Penn.

Preservation of recombinant adenovirus stocks of high titer using albumin; for gene therapy.

Bionebraska WO 00/09553

Antimicrobial peptides

Lincoln, Neb.

Antimicrobial peptides isolated from the skin of American Rana frogs, modified and truncated versions.

Bridgehead Technol. WO 00/09167

Proteosome inhibition

Melton Mowbray, U.K.

Virally-mediated targeting of drugs and genetic material for inhibiting proteosomal function.

Burnham Inst. WO 00/09759

Cancer diagnosis methods

La Jolla, Calif.

Methods for identifying somatic changes in genomic sequences; for cancer diagnosis and prognosis.

California, Univ. of EPO 982 398

_-lactamase reporter

Oakland, Calif.

Expression control gene sequences from the _-lactamase gene, for expressing _-lactamase and using it as a reporter.

California, Univ. of WO 00/09733

Intracellular delivery vehicle

Oakland, Calif.

Non-virulent bacteria transfected with therapeutic genes; for intracellular delivery of therapeutics.

California, Univ. of WO 00/09758

Cancer-associated gene sequences

Oakland, Calif.

Gene sequences in the 20q13 region of human chromosome 20 that are associated with cancer.

California Inst. Technol. WO 00/09532

Transcription modulation

Pasadena, Calif.

Modulation of transcription by the use of antibodies to transcription factors introduced into cells by viruses.

California Inst. Technol. WO 00/09676

Neuron formation

Pasadena, Calif.

Methods of inducing non-neuronal cells to differentiate into neurons; for neuron formation.

California Pacific Med. Ctr. WO 00/09655

Cancer-associated genes

San Francisco

Detection of cancer-associated genes using differential expression techniques; for diagnostics and therapeutics.

Caliper Technol. WO 00/09753

Fluorescent DNA sequencing

Mountain View, Calif.

Distinguishing various fluorophores based on decay times of their fluorescence; for DNA sequencing methods.

Canadian Blood Services WO 00/09745

Gene variation identification

Ottawa, Ont.

Primer-specific and mispair extension assay for identifying gene variation.

Children's Hosp. WO 00 /09668

Neural stem cells


Neural stem cells isolated from fetal telencephalon; for transplantation into the central nervous system.

Chiron EPO 982 405

Alphavirus vectors

Emeryville, Calif.

Recombinant alphavirus vectors free of contamination with wild type virus; for making gene therapy vectors.

Chiron WO 00/09665

Engineered antigen-presenting cells

Emeryville, Calif.

Differential expression assays on target cells; for finding antigen genes to transfect into antigen presenting cells.

Chiron WO 00/09680

Purifying non-chromosomal DNA

Emeryville, Calif.

Methods for purifying non-chromosomal nucleic acids from cells by applying lysates to depth filters.

Chiron WO 00/09699

HPV capsid antibodies

Emeryville, Calif.

Viral-like particles with capsid proteins from HPV-6 and 16, expression in yeast; for raising antibodies.

Columbia Univ. WO 00/09662

Long-term memory modulators

New York

Transgenics with increased brain-specific calcineurin activity; for long-term memory modulator screens.

Danisco WO 00/09705

Cell selection


Selection of genetically transformed cells from a cell population using expressed products.

Darwin Discovery WO 00/09693

immunomodulatory therapeutics

Cambridge, U.K.

Mouse scurfy phenotype gene, human ortholog; for developing therapeutics that modulate the immune system.

DNAVec Res. WO 00/09700

RNA gene therapy vector

Ibaraki, Japan

RNA virus vector having contact infiltration capability; for gene transfer in gene therapy.

East Carolina Univ. WO 00/09525

Airway disease antisense

Greenville, N.C.

Low adenosine antisense oligonucleotides for genes involved in airway diseases.

Elan Pharma WO 00/09534

Potassium channel

S. San Francisco

Potassium channel subunit, encoding gene, antibodies, screening assays; for diagnostics and therapeutics.

European Molec. Biol. Lab WO 00/09716

Detecting protein complexes

Heidelberg, Germany

Detection and purification of proteins and protein complexes using fusion proteins, encoding genes, and vectors.

Galili, U. WO 00/09155

Preventing xenograft rejection

Chicago, Ill.

Toxin complexes that recognize xenograft antigen binding sites; for preventing rejection.

Genetics Inst. WO 00/09551

Chordin-related proteins

Cambridge, Mass.

Human chordin-related proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.

Genetics Inst. WO 00/09552

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

Genzyme WO 00/09153

Fabry disease therapy

Framingham, Mass.

Expression of active human a-galactosidase A in cells of Fabry disease patients; for disease treatment.

Georgetown Univ. WO 00/09549

Benzodiazepine receptor modulation

Washington, D.C.

Peripheral-type benzodiazepine receptor-associated proteins, encoding gene sequences; for receptor modulation.

Haldane Res. WO 00/09731

Gene therapy parasites

Huntingdon, U.K.

Transgenic, non-pathogenic parasites; for delivery to eukaryotes as gene therapy agents.

Harvard Univ. WO 00/09657

Anti-angiogenic therapeutics

Cambridge, Mass.

Inhibitors of endothelial PAS domain protein-1 binding to angiogenic factor gene regulator sequences.

Harvard Univ. WO 00/09689

Vascular muscle gene

Cambridge, Mass.

Aortic and striated muscle cell-expressed protein isoforms, encoding gene; for vascular disease therapeutics.

Hawaii, Univ. of WO 00/09674

Transgenic production

Honolulu, Hawaii

Coinjection of unfertilized oocytes with sperm heads and transgenes; for transgenic production.

Human Genome Sciences WO 00/09148


Rockville, Md.

Vascular endothelial cell growth factor (VEGF) 3, encoding gene, antibodies; for diagnostics and therapeutics.

Incyte Pharma WO 00/09690

Extracellular adhesive proteins

Palo Alto, Calif.

Extracellular adhesive proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 00/09709


Palo Alto, Calif.

Proteases, protease-associated proteins, encoding gene sequences, antibodies, modulators; for therapeutics.

Intronn Holdings WO 00/09734

RNA trans-splicing

Silver Springs, Md.

Spliceosome-mediated RNA trans-splicing; for exon tagging and adding protein affinity purification tags.

Janssen Pharma EPO 982 401 & WO 00/09695

Yeast infection therapeutics

Beerse, Belgium

Candida albicans yeast strains having mutated growth and survival genes, encoded proteins; for finding modulators.

Japan Sci. & Technol. WO 00/09684

Ras target protein DNA ligand

Saitama, Japan

Nucleic acid sequences that bind to Ras target protein; for finding modulators and making disease therapeutics.

Johns Hopkins Univ. WO 00/09526

Tumor suppressor localization

Baltimore, Md.

Methods an compositions for nuclear localization of a tumor suppressor; for diagnostics and therapeutics.

Johnson & Johnson WO 00/09672

Restenosis DNAzyme

North Sydney, Australia

DNAzyme that specifically cleaves c-myc mRNA; for applying to stents to treat restenosis.

Johnson & Johnson WO 00/09673

Papillomavirus DNAzyme

North Sydney, Australia

DNAzyme that specifically cleaves human papillomavirus mRNA; for inhibiting infection and its progression.

Johnson & Johnson WO 00/09754

Skin disorder gene

Skillman, N.J.

Human stearoyl-CoA desaturase gene, encoded protein, antibodies, transgenics, vectors; for skin disorders.

Kazusa DNA Res. Inst. Fdn. WO 00/09557

Protaglandin transporter

Chiba, Japan

Human-derived protein with prostaglandin transport activity, encoding gene sequences; for diagnostics and therapeutics.

Kazusa DNA Res. Inst. Fdn. WO 00/09688

Oxysterol binding protein

Chiba, Japan

Oxysterol binding protein derived from human brain, encoding gene sequence; for identifying modulators.

Lexicon Genetics WO 00/09681

Normalized cDNA libraries

The Woodlands, Texas

Efficient construction of normalized cDNA libraries from eukaryotic cells using transgenic construct markers.

Loma Linda Univ. WO 00/09156

Peridontal disease treatment

Loma Linda, Calif.

Non-virulent recA defective mutant of Porphyromonas gingivalis; for treating periodontal disease.

MRC (Med. Res. Counc.) WO 00/09686

Obesity induction transgenics


Gene responsible for inducing obesity and infertility in transgenics, produced transgenics; for finding modulators.

Medvet Science WO 00/09561

Cytokine antibodies

Adelaide, Australia

Monoclonal inhibitor of GM-CSF, interleukin (IL)-3, IL-5, and other cytokines, fragments.

Meiji Milk Products WO 00/09718

MK family protein production


Yeast strains transfected with MK family protein genes; for secretion of MK family proteins.

Merck WO 00/09157

Papillomavirus vaccines

Rahway, N.J.

Protein delivery system using human papillomavirus-like particles having modified fused L2 proteins; for vaccines.

Michigan, Univ. of WO 00/09533

von Willebrand disease therapy

Ann Arbor, Mich.

Gene sequences encoding von Willebrand Factor, encoded protein; for disease diagnostics and therapeutics.

New York, State Univ. of WO 00/09550

Anti-fungal screens

Albany, N.Y.

Vanadate resistance glycosylation 4 gene, pathogenic fungi sugar transporter; for anti-fungal screens.

New York Blood Ctr. WO 00/09562

Fibrinolytic state diagnosis

New York

Cleaved fragments of fibrinogen, encoding gene sequences, antibodies; for diagnosis of fibrinolytic states.

NIH (Natl. Inst. Hlth.) WO 00/09111

Inhibiting amyloid formation

Bethesda, Md.

Tetrapyrroles and metal ion complexes; for inhibiting amyloid protein formation.

NIH (Natl. Inst. Hlth.) WO 00/09168

Cellular transfection

Bethesda, Md.

Cellular transfection in a flexible culture container using viral vectors and multi-functional chemical moieties.

NIH (Natl. Inst. Hlth. WO 00/09666

Cellular diabetes treatment

Bethesda, Md.

Differentiation of non-insulin producing cells into insulin producing cells using growth factors; for diabetes.

NIH (Natl. Inst. Hlth.) WO 00/09760

Pneumocystis carinii detection

Bethesda, Md.

Major surface glycoprotein gene of human Pneumocystis carinii; for PCR-based detection in AIDS patients.

Oregon, Univ. of WO 00/09658

Circadian clock proteins

Eugene, Ore.

Genes encoding proteins that regulate circadian clock function and photoperiodism.

Packard Bioscience WO 00/09738

Gene sequencing

Meriden, Conn.

Rolling circle-based analysis of nucleotide sequences; for gene sequencing.

Pangene WO 00/09755

Domain-specific gene evolution

Mountain View, Calif.

Rapid evolution of specific protein domains using a recombinase and recombination intermediates.

Pennsylvania, Univ. of WO 00/09741

Interacting protein isolation


Methods of identifying and isolating proteins that interact with other biomolecules.

Pennsylvania, Univ. of WO 00/09750

Hydrodynamic stress genes


Identification of genes whose expression is regulated by cellular hydrodynamic stress.

Pennsylvania, Univ. of WO 00/09752

Prostate cancer diagnostic


Cytochrome P3A4 gene variant, encoded protein; for diagnosing increased risk for developing prostate cancer.

Perkin-Elmer WO 00/09756

Gene expression analysis

Foster City, Calif.

Terminal and internal fragment probes; for adapter-directed gene expression analysis.

Perry, A.C.F., et al. WO 00/08924

Transgenesis methods

Honolulu, Hawaii

Piezo-electric actuated microinjection of nucleic acids and nuclei into unfertilized oocytes; for making transgenics.

Phylos WO 00/09737

RNA-protein fusion formation

Lexington, Mass.

Production of nucleic acids lacking 3'-untranslated regions; for optimizing cellular RNA-protein fusion formation.

Proteus WO 00/09679

Recombined nucleotide sequences

Nimes, France

Methods for obtaining in vitro recombined polynucleotide sequences using sequence banks, resulting sequences.

Scripps Res. Inst. WO 00/09715

Phage peptide display

La Jolla, Calif.

Modulation of peptide display on modified filamentous phage; for presenting foreign proteins.

Scripps Res. Inst. WO 00/09736

Bacterial polysaccharide analysis

La Jolla, Calif.

a2,8/2,9 polysialyltransferase; for analyzing E. coli capsular polysaccharides.

Shanghai Second Med. Univ. WO 00/09554

Human HSPC018 gene


Human HSPC018 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 00/09555

Human HSPC021 gene


Human HSPC021 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 00/09556

Human lysophospholipase


Human lysophospholipase gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.

Shanghai Second Medical Univ. WO 00/09685

Human HSPC011 gene


Human HSPC011 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.

Signal Pharma WO 00/09669

Cellular Parkinson's therapy

San Diego, Calif.

Conditionally-immortalized mesencephalon cell lines; for generating dopaminergic neurons to treat Parkinson's.

SmithKline Beecham EPO 982 400

Glycine transporter

Brentford, U.K.

Human glycine transporter, encoding gene sequences, production techniques; for diagnostics and therapeutics.

SmithKline Beecham WO 00/09541

Bacterial nrdE proteins


Bacterial nrdE proteins, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/09694

Moraxella antigen

Rixensart, Belgium

Moraxella catarrhalis antigen, encoding gene sequences, production methods; for diagnostics and therapeutics.

Stichting Blood Inst. EPO 982 397

Factor XII mimics


Peptide mimics of a Factor XII fragment; for preventing activation of blood coagulation by surface contact.

Stichting Endocrinology Inst. EPO 982 399

Thyroid hormone transporters

Rotterdam, Netherlands

Thyroid hormone transporters, encoding gene sequences, modulators; for diagnostics and therapeutics.

Stichting Health Inst. EPO 982 402 & WO 00/09701

Pestivirus vaccines

Lelystad, Netherlands

Gene sequences from pestivirus, encoded proteins, chimeric viruses; for vaccines.

Stichting Inst. WO 00/09749

Stable gene expression promotion

Nieuwegein, Netherlands

Detection of nucleic acid sequences that contribute to the promotion of stable gene expression.

Taisho Pharma WO 00/09687

Inflammation regulator


Human monocyte derived-protein, encoding gene sequences; for regulating inflammation.

Texas, Univ. of WO 00/09667

Altering muscle phenotype

Austin, Texas

Alteration and regulation of muscle cell fiber type by calcineurin modulation.

Texas, Univ. of WO 00/09677

Sterol-regulated protease modulators

Austin, Texas

Sterol-regulated site-1 protease, transgenics; for identifying modulators.

Thomas Jefferson Univ. WO 00/09145

Cancer immunoreponse


Culturing tumor cells with a pro-apoptotic agent, insertion into patients; for inducing immunoresponse to cancer.

Thomas Jefferson Univ. WO 00/09730

Vector internalization


Cell type-specific gene transfer with retroviral vectors having antibody-envelope fusion proteins for cell uptake.

Tularik WO 00/09678

IRAK3 kinase

S. San Francisco

IRAK3 kinase, encoding gene, recombinant production methods, antibodies; for diagnostics and therapeutics.

Urogenesys WO 00/09691

Prostate cancer diagnostic

Santa Monica, Calif.

Brain-specific protein expressed by prostate and bladder cancer; for cancer diagnostics and therapeutics.

Vasopharm Biotech WO 00/09711

NO metabolism control

Wurzburg, Germany

Human soluble guanylylcyclase a1/_1, encoding gene, antibodies; for modulating nitric oxide (NO) metabolism.

Wallaart, T.E. EPO 982 404

Anti-malarial drugs

Groningen, Netherlands

Gene sequences encoding amorpha-4,11-diene synthase, production methods; for making anti-malarial drugs.

Walter Reed Army Inst. Res. WO 00/09154

Bacterial superantigen vaccine

Washington, D.C.

Altered superantigen toxin where superantigen activity is absent but it is effectively recognized; for vaccines.

Warner-Lambert WO 00/09732

Cryoprotectant transfection

Morris Plains, N.J.

Electroporation buffer having cryoprotectant capabilities; for simultaneous transfection and long-term storage.

Western Ontario, Univ. of WO 00/09703

HIV vaccines

London, Ont.

Avirulent, non-cytolytic recombinant HIV strain having the nef gene deleted; for vaccines.

Zeneca WO 00/09704

Gene switch


Chemically inducible promoter sequences linked to a reporter gene; for gene activity assays.

Zeneca WO 00/09708

Cell function inhibitors


Protease genes controlled by inducible promoters; for identifying inhibitors of cell function and growth.

Zycos WO 00/9654

EST profiles

Cambridge, Mass.

Profiling and cataloging expressed protein tags (ESTs) in any given cell, computer-assisted manipulation of profiles.