Published March 1 (EPO); February 24 (WO)
Advanced Res. & Technol. Inst. WO 00/09670
Papillomavirus vaccines
Bloomington, Ind.
Purified live, infectious human papillomavirus; for testing vaccines and antiviral agents.
Alberta, Univ. of WO 00/09710
Fatty acid oxidation modulators
Edmonton, Alberta
Mammalian malonyl CoA decarboxylase, encoding genes; for finding modulators to control fatty acid oxidation.
Amgen WO 00/09692
Heart disease modulators
Thousand Oaks, Calif.
Peptides that modulate inflammatory heart disease, encoding gene sequences, production methods; for therapeutics.
Amgen WO 00/09714
Cyclin D-mediated gene expression
Thousand Oaks, Calif.
Cyclin D-mediated overexpression of gene transfected into eukaryotic cells.
Angeletti Molec. Biol. Res. Inst. WO 00/09713
EPO anemia treatment
Pomezia, Italy
Adenoviral vectors encoding erythropoietin (EPO); for repeat administration to treat anemias and _-thalassemia.
Asahi WO 00/09683
Bacterial detection probes
Tokyo
Gene probes from ribosomal RNA for detecting Pectinatus bacteria.
Aventis Pharma WO 00/09675
Adenovirus vector storage
Collegeville, Penn.
Preservation of recombinant adenovirus stocks of high titer using albumin; for gene therapy.
Bionebraska WO 00/09553
Antimicrobial peptides
Lincoln, Neb.
Antimicrobial peptides isolated from the skin of American Rana frogs, modified and truncated versions.
Bridgehead Technol. WO 00/09167
Proteosome inhibition
Melton Mowbray, U.K.
Virally-mediated targeting of drugs and genetic material for inhibiting proteosomal function.
Burnham Inst. WO 00/09759
Cancer diagnosis methods
La Jolla, Calif.
Methods for identifying somatic changes in genomic sequences; for cancer diagnosis and prognosis.
California, Univ. of EPO 982 398
_-lactamase reporter
Oakland, Calif.
Expression control gene sequences from the _-lactamase gene, for expressing _-lactamase and using it as a reporter.
California, Univ. of WO 00/09733
Intracellular delivery vehicle
Oakland, Calif.
Non-virulent bacteria transfected with therapeutic genes; for intracellular delivery of therapeutics.
California, Univ. of WO 00/09758
Cancer-associated gene sequences
Oakland, Calif.
Gene sequences in the 20q13 region of human chromosome 20 that are associated with cancer.
California Inst. Technol. WO 00/09532
Transcription modulation
Pasadena, Calif.
Modulation of transcription by the use of antibodies to transcription factors introduced into cells by viruses.
California Inst. Technol. WO 00/09676
Neuron formation
Pasadena, Calif.
Methods of inducing non-neuronal cells to differentiate into neurons; for neuron formation.
California Pacific Med. Ctr. WO 00/09655
Cancer-associated genes
San Francisco
Detection of cancer-associated genes using differential expression techniques; for diagnostics and therapeutics.
Caliper Technol. WO 00/09753
Fluorescent DNA sequencing
Mountain View, Calif.
Distinguishing various fluorophores based on decay times of their fluorescence; for DNA sequencing methods.
Canadian Blood Services WO 00/09745
Gene variation identification
Ottawa, Ont.
Primer-specific and mispair extension assay for identifying gene variation.
Children's Hosp. WO 00 /09668
Neural stem cells
Boston
Neural stem cells isolated from fetal telencephalon; for transplantation into the central nervous system.
Chiron EPO 982 405
Alphavirus vectors
Emeryville, Calif.
Recombinant alphavirus vectors free of contamination with wild type virus; for making gene therapy vectors.
Chiron WO 00/09665
Engineered antigen-presenting cells
Emeryville, Calif.
Differential expression assays on target cells; for finding antigen genes to transfect into antigen presenting cells.
Chiron WO 00/09680
Purifying non-chromosomal DNA
Emeryville, Calif.
Methods for purifying non-chromosomal nucleic acids from cells by applying lysates to depth filters.
Chiron WO 00/09699
HPV capsid antibodies
Emeryville, Calif.
Viral-like particles with capsid proteins from HPV-6 and 16, expression in yeast; for raising antibodies.
Columbia Univ. WO 00/09662
Long-term memory modulators
New York
Transgenics with increased brain-specific calcineurin activity; for long-term memory modulator screens.
Danisco WO 00/09705
Cell selection
Copenhagen
Selection of genetically transformed cells from a cell population using expressed products.
Darwin Discovery WO 00/09693
immunomodulatory therapeutics
Cambridge, U.K.
Mouse scurfy phenotype gene, human ortholog; for developing therapeutics that modulate the immune system.
DNAVec Res. WO 00/09700
RNA gene therapy vector
Ibaraki, Japan
RNA virus vector having contact infiltration capability; for gene transfer in gene therapy.
East Carolina Univ. WO 00/09525
Airway disease antisense
Greenville, N.C.
Low adenosine antisense oligonucleotides for genes involved in airway diseases.
Elan Pharma WO 00/09534
Potassium channel
S. San Francisco
Potassium channel subunit, encoding gene, antibodies, screening assays; for diagnostics and therapeutics.
European Molec. Biol. Lab WO 00/09716
Detecting protein complexes
Heidelberg, Germany
Detection and purification of proteins and protein complexes using fusion proteins, encoding genes, and vectors.
Galili, U. WO 00/09155
Preventing xenograft rejection
Chicago, Ill.
Toxin complexes that recognize xenograft antigen binding sites; for preventing rejection.
Genetics Inst. WO 00/09551
Chordin-related proteins
Cambridge, Mass.
Human chordin-related proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.
Genetics Inst. WO 00/09552
Secreted proteins
Cambridge, Mass.
Secreted proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
Genzyme WO 00/09153
Fabry disease therapy
Framingham, Mass.
Expression of active human a-galactosidase A in cells of Fabry disease patients; for disease treatment.
Georgetown Univ. WO 00/09549
Benzodiazepine receptor modulation
Washington, D.C.
Peripheral-type benzodiazepine receptor-associated proteins, encoding gene sequences; for receptor modulation.
Haldane Res. WO 00/09731
Gene therapy parasites
Huntingdon, U.K.
Transgenic, non-pathogenic parasites; for delivery to eukaryotes as gene therapy agents.
Harvard Univ. WO 00/09657
Anti-angiogenic therapeutics
Cambridge, Mass.
Inhibitors of endothelial PAS domain protein-1 binding to angiogenic factor gene regulator sequences.
Harvard Univ. WO 00/09689
Vascular muscle gene
Cambridge, Mass.
Aortic and striated muscle cell-expressed protein isoforms, encoding gene; for vascular disease therapeutics.
Hawaii, Univ. of WO 00/09674
Transgenic production
Honolulu, Hawaii
Coinjection of unfertilized oocytes with sperm heads and transgenes; for transgenic production.
Human Genome Sciences WO 00/09148
VEGF 3
Rockville, Md.
Vascular endothelial cell growth factor (VEGF) 3, encoding gene, antibodies; for diagnostics and therapeutics.
Incyte Pharma WO 00/09690
Extracellular adhesive proteins
Palo Alto, Calif.
Extracellular adhesive proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 00/09709
Proteases
Palo Alto, Calif.
Proteases, protease-associated proteins, encoding gene sequences, antibodies, modulators; for therapeutics.
Intronn Holdings WO 00/09734
RNA trans-splicing
Silver Springs, Md.
Spliceosome-mediated RNA trans-splicing; for exon tagging and adding protein affinity purification tags.
Janssen Pharma EPO 982 401 & WO 00/09695
Yeast infection therapeutics
Beerse, Belgium
Candida albicans yeast strains having mutated growth and survival genes, encoded proteins; for finding modulators.
Japan Sci. & Technol. WO 00/09684
Ras target protein DNA ligand
Saitama, Japan
Nucleic acid sequences that bind to Ras target protein; for finding modulators and making disease therapeutics.
Johns Hopkins Univ. WO 00/09526
Tumor suppressor localization
Baltimore, Md.
Methods an compositions for nuclear localization of a tumor suppressor; for diagnostics and therapeutics.
Johnson & Johnson WO 00/09672
Restenosis DNAzyme
North Sydney, Australia
DNAzyme that specifically cleaves c-myc mRNA; for applying to stents to treat restenosis.
Johnson & Johnson WO 00/09673
Papillomavirus DNAzyme
North Sydney, Australia
DNAzyme that specifically cleaves human papillomavirus mRNA; for inhibiting infection and its progression.
Johnson & Johnson WO 00/09754
Skin disorder gene
Skillman, N.J.
Human stearoyl-CoA desaturase gene, encoded protein, antibodies, transgenics, vectors; for skin disorders.
Kazusa DNA Res. Inst. Fdn. WO 00/09557
Protaglandin transporter
Chiba, Japan
Human-derived protein with prostaglandin transport activity, encoding gene sequences; for diagnostics and therapeutics.
Kazusa DNA Res. Inst. Fdn. WO 00/09688
Oxysterol binding protein
Chiba, Japan
Oxysterol binding protein derived from human brain, encoding gene sequence; for identifying modulators.
Lexicon Genetics WO 00/09681
Normalized cDNA libraries
The Woodlands, Texas
Efficient construction of normalized cDNA libraries from eukaryotic cells using transgenic construct markers.
Loma Linda Univ. WO 00/09156
Peridontal disease treatment
Loma Linda, Calif.
Non-virulent recA defective mutant of Porphyromonas gingivalis; for treating periodontal disease.
MRC (Med. Res. Counc.) WO 00/09686
Obesity induction transgenics
London
Gene responsible for inducing obesity and infertility in transgenics, produced transgenics; for finding modulators.
Medvet Science WO 00/09561
Cytokine antibodies
Adelaide, Australia
Monoclonal inhibitor of GM-CSF, interleukin (IL)-3, IL-5, and other cytokines, fragments.
Meiji Milk Products WO 00/09718
MK family protein production
Tokyo
Yeast strains transfected with MK family protein genes; for secretion of MK family proteins.
Merck WO 00/09157
Papillomavirus vaccines
Rahway, N.J.
Protein delivery system using human papillomavirus-like particles having modified fused L2 proteins; for vaccines.
Michigan, Univ. of WO 00/09533
von Willebrand disease therapy
Ann Arbor, Mich.
Gene sequences encoding von Willebrand Factor, encoded protein; for disease diagnostics and therapeutics.
New York, State Univ. of WO 00/09550
Anti-fungal screens
Albany, N.Y.
Vanadate resistance glycosylation 4 gene, pathogenic fungi sugar transporter; for anti-fungal screens.
New York Blood Ctr. WO 00/09562
Fibrinolytic state diagnosis
New York
Cleaved fragments of fibrinogen, encoding gene sequences, antibodies; for diagnosis of fibrinolytic states.
NIH (Natl. Inst. Hlth.) WO 00/09111
Inhibiting amyloid formation
Bethesda, Md.
Tetrapyrroles and metal ion complexes; for inhibiting amyloid protein formation.
NIH (Natl. Inst. Hlth.) WO 00/09168
Cellular transfection
Bethesda, Md.
Cellular transfection in a flexible culture container using viral vectors and multi-functional chemical moieties.
NIH (Natl. Inst. Hlth. WO 00/09666
Cellular diabetes treatment
Bethesda, Md.
Differentiation of non-insulin producing cells into insulin producing cells using growth factors; for diabetes.
NIH (Natl. Inst. Hlth.) WO 00/09760
Pneumocystis carinii detection
Bethesda, Md.
Major surface glycoprotein gene of human Pneumocystis carinii; for PCR-based detection in AIDS patients.
Oregon, Univ. of WO 00/09658
Circadian clock proteins
Eugene, Ore.
Genes encoding proteins that regulate circadian clock function and photoperiodism.
Packard Bioscience WO 00/09738
Gene sequencing
Meriden, Conn.
Rolling circle-based analysis of nucleotide sequences; for gene sequencing.
Pangene WO 00/09755
Domain-specific gene evolution
Mountain View, Calif.
Rapid evolution of specific protein domains using a recombinase and recombination intermediates.
Pennsylvania, Univ. of WO 00/09741
Interacting protein isolation
Philadelphia
Methods of identifying and isolating proteins that interact with other biomolecules.
Pennsylvania, Univ. of WO 00/09750
Hydrodynamic stress genes
Philadelphia
Identification of genes whose expression is regulated by cellular hydrodynamic stress.
Pennsylvania, Univ. of WO 00/09752
Prostate cancer diagnostic
Philadelphia
Cytochrome P3A4 gene variant, encoded protein; for diagnosing increased risk for developing prostate cancer.
Perkin-Elmer WO 00/09756
Gene expression analysis
Foster City, Calif.
Terminal and internal fragment probes; for adapter-directed gene expression analysis.
Perry, A.C.F., et al. WO 00/08924
Transgenesis methods
Honolulu, Hawaii
Piezo-electric actuated microinjection of nucleic acids and nuclei into unfertilized oocytes; for making transgenics.
Phylos WO 00/09737
RNA-protein fusion formation
Lexington, Mass.
Production of nucleic acids lacking 3'-untranslated regions; for optimizing cellular RNA-protein fusion formation.
Proteus WO 00/09679
Recombined nucleotide sequences
Nimes, France
Methods for obtaining in vitro recombined polynucleotide sequences using sequence banks, resulting sequences.
Scripps Res. Inst. WO 00/09715
Phage peptide display
La Jolla, Calif.
Modulation of peptide display on modified filamentous phage; for presenting foreign proteins.
Scripps Res. Inst. WO 00/09736
Bacterial polysaccharide analysis
La Jolla, Calif.
a2,8/2,9 polysialyltransferase; for analyzing E. coli capsular polysaccharides.
Shanghai Second Med. Univ. WO 00/09554
Human HSPC018 gene
Shanghai
Human HSPC018 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 00/09555
Human HSPC021 gene
Shanghai
Human HSPC021 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 00/09556
Human lysophospholipase
Shanghai
Human lysophospholipase gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.
Shanghai Second Medical Univ. WO 00/09685
Human HSPC011 gene
Shanghai
Human HSPC011 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.
Signal Pharma WO 00/09669
Cellular Parkinson's therapy
San Diego, Calif.
Conditionally-immortalized mesencephalon cell lines; for generating dopaminergic neurons to treat Parkinson's.
SmithKline Beecham EPO 982 400
Glycine transporter
Brentford, U.K.
Human glycine transporter, encoding gene sequences, production techniques; for diagnostics and therapeutics.
SmithKline Beecham WO 00/09541
Bacterial nrdE proteins
Philadelphia
Bacterial nrdE proteins, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/09694
Moraxella antigen
Rixensart, Belgium
Moraxella catarrhalis antigen, encoding gene sequences, production methods; for diagnostics and therapeutics.
Stichting Blood Inst. EPO 982 397
Factor XII mimics
Amsterdam
Peptide mimics of a Factor XII fragment; for preventing activation of blood coagulation by surface contact.
Stichting Endocrinology Inst. EPO 982 399
Thyroid hormone transporters
Rotterdam, Netherlands
Thyroid hormone transporters, encoding gene sequences, modulators; for diagnostics and therapeutics.
Stichting Health Inst. EPO 982 402 & WO 00/09701
Pestivirus vaccines
Lelystad, Netherlands
Gene sequences from pestivirus, encoded proteins, chimeric viruses; for vaccines.
Stichting Inst. WO 00/09749
Stable gene expression promotion
Nieuwegein, Netherlands
Detection of nucleic acid sequences that contribute to the promotion of stable gene expression.
Taisho Pharma WO 00/09687
Inflammation regulator
Tokyo
Human monocyte derived-protein, encoding gene sequences; for regulating inflammation.
Texas, Univ. of WO 00/09667
Altering muscle phenotype
Austin, Texas
Alteration and regulation of muscle cell fiber type by calcineurin modulation.
Texas, Univ. of WO 00/09677
Sterol-regulated protease modulators
Austin, Texas
Sterol-regulated site-1 protease, transgenics; for identifying modulators.
Thomas Jefferson Univ. WO 00/09145
Cancer immunoreponse
Philadelphia
Culturing tumor cells with a pro-apoptotic agent, insertion into patients; for inducing immunoresponse to cancer.
Thomas Jefferson Univ. WO 00/09730
Vector internalization
Philadelphia
Cell type-specific gene transfer with retroviral vectors having antibody-envelope fusion proteins for cell uptake.
Tularik WO 00/09678
IRAK3 kinase
S. San Francisco
IRAK3 kinase, encoding gene, recombinant production methods, antibodies; for diagnostics and therapeutics.
Urogenesys WO 00/09691
Prostate cancer diagnostic
Santa Monica, Calif.
Brain-specific protein expressed by prostate and bladder cancer; for cancer diagnostics and therapeutics.
Vasopharm Biotech WO 00/09711
NO metabolism control
Wurzburg, Germany
Human soluble guanylylcyclase a1/_1, encoding gene, antibodies; for modulating nitric oxide (NO) metabolism.
Wallaart, T.E. EPO 982 404
Anti-malarial drugs
Groningen, Netherlands
Gene sequences encoding amorpha-4,11-diene synthase, production methods; for making anti-malarial drugs.
Walter Reed Army Inst. Res. WO 00/09154
Bacterial superantigen vaccine
Washington, D.C.
Altered superantigen toxin where superantigen activity is absent but it is effectively recognized; for vaccines.
Warner-Lambert WO 00/09732
Cryoprotectant transfection
Morris Plains, N.J.
Electroporation buffer having cryoprotectant capabilities; for simultaneous transfection and long-term storage.
Western Ontario, Univ. of WO 00/09703
HIV vaccines
London, Ont.
Avirulent, non-cytolytic recombinant HIV strain having the nef gene deleted; for vaccines.
Zeneca WO 00/09704
Gene switch
London
Chemically inducible promoter sequences linked to a reporter gene; for gene activity assays.
Zeneca WO 00/09708
Cell function inhibitors
London
Protease genes controlled by inducible promoters; for identifying inhibitors of cell function and growth.
Zycos WO 00/9654
EST profiles
Cambridge, Mass.
Profiling and cataloging expressed protein tags (ESTs) in any given cell, computer-assisted manipulation of profiles.