Published February 23 (EPO); February 17 (WO); February 23 (GB)

Abbott Labs WO 00/08174

_-casein constructs

Abbott Park, Ill.

_-casein constructs having increased stability in transfected cells; for diagnostics and therapeutics.

Agouron Pharma WO 00/08469

Hepatitis C protease inhibitors

La Jolla, Calif.

Reporter gene system for use in a cell-based assay for inhibitors of hepatitis C virus protease.

Alabama, Univ. of WO 00/08050

Apolipoprotein B receptor

Birmingham, Ala.

Human monocyte-macrophage apolipoprotein B receptor, encoding gene; for cellular uptake of plasma chylomicrons.

Antibioticos WO 00/08168

Hybrid antibiotics

Leon, Spain

Streptomyces strains having modified tyrosine biosynthetic genes; for production of hybrid antibiotics.

Aventis Pharma WO 00/08140 & 08141

VEGF antisense

Frankfurt, Germany

Short antisense oligos to vascular endothelial growth factor (VEGF); for expression inhibition.

Axys Pharma WO 00/08157

Anion transporters

S. San Francisco

Human anion transporters, encoding gene sequences; for identifying homologs and modulators.

British Columbia, Univ. of WO 00/08159

Modified cystatins

Vancouver, B.C.

Cystatins modified by glycosylation to enhance stability and activity, production methods; for inhibiting proteolysis.

BTG Intl. WO 00/07622

Attenuated poliovirus vaccine

London

Poliovirus with a protease 2A gene mutation associated with reduced temperature sensitivity; for attenuated vaccines.

California Inst. Technol. WO 00/08468

Germ cell isolation

Pasadena, Calif.

Identification of cell lineages using cell surface display of serpentine receptors; for isolating germ cells.

Cambridge Univ. Tech. Serv. WO 00/08192 & 08193

Neural gene therapy

Cambridge, U.K.

Herpesvirus vectors in which late genes have inactivating deletions; for gene therapy of nervous tissue.

Cellay WO 00/08212

Gel microdrop genetic analysis

Cambridge, Mass.

Gel microdrops containing cells, viruses, nuclei, or chromosomes; for binding to nucleic acid probes.

CNRS (Natl. Ctr. Sci. Res.) WO 00/08149

Cationic channel

Paris

Human neuronal proton-sensitive cationic channel, encoding gene sequences; for diagnostics and therapeutics.

CNRS (Natl. Ctr. Sci. Res.) WO 00/08183

Recombinant protein production

Paris

Mutant E. coli strains having mutated RNase E genes thus preventing mRNA degradation; for protein production.

Cor Therapeutics WO 00/08137

Glycoprotein V inhibitors

S. San Francisco

Transgenics having a modified glycoprotein V gene; for identifying therapeutics and modulators of function.

Dornier Medtech WO 00/08195

Oligo transfection method

Wessliing, Germany

Methods and devices for transferring oligonucleotides into cells using shock waves.

Du Pont WO 00/08200

4-hydroxyproline epimerase

Wilmington, Del.

Bacterial 4-hydroxyproline epimerase; for modifying and converting proline-containing compounds.

Duke Univ. WO 00/08196

Less immunogenic uricase

Durham, N.C.

Urate oxidase, encoding gene; for making modified proteins with reduced immunogenicity and increased bioavailability.

Genion WO 00/08146

Potassium channel

Hamburg, Germany

Tension-dependent potassium channel, encoding gene sequences; for identifying modulators.

Genset WO 00/08209

Human TBC-1 protein

Paris

Human TBC-1 protein, encoding gene sequences, antibodies, polymorphic markers; for diagnostics.

Geron WO 00/08135

Telomerase activity modulators

Menlo Park, Calif.

In vitro assembly of telomerase using chaperonins; for screening telomerase activity and assembly modulators.

Glycodesign WO 00/08171

N-acetylglycosaminyl transferase

Toronto, Ont.

N-acetylglycosaminyl transferase V genes, encoded proteins; for diagnostics and therapeutics.

Guntaka, R.V. WO 00/08213

Collagen expression inhibition

Columbia, Mo.

Oligomers that inhibit the expression of collagen genes by binding to the promoter region.

Hadasit Med. Res. Serv. & Develop. WO 00/08150

Metastases therapeutics

Jerusalem, Israel

Protease activated receptor (PAR) antisense, PAR antibodies; for therapeutics to treat metastases.

Heska WO 00/08163

Parasitic infection inhibition

Ft. Collins, Colo.

Aromatic amino acid decarboxylase proteins from parasitic helminths, encoding genes; for disease protection.

Human Genome Sciences WO 00/08139

TNF-gamma

Rockville, Md.

Tumor necrosis factor (TNF)-gamma, encoding gene sequences, modulators; for cancer and wound healing therapeutics.

Immunex WO 00/08057

B7L-1 protein

Seattle, Wash.

B7L-1 protein, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

Immunex WO 00/08158

LDCAM proteins

Seattle, Wash.

LDCAM proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

Immunex WO 00/08177

Apoptosis ankyrin peptides

Seattle, Wash.

Death-associated kinase-containing ankyrin peptide repeats, fragments, recombinant production methods.

Immunex WO 00/08178 & 08180

Kinase function proteins

Seattle, Wash.

Mouse gene encoding proteins having kinase functions, encoded proteins, fragments, antibodies.

Immunex WO 00/08179

Kappa B kinase-related kinases

Seattle, Wash.

Kappa B kinase-related kinases, encoding gene sequences, fragments, antibodies, production methods.

Imperial Cancer Res. Technol. WO 00/08054

Modified green fluorescent protein

London

Modified green fluorescent protein, encoding gene sequences; for use as a reporter.

Incyte Pharma WO 00/08155

Receptor-associated proteins

Palo Alto, Calif.

Human receptor-associated proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 00/08156

DNA repair-associated proteins

Palo Alto, Calif.

DNA replication- and repair-associated proteins, encoding gene, antibodies, modulators; for diagnostics/therapeutics.

Jean Dausset Fdn. WO 00/07438

Memory deficiency model

Paris

Animal model system with a disrupted p53 gene; for studying memory deficiency and/or behavioral disorders.

Jean Dausset Fdn. WO 00/08147

Tumor suppression genes

Paris

Genes involved in tumor suppression and resistance to viruses that are modulated by apoptosis.

Jean Dausset Fdn. WO 00/08470

Schizophrenia diagnosis

Paris

Antibody-based assay to detect an acidic protein of 52-57 kDa from lymphoblastoid cells; for schizophrenia diagnosis.

Karube, I., et al. WO 00/08136

Nucleic acid amplification

Kanagawa, Japan

Enzymatic amplification of nucleic acids using organic solvents to eliminate reaction inhibitors.

Krebs Res. Inst. WO 00/08143

Chromosome 17 gene

Heidelberg, Germany

Gene isolated from the short arm of chromosome 17, encoded protein, antibodies; for diagnostics and therapeutics.

Leiden Univ. WO 00/08151

Calcium-dependent kinase

Leiden, Netherlands

Calcium/calmodulin-dependent kinase, alternative splice product; for regulating calcium-dependent processes.

Lion Bioscience WO 00/08164

Nucleic acid elongation

Heidelberg, Germany

Thermostable in vitro complex of staple and elongation proteins; for template-dependent nucleic acid elongation.

Ludwig Inst. Cancer Res. WO 00/08173

Ribosomal S6 protein kinase

New York

Ribosomal S6 protein kinase, encoding gene sequences, modulators; for diagnostics and therapeutics.

Massachusetts, Univ. of WO 00/08132

Making bird transgenics

Amherst, Mass.

Prolonged culture of bird primordial germ cells using specific growth factors; for making transgenics.

MRC (Med. Res. Counc.) WO 00/08208

Expression profiling

London

Reverse transcription and amplification processes and primers; for expression profiling.

Mercian WO 00/08170

Homo-glutamic acid production

Tokyo

Gene participating in the production of homo-glutamic acid that is isolated from Flavobacterium lutescens.

Merck WO 00/08133

G protein-coupled receptors

Rahway, N.J.

Human G protein-coupled receptors, encoding gene sequences; for identifying modulators.

Merck WO 00/08197

Antibiotic production

Rahway, N.J.

Process for chemically producing antibiotics using amino acids and divalent cations.

Metabolix WO 00/08198

PHA biopolymers

Cambridge, Mass.

Microorganisms having enzymes that use polyols to produce polyhydroxyalkanoate (PHA) biopolymers.

Millennium Biotherapeutics WO 00/08045

Tango 93 family members

Cambridge, Mass.

Tango 93-related protein family members, encoding genes, fusions, antibodies; for modulator screens.

Molec. Immunol. Develop. Assoc. WO 00/08148

AT2 receptor ligand

Paris

AT2 receptor protein ligand, encoding gene sequences; for diagnostics and therapeutics.

Molec. Plant & Protein Technol. WO 00/08142

Producing fibrous proteins

Cologne, Germany

Production of fibrous proteins in plant cells, subsequent purification methods.

Montana, Univ. of WO 00/08043

Wide-spectrum antivirals

Missoula, Mont.

Fusion-related molecular structures from viral proteins; for making vaccines with a wide spectrum of activity.

Montreal, Univ. Hosp. WO 00/07618

Anti-apoptotic agent

Montreal, Que.

R1 subunit of herpes simplex virus ribonucleotide reductase, its N-terminal portion; for use as an anti-apoptotic agent.

Mountain View Pharma WO 00/07629

Conjugated urate oxidase

Menlo Park, Calif.

Urate oxidase covalently conjugated to polyethylene glycol; for reduced immunogenicity while maintaining activity.

Neurovex WO 00/08191

Immunotherapeutic vector

London

Herpes virus vectors that efficiently infect dendritic cells without preventing antigen processing; for immunotherapy.

Neurovex WO 00/08194

Propagating mutant herpes

London

Cell lines for propagating herpes viruses having defects in intermediate genes and VP16 mutations.

New York, State Univ. of WO 00/08166

Oncolytic poliovirus

Albany, N.Y.

Non-pathogenic, recombinant poliovirus having its internal ribosomal entry site replaced; for treating cancer.

Novartis WO 00/08134

Osteoarthritis serine protease

Basel, Switzerland

Human serine protease, encoding gene sequences; for osteoarthritis and cancer therapeutics.

Novartis WO 00/08145

Hematopoiesis genes

Basel, Switzerland

Hematopoiesis control genes, fragments, encoded proteins; for diagnostics and therapeutics.

Ono Pharma WO 00/08056

Hematopoietic cell regulator

Osaka, Japan

Human polypeptide with hematopoietic cell regulatory activity, encoding gene sequence.

Onyx Pharma WO 00/08181

Cell signaling protein

Richmond, Calif.

CHP polypeptide, fragments, encoding gene sequences; for regulating cell signaling pathways.

Pasteur Merieux WO 00/08167

HIV vaccines

Lyon, France

Trimer of HIV env gene expression product; for making HIV vaccines.

Phogen WO 00/08182

Herpes infection progress

Cambridge, U.K.

Herpesvirus particle preparations having a fluorescent VP22 protein fusion; for following infection progress.

Purdue Univ. WO 00/08131

Antiviral screens

W. Lafayette, Ind.

Pseudotyped retroviruses having a broad host range, stable production cell lines; for antiviral screens.

Regeneron Pharma WO 00/08152

Orphan cytokine receptors

Tarrytown, N.Y.

Orphan cytokine receptors, encoding gene sequences; for detecting modulators and developing therapeutics.

Rigel Pharma WO 00/07545

Apoptosis modulation

S. San Francisco

Apoptosis proteins, encoding gene sequences, chimeras proteins, antibodies; for modulating apoptosis.

Roslin Inst. GB 2 340 493

Transgenic production

Roslin, U.K.

Unactivated oocytes as cytoplast recipients for transfer of nuclei in the quiescent G0 phase; for making transgenics.

St. Jude's Children's Hosp. WO 00/08153

Cell cycle regulator

Memphis, Tenn.

Mammalian cell cycle regulator, encoding gene; for blocking kinases from phosphorylating the retinoblastoma protein.

Schering WO 00/08144

Apoptosis inhibitor

Berlin

Human inhibitor of apoptosis protein, encoding gene sequences; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 00/08055

Human VAMP 2-like gene

Shanghai

Human VAMP 2-like gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/08199

7-transmembrane receptor

Philadelphia

7-transmembrane receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Takara Shuzo EPO 980 912

Bacterial ceraminidase

Kyoto, Japan

Pseudomonas aeruginosa alkaline ceraminidase, variants, encoding genes, probes, antibodies; for diagnostics.

Takeda Chemical WO 00/08053

G-protein coupled receptor

Osaka, Japan

G-protein coupled receptor, encoding gene sequences; for making transgenics and screening modulators.

Tufts Univ. WO 00/08138

Antibiotic selection

Medford, Mass.

Bacteria having alterable tRNA operons; for selection of antibiotics against pathogens.

Tularik WO 00/08052

Retinal nuclear receptor

S. San Francisco

Retinal nuclear hormone receptor, encoding gene sequences; for regulating gene expression and finding modulators.

Washington, Univ. of WO 00/08051

Herpes virus antigens

Seattle, Wash.

Herpes simplex virus antigens, encoding gene sequences; for recognition by T cells.

Yale Univ. WO 00/07610

Autoantigen interacting proteins

New Haven, Conn.

Peptides and fragments that interact with autoantigens; for screening modulators for type 1 diabetes.

Zymogenetics WO 00/08154

Pancreatic protein

Seattle, Wash.

Pancreatic and ovarian polypeptide, encoding gene sequences, antibodies, production methods; for therapeutics.

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