Published February 23 (EPO); February 17 (WO); February 23 (GB)
Abbott Labs WO 00/08174
Abbott Park, Ill.
_-casein constructs having increased stability in transfected cells; for diagnostics and therapeutics.
Agouron Pharma WO 00/08469
Hepatitis C protease inhibitors
La Jolla, Calif.
Reporter gene system for use in a cell-based assay for inhibitors of hepatitis C virus protease.
Alabama, Univ. of WO 00/08050
Apolipoprotein B receptor
Human monocyte-macrophage apolipoprotein B receptor, encoding gene; for cellular uptake of plasma chylomicrons.
Antibioticos WO 00/08168
Streptomyces strains having modified tyrosine biosynthetic genes; for production of hybrid antibiotics.
Aventis Pharma WO 00/08140 & 08141
Short antisense oligos to vascular endothelial growth factor (VEGF); for expression inhibition.
Axys Pharma WO 00/08157
S. San Francisco
Human anion transporters, encoding gene sequences; for identifying homologs and modulators.
British Columbia, Univ. of WO 00/08159
Cystatins modified by glycosylation to enhance stability and activity, production methods; for inhibiting proteolysis.
BTG Intl. WO 00/07622
Attenuated poliovirus vaccine
Poliovirus with a protease 2A gene mutation associated with reduced temperature sensitivity; for attenuated vaccines.
California Inst. Technol. WO 00/08468
Germ cell isolation
Identification of cell lineages using cell surface display of serpentine receptors; for isolating germ cells.
Cambridge Univ. Tech. Serv. WO 00/08192 & 08193
Neural gene therapy
Herpesvirus vectors in which late genes have inactivating deletions; for gene therapy of nervous tissue.
Cellay WO 00/08212
Gel microdrop genetic analysis
Gel microdrops containing cells, viruses, nuclei, or chromosomes; for binding to nucleic acid probes.
CNRS (Natl. Ctr. Sci. Res.) WO 00/08149
Human neuronal proton-sensitive cationic channel, encoding gene sequences; for diagnostics and therapeutics.
CNRS (Natl. Ctr. Sci. Res.) WO 00/08183
Recombinant protein production
Mutant E. coli strains having mutated RNase E genes thus preventing mRNA degradation; for protein production.
Cor Therapeutics WO 00/08137
Glycoprotein V inhibitors
S. San Francisco
Transgenics having a modified glycoprotein V gene; for identifying therapeutics and modulators of function.
Dornier Medtech WO 00/08195
Oligo transfection method
Methods and devices for transferring oligonucleotides into cells using shock waves.
Du Pont WO 00/08200
Bacterial 4-hydroxyproline epimerase; for modifying and converting proline-containing compounds.
Duke Univ. WO 00/08196
Less immunogenic uricase
Urate oxidase, encoding gene; for making modified proteins with reduced immunogenicity and increased bioavailability.
Genion WO 00/08146
Tension-dependent potassium channel, encoding gene sequences; for identifying modulators.
Genset WO 00/08209
Human TBC-1 protein
Human TBC-1 protein, encoding gene sequences, antibodies, polymorphic markers; for diagnostics.
Geron WO 00/08135
Telomerase activity modulators
Menlo Park, Calif.
In vitro assembly of telomerase using chaperonins; for screening telomerase activity and assembly modulators.
Glycodesign WO 00/08171
N-acetylglycosaminyl transferase V genes, encoded proteins; for diagnostics and therapeutics.
Guntaka, R.V. WO 00/08213
Collagen expression inhibition
Oligomers that inhibit the expression of collagen genes by binding to the promoter region.
Hadasit Med. Res. Serv. & Develop. WO 00/08150
Protease activated receptor (PAR) antisense, PAR antibodies; for therapeutics to treat metastases.
Heska WO 00/08163
Parasitic infection inhibition
Ft. Collins, Colo.
Aromatic amino acid decarboxylase proteins from parasitic helminths, encoding genes; for disease protection.
Human Genome Sciences WO 00/08139
Tumor necrosis factor (TNF)-gamma, encoding gene sequences, modulators; for cancer and wound healing therapeutics.
Immunex WO 00/08057
B7L-1 protein, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
Immunex WO 00/08158
LDCAM proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
Immunex WO 00/08177
Apoptosis ankyrin peptides
Death-associated kinase-containing ankyrin peptide repeats, fragments, recombinant production methods.
Immunex WO 00/08178 & 08180
Kinase function proteins
Mouse gene encoding proteins having kinase functions, encoded proteins, fragments, antibodies.
Immunex WO 00/08179
Kappa B kinase-related kinases
Kappa B kinase-related kinases, encoding gene sequences, fragments, antibodies, production methods.
Imperial Cancer Res. Technol. WO 00/08054
Modified green fluorescent protein
Modified green fluorescent protein, encoding gene sequences; for use as a reporter.
Incyte Pharma WO 00/08155
Palo Alto, Calif.
Human receptor-associated proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 00/08156
DNA repair-associated proteins
Palo Alto, Calif.
DNA replication- and repair-associated proteins, encoding gene, antibodies, modulators; for diagnostics/therapeutics.
Jean Dausset Fdn. WO 00/07438
Memory deficiency model
Animal model system with a disrupted p53 gene; for studying memory deficiency and/or behavioral disorders.
Jean Dausset Fdn. WO 00/08147
Tumor suppression genes
Genes involved in tumor suppression and resistance to viruses that are modulated by apoptosis.
Jean Dausset Fdn. WO 00/08470
Antibody-based assay to detect an acidic protein of 52-57 kDa from lymphoblastoid cells; for schizophrenia diagnosis.
Karube, I., et al. WO 00/08136
Nucleic acid amplification
Enzymatic amplification of nucleic acids using organic solvents to eliminate reaction inhibitors.
Krebs Res. Inst. WO 00/08143
Chromosome 17 gene
Gene isolated from the short arm of chromosome 17, encoded protein, antibodies; for diagnostics and therapeutics.
Leiden Univ. WO 00/08151
Calcium/calmodulin-dependent kinase, alternative splice product; for regulating calcium-dependent processes.
Lion Bioscience WO 00/08164
Nucleic acid elongation
Thermostable in vitro complex of staple and elongation proteins; for template-dependent nucleic acid elongation.
Ludwig Inst. Cancer Res. WO 00/08173
Ribosomal S6 protein kinase
Ribosomal S6 protein kinase, encoding gene sequences, modulators; for diagnostics and therapeutics.
Massachusetts, Univ. of WO 00/08132
Making bird transgenics
Prolonged culture of bird primordial germ cells using specific growth factors; for making transgenics.
MRC (Med. Res. Counc.) WO 00/08208
Reverse transcription and amplification processes and primers; for expression profiling.
Mercian WO 00/08170
Homo-glutamic acid production
Gene participating in the production of homo-glutamic acid that is isolated from Flavobacterium lutescens.
Merck WO 00/08133
G protein-coupled receptors
Human G protein-coupled receptors, encoding gene sequences; for identifying modulators.
Merck WO 00/08197
Process for chemically producing antibiotics using amino acids and divalent cations.
Metabolix WO 00/08198
Microorganisms having enzymes that use polyols to produce polyhydroxyalkanoate (PHA) biopolymers.
Millennium Biotherapeutics WO 00/08045
Tango 93 family members
Tango 93-related protein family members, encoding genes, fusions, antibodies; for modulator screens.
Molec. Immunol. Develop. Assoc. WO 00/08148
AT2 receptor ligand
AT2 receptor protein ligand, encoding gene sequences; for diagnostics and therapeutics.
Molec. Plant & Protein Technol. WO 00/08142
Producing fibrous proteins
Production of fibrous proteins in plant cells, subsequent purification methods.
Montana, Univ. of WO 00/08043
Fusion-related molecular structures from viral proteins; for making vaccines with a wide spectrum of activity.
Montreal, Univ. Hosp. WO 00/07618
R1 subunit of herpes simplex virus ribonucleotide reductase, its N-terminal portion; for use as an anti-apoptotic agent.
Mountain View Pharma WO 00/07629
Conjugated urate oxidase
Menlo Park, Calif.
Urate oxidase covalently conjugated to polyethylene glycol; for reduced immunogenicity while maintaining activity.
Neurovex WO 00/08191
Herpes virus vectors that efficiently infect dendritic cells without preventing antigen processing; for immunotherapy.
Neurovex WO 00/08194
Propagating mutant herpes
Cell lines for propagating herpes viruses having defects in intermediate genes and VP16 mutations.
New York, State Univ. of WO 00/08166
Non-pathogenic, recombinant poliovirus having its internal ribosomal entry site replaced; for treating cancer.
Novartis WO 00/08134
Osteoarthritis serine protease
Human serine protease, encoding gene sequences; for osteoarthritis and cancer therapeutics.
Novartis WO 00/08145
Hematopoiesis control genes, fragments, encoded proteins; for diagnostics and therapeutics.
Ono Pharma WO 00/08056
Hematopoietic cell regulator
Human polypeptide with hematopoietic cell regulatory activity, encoding gene sequence.
Onyx Pharma WO 00/08181
Cell signaling protein
CHP polypeptide, fragments, encoding gene sequences; for regulating cell signaling pathways.
Pasteur Merieux WO 00/08167
Trimer of HIV env gene expression product; for making HIV vaccines.
Phogen WO 00/08182
Herpes infection progress
Herpesvirus particle preparations having a fluorescent VP22 protein fusion; for following infection progress.
Purdue Univ. WO 00/08131
W. Lafayette, Ind.
Pseudotyped retroviruses having a broad host range, stable production cell lines; for antiviral screens.
Regeneron Pharma WO 00/08152
Orphan cytokine receptors
Orphan cytokine receptors, encoding gene sequences; for detecting modulators and developing therapeutics.
Rigel Pharma WO 00/07545
S. San Francisco
Apoptosis proteins, encoding gene sequences, chimeras proteins, antibodies; for modulating apoptosis.
Roslin Inst. GB 2 340 493
Unactivated oocytes as cytoplast recipients for transfer of nuclei in the quiescent G0 phase; for making transgenics.
St. Jude's Children's Hosp. WO 00/08153
Cell cycle regulator
Mammalian cell cycle regulator, encoding gene; for blocking kinases from phosphorylating the retinoblastoma protein.
Schering WO 00/08144
Human inhibitor of apoptosis protein, encoding gene sequences; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 00/08055
Human VAMP 2-like gene
Human VAMP 2-like gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/08199
7-transmembrane receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Takara Shuzo EPO 980 912
Pseudomonas aeruginosa alkaline ceraminidase, variants, encoding genes, probes, antibodies; for diagnostics.
Takeda Chemical WO 00/08053
G-protein coupled receptor
G-protein coupled receptor, encoding gene sequences; for making transgenics and screening modulators.
Tufts Univ. WO 00/08138
Bacteria having alterable tRNA operons; for selection of antibiotics against pathogens.
Tularik WO 00/08052
Retinal nuclear receptor
S. San Francisco
Retinal nuclear hormone receptor, encoding gene sequences; for regulating gene expression and finding modulators.
Washington, Univ. of WO 00/08051
Herpes virus antigens
Herpes simplex virus antigens, encoding gene sequences; for recognition by T cells.
Yale Univ. WO 00/07610
Autoantigen interacting proteins
New Haven, Conn.
Peptides and fragments that interact with autoantigens; for screening modulators for type 1 diabetes.
Zymogenetics WO 00/08154
Pancreatic and ovarian polypeptide, encoding gene sequences, antibodies, production methods; for therapeutics.