Published February 9 (EPO); February 3 (WO); February 9 (GB)

Agricultural Res. Counc. WO 00/05252

Botulism vaccines

Pretoria, South Africa

Non-toxic immunogenic derivative of Clostridium botulinum type D neurotoxin; for botulism vaccines.

Alabama, Univ. of WO 00/05403

Ig-A receptor polymorphisms

Birmingham, Ala.

Single nucleotide polymorphisms in the immunoglobulin (Ig)-A receptor; for genotyping.

Alabama, Univ. of WO 00/05413

Complement receptor polymorphisms

Birmingham, Ala.

Single nucleotide polymorphisms in the complement receptor; for detecting susceptibility to autoimmune disease.

Allegheney Univ. Hlth. Sci. WO 00/04927

Cellular cancer immunogens


Allogeneic cellular immunogens that have been transfected with oncogenes; for cancer therapeutics.

Amsterdam Ctr. Drug Res. EPO 978 562

Calmodulin-dependent kinase

Leiden, Netherlands

Calcium/calmodulin-dependent kinase, alternative splice variants; for therapeutics.

Aventis Res. & Technol. WO 00/05388

DEAD box proteins

Frankfurt, Germany

Genes of the DEAD box protein family, encoding gene sequences; for diagnostics and therapeutics.

Bayer EPO 978 286

Herpes vaccines


Equine herpesvirus preparations; for vaccines for cross-species protection.

Baylor Coll. Med. WO 00/05355

Rapid subcloning


Subcloning methods using site-specific recombination methods; for rapid transfer of genes.

Becton Dickinson EPO 978 557

Cell disruption

Franklin Lakes, N.J.

Cell disruption using sonication in the absence of beads; for isolating cell components.

Boehringer Ingelheim WO 00/05380

Papillomavirus helicase oligomers

Laval, Que.

Papillomavirus E1 helicase region for oligomerization, derivatives, variants, fragments, encoding genes.

British Defense Ministry WO 00/05408

Nucleic acid detection

Farnborough, UK

Nucleic acid formation into a triple helix using a peptide-nucleic acid, measurement by surface plasmon resonance.

Bruker Deltonik GB 2 339 905

Polymorphism detection

Bremen, Germany

Mass spectroscopy on defined nucleic acid fragments; for detection of polymorphisms.

BTG Intl. WO 00/05268

CD3 antibodies


Hybrid human-rodent immunoglobulin G antibodies to CD3, fragments, variants.

Bukwang Pharma WO 00/05411

DNA detection in gels

Seoul, S. Korea

Methods of detecting DNA on polymer gels using a counter-dye composition and regular illumination.

Byk Gulden WO 00/05585

Pulmonary surfactant

Konstanz, Germany

Strongly hydrophobic pulmonary surfactant SP-C, encoding gene, antibodies.

California, Univ. of WO 00/05240

Spirochete vaccines

Oakland, Calif.

Outer membrane protein antigens from Leptospira, encoding gene, antibodies; for spirochete disease vaccines.

Carnegie Inst. WO 00/05344

Germline stem cell growth


Maintenance and propagation of germline stem cells using TGF-_ family growth factors, especially BMPs 2 and 4.

Children's Hosp. WO 00/05356

Antiangiogenic proteins


Antiangiogenic proteins and peptides, encoding gene sequences; for inhibiting endothelial proliferation.

Chugai Res. Inst. Molec. Med. EPO 978 519

Transcriptional regulators

Ibaraki, Japan

Transcriptional regulators having bromo domains; for gene expression modulation.

Claragen WO 00/04863

Recombinant uteroglobin

College Park, Md.

Recombinant human uteroglobin; for targeting the receptor in inflammatory and fibrotic diseases and cancer.

Cobra Therapeutics WO 00/05393

Chromatin opening element

Keele, U.K.

Ubiquitous chromatin opening element, encoding gene; for maintaining expression in operably-linked genes.

Connecticut, Univ. of WO 00/05262

Cell growth modulation

Farmington, Conn.

Administration of the E domain peptide from insulin-like growth factor 1; for affecting growth of cells and cancer.

Connex WO 00/05266

Hepatitis C antigens

Martinsried, Germany

Antibodies to conformation dependent epitopes of the hepatitis C glycoprotein E2; for adoptive immunotherapy.

Curagen WO 00/05369

Angiogenesis-related proteins

New Haven, Conn.

Secreted proteins involved in angiogenesis and its inhibition, encoding genes; for therapeutics.

Du Pont WO 00/05377

Transcriptional activators

Wilmington, Del.

PC4 transcriptional activators, encoding gene sequences, antisense, chimeric genes; for altering expression levels.

Duke Univ. WO 00/04770

Oxidative stress model

Durham, N.C.

Transgenic mice having an inserted human inducible nitric oxide synthase gene; for modeling oxidative stress.

Eli Lilly WO 00/05241

Angiopoietin-related gene


Angiopoietin-related gene sequence Scarface 2, encoded protein; for identifying modulators.

Eli Lilly WO 00/05248

Human GDF-3


Human GDF-3, encoding gene sequences, production methods, transgenics, chimerics, antibodies.

Estivill Palleja, X. WO 00/05407

Anxiety-associated genes

Barcelona, Spain

Duplications of human chromosome 15q24-25 associated with anxiety disorders; for diagnostics.

Gen-Probe EPO 978 570

Tuberculosis diagnostics

San Diego, Calif.

Detection of Mycobacterium tuberculosis by amplification of ribosomal RNA and hybridization to specific probes.

Gen-Probe WO 00/05418

Spliced mRNA identification

San Diego

Preparation of spliced mRNAs from biological samples for subsequent amplification; for sequence identification.

Genetic Engineering & Biotech Ctr. EPO 978 564

Microbial infection diagnostics

Havana, Cuba

Recombinant fusion proteins based on bacterial adhesins; for developing diagnostics.

Genset WO 00/05382

Mevalonic acid pathway disorders


Geranyl-geranyl pyrophosphate synthetase gene, polymorphic markers; for mevalonic acid biosynthesis pathway disorders.

Georgetown Univ. WO 00/05416

FGF binding protein


Fibroblast growth factor (FGF) binding protein, encoding gene; for treating cancer and wounds.

Hoechst Marion Roussel EPO 978 561

VEGF antisense

Frankfurt, Germany

Antisense for the inhibition of vascular endothelial growth factor (VEGF) expression.

HSC Res. & Develop. WO 00/05360

Receptor-regulated Smad proteins

Toronto, Ont.

Receptor-regulated Smad proteins; for modulating signal transduction by TGF-_, activin, and BMPs.

Human Genome Sciences WO 00/05371

Keratinocyte-derived interferon

Rockville, Md.

Keratinocyte-derived interferon, encoding gene sequences, recombinant production methods; for therapeutics.

Immusol WO 00/05415

Ribozyme libraries

San Diego

Substantially complete ribozyme libraries having randomized recognition sequences; for finding target RNAs.

Incyte Pharma WO 00/05368

Calcium regulatory proteins

Palo Alto, Calif.

Human calcium regulatory proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 00/05372

Ion transport-like protein

Palo Alto, Calif.

Human ion transport-like protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 00/05374

Cell proliferation molecules

Palo Alto, Calif.

Molecules associated with proliferation, encoding gene, antibodies, modulators; for diagnostics and therapeutics.

Inst. Phys. & Chem. Res. EPO 978 569

DNA sequencing method

Wako, Japan

DNA sequencing method using mutated RNA polymerases that enhance precursor uptake; for making longer chains.

Introgene EPO 978 566

Chimeric adenovirus vectors

Leiden, Netherlands

Chimeric adenoviruses having less antigenicity and modified host range; for gene therapy vectors.

Japanese Agency Ind. Sci. & Technol. WO 00/05357

Combinatorial chemistry markers


Labeling substances for marking compounds produced by combinatorial chemistry; for separation.

Leicester, Univ. of WO 00/05347

Hepatitis B virus culture

Leicester, U.K.

In vitro culture system for hepatitis B virus, virus variants; for diagnostics and therapeutics.

Leukosite WO 00/05265

CCR2 antibodies

Cambridge, Mass.

CC-chemokine receptor 2 (CCR2) antibodies, functional fragments; for diagnostics and therapeutics.

Lumigen WO 00/05412

Polynucleotide synthesis

Southfield, Mich.

Synthesis of polynucleotides by ligation of multiple oligomers; for sequence and gene expression analysis.

M&E Biotech WO 00/05406

Gene function identification

Horsholm, Denmark

Transfecting cells with genes tagged with identifier sequences; for identifying gene function.

Max Planck Inst. WO 00/05253

CRF receptor antagonists

Berlin, Germany

Antagonists for corticotropin-releasing factor (CRF) receptor type 2; for diagnostics and therapeutics.

Millennium Pharma WO 00/05346

Potassium channel

Cambridge, Mass.

Potassium channel, encoding gene sequences, fusions, antibodies, antisense, transgenics; for diagnostics.

Millennium Pharma WO 00/05373

Weight disorder therapeutics

Cambridge, Mass.

Mammalian mahogany genes, encoding proteins, antibodies, transgenics; for treating body weight disorders.

Mitsui Chemicals EPO 978 287

Autoimmunity therapeutics


Binding inhibitors of gp34, including antibodies; for treating autoimmune and inflammatory diseases.

NIH (Natl. Inst. Hlth.) WO 00/04861

Cytochrome P450 2A6 antibodies

Bethesda, Md.

Monoclonal antibodies and other agents that bind and inhibit human cytochrome P450 2A6; for measuring enzyme levels.

NIH (Natl. Inst. Hlth.) WO 00/04864

Cytochrome P450 1A2 antibodies

Bethesda, Md.

Monoclonal antibodies and other agents that bind and inhibit human cytochrome P450 1A2; for measuring enzyme levels.

NIH (Natl. Inst. Hlth.) WO 00/05343

Neural transplantation

Bethesda, Md.

Cell expansion system for proliferation and differentiation of neural stem cells; for transplantation.

NIH (Natl. Inst. Hlth.) WO 00/05376

Prostate cancer diagnostics

Bethesda, Md.

PB39 gene that is upregulated and overexpressed in prostate cancer, encoded protein; for diagnostics.

New Jersey, Med. & Dent. Univ. WO 00/05586

Translation termination modulators

New Brunswick, N.J.

RNA helicase subfamily involved in modulating the fidelity of translation termination; for finding modulators.

Novartis WO 00/05392

Transfection methods

Basel, Switzerland

Transfection of animal cells using designed nucleic acid-protein complexes and oligos for VirD2/E2 protein.

Oklahoma Med. Res. Fdn. WO 00/05359

Prohibitin for cancer

Oklahoma City, Okla.

Single-stranded RNAs transcribed from wild type prohibitin 3' untranslated regions; for cancer therapy.

Ottawa, Univ. of WO 00/05366

Internal ribosome entry site

Ottawa, Ont.

Nucleic acid sequences encoding an internal ribosome entry site from the X-linked inhibitor of apoptosis gene.

Pharmagene Labs WO 00/05409

Gene expression analysis

Royston, U.K.

Quantitative analysis of gene expression using PCR amplification techniques and fluorescent reporter signals.

Pharmaspec WO 00/04928

Revascularizing tissue

Redmond, Wash.

Retrograde perfusion of angiogenic gene therapy vectors; for revascularizing ischemic tissue.

Procter & Gamble WO 00/05352

Pseudomonas protease

Cincinnati, Ohio

Pseudomonas strain that produces a keratinolytic and caseinolytic protease, expressed protease.

Prodigene WO 00/05384

Protease production in plants

College Stn., Texas

Production of heterologous proteases in plants at 0.1% of total protein without damaging cells.

Rapoport, B., et al. WO 00/05345

Thyrotropin receptor

Santa Monica, Calif.

Human thyrotropin receptor compositions; for diagnostics and therapeutics.

Regeneron Pharma WO 00/05370

Orphan cytokine receptor

Tarrytown, N.Y.

Orphan cytokine receptor, encoding gene sequences; for modulator assays, diagnostics, and therapeutics.

Rhone-Poulenc Rorer WO 00/05362

Kinase modulators

Antony, France

Serine threonine kinase interacting forkhead-associated domain protein, encoding gene; for finding modulators.

Rhone-Poulenc Rorer WO 00/05394

Baculovirus vectors for neurons

Antony, France

Vectors derived from baculoviruses; for transferring nucleic acids into vertebrate nerve cells to treat disease.

Rockefeller Univ. WO 00/05258

Tumor growth inhibitors

New York

Crystals of the complex formed by Ras and Son of sevenless protein; for identifying tumor growth inhibitors.

Rutgers Univ. WO 00/05414

Gene function determination

Piscataway, N.J.

Linking gene sequence to function by three-dimensional protein structure determination using bioinformatics.

Sagami Chem. Res. Ctr. WO 00/05367

Hydrophobic domain proteins

Sagamihara, Japan

Human proteins having hydrophobic domains, encoding gene sequences, expression vectors.

Savage, P.M. GB 2 339 782

Cancer antigen presentation

Redland, U.K.

Chimeric proteins with cell targeting and HLA class I antigen domains; for increased cancer antigen presentation.

Scherer, S.W., et al. WO 00/05405

Laflora's disease gene


Laflora's disease-associated gene, deletions, mutations, encoded protein tyrosine kinase; for diagnostics.

Shionogi EPO 978 560

L-methionine lyase crystals

Osaka, Japan

Production of L-methionine gamma-lyase crystals using polyethylene glycol.

Small Molecule Therapeutics WO 00/05417

Protein function determination

Monmouth Junction, N.J.

Libraries of tag dominant-negative elements; for tagging proteins to determine protein-protein interactions.

SmithKline Beecham WO 00/04923

Cysteine-rich protein-5


Secreted cysteine-rich protein-5, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/05244

Bombesin receptor


Human bombesin receptor subtype-3sb, encoding gene, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/05259

Cysteine-rich protein-6


Secreted cysteine-rich protein-6, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/05348

Pneumococcal antibacterials


Pneumococcal nrdG protein, encoding gene, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/05361

Neurotrophic factor homolog

Brentford, U.K.

Human protein having homology to the prosaposin family of neurotrophic factors, encoding gene sequences.

SmithKline Beecham WO 00/05364

Neuroendocrine protein homolog

Brentford, U.K.

Protein homologous to neuroendocrine-specific protein, encoding gene, production methods; for diagnostics.

SmithKline Beecham WO 00/05365

Human LCB kinase 1

Brentford, U.K.

Human LCB kinase 1, encoding gene sequences, recombinant production methods; for diagnostic assays.

South Alabama Med. Sci. Fdn. WO 00/04929

Inflammation reduction

Mobile, Ala.

Decreasing levels of pulmonary endothelial gene products that allow inflammatory cells to traverse the cell layer.

Suntory EPO 978 563

Delta 9-desaturase

Osaka, Japan

Delta 9-desaturase gene, encoded protein, production methods; for modulating unsaturated fatty acid synthesis.

Suntory EPO 978 565

Protein production

Osaka, Japan

Fusion proteins having an accessory peptide preventing agglutination during production; for purification.

Takeda Chemical WO 00/05264

G protein-conjugated receptor

Osaka, Japan

G protein-conjugated receptor from brain tissue, encoding gene; for identifying modulators.

Takeda Chemical WO 00/05383

Phosphodiesterase V

Osaka, Japan

Phosphodiesterase V, partial peptides, encoding gene sequences; for finding modulators.

Technion Res. & Develop. Fdn. WO 00/05410

Protein-protein interactions

Haifa, Israel

Methods for detecting protein-protein interactions using a Ras-encoded mutant fusion protein.

Unilever WO 00/05389

Protein production methods

Rotterdam, Netherlands

Protein production in lower eukaryotic cells in which glycosylation is increased to increase secretion.

Valentis WO 00/05358

Gene therapy vector production

Burlingame, Calif.

Scaleable automated process for purification of nucleic acids; for making gene therapy vectors

Vanderbilt Univ. WO 00/05375

GBS toxin receptor

Nashville, Tenn.

GBS toxin receptor, encoding gene sequences; for modulator screens, diagnostics, and therapeutics.

Voekel, H. WO 00/05363

Calcineurin modulator screen

Ulm, Germany

Screening for calcineurin modulators using the interaction between calcineurin and superoxide dismutase.

Yeda Res. & Develop. WO 00/05419

Cancer metastasis prevention

Rehovot, Israel

Prevention of metastases using 5-aza-2'-deoxycytidine in patient tumor cells producing DAP-kinase protein.

- Compiled by Chester A. Bisbee