Published February 9 (EPO); February 3 (WO); February 9 (GB)
Agricultural Res. Counc. WO 00/05252
Botulism vaccines
Pretoria, South Africa
Non-toxic immunogenic derivative of Clostridium botulinum type D neurotoxin; for botulism vaccines.
Alabama, Univ. of WO 00/05403
Ig-A receptor polymorphisms
Birmingham, Ala.
Single nucleotide polymorphisms in the immunoglobulin (Ig)-A receptor; for genotyping.
Alabama, Univ. of WO 00/05413
Complement receptor polymorphisms
Birmingham, Ala.
Single nucleotide polymorphisms in the complement receptor; for detecting susceptibility to autoimmune disease.
Allegheney Univ. Hlth. Sci. WO 00/04927
Cellular cancer immunogens
Philadelphia
Allogeneic cellular immunogens that have been transfected with oncogenes; for cancer therapeutics.
Amsterdam Ctr. Drug Res. EPO 978 562
Calmodulin-dependent kinase
Leiden, Netherlands
Calcium/calmodulin-dependent kinase, alternative splice variants; for therapeutics.
Aventis Res. & Technol. WO 00/05388
DEAD box proteins
Frankfurt, Germany
Genes of the DEAD box protein family, encoding gene sequences; for diagnostics and therapeutics.
Bayer EPO 978 286
Herpes vaccines
Pittsburgh
Equine herpesvirus preparations; for vaccines for cross-species protection.
Baylor Coll. Med. WO 00/05355
Rapid subcloning
Houston
Subcloning methods using site-specific recombination methods; for rapid transfer of genes.
Becton Dickinson EPO 978 557
Cell disruption
Franklin Lakes, N.J.
Cell disruption using sonication in the absence of beads; for isolating cell components.
Boehringer Ingelheim WO 00/05380
Papillomavirus helicase oligomers
Laval, Que.
Papillomavirus E1 helicase region for oligomerization, derivatives, variants, fragments, encoding genes.
British Defense Ministry WO 00/05408
Nucleic acid detection
Farnborough, UK
Nucleic acid formation into a triple helix using a peptide-nucleic acid, measurement by surface plasmon resonance.
Bruker Deltonik GB 2 339 905
Polymorphism detection
Bremen, Germany
Mass spectroscopy on defined nucleic acid fragments; for detection of polymorphisms.
BTG Intl. WO 00/05268
CD3 antibodies
London
Hybrid human-rodent immunoglobulin G antibodies to CD3, fragments, variants.
Bukwang Pharma WO 00/05411
DNA detection in gels
Seoul, S. Korea
Methods of detecting DNA on polymer gels using a counter-dye composition and regular illumination.
Byk Gulden WO 00/05585
Pulmonary surfactant
Konstanz, Germany
Strongly hydrophobic pulmonary surfactant SP-C, encoding gene, antibodies.
California, Univ. of WO 00/05240
Spirochete vaccines
Oakland, Calif.
Outer membrane protein antigens from Leptospira, encoding gene, antibodies; for spirochete disease vaccines.
Carnegie Inst. WO 00/05344
Germline stem cell growth
Washington
Maintenance and propagation of germline stem cells using TGF-_ family growth factors, especially BMPs 2 and 4.
Children's Hosp. WO 00/05356
Antiangiogenic proteins
Boston
Antiangiogenic proteins and peptides, encoding gene sequences; for inhibiting endothelial proliferation.
Chugai Res. Inst. Molec. Med. EPO 978 519
Transcriptional regulators
Ibaraki, Japan
Transcriptional regulators having bromo domains; for gene expression modulation.
Claragen WO 00/04863
Recombinant uteroglobin
College Park, Md.
Recombinant human uteroglobin; for targeting the receptor in inflammatory and fibrotic diseases and cancer.
Cobra Therapeutics WO 00/05393
Chromatin opening element
Keele, U.K.
Ubiquitous chromatin opening element, encoding gene; for maintaining expression in operably-linked genes.
Connecticut, Univ. of WO 00/05262
Cell growth modulation
Farmington, Conn.
Administration of the E domain peptide from insulin-like growth factor 1; for affecting growth of cells and cancer.
Connex WO 00/05266
Hepatitis C antigens
Martinsried, Germany
Antibodies to conformation dependent epitopes of the hepatitis C glycoprotein E2; for adoptive immunotherapy.
Curagen WO 00/05369
Angiogenesis-related proteins
New Haven, Conn.
Secreted proteins involved in angiogenesis and its inhibition, encoding genes; for therapeutics.
Du Pont WO 00/05377
Transcriptional activators
Wilmington, Del.
PC4 transcriptional activators, encoding gene sequences, antisense, chimeric genes; for altering expression levels.
Duke Univ. WO 00/04770
Oxidative stress model
Durham, N.C.
Transgenic mice having an inserted human inducible nitric oxide synthase gene; for modeling oxidative stress.
Eli Lilly WO 00/05241
Angiopoietin-related gene
Indianapolis
Angiopoietin-related gene sequence Scarface 2, encoded protein; for identifying modulators.
Eli Lilly WO 00/05248
Human GDF-3
Indianapolis
Human GDF-3, encoding gene sequences, production methods, transgenics, chimerics, antibodies.
Estivill Palleja, X. WO 00/05407
Anxiety-associated genes
Barcelona, Spain
Duplications of human chromosome 15q24-25 associated with anxiety disorders; for diagnostics.
Gen-Probe EPO 978 570
Tuberculosis diagnostics
San Diego, Calif.
Detection of Mycobacterium tuberculosis by amplification of ribosomal RNA and hybridization to specific probes.
Gen-Probe WO 00/05418
Spliced mRNA identification
San Diego
Preparation of spliced mRNAs from biological samples for subsequent amplification; for sequence identification.
Genetic Engineering & Biotech Ctr. EPO 978 564
Microbial infection diagnostics
Havana, Cuba
Recombinant fusion proteins based on bacterial adhesins; for developing diagnostics.
Genset WO 00/05382
Mevalonic acid pathway disorders
Paris
Geranyl-geranyl pyrophosphate synthetase gene, polymorphic markers; for mevalonic acid biosynthesis pathway disorders.
Georgetown Univ. WO 00/05416
FGF binding protein
Washington
Fibroblast growth factor (FGF) binding protein, encoding gene; for treating cancer and wounds.
Hoechst Marion Roussel EPO 978 561
VEGF antisense
Frankfurt, Germany
Antisense for the inhibition of vascular endothelial growth factor (VEGF) expression.
HSC Res. & Develop. WO 00/05360
Receptor-regulated Smad proteins
Toronto, Ont.
Receptor-regulated Smad proteins; for modulating signal transduction by TGF-_, activin, and BMPs.
Human Genome Sciences WO 00/05371
Keratinocyte-derived interferon
Rockville, Md.
Keratinocyte-derived interferon, encoding gene sequences, recombinant production methods; for therapeutics.
Immusol WO 00/05415
Ribozyme libraries
San Diego
Substantially complete ribozyme libraries having randomized recognition sequences; for finding target RNAs.
Incyte Pharma WO 00/05368
Calcium regulatory proteins
Palo Alto, Calif.
Human calcium regulatory proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 00/05372
Ion transport-like protein
Palo Alto, Calif.
Human ion transport-like protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 00/05374
Cell proliferation molecules
Palo Alto, Calif.
Molecules associated with proliferation, encoding gene, antibodies, modulators; for diagnostics and therapeutics.
Inst. Phys. & Chem. Res. EPO 978 569
DNA sequencing method
Wako, Japan
DNA sequencing method using mutated RNA polymerases that enhance precursor uptake; for making longer chains.
Introgene EPO 978 566
Chimeric adenovirus vectors
Leiden, Netherlands
Chimeric adenoviruses having less antigenicity and modified host range; for gene therapy vectors.
Japanese Agency Ind. Sci. & Technol. WO 00/05357
Combinatorial chemistry markers
Tokyo
Labeling substances for marking compounds produced by combinatorial chemistry; for separation.
Leicester, Univ. of WO 00/05347
Hepatitis B virus culture
Leicester, U.K.
In vitro culture system for hepatitis B virus, virus variants; for diagnostics and therapeutics.
Leukosite WO 00/05265
CCR2 antibodies
Cambridge, Mass.
CC-chemokine receptor 2 (CCR2) antibodies, functional fragments; for diagnostics and therapeutics.
Lumigen WO 00/05412
Polynucleotide synthesis
Southfield, Mich.
Synthesis of polynucleotides by ligation of multiple oligomers; for sequence and gene expression analysis.
M&E Biotech WO 00/05406
Gene function identification
Horsholm, Denmark
Transfecting cells with genes tagged with identifier sequences; for identifying gene function.
Max Planck Inst. WO 00/05253
CRF receptor antagonists
Berlin, Germany
Antagonists for corticotropin-releasing factor (CRF) receptor type 2; for diagnostics and therapeutics.
Millennium Pharma WO 00/05346
Potassium channel
Cambridge, Mass.
Potassium channel, encoding gene sequences, fusions, antibodies, antisense, transgenics; for diagnostics.
Millennium Pharma WO 00/05373
Weight disorder therapeutics
Cambridge, Mass.
Mammalian mahogany genes, encoding proteins, antibodies, transgenics; for treating body weight disorders.
Mitsui Chemicals EPO 978 287
Autoimmunity therapeutics
Tokyo
Binding inhibitors of gp34, including antibodies; for treating autoimmune and inflammatory diseases.
NIH (Natl. Inst. Hlth.) WO 00/04861
Cytochrome P450 2A6 antibodies
Bethesda, Md.
Monoclonal antibodies and other agents that bind and inhibit human cytochrome P450 2A6; for measuring enzyme levels.
NIH (Natl. Inst. Hlth.) WO 00/04864
Cytochrome P450 1A2 antibodies
Bethesda, Md.
Monoclonal antibodies and other agents that bind and inhibit human cytochrome P450 1A2; for measuring enzyme levels.
NIH (Natl. Inst. Hlth.) WO 00/05343
Neural transplantation
Bethesda, Md.
Cell expansion system for proliferation and differentiation of neural stem cells; for transplantation.
NIH (Natl. Inst. Hlth.) WO 00/05376
Prostate cancer diagnostics
Bethesda, Md.
PB39 gene that is upregulated and overexpressed in prostate cancer, encoded protein; for diagnostics.
New Jersey, Med. & Dent. Univ. WO 00/05586
Translation termination modulators
New Brunswick, N.J.
RNA helicase subfamily involved in modulating the fidelity of translation termination; for finding modulators.
Novartis WO 00/05392
Transfection methods
Basel, Switzerland
Transfection of animal cells using designed nucleic acid-protein complexes and oligos for VirD2/E2 protein.
Oklahoma Med. Res. Fdn. WO 00/05359
Prohibitin for cancer
Oklahoma City, Okla.
Single-stranded RNAs transcribed from wild type prohibitin 3' untranslated regions; for cancer therapy.
Ottawa, Univ. of WO 00/05366
Internal ribosome entry site
Ottawa, Ont.
Nucleic acid sequences encoding an internal ribosome entry site from the X-linked inhibitor of apoptosis gene.
Pharmagene Labs WO 00/05409
Gene expression analysis
Royston, U.K.
Quantitative analysis of gene expression using PCR amplification techniques and fluorescent reporter signals.
Pharmaspec WO 00/04928
Revascularizing tissue
Redmond, Wash.
Retrograde perfusion of angiogenic gene therapy vectors; for revascularizing ischemic tissue.
Procter & Gamble WO 00/05352
Pseudomonas protease
Cincinnati, Ohio
Pseudomonas strain that produces a keratinolytic and caseinolytic protease, expressed protease.
Prodigene WO 00/05384
Protease production in plants
College Stn., Texas
Production of heterologous proteases in plants at 0.1% of total protein without damaging cells.
Rapoport, B., et al. WO 00/05345
Thyrotropin receptor
Santa Monica, Calif.
Human thyrotropin receptor compositions; for diagnostics and therapeutics.
Regeneron Pharma WO 00/05370
Orphan cytokine receptor
Tarrytown, N.Y.
Orphan cytokine receptor, encoding gene sequences; for modulator assays, diagnostics, and therapeutics.
Rhone-Poulenc Rorer WO 00/05362
Kinase modulators
Antony, France
Serine threonine kinase interacting forkhead-associated domain protein, encoding gene; for finding modulators.
Rhone-Poulenc Rorer WO 00/05394
Baculovirus vectors for neurons
Antony, France
Vectors derived from baculoviruses; for transferring nucleic acids into vertebrate nerve cells to treat disease.
Rockefeller Univ. WO 00/05258
Tumor growth inhibitors
New York
Crystals of the complex formed by Ras and Son of sevenless protein; for identifying tumor growth inhibitors.
Rutgers Univ. WO 00/05414
Gene function determination
Piscataway, N.J.
Linking gene sequence to function by three-dimensional protein structure determination using bioinformatics.
Sagami Chem. Res. Ctr. WO 00/05367
Hydrophobic domain proteins
Sagamihara, Japan
Human proteins having hydrophobic domains, encoding gene sequences, expression vectors.
Savage, P.M. GB 2 339 782
Cancer antigen presentation
Redland, U.K.
Chimeric proteins with cell targeting and HLA class I antigen domains; for increased cancer antigen presentation.
Scherer, S.W., et al. WO 00/05405
Laflora's disease gene
Toronto
Laflora's disease-associated gene, deletions, mutations, encoded protein tyrosine kinase; for diagnostics.
Shionogi EPO 978 560
L-methionine lyase crystals
Osaka, Japan
Production of L-methionine gamma-lyase crystals using polyethylene glycol.
Small Molecule Therapeutics WO 00/05417
Protein function determination
Monmouth Junction, N.J.
Libraries of tag dominant-negative elements; for tagging proteins to determine protein-protein interactions.
SmithKline Beecham WO 00/04923
Cysteine-rich protein-5
Philadelphia
Secreted cysteine-rich protein-5, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/05244
Bombesin receptor
Philadelphia
Human bombesin receptor subtype-3sb, encoding gene, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/05259
Cysteine-rich protein-6
Philadelphia
Secreted cysteine-rich protein-6, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/05348
Pneumococcal antibacterials
Philadelphia
Pneumococcal nrdG protein, encoding gene, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/05361
Neurotrophic factor homolog
Brentford, U.K.
Human protein having homology to the prosaposin family of neurotrophic factors, encoding gene sequences.
SmithKline Beecham WO 00/05364
Neuroendocrine protein homolog
Brentford, U.K.
Protein homologous to neuroendocrine-specific protein, encoding gene, production methods; for diagnostics.
SmithKline Beecham WO 00/05365
Human LCB kinase 1
Brentford, U.K.
Human LCB kinase 1, encoding gene sequences, recombinant production methods; for diagnostic assays.
South Alabama Med. Sci. Fdn. WO 00/04929
Inflammation reduction
Mobile, Ala.
Decreasing levels of pulmonary endothelial gene products that allow inflammatory cells to traverse the cell layer.
Suntory EPO 978 563
Delta 9-desaturase
Osaka, Japan
Delta 9-desaturase gene, encoded protein, production methods; for modulating unsaturated fatty acid synthesis.
Suntory EPO 978 565
Protein production
Osaka, Japan
Fusion proteins having an accessory peptide preventing agglutination during production; for purification.
Takeda Chemical WO 00/05264
G protein-conjugated receptor
Osaka, Japan
G protein-conjugated receptor from brain tissue, encoding gene; for identifying modulators.
Takeda Chemical WO 00/05383
Phosphodiesterase V
Osaka, Japan
Phosphodiesterase V, partial peptides, encoding gene sequences; for finding modulators.
Technion Res. & Develop. Fdn. WO 00/05410
Protein-protein interactions
Haifa, Israel
Methods for detecting protein-protein interactions using a Ras-encoded mutant fusion protein.
Unilever WO 00/05389
Protein production methods
Rotterdam, Netherlands
Protein production in lower eukaryotic cells in which glycosylation is increased to increase secretion.
Valentis WO 00/05358
Gene therapy vector production
Burlingame, Calif.
Scaleable automated process for purification of nucleic acids; for making gene therapy vectors
Vanderbilt Univ. WO 00/05375
GBS toxin receptor
Nashville, Tenn.
GBS toxin receptor, encoding gene sequences; for modulator screens, diagnostics, and therapeutics.
Voekel, H. WO 00/05363
Calcineurin modulator screen
Ulm, Germany
Screening for calcineurin modulators using the interaction between calcineurin and superoxide dismutase.
Yeda Res. & Develop. WO 00/05419
Cancer metastasis prevention
Rehovot, Israel
Prevention of metastases using 5-aza-2'-deoxycytidine in patient tumor cells producing DAP-kinase protein.
- Compiled by Chester A. Bisbee