Published January 26 (EPO); January 20 (WO)
Ajinomoto EPO 974 653
Gastric cancer antigen
Human gastric cancer antigen, encoding gene sequences; for inducing cancer immunoresponses.
Amgen EPO 974 655
Thousand Oaks, Calif.
Granulocyte colony stimulating factor (G-CSF) analogs, encoding gene, computer-based design methods.
Amsterdam Molec. Therapeutics WO 00/03013
Liver regeneration gene
Gene involved in liver regeneration, encoded protein, antibodies; for therapeutics.
Banyu Pharma EPO 974 652
Cancer metastasis-associated gene, encoded protein, antisense; for finding inhibitors.
Calgene WO 00/03012 & 03017
Expression of eukaryotic proteins in plant plastids using plastid-targeting and enhancer sequences; for therapeutics.
Chugai EPO 974 648
Mesenchymal cell lines
Undifferentiated mesenchymal cell lines; for differentiation into chondrocytes and adipocytes.
CSIRO (Comm. Sci. & Ind. Res. Org.) WO 00/03006
Sucrose biosynthesis genes
Sucrose biosynthesis genes, encoded proteins; for stable expression and sucrose production.
Connex WO 00/03016
Antibody fragments reacting with zeta- and eta-chains expressed on natural killer cells; for therapeutics.
Cornell Univ. WO 00/02996
Heterologous protein secretion
Recombinant constructs combining genes encoding a functional type III secretion system and a therapeutic protein.
Curagen WO 00/02911
New Haven, Conn.
Human _-amyloid precursor protein complexed with human LON protease-like protein; for treating neurodegeneration.
Daicel Chemical EPO 974 662
Bacterial metabolite production
Process for producing dihydroxyacetone 3-phosphate in transformed bacteria.
Dresden Technical Univ. WO 00/03008
Cytochrome P450 expression
Recombinant haploid and diploid Yarrowia yeast strains; for heterologous cytochrome P450 expression.
Du Pont WO 00/03026
Transcription coactivators, encoding gene sequences, chimeric genes; for altering transcription levels.
Fuso Pharma EPO 974 658
DNA probes for Streptococcus pyogenes strains; for the detection and diagnosis of infections.
Glaxo WO 00/03014
Wound healing therapy
NAB1/2 peptides, active fragments, encoding gene sequences; for gene therapy for cell growth in wound healing.
Hayashibara Seibutsu EPO 974 600
Antibodies to interleukin (IL)-18, fragments, humanized antibodies; for inflammatory and autoimmune diseases.
Incyte Pharma WO 00/03005
Human checkpoint kinase
Palo Alto, Calif.
Human checkpoint kinase, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 00/03015
Transport protein homologs
Palo Alto, Calif.
Human transport protein homologs, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Introgene WO 00/03029
Chimeric recombinant adenoviruses having sequences from various serotypes; for improved gene therapy.
Ioannina, Univ. of EPO 974 650
Endothelial growth inhibitors
Endothelial cell growth inhibitors, encoding gene sequences; for controlling endothelial cell growth.
Itoh, K., et al. WO 00/02907
Cancer antigen peptides
Tumor antigen peptide derived from SART-1, derivatives; for cancer diagnostics and therapeutics.
Japan Tobacco EPO 974 651
Proteins expressed during arteriosclerosis and coronary restenosis, encoding genes; for therapeutics.
Johns Hopkins Univ. WO 00/02910
Forkhead signal transducer
Human forkhead activin signal transducer gene, encoding gene; for activating genes responsive to TGF-_ ligands.
Leiden State Univ. EPO 974 657
Enhanced fungal growth
Reducing branching and enhancing fragmentation in fungi cultures using the Streptomyces griseus ssgA gene.
Loyola Univ. WO 00/03018
Bacillus antibiotic protein
Antibiotic protein with Bacillus subtilis TasA protein properties, fusion protein; for secretion into spores.
Max Delbruck Ctr. Molec. Med. WO 00/03027
Improving gene transfer
Methods for improving gene transfer in mammalian cells using the cell cycle regulator p21.
Max Delbruck Ctr. Molec. Med. WO 00/03028
Optimizing adenovirus production
Methods for optimizing the production of adenovirus vectors using overexpression of the cell cycle regulator p21.
MRC (Med. Res. Counc.) WO 00/03019
Conditional influenza mutants
Conditional mutants of influenza virus M2 protein that cause growth arrest in mammalian cells.
Merck WO 00/02918 & 02919
Modifying GH release
Growth hormone (GH) secretogogue-related receptors, encoding genes; for identifying modulators of growth hormone release.
Merck Frosst Canada WO 00/03023
Apoptosis controlling protein
Usurpin, a mammalian DED-caspase homolog that precludes caspase-8 recruitment and activation; for apoptosis control.
Merial EPO 974 659
Marek's disease vaccine
Marek's disease virus and other virus genes; for diagnostics and vaccines.
Mitsui Chemicals EPO 974 654
Growth hormone production
Human growth hormone gene linked to the E. coli OppA gene; for secretory recombinant hormone production.
Newcastle Univ. WO 00/03010
Gene expression limitation
Prokaryotic expression system with dlt operon alterations; for limiting the expression of genes linked to this operon.
Nielsen, J., et al. WO 00/03020 & 03021
Altered metabolite production
Genetically engineered microbial cell with a modified redox activity resulting in altered metabolite production.
Oriental Yeast EPO 974 665
Recombinant yeast protein disulfide isomerase (PDI), encoding gene; for secretion and purification.
Pharmacia & Upjohn WO 00/02900
Low trisulfide proteins
Production of recombinant proteins having low amounts of trisulfides by using metal salts.
Plant Genetics Inst. WO 00/03009
Glucosamine synthesis inhibition
Genes for the biosynthesis of anticapsin and bacilysine; for use as antagonists of glucosamine synthesis.
Rockefeller Univ. WO 00/03024
Mu opioid receptor alleles
Alleles of the mu opioid receptor; for diagnostics, therapeutics, and selecting pain modulators.
Schering-Plough WO 00/03030
Recombinant raccoonpox viruses having inserted foreign genes; for mammalian vaccines.
Scios WO 00/03011
Production of peptides having a pI above 8 or below 5 using a fusion partner system; for ease of purification.
SES Europe WO 00/03025
Viral genetic modification
Genetic modification of wild type viral sequences; for reducing deleterious effects in cell transformants.
SmithKline Beecham EPO 974 663
Lipoprotein-associated phospholipase A2 (Lp-PLA2), encoding gene, inhibitors; for diagnostics and therapeutics.
SmithKline Beecham EPO 974 664
Mouse testes-specific angiotensin converting enzyme (ACE) homologs, encoding genes; for diagnostics and therapeutics.
Southern California, Univ. of WO 00/02909
Amphiphilic peptides isolated from cytoplasmic tails of viral envelope proteins; for linkage to targeting peptides.
Stichting Inst. EPO 974 660
Newcastle disease vaccines
Generation of infectious, attenuated Newcastle disease virus strains; for vaccines.
Tanabe EPO 974 656
DNA gyrase inhibitors
Bacterial DNA gyrase inhibitor, encoding gene sequences, production methods; for designing inhibitors.
Teikoku Hormone EPO 974 599
Gonadotropin activity increase
Recombinant equine chorionic gonadotropin having both domains linked together; for increased activity.
Toyota Jidosha EPO 974 661
Geranyl diphosphate synthase
Geranyl diphosphate synthase genes, modifications, encoding gene sequences; for diagnostics and therapeutics.
Transgene EPO 974 668
Recombinant adenoviral vectors retaining sufficient E4 sequences to improve expression and its persistence.
Wisconsin, Univ. of WO 00/02997
Transgenic mice expressing humanized green fluorescent protein in astrocytes; for assaying neurotoxins.
Yakult Honsha EPO 974 666
Transferring genes into chromosomes using vectors and a lysogenic phage that deletes unnecessary vector genes.
Zurich Univ. EPO 974 649
Cells transformed with a DNA library encoding modulators; for screening modulator peptides.
- Compiled by Chester A. Bisbee