Published January 12 (EPO); January 6 (WO)
Akzo Nobel WO 00/00638
Tagging RNA amplicons
Tagging of RNA amplicons generated by transcription-based amplification with non-target sequences.
American Cyanamid WO 00/00614
Helicobacter pylori surface antigens, encoding gene sequences; for ulcer diagnostics and therapeutics.
Aventis Res. & Technol. WO 00/00596
Poly(A)-specific 3'-exonuclease, production methods; for polyadenylation of 3'-poly(A) nucleic acid tails.
Avigen WO 00/00589
Production of high titer recombinant adeno-associated virus (AAV) vectors, AAV helper function vectors.
Bae, Y.S. WO 00/00592
Dendritic cell antibodies
Taejon, S. Korea
Monoclonal antibodies that are specific for the surface of dendritic cells.
Biomira WO 00/00828
T cell activation detection
Methods for detecting T cell activation by monitoring MUC-1 mucin expression.
Biotica Technol. WO 00/00618
Multienzyme complex containing polyketide synthases; for antibiotic production.
Buckingham, Univ. of WO 00/00639
Leptin modulator screens
Screening modulators of leptin function using the leptin-activated signal transducer linked to a reporter.
Cell Therapeutics WO 00/00635
Phosphatidylcholine phospholipase D
Phosphatidylcholine phospholipase D, encoding gene, recombinant production methods; for screening modulators.
CDC (Ctr. Disease Control) WO 00/00829
Detecting xenotransplant retroviruses
Methods, devices, and compositions for detecting endogenous retroviruses in xenotransplant materials.
CNRS (Natl. Ctr. Sci. Res.) WO 00/00595
Insect cell enzymes with a-galactosyltransferase activity; for transferring galactose residues to specific substrates.
Chang, L.-J. WO 00/00600
Lentiviral vectors encoding gag and pol proteins; for use in gene therapy.
Chen, H.-M., et al. WO 00/00503
Tumor suppressor locus
Human AZ-1 gene localized to a tumor suppressor locus on chromosome 10q26, variants, encoded proteins, antibodies.
Columbia Univ. WO 00/00185
Cloning of the BCL-6 genetic locus; for regulating transcript levels in treating lymphoma.
Corixa WO 00/00615
Ehrlichia antigens, encoding gene sequences; for vaccines to treat human granulocytic ehrlichiosis.
Croptech Develop. WO 00/00624
Plant urokinase production
Production of recombinant urokinase in plant-based expression systems; for manufacturing therapeutics.
Daewoong Pharma WO 00/00612
Seoul, S. Korea
Human thrombopoietin muteins, encoding genes; for treating thrombocytopenia and enhancing platelet production.
Dartmouth College WO 00/00156
Modulation of humoral immunoresponse by antigen targeting to antigen-presenting cells using anti-CD40 ligands.
Diacrin WO 00/00588
Spinal chord injury treatment
Porcine spinal chord cells having modified cell surface antigens; for treating spinal chord injury.
Dundee, Univ. of WO 00/00599
Combination of an opioid-like and an NF-kappaB activating agent; for inducing apoptosis.
Enzo Diagnostics EPO 971 039
Linear and non-linear nucleic acid amplification procedures; for making sequences with decreased thermodynamic stability.
Garvan Inst. Med. Res. WO 00/00602
GABA-B receptor modulators
GABA-B receptor, encoding gene sequences; for screening neurotransmitter receptor modulators.
Garvan Inst. Med. Res. WO 00/00606
Neuropeptide Y receptor
Neuropeptide Y receptor, encoding gene sequences; for screening modulators.
Genset WO 00/00607
Rb binding protein
Retinoblastoma (Rb) binding protein gene, polymorphic markers, antibodies; for diagnostics and therapeutics.
Genvec WO 00/00628
Making recombinant retroviruses
Replicon-defective recombinant adenovirus with a mutated major late promoter; for making recombinant retroviruses.
GVS Plant Res. Inst. WO 00/00593
Sphingolipid desaturase, encoding gene sequences; for modifying sphingolipid structure.
Hagiwara, Y. EPO 971 034
Algal antibody production
Transformation of blue-green algae cells with antibody heavy chain genes; for producing antibodies.
HSC Res. & Develop. WO 00/00512
Intracellular antifreeze proteins from sculpin skin and gills, encoding genes; for cell and tissue preservation.
Hyseq WO 00/00515
Chemokine receptor from fetal liver-spleen cDNA library, encoding gene, antibodies; for diagnostics and therapeutics.
Imp. Coll. Sci. & Med. EPO 971 033
Gene sequences encoding an amyloid precursor protein or variants; for determining predisposition to Alzheimer's.
Incyte Pharma WO 00/00510
Growth factor modulators
Palo Alto, Calif.
Growth factor modulators, encoding genes, antibodies, agonists, antagonists; for diagnostics and therapeutics.
Incyte Pharma WO 00/00594
Palo Alto, Calif.
Human transferases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 00/00608
Immune system molecules
Palo Alto, Calif.
Immune system molecules, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 00/00609
Palo Alto, Calif.
Apoptosis-associated molecules, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 00/00610
Signal-peptide containing proteins
Palo Alto, Calif.
Human signal-peptide containing proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 00/00622
Human oxidoreductase proteins
Palo Alto, Calif.
Human oxidoreductase proteins, encoding gene sequences, antibiotics, modulators; for diagnostics and therapeutics.
Isis Pharma WO 00/00504
TNF receptor 1 antisense
Antisense to tumor necrosis factor (TNF) receptor 1; for expression modulation.
Kaltoft, K., et al. WO 00/00587
T cell vaccines
Selecting and expanding disease-associated T cell lines; for identifying disease-associated antigens and making vaccines.
Karolinska Innovations WO 00/00621
Parkinson's disease-related mutations in the alcohol dehydrogenase gene; for diagnostics.
Krebs Res. Inst. WO 00/00603
Modularly constructed RNA molecules having three-dimensional structure-maintaining and ligand-binding regions.
Leiden State Univ. WO 00/00613
Reducing branching and enhancing fragmentation in cultured filamentous fungi using the Streptomyces ssgA gene.
Ludwig Inst. Cancer Res. WO 00/00642
Cancer diagnosis with antigens
Quantifying the levels of multiple tumor rejection antigen precursors; for melanoma and breast cancer diagnosis.
Ludwig Inst. Cancer Res. WO 00/00824
Determining the expression of the SSX gene whose product complexes with HLA molecules; for cancer detection.
Masstrace WO 00/00636
Metabolic state management
Using labelled tracer probes of enzymes marking regulatory points in synthetic pathway to determine metabolic function.
Miami Univ. WO 00/00643
Fungal pathogen detection
Hybridization probes, PCR primers, antibodies, and epitopes to a-aminoapidate reductase; for fungal pathogen detection.
Millennium Pharma WO 00/00611
G-protein coupled receptor
G-protein coupled receptor, encoding gene sequence; for modulator screens, diagnostics, and therapeutics.
Millennium Pharma WO 00/00633
Sugar transporter homologs
Organic acid and sugar transporter family protein homologs, encoding genes, fusions, antibodies, transgenics.
Minnesota, Univ. of WO 00/00620
Biosynthetic gene complexes encoding enzymes for synthesizing methymycin, puromycin, and desosamine.
Myriad Genetics WO 00/00605
Tumor suppressor gene
Salt Lake City, Utah
Human tumor suppressor gene, encoded protein, mutants, mimetics; for diagnostics and therapeutics.
November Inst. Molec. Med. WO 00/00224
Cell nucleus targeting
Modified viral proteins associated with therapeutic molecules; for transport to the cellular nucleus.
Pasteur Inst. WO 00/00634
Preventing Helicobacter infection
Screening agents that inhibit the activity of Helicobacter pylori UreI; for infection prevention.
Pasteur Merieux WO 00/00216
Enhancing specific immunoresponses using a combination of immunogenic agents, recombinant poxviruses, and antigens.
Pasteur Merieux WO 00/00217 & 00218
Mucosal targeting immunization
Immunogens from pathogens entering via mucous membranes; for surface administration to elicit a local immunoresponse.
Phylos WO 00/00632
Diverse DNA libraries
Methods for generating highly diverse nucleic acid libraries; for diagnostics and therapeutics.
PPL Therapeutics WO 00/00625
Authentic peptides in milk
DNA constructs that can produce peptides with authentic N-terminal regions in milk when used in transgenic animals.
Procter & Gamble WO 00/00161
Matrix metalloprotease diseases
Screening methods for TEF-3 activity inhibitors; for treating matrix metalloprotease-mediated diseases.
Rapoport, B., et al. WO 00/00590
Santa Monica, Calif.
Human thyrotropin receptor, encoding gene sequences; for diagnostics and therapeutics.
Rhone-Poulenc WO 00/00626
Glucosylating aromatic derivatives
UDP-glucose:glucosyl transferase for the glucosylation of aromatic derivatives, encoding gene sequences.
Rockefeller Univ. WO 00/00825
Modulating cellular immunity
Enhancing cytotoxic T cell production by stimulating antigen presenting cells with immune-privileged antigens.
Sagami Chem. Res. Ctr. WO 00/00506
Hydrophobic domain proteins
Human proteins having hydrophobic domains, encoding gene sequences, expression vector for protein production.
Scripps Res. Inst. WO 00/00645 & 00646
Differentially expressed mRNAs
La Jolla, Calif.
Simultaneous identification of differentially expressed mRNAs and measurement of their relative concentrations.
Shanghai Second Med. Univ. WO 00/00513
Human KRAB-NP gene
Human KRAB-NP gene, encoded proteins, recombinant production methods; for diagnostics and therapeutics.
Sloan-Kettering Inst. WO 00/00644
Increasing DNA damage
Antisense to DNA protein kinase; for increasing heat-, chemical-, or radiation-induced DNA damage.
Takara Shuzo EPO 970 966
Suppressing fungal allergies
Fungal antigens, encoding gene sequences, production methods; for suppressing allergic reactions.
U.S. Agriculture Dept. WO 00/00505
Johne's disease probes
Specific probes for Mycobacterium paratuberculosis; for species-specific genetic identification in Johne's disease.
U.S. Army WO 00/00616
Marburg virus vaccines
Marburg virus antigens, encoding gene sequences; for making vaccines.
U.S. Army WO 00/00617
Ebola virus virion protein antigens expressed from Venezuelan equine encephalitis replicons; for vaccines.
Utah, Univ. of WO 00/00647
Salt Lake City
Determination of angiotensinogen gene variants; for detecting predisposition to hypertension.
Victoria Univ. WO 00/00641
Quantification of transforming growth factor (TGF)-_ using a TGF-_ responsive element linked to a reporter gene.
Virginia, Univ. of WO 00/00604
5' gene regulatory region of the testis-enriched protein SP-10; for screening spermatogenesis modulators.
Viromed WO 00/00629
Retroviral gene therapy vectors
Seoul, S. Korea
High efficiency retroviral vectors for gene therapy that contain no viral coding sequences.
Visible Genetics WO 00/00637
Reduced error sequencing
Methods for sequencing nucleic acids with reduced errors by using a confidence algorithm on accumulated data sets.
Wales, Univ. Coll. Med. WO 00/00640
Determining the angiotensin converting enzyme genotype as an indication of predisposition to Alzheimer's disease.
Zetesis WO 00/00591
Tumor antigen antibodies
Human monoclonal antibodies against the tumor antigen UK114, production hybridomas; for diagnostics and therapeutics.