Published January 12 (EPO); January 6 (WO)

Akzo Nobel WO 00/00638

Tagging RNA amplicons

Arnhem, Netherlands

Tagging of RNA amplicons generated by transcription-based amplification with non-target sequences.

American Cyanamid WO 00/00614

Ulcer diagnostics

Madison, N.J.

Helicobacter pylori surface antigens, encoding gene sequences; for ulcer diagnostics and therapeutics.

Aventis Res. & Technol. WO 00/00596


Frankfurt, Germany

Poly(A)-specific 3'-exonuclease, production methods; for polyadenylation of 3'-poly(A) nucleic acid tails.

Avigen WO 00/00589

AAV vectors

Alameda, Calif.

Production of high titer recombinant adeno-associated virus (AAV) vectors, AAV helper function vectors.

Bae, Y.S. WO 00/00592

Dendritic cell antibodies

Taejon, S. Korea

Monoclonal antibodies that are specific for the surface of dendritic cells.

Biomira WO 00/00828

T cell activation detection

Edmonton, Alberta

Methods for detecting T cell activation by monitoring MUC-1 mucin expression.

Biotica Technol. WO 00/00618

Antibiotic production

Cambridge, UK

Multienzyme complex containing polyketide synthases; for antibiotic production.

Buckingham, Univ. of WO 00/00639

Leptin modulator screens

Buckingham, UK

Screening modulators of leptin function using the leptin-activated signal transducer linked to a reporter.

Cell Therapeutics WO 00/00635

Phosphatidylcholine phospholipase D

Seattle, Wash.

Phosphatidylcholine phospholipase D, encoding gene, recombinant production methods; for screening modulators.

CDC (Ctr. Disease Control) WO 00/00829

Detecting xenotransplant retroviruses


Methods, devices, and compositions for detecting endogenous retroviruses in xenotransplant materials.

CNRS (Natl. Ctr. Sci. Res.) WO 00/00595



Insect cell enzymes with a-galactosyltransferase activity; for transferring galactose residues to specific substrates.

Chang, L.-J. WO 00/00600

Lentiviral vectors

Gainesville, Fla.

Lentiviral vectors encoding gag and pol proteins; for use in gene therapy.

Chen, H.-M., et al. WO 00/00503

Tumor suppressor locus

Richmond, Calif.

Human AZ-1 gene localized to a tumor suppressor locus on chromosome 10q26, variants, encoded proteins, antibodies.

Columbia Univ. WO 00/00185

Lymphoma therapeutics

New York

Cloning of the BCL-6 genetic locus; for regulating transcript levels in treating lymphoma.

Corixa WO 00/00615

Ehrlichiosis therapy


Ehrlichia antigens, encoding gene sequences; for vaccines to treat human granulocytic ehrlichiosis.

Croptech Develop. WO 00/00624

Plant urokinase production

Blacksburg, Va.

Production of recombinant urokinase in plant-based expression systems; for manufacturing therapeutics.

Daewoong Pharma WO 00/00612

Thrombopoietin muteins

Seoul, S. Korea

Human thrombopoietin muteins, encoding genes; for treating thrombocytopenia and enhancing platelet production.

Dartmouth College WO 00/00156

Immunoresponse modulation

Hanover, N.H.

Modulation of humoral immunoresponse by antigen targeting to antigen-presenting cells using anti-CD40 ligands.

Diacrin WO 00/00588

Spinal chord injury treatment

Charlestown, Mass.

Porcine spinal chord cells having modified cell surface antigens; for treating spinal chord injury.

Dundee, Univ. of WO 00/00599

Apoptosis induction

Dundee, U.K.

Combination of an opioid-like and an NF-kappaB activating agent; for inducing apoptosis.

Enzo Diagnostics EPO 971 039

Amplification procedures

New York

Linear and non-linear nucleic acid amplification procedures; for making sequences with decreased thermodynamic stability.

Garvan Inst. Med. Res. WO 00/00602

GABA-B receptor modulators

Darlinghurst, Australia

GABA-B receptor, encoding gene sequences; for screening neurotransmitter receptor modulators.

Garvan Inst. Med. Res. WO 00/00606

Neuropeptide Y receptor

Darlinghurst, Australia

Neuropeptide Y receptor, encoding gene sequences; for screening modulators.

Genset WO 00/00607

Rb binding protein


Retinoblastoma (Rb) binding protein gene, polymorphic markers, antibodies; for diagnostics and therapeutics.

Genvec WO 00/00628

Making recombinant retroviruses

Gaithersburg, Md.

Replicon-defective recombinant adenovirus with a mutated major late promoter; for making recombinant retroviruses.

GVS Plant Res. Inst. WO 00/00593

Sphingolipid desaturase

Bonn, Germany

Sphingolipid desaturase, encoding gene sequences; for modifying sphingolipid structure.

Hagiwara, Y. EPO 971 034

Algal antibody production

Takarazuka, Japan

Transformation of blue-green algae cells with antibody heavy chain genes; for producing antibodies.

HSC Res. & Develop. WO 00/00512

Antifreeze proteins

Toronto, Ont.

Intracellular antifreeze proteins from sculpin skin and gills, encoding genes; for cell and tissue preservation.

Hyseq WO 00/00515

Chemokine receptor

Sunnyvale, Calif.

Chemokine receptor from fetal liver-spleen cDNA library, encoding gene, antibodies; for diagnostics and therapeutics.

Imp. Coll. Sci. & Med. EPO 971 033

Alzheimer's diagnostics


Gene sequences encoding an amyloid precursor protein or variants; for determining predisposition to Alzheimer's.

Incyte Pharma WO 00/00510

Growth factor modulators

Palo Alto, Calif.

Growth factor modulators, encoding genes, antibodies, agonists, antagonists; for diagnostics and therapeutics.

Incyte Pharma WO 00/00594

Human transferases

Palo Alto, Calif.

Human transferases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 00/00608

Immune system molecules

Palo Alto, Calif.

Immune system molecules, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 00/00609

Apoptosis-associated molecules

Palo Alto, Calif.

Apoptosis-associated molecules, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 00/00610

Signal-peptide containing proteins

Palo Alto, Calif.

Human signal-peptide containing proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 00/00622

Human oxidoreductase proteins

Palo Alto, Calif.

Human oxidoreductase proteins, encoding gene sequences, antibiotics, modulators; for diagnostics and therapeutics.

Isis Pharma WO 00/00504

TNF receptor 1 antisense

Carlsbad, Calif.

Antisense to tumor necrosis factor (TNF) receptor 1; for expression modulation.

Kaltoft, K., et al. WO 00/00587

T cell vaccines

Hammel, Denmark

Selecting and expanding disease-associated T cell lines; for identifying disease-associated antigens and making vaccines.

Karolinska Innovations WO 00/00621

Parkinson's diagnostics

Stockholm, Sweden

Parkinson's disease-related mutations in the alcohol dehydrogenase gene; for diagnostics.

Krebs Res. Inst. WO 00/00603

Modular RNA

Heidelberg, Germany

Modularly constructed RNA molecules having three-dimensional structure-maintaining and ligand-binding regions.

Leiden State Univ. WO 00/00613

Fungi culture

Leiden, Netherlands

Reducing branching and enhancing fragmentation in cultured filamentous fungi using the Streptomyces ssgA gene.

Ludwig Inst. Cancer Res. WO 00/00642

Cancer diagnosis with antigens

New York

Quantifying the levels of multiple tumor rejection antigen precursors; for melanoma and breast cancer diagnosis.

Ludwig Inst. Cancer Res. WO 00/00824

Cancer detection

New York

Determining the expression of the SSX gene whose product complexes with HLA molecules; for cancer detection.

Masstrace WO 00/00636

Metabolic state management

Woburn, Mass.

Using labelled tracer probes of enzymes marking regulatory points in synthetic pathway to determine metabolic function.

Miami Univ. WO 00/00643

Fungal pathogen detection

Oxford, Ohio

Hybridization probes, PCR primers, antibodies, and epitopes to a-aminoapidate reductase; for fungal pathogen detection.

Millennium Pharma WO 00/00611

G-protein coupled receptor

Cambridge, Mass.

G-protein coupled receptor, encoding gene sequence; for modulator screens, diagnostics, and therapeutics.

Millennium Pharma WO 00/00633

Sugar transporter homologs

Cambridge, Mass.

Organic acid and sugar transporter family protein homologs, encoding genes, fusions, antibodies, transgenics.

Minnesota, Univ. of WO 00/00620

Antibiotic production

Minneapolis, Minn.

Biosynthetic gene complexes encoding enzymes for synthesizing methymycin, puromycin, and desosamine.

Myriad Genetics WO 00/00605

Tumor suppressor gene

Salt Lake City, Utah

Human tumor suppressor gene, encoded protein, mutants, mimetics; for diagnostics and therapeutics.

November Inst. Molec. Med. WO 00/00224

Cell nucleus targeting

Erlangen, Germany

Modified viral proteins associated with therapeutic molecules; for transport to the cellular nucleus.

Pasteur Inst. WO 00/00634

Preventing Helicobacter infection


Screening agents that inhibit the activity of Helicobacter pylori UreI; for infection prevention.

Pasteur Merieux WO 00/00216

Enhancing immunoresponses

Lyon, France

Enhancing specific immunoresponses using a combination of immunogenic agents, recombinant poxviruses, and antigens.

Pasteur Merieux WO 00/00217 & 00218

Mucosal targeting immunization

Lyon, France

Immunogens from pathogens entering via mucous membranes; for surface administration to elicit a local immunoresponse.

Phylos WO 00/00632

Diverse DNA libraries

Lexington, Mass.

Methods for generating highly diverse nucleic acid libraries; for diagnostics and therapeutics.

PPL Therapeutics WO 00/00625

Authentic peptides in milk

Roslin, U.K.

DNA constructs that can produce peptides with authentic N-terminal regions in milk when used in transgenic animals.

Procter & Gamble WO 00/00161

Matrix metalloprotease diseases

Cincinnati, Ohio

Screening methods for TEF-3 activity inhibitors; for treating matrix metalloprotease-mediated diseases.

Rapoport, B., et al. WO 00/00590

Thyrotropin receptor

Santa Monica, Calif.

Human thyrotropin receptor, encoding gene sequences; for diagnostics and therapeutics.

Rhone-Poulenc WO 00/00626

Glucosylating aromatic derivatives

Lyon, France

UDP-glucose:glucosyl transferase for the glucosylation of aromatic derivatives, encoding gene sequences.

Rockefeller Univ. WO 00/00825

Modulating cellular immunity

New York

Enhancing cytotoxic T cell production by stimulating antigen presenting cells with immune-privileged antigens.

Sagami Chem. Res. Ctr. WO 00/00506

Hydrophobic domain proteins

Sagamihara, Japan

Human proteins having hydrophobic domains, encoding gene sequences, expression vector for protein production.

Scripps Res. Inst. WO 00/00645 & 00646

Differentially expressed mRNAs

La Jolla, Calif.

Simultaneous identification of differentially expressed mRNAs and measurement of their relative concentrations.

Shanghai Second Med. Univ. WO 00/00513

Human KRAB-NP gene

Shanghai, China

Human KRAB-NP gene, encoded proteins, recombinant production methods; for diagnostics and therapeutics.

Sloan-Kettering Inst. WO 00/00644

Increasing DNA damage

New York

Antisense to DNA protein kinase; for increasing heat-, chemical-, or radiation-induced DNA damage.

Takara Shuzo EPO 970 966

Suppressing fungal allergies

Kyoto, Japan

Fungal antigens, encoding gene sequences, production methods; for suppressing allergic reactions.

U.S. Agriculture Dept. WO 00/00505

Johne's disease probes


Specific probes for Mycobacterium paratuberculosis; for species-specific genetic identification in Johne's disease.

U.S. Army WO 00/00616

Marburg virus vaccines

Frederick, Md.

Marburg virus antigens, encoding gene sequences; for making vaccines.

U.S. Army WO 00/00617

Ebola vaccines

Frederick, Md.

Ebola virus virion protein antigens expressed from Venezuelan equine encephalitis replicons; for vaccines.

Utah, Univ. of WO 00/00647

Hypertension predisposition

Salt Lake City

Determination of angiotensinogen gene variants; for detecting predisposition to hypertension.

Victoria Univ. WO 00/00641

TGF-_ quantification

Manchester, U.K.

Quantification of transforming growth factor (TGF)-_ using a TGF-_ responsive element linked to a reporter gene.

Virginia, Univ. of WO 00/00604

Spermatogenesis modulators

Charlottesville, Va.

5' gene regulatory region of the testis-enriched protein SP-10; for screening spermatogenesis modulators.

Viromed WO 00/00629

Retroviral gene therapy vectors

Seoul, S. Korea

High efficiency retroviral vectors for gene therapy that contain no viral coding sequences.

Visible Genetics WO 00/00637

Reduced error sequencing

Toronto, Ont.

Methods for sequencing nucleic acids with reduced errors by using a confidence algorithm on accumulated data sets.

Wales, Univ. Coll. Med. WO 00/00640

Alzheimer's predisposition

Cardiff, U.K.

Determining the angiotensin converting enzyme genotype as an indication of predisposition to Alzheimer's disease.

Zetesis WO 00/00591

Tumor antigen antibodies

Milan, Italy

Human monoclonal antibodies against the tumor antigen UK114, production hybridomas; for diagnostics and therapeutics.