Published September 8 (EPO); September 2 (WO)

Akzo Nobel WO 99/43850

Differential expression assay

Arnhem, Netherlands

Non-specific generation of multiple copies of mRNAs from a sample pool; for screening differential expression.

Axys Pharma WO 99/43696

Potassium channel genes

S. San Francisco

Human potassium channel genes, encoded proteins; for diagnostics and therapeutics.

Beckman Coulter WO 99/43710

PSA immunoassay

Fullerton, Calif.

Prostate-specific antigens (PSAs) substantially free of other human proteins, antibodies; for immunoassay.

Bern Univ. WO 99/43833

Potato disease resistance

Bern, Switzerland

Potatoes having an enhanced level of pyruvate decarboxylase; for stimulating disease resistance.

Boehringer Ingelheim WO 99/43840

Inflammatory cell apoptosis

Ridgefield, Conn.

Vector with TNFa promoter linked to an apoptosis-inducing gene; for self-regulated apoptosis in inflammatory cells.

British Columbia, Univ. of WO 99/43848

Unknown gene identification

Vancouver, B.C.

Methods combining gene trap and two-hybrid systems; for finding unknown genes by protein-protein interactions.

California, Univ. of WO 99/43704

Inflammation inhibition

Oakland, Calif.

Mutant NIK proteins used to interrupt NIK-IKK interaction and the induced inflammatory response.

California, Univ. of WO 99/43709

Melanocortin receptor antagonists

Oakland, Calif.

Melanocortin receptor antagonists; for affecting the activity of melanocortin receptors and treating melanoma.

California, Univ. of WO 99/43789

Efficient AAV vectors

Oakland, Calif.

Efficient adeno-associated virus (AAV) vectors; for delivering therapeutic nucleic acids during gene therapy.

California, Univ. of WO 99/43809

Protease-activated receptor 4

Oakland, Calif.

Protease-activated receptor 4, encoding gene, fragments, analogs, antibodies; for coagulation antagonists.

Canadian Agriculture Ministry WO 99/43795

In situ mammary transfection

Ottawa, Ont.

In situ transfection of mammary epithelial cells with viral-based vectors; for producing therapeutics.

Cancer Res. Camp. Technol. WO 99/43800

Cancer vaccines


Tumor-associated antigen 791Tgp72 of the CD55 family, fragments, derivatives; for cancer vaccines.

Cancer Res. Camp. Technol. WO 99/43801

Anti-angiogenic vaccines


Tek protein epitopes that bind to MHC antigens, encoding gene sequences, antibodies; for anti-angiogenic vaccines.

Cargill WO 99/43202

Brassica transformation

Wayzata, Minn.

Methods for transforming cultured Brassica cells by particle bombardment; for whole plant regeneration.

Chugai WO 99/43703

HM1.24 antibody assay


Immunochemical assay for anti-HM1.24 antibodies using soluble antigens.

Chugai WO 99/43803

HM1.24 antigen


HM1.24 antigen, encoding gene sequences, promoter sequence, splice variant, fragments.

CLI Oncology WO 99/43798

Soluble IL-2 receptors

Jamestown, N.Y.

Soluble interleukin (IL)-2 receptors produced by metastatic cells, encoding gene sequences; for diagnostics.

Cold Spring Harbor Labs EPO 940 469

cAMP pathway genes

Cold Spring Harbor, N.Y.

Identification of mammalian cDNAs that affect cAMP pathways using yeast complementation systems.

Columbia Univ. WO 99/43844

Reciprocal subtraction display

New York

Reciprocal subtraction of nucleic acid libraries; for identifying differentially expressed genes.

Columbia Univ. WO 99/43857

Metastatic prostate cancer

New York

Prostate carcinoma tumor antigen gene, probes, primers; for detecting metastatic prostate cancer.

Dow Chemical WO 99/43816

Humanized cancer antibodies

Midland, Mich.

High affinity humanized anti-TAG-72 antibodies, fragments, derivatives; for cancer diagnostics and therapeutics.

Dow Chemical WO 99/43817

Humanized CEA antibodies

Midland, Mich.

High affinity humanized carcinoembryonic antigen (CEA) antibodies; for cancer diagnostics and therapeutics.

Du Pont WO 99/43820

Plant translation factor eIF-4E

Wilmington, Del.

Plant translation factor eIF-4E, encoding gene sequences; for constructing chimeric genes.

Du Pont WO 99/43825

Plant flavone-3-hydroxylase

Wilmington, Del.

Plant flavone-3-hydroxylase, encoding gene sequences; for making chimeric genes to affect enzyme expression.

Du Pont WO 99/43827

Cyclopropane synthase

Wilmington, Del.

Cyclopropane fatty acyl phospholipid synthase, encoding gene sequence, chimeric genes; for affecting enzyme levels.

Energy Biosystems WO 99/43826

Fuel desulfurization

The Woodlands, Texas

Thiophene desulfurization enzyme, encoding gene, fragments, transduced microbes; for fossil fuel desulfurization.

Finnish Immunotechnol. WO 99/43841

HIV immunization

Tarnpere, Finland

Self-replicating papillomavirus-based vectors encoding an HIV regulatory protein; for DNA immunization against HIV.

Genentech EPO 940 468

Humanized antibodies

S. San Francisco

Humanized antibody variable domains having non-human complementarity determining regions.

Genentech WO 99/43828

Drosophila fused gene homolog

S. San Francisco

Human homolog of Drosophila fused gene, expressed sequence tags, probes, encoded proteins; for finding modulators.

Genetics Inst. WO 99/43834

P-selectin ligand

Cambridge, Mass.

P-selectin ligand glycoprotein, tetrameric fusions, encoding gene sequences; for treating adhesion-based inflammation.

Genomics Collaborative WO 99/43855

Polymorphism labelling

Cambridge, Mass.

Internal labelling of biological samples using inherent polymorphisms; for identifying sample source.

Glasgow, Univ. of WO 99/43845

Sequencing methods

Glasgow, U.K.

Nucleic acid sequencing using restriction enzymes cleaving at a site removed from the recognition site.

Harvard Univ. WO 99/43808

Human c-Maf proteins

Cambridge, Mass.

Human c-Maf proteins, encoding gene sequences, antisense, transgenics; for identifying modulators.

Human Genome Sciences WO 99/43693

36 secreted proteins

Rockville, Md.

36 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Immuno WO 99/43712

Plasma Factor VIII

Vienna, Austria

Production of Factor VIII/von Willebrand Factor complex from plasma by cation exchange chromatography.

Incyte Pharma WO 99/43805

Protein kinase C inhibitor

Palo Alto, Calif.

Human protein kinase C inhibitor, encoding gene sequence, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 99/43806

SMN-like protein

Palo Alto, Calif.

Human SMN-like protein, encoding gene sequence, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 99/43807

Channel-related proteins

Palo Alto, Calif.

Human channel-related proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 99/43829

Cell cycle-related proteins

Palo Alto, Calif.

Cell cycle-related proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 99/43832

Human proteinases

Palo Alto, Calif.

Human proteinases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Iomai WO 99/43350

Transcutaneous immunoresponse


Skin penetration enhancers; for transcutaneous systemic or mucosal immune response to ADP-ribosylating exotoxin.

Ireland, Natl. Univ. of WO 99/43851

Miscarriage susceptibility gene

Cork, Ireland

HLA-linked pre-eclampsia and miscarriage susceptibility gene; for diagnostics and therapeutics.

Japan Tobacco WO 99/43818

Flower organ promoters


Nucleic acid sequences for flower organ-specific promoters; for control of gene expression in plant flowers.

Johns Hopkins Univ. WO 99/43843

Recombinant adenovirus production

Baltimore, Md.

Simplified generation and production of recombinant adenoviruses obtainable without plaque purification.

Lexigen Pharma WO 99/43713

Antibody-based fusions

Lexington, Mass.

Antibody-based fusion proteins unable to bind immunoglobulin Fc receptors because of isotype or mutagenesis.

Lilly WO 99/43792

Hepatitis C polymerase

Indianapolis, Ind.

Soluble, recombinant RNA-dependent polymerase from the human hepatitis C viral genome; for therapeutics.

Mass. Gen. Hosp. WO 99/43208

Helios gene


Helios gene, encoded protein, production methods; for diagnostics and therapeutics.

McGinnis, R.E., et al. WO 99/43858

Localizing trait genes

Sawbridgeworth, U.K.

Two-dimensional linkage study techniques using bi-allelic markers to localize trait-causing genes.

Med. Coll. Hampton Roads WO 99/43785

Embryonic stem cells

Norfolk, Va.

Derivation of embryonic stem cells from pre-stem morulae or blastocysts; for transplantation therapy.

Merck WO 99/43695

Macular dystrophy gene

Rahway, N.J.

Best's macular dystrophy gene, encoded protein, recombinant expression methods; for diagnostics.

Nanogen WO 99/43853

DNA length polymorphisms

San Diego

Methods and apparatus for determining length polymorphisms in DNA by assaying repeat units.

NIH (Natl. Inst. Hlth.) WO 99/43711

G-protein receptor antagonists

Bethesda, Md.

G-protein coupled receptor antagonists made from peptides of the seven transmembrane domains.

NIH (Natl. Inst. Hlth.) WO 99/43811

B5T over-expressed gene

Bethesda, Md.

B5T over-expressed gene, encoded protein; for modulating pRb-protein interactions and transformed cells.

NIH (Natl. Inst. Hlth.) WO 99/43812

Liver cancer gene deletion

Bethesda, Md.

DLC-1 gene which is frequently deleted in liver cancer; for cancer diagnostics and therapeutics.

NIH (Natl. Inst. Hlth.) WO 99/43814

ICER synthesis blockade

Bethesda, Md.

Therapeutic blockade of ICER synthesis; for preventing ICER-mediated inhibition of immune cell activity.

Neurovir WO 99/43842

Recombinant virus formation

Vancouver, B.C.

Artificial chromosome constructs containing nucleic acid sequences for directing recombinant virus formation.

Nevada, Univ. of WO 99/43697

SOD isoforms

Reno, Nev.

Manganese superoxide dismutase (SOD) isoforms with exon 3 deleted, encoding genes; for diagnostics and therapeutics.

Nippon Meat Packers EPO 940 467

Pig xenotransplants

Osaka, Japan

Promoters for pig complement inhibitor genes; for making transgenic pigs for xenotransplantation.

North Carolina, Univ. of WO 99/43810

Mutant heparin cofactor II

Chapel Hill, N.C.

Mutant heparin cofactor II having a carboxy terminal extension; for enhanced anti-thrombotic effects.

Novo Nordisk WO 99/43705-43708

GLP-1 derivatives

Bagsvaerd, Denmark

N-terminal modified and truncated glucagon-like peptide (GLP)-1, lipophilic analogs; for diabetes and obesity.

Novo Nordisk Biotech WO 99/43835

Bacillus production system

Davis, Calif.

Production of recombinant proteins in Bacillus using gene constructs having mRNA processing stabilizing sequences.

Novopharm Biotech WO 99/43815

Tumor ganglioside antibodies


Human monoclonal antibodies against major tumor-associated gangliosides; for cancer diagnostics and therapeutics.

NST Neurosurvival Technol. WO 99/43701

Apoptosis inhibition

Petach Tikva, Israel

RY domain peptides; for preventing inappropriate activation of apoptosis.

Ohio State Univ. WO 99/43854

Specific site cleavage

Columbus, Ohio

Cleavage of single- and double-stranded DNA at specific sites using nucleotide integrase; for sequence insertion.

Pennsylvania, Univ. of WO 99/43360

Muscular dystrophy gene therapy


Gene therapy for muscle cells using a sarcoglycan-encoding gene; for preventing dystrophic sarcolemmal degeneration.

Pennsylvania, Univ. of WO 99/43839

Autoimmune disease vaccines


Nucleic acid sequences encoding immunomodulatory proteins; for DNA, protein, and live attenuated vaccines.

Pharmacia & Upjohn WO 99/43830

Platelet heparanase

Kalamazoo, Mich.

Human platelet heparanase, encoding gene sequences; for identifying modulators.

Pioneer Hi-Bred WO 99/43797 & 43819

Constitutive maize promoters

Des Moines, Iowa

Constitutive maize promoters, pathogenesis-related gene; for regulating gene expression in plants.

Pioneer Hi-Bred WO 99/43821-43823

Plant pathogen defense

Des Moines, Iowa

Genes with nitric oxide-inducible and constitutive promoters; for activating plant pathogen defense systems.

Pioneer Hi-Bred WO 99/43838

Synthetic plant promoters

Des Moines, Iowa

Synthetic promoters that enhance the expression of heterologous genes in plants; for transgenics.

Plant Biosciences WO 99/43836

Banana streak virus detection

Norwich, U.K.

Banana streak virus promoter, vectors for transgenic gene expression; for infection detection.

Promega WO 99/43856

Polymorphism analysis

Madison, Wis.

Allelic ladders for short tandem repeat loci; for analyzing polymorphisms.

Regeneron Pharma WO 99/43813

Modified CNTF

Tarrytown, N.Y.

Modified ciliary neurotrophic factor (CNTF), production methods; for treating Huntington's disease and diabetes.

Roche Diagnostics WO 99/43849

Highly concentrated nucleic acids

Mannheim, Germany

Utilizing a defined excess of primers in amplification reactions to identify highly concentrated nucleic acids.

Rutgers Univ. WO 99/43796

Pathogen-activated MAP kinase

New Brunswick, N.J.

Pathogen-activatable mitogen-activated (MAP) kinase; for making disease-resistant plants.

Sagami Chem. Res. Ctr. WO 99/43802

Transmembrane domain proteins

Sagamihara, Japan

Human proteins having transmembrane domains, encoding cDNAs; for expression in heterologous cells.

Samsung Fine Chemicals WO 99/43852

Neuropsychiatric disease diagnosis

Ulsan, S. Korea

Diagnostic methods and kits for finding CAG trinucleotide repeats characteristic of neuropsychiatric disease.

Scripps Inst. WO 99/43783

N-CAM modulators

La Jolla, Calif.

Transgenic mouse with LacZ reporter gene controlled by the N-CAM promoter; for detecting modulators.

SmithKline Beecham WO 99/43692

Streptococcus antibacterials


Streptococcus pneumoniae pyrH gene sequences, encoded polypeptides; for antibacterial screens.

SmithKline Beecham WO 99/43831

Human cysteine protease

Brentford, U.K.

Human cysteine protease, encoding gene sequences, production methods; for diagnostics and therapeutics.

Sumitomo Electric WO 99/43702

NE-dig binding protein

Osaka, Japan

Protein that binds NE-dig having no known homologies to other mammalian proteins.

Takeda Chemical WO 99/43799

Endocrine disrupter antibodies

Osaka, Japan

Monoclonal antibodies to endocrine disrupting substances; for immunological assays of the disrupter and its products.

Utrecht Univ. WO 99/43804

Affecting tumorigenesis

Utrecht, Netherlands

TCF-3/4 protein with a _-catenin binding domain; for treating tumorigenesis related to Wnt/Wingless signalling.

Van Aardappelmeel Coop WO 99/43837

Steroid glycoalkaloid removal

Veendam, Netherlands

Microbes for converting and removing steroid glycoalkaloids from potatoes; for making edible disease-resistant plants.

Wake Forest Univ. WO 99/43784

Bone growth genes

Winston-Salem, N.C.

Human DLX3 genes, encoded proteins involved in craniofacial development; for bone growth and repair.

Wallac EPO 940 470

Diabetes autoantigens

Turku, Finland

Fusion protein with epitopes from diabetes autoantigens, encoding gene sequences; for autoantibody detection.

Wisconsin, Univ. of WO 99/43203

Mycorrhizal resistance

Madison, Wis.

Maize plant strains having mycorrhizal resistance and enhanced ability to extract phosphorus from soils.

Wisconsin, Univ. of WO 99/43824

Rice blast resistance

Madison, Wis.

Rice blast avirulence gene; for improving the resistance of rice to rice blast.