Published September 8 (EPO); September 2 (WO)
Akzo Nobel WO 99/43850
Differential expression assay
Non-specific generation of multiple copies of mRNAs from a sample pool; for screening differential expression.
Axys Pharma WO 99/43696
Potassium channel genes
S. San Francisco
Human potassium channel genes, encoded proteins; for diagnostics and therapeutics.
Beckman Coulter WO 99/43710
Prostate-specific antigens (PSAs) substantially free of other human proteins, antibodies; for immunoassay.
Bern Univ. WO 99/43833
Potato disease resistance
Potatoes having an enhanced level of pyruvate decarboxylase; for stimulating disease resistance.
Boehringer Ingelheim WO 99/43840
Inflammatory cell apoptosis
Vector with TNFa promoter linked to an apoptosis-inducing gene; for self-regulated apoptosis in inflammatory cells.
British Columbia, Univ. of WO 99/43848
Unknown gene identification
Methods combining gene trap and two-hybrid systems; for finding unknown genes by protein-protein interactions.
California, Univ. of WO 99/43704
Mutant NIK proteins used to interrupt NIK-IKK interaction and the induced inflammatory response.
California, Univ. of WO 99/43709
Melanocortin receptor antagonists
Melanocortin receptor antagonists; for affecting the activity of melanocortin receptors and treating melanoma.
California, Univ. of WO 99/43789
Efficient AAV vectors
Efficient adeno-associated virus (AAV) vectors; for delivering therapeutic nucleic acids during gene therapy.
California, Univ. of WO 99/43809
Protease-activated receptor 4
Protease-activated receptor 4, encoding gene, fragments, analogs, antibodies; for coagulation antagonists.
Canadian Agriculture Ministry WO 99/43795
In situ mammary transfection
In situ transfection of mammary epithelial cells with viral-based vectors; for producing therapeutics.
Cancer Res. Camp. Technol. WO 99/43800
Tumor-associated antigen 791Tgp72 of the CD55 family, fragments, derivatives; for cancer vaccines.
Cancer Res. Camp. Technol. WO 99/43801
Tek protein epitopes that bind to MHC antigens, encoding gene sequences, antibodies; for anti-angiogenic vaccines.
Cargill WO 99/43202
Methods for transforming cultured Brassica cells by particle bombardment; for whole plant regeneration.
Chugai WO 99/43703
HM1.24 antibody assay
Immunochemical assay for anti-HM1.24 antibodies using soluble antigens.
Chugai WO 99/43803
HM1.24 antigen, encoding gene sequences, promoter sequence, splice variant, fragments.
CLI Oncology WO 99/43798
Soluble IL-2 receptors
Soluble interleukin (IL)-2 receptors produced by metastatic cells, encoding gene sequences; for diagnostics.
Cold Spring Harbor Labs EPO 940 469
cAMP pathway genes
Cold Spring Harbor, N.Y.
Identification of mammalian cDNAs that affect cAMP pathways using yeast complementation systems.
Columbia Univ. WO 99/43844
Reciprocal subtraction display
Reciprocal subtraction of nucleic acid libraries; for identifying differentially expressed genes.
Columbia Univ. WO 99/43857
Metastatic prostate cancer
Prostate carcinoma tumor antigen gene, probes, primers; for detecting metastatic prostate cancer.
Dow Chemical WO 99/43816
Humanized cancer antibodies
High affinity humanized anti-TAG-72 antibodies, fragments, derivatives; for cancer diagnostics and therapeutics.
Dow Chemical WO 99/43817
Humanized CEA antibodies
High affinity humanized carcinoembryonic antigen (CEA) antibodies; for cancer diagnostics and therapeutics.
Du Pont WO 99/43820
Plant translation factor eIF-4E
Plant translation factor eIF-4E, encoding gene sequences; for constructing chimeric genes.
Du Pont WO 99/43825
Plant flavone-3-hydroxylase, encoding gene sequences; for making chimeric genes to affect enzyme expression.
Du Pont WO 99/43827
Cyclopropane fatty acyl phospholipid synthase, encoding gene sequence, chimeric genes; for affecting enzyme levels.
Energy Biosystems WO 99/43826
The Woodlands, Texas
Thiophene desulfurization enzyme, encoding gene, fragments, transduced microbes; for fossil fuel desulfurization.
Finnish Immunotechnol. WO 99/43841
Self-replicating papillomavirus-based vectors encoding an HIV regulatory protein; for DNA immunization against HIV.
Genentech EPO 940 468
S. San Francisco
Humanized antibody variable domains having non-human complementarity determining regions.
Genentech WO 99/43828
Drosophila fused gene homolog
S. San Francisco
Human homolog of Drosophila fused gene, expressed sequence tags, probes, encoded proteins; for finding modulators.
Genetics Inst. WO 99/43834
P-selectin ligand glycoprotein, tetrameric fusions, encoding gene sequences; for treating adhesion-based inflammation.
Genomics Collaborative WO 99/43855
Internal labelling of biological samples using inherent polymorphisms; for identifying sample source.
Glasgow, Univ. of WO 99/43845
Nucleic acid sequencing using restriction enzymes cleaving at a site removed from the recognition site.
Harvard Univ. WO 99/43808
Human c-Maf proteins
Human c-Maf proteins, encoding gene sequences, antisense, transgenics; for identifying modulators.
Human Genome Sciences WO 99/43693
36 secreted proteins
36 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Immuno WO 99/43712
Plasma Factor VIII
Production of Factor VIII/von Willebrand Factor complex from plasma by cation exchange chromatography.
Incyte Pharma WO 99/43805
Protein kinase C inhibitor
Palo Alto, Calif.
Human protein kinase C inhibitor, encoding gene sequence, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 99/43806
Palo Alto, Calif.
Human SMN-like protein, encoding gene sequence, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 99/43807
Palo Alto, Calif.
Human channel-related proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 99/43829
Cell cycle-related proteins
Palo Alto, Calif.
Cell cycle-related proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 99/43832
Palo Alto, Calif.
Human proteinases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Iomai WO 99/43350
Skin penetration enhancers; for transcutaneous systemic or mucosal immune response to ADP-ribosylating exotoxin.
Ireland, Natl. Univ. of WO 99/43851
Miscarriage susceptibility gene
HLA-linked pre-eclampsia and miscarriage susceptibility gene; for diagnostics and therapeutics.
Japan Tobacco WO 99/43818
Flower organ promoters
Nucleic acid sequences for flower organ-specific promoters; for control of gene expression in plant flowers.
Johns Hopkins Univ. WO 99/43843
Recombinant adenovirus production
Simplified generation and production of recombinant adenoviruses obtainable without plaque purification.
Lexigen Pharma WO 99/43713
Antibody-based fusion proteins unable to bind immunoglobulin Fc receptors because of isotype or mutagenesis.
Lilly WO 99/43792
Hepatitis C polymerase
Soluble, recombinant RNA-dependent polymerase from the human hepatitis C viral genome; for therapeutics.
Mass. Gen. Hosp. WO 99/43208
Helios gene, encoded protein, production methods; for diagnostics and therapeutics.
McGinnis, R.E., et al. WO 99/43858
Localizing trait genes
Two-dimensional linkage study techniques using bi-allelic markers to localize trait-causing genes.
Med. Coll. Hampton Roads WO 99/43785
Embryonic stem cells
Derivation of embryonic stem cells from pre-stem morulae or blastocysts; for transplantation therapy.
Merck WO 99/43695
Macular dystrophy gene
Best's macular dystrophy gene, encoded protein, recombinant expression methods; for diagnostics.
Nanogen WO 99/43853
DNA length polymorphisms
Methods and apparatus for determining length polymorphisms in DNA by assaying repeat units.
NIH (Natl. Inst. Hlth.) WO 99/43711
G-protein receptor antagonists
G-protein coupled receptor antagonists made from peptides of the seven transmembrane domains.
NIH (Natl. Inst. Hlth.) WO 99/43811
B5T over-expressed gene
B5T over-expressed gene, encoded protein; for modulating pRb-protein interactions and transformed cells.
NIH (Natl. Inst. Hlth.) WO 99/43812
Liver cancer gene deletion
DLC-1 gene which is frequently deleted in liver cancer; for cancer diagnostics and therapeutics.
NIH (Natl. Inst. Hlth.) WO 99/43814
ICER synthesis blockade
Therapeutic blockade of ICER synthesis; for preventing ICER-mediated inhibition of immune cell activity.
Neurovir WO 99/43842
Recombinant virus formation
Artificial chromosome constructs containing nucleic acid sequences for directing recombinant virus formation.
Nevada, Univ. of WO 99/43697
Manganese superoxide dismutase (SOD) isoforms with exon 3 deleted, encoding genes; for diagnostics and therapeutics.
Nippon Meat Packers EPO 940 467
Promoters for pig complement inhibitor genes; for making transgenic pigs for xenotransplantation.
North Carolina, Univ. of WO 99/43810
Mutant heparin cofactor II
Chapel Hill, N.C.
Mutant heparin cofactor II having a carboxy terminal extension; for enhanced anti-thrombotic effects.
Novo Nordisk WO 99/43705-43708
N-terminal modified and truncated glucagon-like peptide (GLP)-1, lipophilic analogs; for diabetes and obesity.
Novo Nordisk Biotech WO 99/43835
Bacillus production system
Production of recombinant proteins in Bacillus using gene constructs having mRNA processing stabilizing sequences.
Novopharm Biotech WO 99/43815
Tumor ganglioside antibodies
Human monoclonal antibodies against major tumor-associated gangliosides; for cancer diagnostics and therapeutics.
NST Neurosurvival Technol. WO 99/43701
Petach Tikva, Israel
RY domain peptides; for preventing inappropriate activation of apoptosis.
Ohio State Univ. WO 99/43854
Specific site cleavage
Cleavage of single- and double-stranded DNA at specific sites using nucleotide integrase; for sequence insertion.
Pennsylvania, Univ. of WO 99/43360
Muscular dystrophy gene therapy
Gene therapy for muscle cells using a sarcoglycan-encoding gene; for preventing dystrophic sarcolemmal degeneration.
Pennsylvania, Univ. of WO 99/43839
Autoimmune disease vaccines
Nucleic acid sequences encoding immunomodulatory proteins; for DNA, protein, and live attenuated vaccines.
Pharmacia & Upjohn WO 99/43830
Human platelet heparanase, encoding gene sequences; for identifying modulators.
Pioneer Hi-Bred WO 99/43797 & 43819
Constitutive maize promoters
Des Moines, Iowa
Constitutive maize promoters, pathogenesis-related gene; for regulating gene expression in plants.
Pioneer Hi-Bred WO 99/43821-43823
Plant pathogen defense
Des Moines, Iowa
Genes with nitric oxide-inducible and constitutive promoters; for activating plant pathogen defense systems.
Pioneer Hi-Bred WO 99/43838
Synthetic plant promoters
Des Moines, Iowa
Synthetic promoters that enhance the expression of heterologous genes in plants; for transgenics.
Plant Biosciences WO 99/43836
Banana streak virus detection
Banana streak virus promoter, vectors for transgenic gene expression; for infection detection.
Promega WO 99/43856
Allelic ladders for short tandem repeat loci; for analyzing polymorphisms.
Regeneron Pharma WO 99/43813
Modified ciliary neurotrophic factor (CNTF), production methods; for treating Huntington's disease and diabetes.
Roche Diagnostics WO 99/43849
Highly concentrated nucleic acids
Utilizing a defined excess of primers in amplification reactions to identify highly concentrated nucleic acids.
Rutgers Univ. WO 99/43796
Pathogen-activated MAP kinase
New Brunswick, N.J.
Pathogen-activatable mitogen-activated (MAP) kinase; for making disease-resistant plants.
Sagami Chem. Res. Ctr. WO 99/43802
Transmembrane domain proteins
Human proteins having transmembrane domains, encoding cDNAs; for expression in heterologous cells.
Samsung Fine Chemicals WO 99/43852
Neuropsychiatric disease diagnosis
Ulsan, S. Korea
Diagnostic methods and kits for finding CAG trinucleotide repeats characteristic of neuropsychiatric disease.
Scripps Inst. WO 99/43783
La Jolla, Calif.
Transgenic mouse with LacZ reporter gene controlled by the N-CAM promoter; for detecting modulators.
SmithKline Beecham WO 99/43692
Streptococcus pneumoniae pyrH gene sequences, encoded polypeptides; for antibacterial screens.
SmithKline Beecham WO 99/43831
Human cysteine protease
Human cysteine protease, encoding gene sequences, production methods; for diagnostics and therapeutics.
Sumitomo Electric WO 99/43702
NE-dig binding protein
Protein that binds NE-dig having no known homologies to other mammalian proteins.
Takeda Chemical WO 99/43799
Endocrine disrupter antibodies
Monoclonal antibodies to endocrine disrupting substances; for immunological assays of the disrupter and its products.
Utrecht Univ. WO 99/43804
TCF-3/4 protein with a _-catenin binding domain; for treating tumorigenesis related to Wnt/Wingless signalling.
Van Aardappelmeel Coop WO 99/43837
Steroid glycoalkaloid removal
Microbes for converting and removing steroid glycoalkaloids from potatoes; for making edible disease-resistant plants.
Wake Forest Univ. WO 99/43784
Bone growth genes
Human DLX3 genes, encoded proteins involved in craniofacial development; for bone growth and repair.
Wallac EPO 940 470
Fusion protein with epitopes from diabetes autoantigens, encoding gene sequences; for autoantibody detection.
Wisconsin, Univ. of WO 99/43203
Maize plant strains having mycorrhizal resistance and enhanced ability to extract phosphorus from soils.
Wisconsin, Univ. of WO 99/43824
Rice blast resistance
Rice blast avirulence gene; for improving the resistance of rice to rice blast.