Published September 1 (EPO); August 26 (WO)
Genome Dynamics WO 99/42474
DNA-binding protein design
Designing zinc finger DNA-binding proteins for defined double-stranded DNA targets using computer-based methods.
German Hlth. & Welfare Res. Ctr. EPO 939 125
RNA polymerase vector
Expression vector for the conditional regulation of a-amanitin resistant RNA polymerase II [in German].
Harvard Univ. WO 99/42473
Toxin translocation inhibition
Mutant pore-forming toxin that cannot form membrane pores, encoding gene; for inhibiting toxin translocation.
Harvard Univ. WO 99/42597
MHC binding proteins
Monovalent, multivalent, and multimeric MHC binding proteins and conjugates; for affecting immunoresponse.
Hoechst Schering Agrevo WO 99/42565
Expression vector encoding pantothenate synthetase; for finding herbicides that inhibit this enzyme.
Hoffmann-La Roche EPO 939 121
Tumor necrosis factor (TNF)-binding proteins, encoding gene sequences, fragments, antibodies [in German].
Human Genome Sciences WO 99/42584
Apoptosis-inducing molecule II of the TNF ligand family, encoding gene sequences; for identifying modulators.
Icos WO 99/42596
Phosphodiesterase 10, encoding gene sequences, antisense, antibodies, production methods; for finding modulators.
Igen Intl. WO 99/42472
Ubiquitin fusion vaccines
Heat shock fusion proteins based on ubiquitin containing antigenic epitopes, encoding gene sequences; for vaccines.
Incyte Pharma WO 99/42579
Palo Alto, Calif.
CAF1-related protein, encoding gene sequences, modulators; for diagnostics and therapeutics.
Inst. Phys. & Chem. Res. EPO 939 130
Modified RNA polymerases
RNA polymerases modified to enhance the incorporation of 3'-deoxyribonuleotides and their derivatives.
Japanese Natl. Inst. EPO 939 128
Hepatitis C isolates
Hepatitis C virus (HCV) isolates having nucleotide and protein sequences distinct from the HCV prototype.
Julich Res. Ctr. WO 99/42574
Ih ionic channel
Ih ionic channel, encoding gene sequences; for treating cardiovascular disorders and consciousness disorders.
Kimron Vet. Inst. WO 99/42569
Integrating DNA into sperm
Bet Dagan, Israel
High efficiency integration of exogenous DNA into sperm genomic DNA using preparations having restriction enzymes.
Kirin Beer WO 99/42572
Yeast protein production system
Candida boidini yeast dihydroxyacetone synthase promoter; for expression of heterologous protein production.
Krebs Res. Ctr. WO 99/42477
Sugar transport protein
Sugar transport protein, encoding gene, antibodies; for transport of sugar-containing therapeutics.
Lek Pharma & Chem. WO 99/42601
HMG-CoA reductase inhibitors
Methods for isolating HMG-CoA reductase inhibitors from mycelium biomass.
Leuven Res. & Develop. EPO 938 904
Bone marrow transduction
Ex vivo transduction of bone marrow stromal cells with an intron-based retroviral vector; for treating hemophilia A.
Leuven Res. & Develop. EPO 939 129
Increased nitrogen fixation
Rhizobium strain with inactivated genes leading to increased nodule number; for greater nitrogen fixation in legumes.
Lonza WO 99/42590
Hydroxybutyric acid derivatives
Methods for microorganism and cell-free production of hydroxybutyric acid derivatives.
Maastricht Univ. EPO 939 118
Pathogen DNA detection
Isolation of DNA and RNA from feces by mixing with water; for diagnosis of human pathogens.
Mass. Inst. Technol. WO 99/42091
Cellular DNA delivery.
Biocompatible endosomolytic cationic polymeric agents; for packaging and delivering DNA.
Max Delbruck Molec. Med. Ctr. WO 99/42481
Peptides derived from LEF-1/TCF-4 transcription factors; for inhibiting _-catenin interactions in Wnt signalling.
Miami, Univ. of WO 99/42121
Modified heat shock protein-antigenic peptide complex, encoding gene sequences; for cancer vaccines.
Neurocrine Biosciences WO 99/42482
Insulin peptide analogs
Methods for treating diabetes using peptide analogs of the insulin B chain.
Nilsson, K. WO 99/42479
Rickettsia helvetica outer membrane protein; for rickettsiosis diagnostics and vaccines.
Novartis WO 99/42589
Insecticidal toxins from Photorhabdus luminescens, encoding gene sequences; for conferring insect resistance.
Novartis WO 99/42602
Fermentative preparation and culture media concentration of cytostatic epothilones, crystal forms.
Novartis WO 99/42609
Wheat fungal pathogens
Internal transcribed spacer DNA sequences from ribosomal RNA of wheat fungal pathogens, probes; for PCR-based detection.
Novartis WO 99/42610
Gene expression profiling
Methods for characterizing and measuring differential mRNA expression; for digital representation of gene expression.
Novimmune WO 99/42571
Transcription factor binding
Screening for inhibitors of the STAT1/USF1 transcription factor interaction.
Novo Nordisk WO 99/42566
Variants of wild-type Humicola lanuginosa lipase; for detergents with good first-wash performance.
Pasteur Inst. WO 99/42612
High-throughput selection of prey polypeptides that bind bait polypeptides in haploid yeast; digital result storage.
Pfizer WO 99/41978
Bacteria expressing proteins causing increased growth or food conversion; for placing in gastrointestinal tracts.
Pharmacia & Upjohn WO 99/42561
Production of taxanes such as paclitaxel by Actinomycetes bacterial strains isolated from plants.
Pioneer Hi-Bred WO 99/42600
Plant gravitropic response
Des Moines, Iowa
Gene for affecting plant gravitropic response, encoded protein; for making transformed plants and seeds.
Promelas Res. WO 99/42617
Winter Haven, Fla.
L-rhamnose or L-fucose containing nucleoside; for inhibiting retroviral reverse transcriptase.
Protein Design Labs EPO 939 127
Humanized immunoglobulins using complementarity determining regions, encoding gene sequences, production methods.
Providence Portland Med. Ctr. WO 99/42585
Enhancing immunoresponse by binding ligands to the OX-40 receptor on T cell surfaces; for immunization.
Quark Biotech WO 99/41985
Growth inhibitory function
p53-dependent induction and secretion of growth inhibitory factors; for reducing abnormal cell growth.
Rao, R.B. EPO 939 084
Non-estrogen receptor estrogen-binding protein, encoding gene sequences, antibodies.
Rigel Pharma WO 99/42586
Exocytotic proteins, encoding gene sequences, antibodies; for inhibiting exocytosis.
Roche Diagnostics EPO 939 126
Tumor suppressor Del-27
Tumor suppressor gene Del-27, probes, encoded protein, production methods.
Rockefeller Univ. WO 99/42564
Cytotoxic T cell induction
Targeting antigens to dendritic cells by apoptotic cells; for inducing cytotoxic T cells.
St. Jude Children's Res. Hosp. WO 99/42593
Carboxylesterase gene; for metabolizing chemotherapeutics and inhibiting tumor growth.
St. Elizabeth's Med. Ctr. WO 99/42570
Treating vascular inflammation
Administration of FLIP compositions; for treating vascular wall inflammation, especially arteriosclerosis.
Sanofi-Synthelabo WO 99/42575
Calcium-activated potassium channel _ subunit gene, encoded protein; for modulating endogenous neurotransmitters.
Sapporo Breweries WO 99/42599
Gene expressed exclusively in hop lupulin glands; for plant transformation and hop breeding.
Searle WO 99/42486
Methods for refolding and purifying endostatin and truncated forms from bacterial inclusion bodies, encoding genes.
SmithKline Beecham EPO 939 123
Estrogen-related polypeptide, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham EPO 939 124
MGBP1 polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham EPO 939 131
Aminopeptidase polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/42484
G-protein coupled receptor
Fishboy, a G-protein coupled receptor, encoding gene sequences; for diagnostics and therapeutics.
SmithKline Beecham WO 99/42485
G-protein coupled receptor
Mucilage, a G-protein coupled receptor, encoding gene sequences; for diagnostics and therapeutics.
SmithKline Beecham WO 99/42562
pgsA polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 99/42576
Cerebellin-2 related peptides
Cerebellin-2 related polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/42580
GABA BP receptor peptides
GABA BP receptor polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/42582
G-protein coupled receptor
Ammaid, a G-protein coupled receptor, encoding gene sequences; for diagnostics and therapeutics.
SmithKline Beecham WO 99/42603
GABAAB-R2a polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
Southern California, Univ. of WO 99/42122
Embryonic stem cell growth
Promoting embryonic stem cell growth using angiotensinogen, angiotensin I/II, fragments, analogs, and agonists.
Southern California, Univ. of WO 99/42123
Neuronal cell growth
Promoting neuronal cell growth using angiotensinogen, angiotensin I/II, fragments, analogs, and agonists.
Tanox WO 99/42133
Factor D inhibitors
Inhibitors of Factor D in complement, including antibodies, peptidomimetics, and small molecule organics.
TM Technol. WO 99/42621
Nucleic acid design
Methods for designing specific structural and energetic characteristics in nucleic acids.
Trevigen WO 99/42595
Mismatch cleavage enzymes
Mismatch cleavage enzymes from extreme thermophilic microorganisms.
Utrecht Univ. EPO 939 122
TCF-3/4 genes, encoded proteins, domains that bind _-catenin; for affecting Wnt/Wingless signalling and cancer.
Vertex Pharma WO 99/42592
Kinase inhibitor design
Designing inhibitors of serine/threonine kinases, mutant kinases, crystallized complexes.
Xcyte Therapies WO 99/42077
Regulation of lymphocyte activation by selectively binding multiple cell surface antigens expressed on the same cell.
Zeneca WO 99/42480
Analgesic peptides from the venom of Grammostola spatilata; for identifying agonists and treating pain.
Zeneca WO 99/42587
Maize gene promoter, expression vector; for transforming plants and pollen to produce male sterile plants.
Zeneca WO 99/42598
Hybrid seed formation
Transgenic plants having genes controlled by chemical inducers; for hybrid seed formation.
Zymogenetics WO 99/42583
Connective tissue growth factor
Connective tissue growth factor homologs, encoding gene sequences, variants, antibodies, production methods.