Published September 1 (EPO); August 26 (WO)

Genome Dynamics WO 99/42474

DNA-binding protein design

Gaithersburg, Md.

Designing zinc finger DNA-binding proteins for defined double-stranded DNA targets using computer-based methods.

German Hlth. & Welfare Res. Ctr. EPO 939 125

RNA polymerase vector

Oberschleissheim, Germany

Expression vector for the conditional regulation of a-amanitin resistant RNA polymerase II [in German].

Harvard Univ. WO 99/42473

Toxin translocation inhibition

Cambridge, Mass.

Mutant pore-forming toxin that cannot form membrane pores, encoding gene; for inhibiting toxin translocation.

Harvard Univ. WO 99/42597

MHC binding proteins

Cambridge, Mass.

Monovalent, multivalent, and multimeric MHC binding proteins and conjugates; for affecting immunoresponse.

Hoechst Schering Agrevo WO 99/42565

Pantothenate herbicides


Expression vector encoding pantothenate synthetase; for finding herbicides that inhibit this enzyme.

Hoffmann-La Roche EPO 939 121

TNF-binding proteins

Basel, Switzerland

Tumor necrosis factor (TNF)-binding proteins, encoding gene sequences, fragments, antibodies [in German].

Human Genome Sciences WO 99/42584

Apotosis inducer

Rockville, Md.

Apoptosis-inducing molecule II of the TNF ligand family, encoding gene sequences; for identifying modulators.

Icos WO 99/42596

Phosphodiesterase 10

Bothell, Wash.

Phosphodiesterase 10, encoding gene sequences, antisense, antibodies, production methods; for finding modulators.

Igen Intl. WO 99/42472

Ubiquitin fusion vaccines

Gaithersburg, Md.

Heat shock fusion proteins based on ubiquitin containing antigenic epitopes, encoding gene sequences; for vaccines.

Incyte Pharma WO 99/42579

CAF1-related protein

Palo Alto, Calif.

CAF1-related protein, encoding gene sequences, modulators; for diagnostics and therapeutics.

Inst. Phys. & Chem. Res. EPO 939 130

Modified RNA polymerases

Wako, Japan

RNA polymerases modified to enhance the incorporation of 3'-deoxyribonuleotides and their derivatives.

Japanese Natl. Inst. EPO 939 128

Hepatitis C isolates


Hepatitis C virus (HCV) isolates having nucleotide and protein sequences distinct from the HCV prototype.

Julich Res. Ctr. WO 99/42574

Ih ionic channel

Julich, Germany

Ih ionic channel, encoding gene sequences; for treating cardiovascular disorders and consciousness disorders.

Kimron Vet. Inst. WO 99/42569

Integrating DNA into sperm

Bet Dagan, Israel

High efficiency integration of exogenous DNA into sperm genomic DNA using preparations having restriction enzymes.

Kirin Beer WO 99/42572

Yeast protein production system


Candida boidini yeast dihydroxyacetone synthase promoter; for expression of heterologous protein production.

Krebs Res. Ctr. WO 99/42477

Sugar transport protein

Heidelberg, Germany

Sugar transport protein, encoding gene, antibodies; for transport of sugar-containing therapeutics.

Lek Pharma & Chem. WO 99/42601

HMG-CoA reductase inhibitors

Ljubljana, Slovenia

Methods for isolating HMG-CoA reductase inhibitors from mycelium biomass.

Leuven Res. & Develop. EPO 938 904

Bone marrow transduction

Leuven, Belgium

Ex vivo transduction of bone marrow stromal cells with an intron-based retroviral vector; for treating hemophilia A.

Leuven Res. & Develop. EPO 939 129

Increased nitrogen fixation

Leuven, Belgium

Rhizobium strain with inactivated genes leading to increased nodule number; for greater nitrogen fixation in legumes.

Lonza WO 99/42590

Hydroxybutyric acid derivatives

Gampel, Switzerland

Methods for microorganism and cell-free production of hydroxybutyric acid derivatives.

Maastricht Univ. EPO 939 118

Pathogen DNA detection

Maastricht, Netherlands

Isolation of DNA and RNA from feces by mixing with water; for diagnosis of human pathogens.

Mass. Inst. Technol. WO 99/42091

Cellular DNA delivery.

Cambridge, Mass.

Biocompatible endosomolytic cationic polymeric agents; for packaging and delivering DNA.

Max Delbruck Molec. Med. Ctr. WO 99/42481

Wnt signalling


Peptides derived from LEF-1/TCF-4 transcription factors; for inhibiting _-catenin interactions in Wnt signalling.

Miami, Univ. of WO 99/42121

Antigenic complexes


Modified heat shock protein-antigenic peptide complex, encoding gene sequences; for cancer vaccines.

Neurocrine Biosciences WO 99/42482

Insulin peptide analogs

San Diego

Methods for treating diabetes using peptide analogs of the insulin B chain.

Nilsson, K. WO 99/42479

Rickettsiosis vaccines

Falun, Sweden

Rickettsia helvetica outer membrane protein; for rickettsiosis diagnostics and vaccines.

Novartis WO 99/42589

Insect resistance

Basel, Switzerland

Insecticidal toxins from Photorhabdus luminescens, encoding gene sequences; for conferring insect resistance.

Novartis WO 99/42602

Cytostatic epothilones


Fermentative preparation and culture media concentration of cytostatic epothilones, crystal forms.

Novartis WO 99/42609

Wheat fungal pathogens

Basel, Switzerland

Internal transcribed spacer DNA sequences from ribosomal RNA of wheat fungal pathogens, probes; for PCR-based detection.

Novartis WO 99/42610

Gene expression profiling

Basel, Switzerland

Methods for characterizing and measuring differential mRNA expression; for digital representation of gene expression.

Novimmune WO 99/42571

Transcription factor binding


Screening for inhibitors of the STAT1/USF1 transcription factor interaction.

Novo Nordisk WO 99/42566

Lipase variants

Bagsvaerd, Denmark

Variants of wild-type Humicola lanuginosa lipase; for detergents with good first-wash performance.

Pasteur Inst. WO 99/42612

Prey-bait peptides


High-throughput selection of prey polypeptides that bind bait polypeptides in haploid yeast; digital result storage.

Pfizer WO 99/41978

Growth enhancement

New York

Bacteria expressing proteins causing increased growth or food conversion; for placing in gastrointestinal tracts.

Pharmacia & Upjohn WO 99/42561

Paclitaxel production

Milan, Italy

Production of taxanes such as paclitaxel by Actinomycetes bacterial strains isolated from plants.

Pioneer Hi-Bred WO 99/42600

Plant gravitropic response

Des Moines, Iowa

Gene for affecting plant gravitropic response, encoded protein; for making transformed plants and seeds.

Promelas Res. WO 99/42617

Anti-retroviral agent

Winter Haven, Fla.

L-rhamnose or L-fucose containing nucleoside; for inhibiting retroviral reverse transcriptase.

Protein Design Labs EPO 939 127

Humanized immunoglobulins

Fremont, Calif.

Humanized immunoglobulins using complementarity determining regions, encoding gene sequences, production methods.

Providence Portland Med. Ctr. WO 99/42585

Enhanced immunoresponse

Portland, Ore.

Enhancing immunoresponse by binding ligands to the OX-40 receptor on T cell surfaces; for immunization.

Quark Biotech WO 99/41985

Growth inhibitory function

Pleasanton, Calif.

p53-dependent induction and secretion of growth inhibitory factors; for reducing abnormal cell growth.

Rao, R.B. EPO 939 084

Estrogen-binding protein


Non-estrogen receptor estrogen-binding protein, encoding gene sequences, antibodies.

Rigel Pharma WO 99/42586

Exocytosis inhibition

Sunnyvale, Calif.

Exocytotic proteins, encoding gene sequences, antibodies; for inhibiting exocytosis.

Roche Diagnostics EPO 939 126

Tumor suppressor Del-27

Mannheim, Germany

Tumor suppressor gene Del-27, probes, encoded protein, production methods.

Rockefeller Univ. WO 99/42564

Cytotoxic T cell induction

New York

Targeting antigens to dendritic cells by apoptotic cells; for inducing cytotoxic T cells.

St. Jude Children's Res. Hosp. WO 99/42593

Prodrug activation


Carboxylesterase gene; for metabolizing chemotherapeutics and inhibiting tumor growth.

St. Elizabeth's Med. Ctr. WO 99/42570

Treating vascular inflammation


Administration of FLIP compositions; for treating vascular wall inflammation, especially arteriosclerosis.

Sanofi-Synthelabo WO 99/42575

Potassium channel


Calcium-activated potassium channel _ subunit gene, encoded protein; for modulating endogenous neurotransmitters.

Sapporo Breweries WO 99/42599

Hop breeding


Gene expressed exclusively in hop lupulin glands; for plant transformation and hop breeding.

Searle WO 99/42486

Endostatin purification


Methods for refolding and purifying endostatin and truncated forms from bacterial inclusion bodies, encoding genes.

SmithKline Beecham EPO 939 123

Estrogen-related peptide

Brentford, U.K.

Estrogen-related polypeptide, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham EPO 939 124

MGBP1 polypeptides

Brentford, U.K.

MGBP1 polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham EPO 939 131


Brentford, U.K.

Aminopeptidase polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 99/42484

G-protein coupled receptor


Fishboy, a G-protein coupled receptor, encoding gene sequences; for diagnostics and therapeutics.

SmithKline Beecham WO 99/42485

G-protein coupled receptor


Mucilage, a G-protein coupled receptor, encoding gene sequences; for diagnostics and therapeutics.

SmithKline Beecham WO 99/42562

pgsA polypeptides


pgsA polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 99/42576

Cerebellin-2 related peptides

Brentford, U.K.

Cerebellin-2 related polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 99/42580

GABA BP receptor peptides


GABA BP receptor polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 99/42582

G-protein coupled receptor


Ammaid, a G-protein coupled receptor, encoding gene sequences; for diagnostics and therapeutics.

SmithKline Beecham WO 99/42603

GABAAB-R2a polypeptides


GABAAB-R2a polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

Southern California, Univ. of WO 99/42122

Embryonic stem cell growth

Los Angeles

Promoting embryonic stem cell growth using angiotensinogen, angiotensin I/II, fragments, analogs, and agonists.

Southern California, Univ. of WO 99/42123

Neuronal cell growth

Los Angeles

Promoting neuronal cell growth using angiotensinogen, angiotensin I/II, fragments, analogs, and agonists.

Tanox WO 99/42133

Factor D inhibitors


Inhibitors of Factor D in complement, including antibodies, peptidomimetics, and small molecule organics.

TM Technol. WO 99/42621

Nucleic acid design

Woburn, Mass.

Methods for designing specific structural and energetic characteristics in nucleic acids.

Trevigen WO 99/42595

Mismatch cleavage enzymes

Gaithersburg, Md.

Mismatch cleavage enzymes from extreme thermophilic microorganisms.

Utrecht Univ. EPO 939 122

Wnt/Wingless signalling

Utrecht, Netherlands

TCF-3/4 genes, encoded proteins, domains that bind _-catenin; for affecting Wnt/Wingless signalling and cancer.

Vertex Pharma WO 99/42592

Kinase inhibitor design

Cambridge, Mass.

Designing inhibitors of serine/threonine kinases, mutant kinases, crystallized complexes.

Xcyte Therapies WO 99/42077

Lymphocyte activation


Regulation of lymphocyte activation by selectively binding multiple cell surface antigens expressed on the same cell.

Zeneca WO 99/42480

Pain peptides


Analgesic peptides from the venom of Grammostola spatilata; for identifying agonists and treating pain.

Zeneca WO 99/42587

Pollen-specific promoter


Maize gene promoter, expression vector; for transforming plants and pollen to produce male sterile plants.

Zeneca WO 99/42598

Hybrid seed formation


Transgenic plants having genes controlled by chemical inducers; for hybrid seed formation.

Zymogenetics WO 99/42583

Connective tissue growth factor


Connective tissue growth factor homologs, encoding gene sequences, variants, antibodies, production methods.