Published September 1 (EPO); August 26 (WO)

Arkansas, Univ. of WO 99/42120

Cancer serine protease

Little Rock, Ark.

An extracellular serine protease overexpressed in breast and ovarian carcinomas, encoding gene sequences.

BASF WO 99/42591

Biotin production

Ludwigshafen, Germany

Genes for enzymes in the biotin synthesis pathway; for transforming microorganisms and producing biotin.

Biochem Vaccins WO 99/42588

Streptococcal vaccines

Sainte-Foy, Que.

Group B streptococcal antigens, encoding gene sequences, production methods; for diagnostics and vaccines.

Biostar WO 99/42573

Modulating myostatin

Saskatoon, Saskatchewan

Myostatin peptide immunogens, immunoconjugates, and multimers; for modulating myostatin activity.

Biotech. Res. Inst. EPO 939 120

Expression cassette exchange

Braunschweig, Germany

Marker-free repetitive DNA expression cassette exchange using FLP recombinase-mediated methods.

Bristol-Myers Squibb WO 99/42075

T cell humoral responses

Princeton, N.J.

Chimeric and humanized CD40 antibodies that block the gp39-CD40 interaction; for modulating T cell humoral responses.

Bromley, P. WO 99/42137

Stress promoter gene therapy

Vessy, France

Controlling therapeutic gene expression using heat shock or stress promoters; for gene therapy protocols.

California, Univ. of WO 99/41974

Modulating seed mass

Oakland, Calif.

Producing transgenic plants having the ADC gene linked to a plant promoter; for modulating seed mass.

California, Univ. of WO 99/42478

Leptospirosis vaccines

Oakland, Calif.

Antigenic outer membrane protein preparations from pathogenic Leptospira, antibodies; for vaccines.

California, Univ. of WO 99/42487

Prion diagnostics

Oakland, Calif.

Concentrating and analyzing disease-related conformations of prion protein complexes; for diagnostics.

City of Hope WO 99/42619

Cardiovascular disease screen

Duarte, Calif.

Detection of serotonin transport gene; for cardiovascular disease screens and developing therapeutics.

Cold Spr. Harbor Labs WO 99/42578

Cell cycle control

Cold Spr. Harbor, N.Y.

Polypeptides capable of bypassing a cell cycle checkpoint; for inducing cell growth.

Connaught Labs WO 99/42130

Meningitis vaccines

North York, Ont.

Multivalent immunogenic bacterial oligosaccharide glycoconjugates; for meningitis vaccines.

Corixa WO 99/42076 & 42118

Tuberculosis vaccines

Seattle

Mycoplasm tuberculosis immunogenic proteins, encoding gene sequences; for tuberculosis diagnosis and vaccines.

Cornell Univ. WO 99/42594

Chitinolytic enzymes

Ithaca, N.Y.

Chitinolytic enzymes, encoding genes; for transforming plants and seeds to control fungi and insects.

Cotton WO 99/41975

Transgenic plants

New York

Transformation of metabolically slowed apical meristems using plasmids or Agrobacterium; for transgenic plants.

Dade Behring WO 99/42615, 426166 & 42618

Detecting nucleic acids

Deerfield, Ill.

Quantitative determination of single-stranded nucleic acids using probes and signals generated by probe binding.

Dana-Farber Cancer Inst. WO 99/42622

Mismatch identification

Boston

Methods for identifying mismatch repair glycosylase reactive sites; for finding mutations and polymorphisms.

Eastern Virginia Med. Sch. WO 99/42581

Sperm binding protein assay

Norfolk, Va.

Fully glycosylated recombinant active human zona pellucida protein; for finding peptides that bind to sperm.

Eurogene WO 99/42577

Biotin binding protein

London

Transmembrane protein having biotin receptor activity, various domains; for binding biotinylated molecules.

Fred Hutchinson Cancer Res. Ctr. WO 99/41984

DNA synthesis checkpoint

Seattle

Interaction between the MEC1-dependent DNA synthesis checkpoint and G1 cyclin function in yeast.

French Atomic Energy Comm. WO 99/42128

HLA-G expressing tumors

Paris

Expression profiling of tumors; for selecting HLA-G positive cancers and developing anti-cancer therapeutics.

Fujisawa Pharma EPO 939 119

Membrane protein genes

Osaka, Japan

Cloning membrane protein genes by isolating signal sequence-containing DNA and N-terminal protein sequencing.

Genetics Inst. WO 99/42470

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences, production methods; for developing diagnostics and therapeutics.

- Compiled by Chester A. Bisbee