Published August 18 (EPO); August 12 (WO); August 18 (GB)

Abken, H. Inhibiting WO 99/40187

Meudt, Germany CD30 expression

Nucleic acids and derivatives that inhibit CD30 antigen expression; for immunomodulation.

Alabama, Univ. of WO 99/39734

Modified adenoviral infectivity

Birmingham, Ala.

Adenoviral vectors having heterologous peptide epitopes in the H1 loop of the fiber knob; for modified infectivity.

Alabama, Univ. of WO 99/40227

HIV-1 drug candidate screen

Birmingham, Ala.

HIV-1 integrase, mutants, and fusions; for screening HIV-1 drug candidates.

BASF EPO 936 270

Prostate serine protease

Ludwigshafen, Germany

Serine protease from prostate tissue, encoding gene; for diagnostics and therapeutics [in German].

Biosyn WO 99/40109

Recombinant mistletoe lectins

Fellbach, Germany

Recombinant mistletoe lectin gene sequences and production methods; for anti-cancer and mood enhancing therapeutics.

Boston Univ. WO 99/40179

Engineered organism containment


Conditional expression of a lethal Streptomyces streptavidin gene; for controlling genetically engineered organisms.

Calgene WO 99/40211

Strawberry gene promoters

Davis, Calif.

Promoters isolated from strawberry plant genomic DNA; for making chimeric genes and expressing heterologous proteins.

CDC (Ctr. Disease Control) WO 99/40200

Pneumonia therapeutics


Streptococcus pneumoniae recombinant lipidated PsaA proteins, preparation for immunogenic therapeutics.

Children's Hosp. WO 99/40103

Medulloblastoma therapy


Promoting apoptosis in medulloblastomas using neurotrophin (NT)-3, identification of NT-3 modulators.

Collateral Therapeutics WO 99/40197

VEGF variants

San Diego

Angiogenic factor vascular endothelial growth factor (VEGF) variants, encoding gene sequences; for therapeutics.

Genentech WO 99/40196

TNF homologs

S. San Francisco

Tumor necrosis factor (TNF) homologs, encoding gene sequences, fusions, chimeras, antibodies.

Genset WO 99/40189

Secreted protein cDNAs


Extended cDNAs encoding secreted proteins; for obtaining antibodies and making expression vectors.

Genzyme WO 99/40214

Targeting nucleic acid delivery

Framingham, Mass.

Nucleic acid delivery vehicles having targeting fragments; for specific binding to cells.

Heska WO 99/39733

Recombinant poxvirus vaccine

Ft. Collins, Colo.

Intranasal and conjunctival delivery of recombinant raccoon poxvirus; for immunization against heterologous antigens.

Hoechst Marion Roussel WO 99/40203

Stabilizing 3_-hydroxysteroids

Puteaux, France

Yeast strains with mutated acetyl-CoA pregnenolone acetyl-transferase activity; for stabilizing 3_-hydroxysteroids.

Human Genome Sciences WO 99/40100

45 human secreted proteins

Rockville, Md.

45 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Human Genome Sciences WO 99/40183

Serine protease and serpin

Rockville, Md.

Human serine protease and serpin polypeptides, encoding gene sequences; for diagnostics and therapeutics.

Human Genome Sciences WO 99/40184

Lymphocyte activator

Rockville, Md.

Dendritic-enriched secreted lymphocyte activation molecule, encoding gene sequences, antibodies; for therapeutics.

Iowa State Univ. WO 99/39582

Pig respiratory syndrome vaccine

Ames, Iowa

Antigenic proteins encoded by pig reproductive and respiratory syndrome virus genes; for vaccines.

Johns Hopkins Univ. WO 99/40181

Increased bone transgenics


Transgenics with disrupted growth differentiation factor-8 genes; for increased muscle tissue and bone content.

Johns Hopkins Univ. WO 99/40225

Neuron intermediate early genes

Baltimore, Md.

Intermediate early genes, encoded polypeptides, antibodies; for modifying neuron intermediate early gene responsiveness.

Kyowa WO 99/40118

VEGF receptor Flt-1 antibodies


Antibodies against vascular endothelial growth factor (VEGF) receptor Flt-1; for treating abnormal neovascularization.

Kyowa WO 99/40205



Protein having _1,4-galactosyltransferase activity, encoding gene sequences; for making galactose-containing saccharides.

Leuven Res. & Develop. WO 99/40198

Less immunogenic staphylokinases

Leuven, Belgium

Staphylokinase derivatives having reduced immunogenicity and clearance, encoding gene sequences.

Lilly WO 99/39725

Desert Hedgehog proteins

Indianapolis, Ind.

Desert Hedgehog proteins, encoding gene sequences; for identifying modulators.

Maryland, Univ. of WO 99/40110

Breast cancer resistance protein


Breast cancer resistance protein, encoding gene sequences; for conferring resistance to cancer chemotherapeutics.

Mass. Gen. Hosp. WO 99/40111

Deregulated Aiolos antibodies


Antibody production in animals and cells having a deregulated Aiolos locus.

Mass. Gen. Hosp. WO 99/40208

Gene lesion screen


In vivo construction of DNA libraries, preparing DNA inserts; for screening for gene lesions.

Melbourne, Univ. of WO 99/40116

Graves' disease diagnosis

Parkville, Australia

Thyroid stimulating hormone (TSH) receptors from a phage expression system, Graves' disease diagnosis methods.

Merck WO 99/40114

GABAA receptor subunit

Rahway, N.J.

GABAA receptor subunit HG20, encoding gene sequences; for identifying modulators.

Methyl-Gene WO 99/40186

DNA methyltransferase antisense

St. Laurent, Que.

Optimized antisense oligonucleotides complementary to DNA methyltransferase gene sequences; for gene therapy.

Millennium Biotherapeutics WO 99/40104

Neokine proteins

Cambridge, Mass.

Neokine proteins, encoding gene sequences, antibodies; for diagnostics, therapeutics, and screening modulators.

Millennium Pharma WO 99/40102

CARD-related protein family

Cambridge, Mass.

CARD-related protein family polypeptides, encoding gene sequences; for screening modulators and diagnostics.

Molec. Immunol. Ctr. WO 99/40119

Tumor antibodies

Havana, Cuba

Monoclonal antibodies against glycosylated oligosaccharides in malignant tumors; for diagnostics and therapeutics.

Novartis WO 99/40180

Stem cell expansion

Basel, Switzerland

Expanding genetically modified human hematopoietic stem cells using culture medium containing chemokines.

Novartis WO 99/40206

Plant invertases

Basel, Switzerland

Plant alkaline and neutral invertases, encoding gene sequences, recombinant production methods.

Novartis WO 99/40207

Human heparanase

Basel, Switzerland

Human heparanase polypeptides, encoding gene sequences, production methods; for degrading heparan sulfate.

Ontario Cancer Inst. WO 99/40185

Cytotoxin construction


Construction of heterodimeric protein combinatorial libraries; for developing cytotoxins.

Otsuka Pharma WO 99/40190

Cell growth genes


Human lung cancer and cell cycle-associated genes, encoded proteins; for affecting the cell cycle and cancer growth.

Oxford BioMedica GB 2 334 257

Non-primate lentiviral vectors

Oxford, UK

Retroviral vectors derived from equine infectious anemia virus; for human and animal cell transfection.

Pioneer Hi-Bred WO 99/40209

Altering seed amino acids

Des Moines, Iowa

Vectors and expression cassettes for elevating preselected amino acids in plant seeds; for enhanced nutritional value.

Promega WO 99/40194

Intermediate tandem repeats

Madison, Wis.

Identifying and analyzing highly polymorphic intermediate tandem repeats using identifiable DNA markers.

Schering WO 99/40195

Mammalian receptors

Kenilworth, N.J.

Mammalian receptor proteins, encoding gene sequences, fragments, antibodies; for diagnostics and therapeutics.

Scriptgen Pharma WO 99/40199

Fungal transcription protein

Waltham, Mass.

Candida albicans fungal protein critical for transcription, encoding gene sequences; for inhibitor screens.

Shimizu, N., et al. WO 99/40191

Parkinson's disease genes

Chiba, Japan

Parkinson's disease-associated genes, encoded proteins; for diagnostics and therapeutics.

SmithKline Beecham WO 99/40188

Tumor-associated MAGE antigens

Rixensart, Belgium

Tumor-associated antigens of the MAGE family, encoding gene sequences; for making fusion proteins for vaccines.

SmithKline Beecham WO 99/40192

Human GPR14 receptor


Human GPR14 receptor polypeptides, encoding gene sequences; for diagnostics and therapeutics.

Spectral Diagnostics WO 99/40204

Single-chain creatinine kinases


Single-chain creatinine B and M kinases, encoding gene sequences; for creatinine assays and making antibodies.

Synthelabo EPO 936 271

Potassium channel subunit

Le Plessis Robinson, France

Calcium-activated potassium channel _ subunit, encoding gene; for modulating neurotransmitter effects.

Tanabe Seiyaku WO 99/40202

NF-kB activation inhibitors

Osaka, Japan

Nuclear factor kappa B (NF-kB) activation inhibitors screen using TGF-_ activated kinase 1 activity modulators.

Toyo Kohan WO 99/40173

DNA-immobilized chips


Substrates for immobilizing and amplifying DNA, DNA-immobilized chips; for DNA sequence detection.

Tranxenogen WO 99/40213

Genetic manipulation of spermatogonia

Shrewsbury, Mass.

In situ infusion of DNA into testicles using DNA uptake enhancers; for genetic manipulation of spermatogonia.

U.S. Agriculture Dept. WO 99/40210

Suppressing plant a-amylase


Suppression of plant a-amylase and protease expression using a serine/threonine protein kinase instead of abscisic acid.

Univ. Technol. Intl. WO 99/40212

Eukaryotic targeted mutagenesis

Calgary, Alberta

Bacteriophage vectors made by phage-plasmid recombination; for targeted mutagenesis in eukaryotic cells.

Vessel Res. Lab WO 99/39571

Arteriosclerosis transgenics


Transgenics having variant smooth muscle myosin heavy chain genes; for studying arteriosclerosis.

Zeneca WO 99/40201

Human E3 ubiquitin ligase


Human E3 ubiquitin ligase, encoding gene sequences; for identifying modulators.

Zymogenetics WO 99/40193

Angiopoietin homologs


Angiopoietin homologs, encoding gene sequences; for identifying modulators and regulating angiogenesis.

- Compiled by Chester A. Bisbee