Published August 18 (EPO); August 12 (WO); August 18 (GB)
Abken, H. Inhibiting WO 99/40187
Meudt, Germany CD30 expression
Nucleic acids and derivatives that inhibit CD30 antigen expression; for immunomodulation.
Alabama, Univ. of WO 99/39734
Modified adenoviral infectivity
Birmingham, Ala.
Adenoviral vectors having heterologous peptide epitopes in the H1 loop of the fiber knob; for modified infectivity.
Alabama, Univ. of WO 99/40227
HIV-1 drug candidate screen
Birmingham, Ala.
HIV-1 integrase, mutants, and fusions; for screening HIV-1 drug candidates.
BASF EPO 936 270
Prostate serine protease
Ludwigshafen, Germany
Serine protease from prostate tissue, encoding gene; for diagnostics and therapeutics [in German].
Biosyn WO 99/40109
Recombinant mistletoe lectins
Fellbach, Germany
Recombinant mistletoe lectin gene sequences and production methods; for anti-cancer and mood enhancing therapeutics.
Boston Univ. WO 99/40179
Engineered organism containment
Boston
Conditional expression of a lethal Streptomyces streptavidin gene; for controlling genetically engineered organisms.
Calgene WO 99/40211
Strawberry gene promoters
Davis, Calif.
Promoters isolated from strawberry plant genomic DNA; for making chimeric genes and expressing heterologous proteins.
CDC (Ctr. Disease Control) WO 99/40200
Pneumonia therapeutics
Atlanta
Streptococcus pneumoniae recombinant lipidated PsaA proteins, preparation for immunogenic therapeutics.
Children's Hosp. WO 99/40103
Medulloblastoma therapy
Boston
Promoting apoptosis in medulloblastomas using neurotrophin (NT)-3, identification of NT-3 modulators.
Collateral Therapeutics WO 99/40197
VEGF variants
San Diego
Angiogenic factor vascular endothelial growth factor (VEGF) variants, encoding gene sequences; for therapeutics.
Genentech WO 99/40196
TNF homologs
S. San Francisco
Tumor necrosis factor (TNF) homologs, encoding gene sequences, fusions, chimeras, antibodies.
Genset WO 99/40189
Secreted protein cDNAs
Paris
Extended cDNAs encoding secreted proteins; for obtaining antibodies and making expression vectors.
Genzyme WO 99/40214
Targeting nucleic acid delivery
Framingham, Mass.
Nucleic acid delivery vehicles having targeting fragments; for specific binding to cells.
Heska WO 99/39733
Recombinant poxvirus vaccine
Ft. Collins, Colo.
Intranasal and conjunctival delivery of recombinant raccoon poxvirus; for immunization against heterologous antigens.
Hoechst Marion Roussel WO 99/40203
Stabilizing 3_-hydroxysteroids
Puteaux, France
Yeast strains with mutated acetyl-CoA pregnenolone acetyl-transferase activity; for stabilizing 3_-hydroxysteroids.
Human Genome Sciences WO 99/40100
45 human secreted proteins
Rockville, Md.
45 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Human Genome Sciences WO 99/40183
Serine protease and serpin
Rockville, Md.
Human serine protease and serpin polypeptides, encoding gene sequences; for diagnostics and therapeutics.
Human Genome Sciences WO 99/40184
Lymphocyte activator
Rockville, Md.
Dendritic-enriched secreted lymphocyte activation molecule, encoding gene sequences, antibodies; for therapeutics.
Iowa State Univ. WO 99/39582
Pig respiratory syndrome vaccine
Ames, Iowa
Antigenic proteins encoded by pig reproductive and respiratory syndrome virus genes; for vaccines.
Johns Hopkins Univ. WO 99/40181
Increased bone transgenics
Baltimore
Transgenics with disrupted growth differentiation factor-8 genes; for increased muscle tissue and bone content.
Johns Hopkins Univ. WO 99/40225
Neuron intermediate early genes
Baltimore, Md.
Intermediate early genes, encoded polypeptides, antibodies; for modifying neuron intermediate early gene responsiveness.
Kyowa WO 99/40118
VEGF receptor Flt-1 antibodies
Tokyo
Antibodies against vascular endothelial growth factor (VEGF) receptor Flt-1; for treating abnormal neovascularization.
Kyowa WO 99/40205
_1,4-galactosyltransferase
Tokyo
Protein having _1,4-galactosyltransferase activity, encoding gene sequences; for making galactose-containing saccharides.
Leuven Res. & Develop. WO 99/40198
Less immunogenic staphylokinases
Leuven, Belgium
Staphylokinase derivatives having reduced immunogenicity and clearance, encoding gene sequences.
Lilly WO 99/39725
Desert Hedgehog proteins
Indianapolis, Ind.
Desert Hedgehog proteins, encoding gene sequences; for identifying modulators.
Maryland, Univ. of WO 99/40110
Breast cancer resistance protein
Baltimore
Breast cancer resistance protein, encoding gene sequences; for conferring resistance to cancer chemotherapeutics.
Mass. Gen. Hosp. WO 99/40111
Deregulated Aiolos antibodies
Boston
Antibody production in animals and cells having a deregulated Aiolos locus.
Mass. Gen. Hosp. WO 99/40208
Gene lesion screen
Boston
In vivo construction of DNA libraries, preparing DNA inserts; for screening for gene lesions.
Melbourne, Univ. of WO 99/40116
Graves' disease diagnosis
Parkville, Australia
Thyroid stimulating hormone (TSH) receptors from a phage expression system, Graves' disease diagnosis methods.
Merck WO 99/40114
GABAA receptor subunit
Rahway, N.J.
GABAA receptor subunit HG20, encoding gene sequences; for identifying modulators.
Methyl-Gene WO 99/40186
DNA methyltransferase antisense
St. Laurent, Que.
Optimized antisense oligonucleotides complementary to DNA methyltransferase gene sequences; for gene therapy.
Millennium Biotherapeutics WO 99/40104
Neokine proteins
Cambridge, Mass.
Neokine proteins, encoding gene sequences, antibodies; for diagnostics, therapeutics, and screening modulators.
Millennium Pharma WO 99/40102
CARD-related protein family
Cambridge, Mass.
CARD-related protein family polypeptides, encoding gene sequences; for screening modulators and diagnostics.
Molec. Immunol. Ctr. WO 99/40119
Tumor antibodies
Havana, Cuba
Monoclonal antibodies against glycosylated oligosaccharides in malignant tumors; for diagnostics and therapeutics.
Novartis WO 99/40180
Stem cell expansion
Basel, Switzerland
Expanding genetically modified human hematopoietic stem cells using culture medium containing chemokines.
Novartis WO 99/40206
Plant invertases
Basel, Switzerland
Plant alkaline and neutral invertases, encoding gene sequences, recombinant production methods.
Novartis WO 99/40207
Human heparanase
Basel, Switzerland
Human heparanase polypeptides, encoding gene sequences, production methods; for degrading heparan sulfate.
Ontario Cancer Inst. WO 99/40185
Cytotoxin construction
Toronto
Construction of heterodimeric protein combinatorial libraries; for developing cytotoxins.
Otsuka Pharma WO 99/40190
Cell growth genes
Tokyo
Human lung cancer and cell cycle-associated genes, encoded proteins; for affecting the cell cycle and cancer growth.
Oxford BioMedica GB 2 334 257
Non-primate lentiviral vectors
Oxford, UK
Retroviral vectors derived from equine infectious anemia virus; for human and animal cell transfection.
Pioneer Hi-Bred WO 99/40209
Altering seed amino acids
Des Moines, Iowa
Vectors and expression cassettes for elevating preselected amino acids in plant seeds; for enhanced nutritional value.
Promega WO 99/40194
Intermediate tandem repeats
Madison, Wis.
Identifying and analyzing highly polymorphic intermediate tandem repeats using identifiable DNA markers.
Schering WO 99/40195
Mammalian receptors
Kenilworth, N.J.
Mammalian receptor proteins, encoding gene sequences, fragments, antibodies; for diagnostics and therapeutics.
Scriptgen Pharma WO 99/40199
Fungal transcription protein
Waltham, Mass.
Candida albicans fungal protein critical for transcription, encoding gene sequences; for inhibitor screens.
Shimizu, N., et al. WO 99/40191
Parkinson's disease genes
Chiba, Japan
Parkinson's disease-associated genes, encoded proteins; for diagnostics and therapeutics.
SmithKline Beecham WO 99/40188
Tumor-associated MAGE antigens
Rixensart, Belgium
Tumor-associated antigens of the MAGE family, encoding gene sequences; for making fusion proteins for vaccines.
SmithKline Beecham WO 99/40192
Human GPR14 receptor
Philadelphia
Human GPR14 receptor polypeptides, encoding gene sequences; for diagnostics and therapeutics.
Spectral Diagnostics WO 99/40204
Single-chain creatinine kinases
Toronto
Single-chain creatinine B and M kinases, encoding gene sequences; for creatinine assays and making antibodies.
Synthelabo EPO 936 271
Potassium channel subunit
Le Plessis Robinson, France
Calcium-activated potassium channel _ subunit, encoding gene; for modulating neurotransmitter effects.
Tanabe Seiyaku WO 99/40202
NF-kB activation inhibitors
Osaka, Japan
Nuclear factor kappa B (NF-kB) activation inhibitors screen using TGF-_ activated kinase 1 activity modulators.
Toyo Kohan WO 99/40173
DNA-immobilized chips
Tokyo
Substrates for immobilizing and amplifying DNA, DNA-immobilized chips; for DNA sequence detection.
Tranxenogen WO 99/40213
Genetic manipulation of spermatogonia
Shrewsbury, Mass.
In situ infusion of DNA into testicles using DNA uptake enhancers; for genetic manipulation of spermatogonia.
U.S. Agriculture Dept. WO 99/40210
Suppressing plant a-amylase
Washington
Suppression of plant a-amylase and protease expression using a serine/threonine protein kinase instead of abscisic acid.
Univ. Technol. Intl. WO 99/40212
Eukaryotic targeted mutagenesis
Calgary, Alberta
Bacteriophage vectors made by phage-plasmid recombination; for targeted mutagenesis in eukaryotic cells.
Vessel Res. Lab WO 99/39571
Arteriosclerosis transgenics
Tokyo
Transgenics having variant smooth muscle myosin heavy chain genes; for studying arteriosclerosis.
Zeneca WO 99/40201
Human E3 ubiquitin ligase
London
Human E3 ubiquitin ligase, encoding gene sequences; for identifying modulators.
Zymogenetics WO 99/40193
Angiopoietin homologs
Seattle
Angiopoietin homologs, encoding gene sequences; for identifying modulators and regulating angiogenesis.
- Compiled by Chester A. Bisbee