Published August 11 (EPO); August 5 (WO)
Advanced Tissue Sciences WO 99/38952
Regulatory protein increase
La Jolla, Calif.
Cells and tissues having increased amounts of regulatory proteins induced by cryopreservation; for therapy.
Akzo Nobel WO 99/39000
Nucleic acid isolation
Isolation of nucleic acids using chaotropic agents and solid phase binding.
Alabama, Univ. of WO 99/39007
Nucleic acid probes for detecting Ureaplasma urealyticum using PCR amplification and DNA chip analysis.
Amgen WO 99/38985
E. coli expression system
Thousand Oaks, Calif.
Vectors using transcriptional control and translational repressor systems to express exogenous gene in E. coli.
Angeletti Inst. Molec. Biol. Res. WO 99/38888
Hepatitis C diagnostics
Peptide inhibitors of hepatitis C virus NS3 protein serine protease activity; for diagnostics.
Arkansas, Univ. of WO 99/38978
Masking IgE binding sites
Little Rock, Ark.
Masking of immunoglobulin (Ig) E binding sites in allergens; for decreasing allergic reactions.
Baylor Coll. Med. WO 99/38992
Enhanced ovarian cancer therapy
Adenovirus-mediated thymidine kinase gene therapy enhances ovarian cancer cell sensitivity to topoisomerase inhibitors.
Beth Israel Deaconess Hosp. WO 99/38890
Secretable erythropoietin (EPO) with altered biological activity, methods of altering EPO activity.
Biochemie WO 99/38982
Cephalosporin acetyltransferase from Bacillus subtilis, encoding gene sequences; for preparing cephalosporins.
Boehringer Mannheim EPO 934 953
Prostate cancer diagnostics
Preparation of monoclonal antibodies to a prostate specific antigen/anti-chymotrypsin complex; for diagnostics.
California, Univ. of WO 99/38989
Plant disease resistance
Constitutively active genetically engineered plant disease resistance genes, encoded proteins.
Cancer Res. Camp. Technol. WO 99/38964
Promoter regions of the mouse and human telomerase RNA component genes; for identifying modulators.
Chiron WO 99/38972
Human genes, encoded protein, variants, probes, antisense, antibodies; for diagnostics and therapeutics.
Chugai Molec. Med. Res. Inst. EPO 935 001
Vascular endothelial growth factor (VEGF)-like genes, encoded proteins, production methods; for therapeutics.
Columbia Univ. WO 99/38965
Human hairless gene
Human hairless gene, mutations, encoded proteins, transgenics; for therapeutics.
Corixa WO 99/38973
Lung cancer therapeutics
Lung cancer antigens or fragments, encoding gene sequences; for immunotherapy and vaccines.
Diagnostic Technologies WO 99/38970
Placental protein 13
Placental protein 13, fragments, encoding gene sequences; for diagnosing pregnancy-related complications.
Dompe WO 99/38967 & 38968
Recombined proteins of HGF and MSP growth factor structural domains; for preventing chemotherapeutic-induced apoptosis.
Dow Agrosciences WO 99/38979
Plant cell transformation
Transformation of plant cell aggregates and tissues using elongated needle-like structures called whiskers.
Duke Univ. WO 99/39011
In vivo methods for assaying RNA-protein interactions, measurement kits.
GeneSense Technol. WO 99/38963
Cancer therapy antisense
Oligonucleotide sequences complementary to thioredoxin or thioredoxin reductase genes; for cancer therapy.
Genetics Inst. WO 99/38959
Secreted proteins, encoding gene sequences; for diagnostics and therapeutics.
Genoplex WO 99/39006
Therapeutic sequence targeting
Comparison of human and primate gene sequences; for identifying potential therapeutic targets.
Gentra Systems WO 99/38962
DNA isolation by lysis
Compositions and methods for using a lysing matrix for isolating DNA.
Gentra Systems WO 99/39009 & 39010
Isolation, amplification, and characterization of DNA from biological materials, methods, reagents, kits.
Genzyme WO 99/39003
Methods for detecting and identifying mutations and alterations in nucleic acid sequences.
Hemosol WO 99/38953
Developing T cell populations enriched in cells having production profiles characteristic of Th2-like cells.
Heska WO 99/38974
Ft. Collins, Colo.
Horse Fc epsilon receptor a chain gene sequences, encoded proteins, antibodies; for detecting immunoglobulin (Ig) E.
Human Genome Sciences WO 99/38881
67 secreted protein
67 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics,
Human Genome Sciences WO 99/38882
Human cytostatin F, encoding gene sequences, modulators, production methods; for diagnostics and therapeutics.
Incyte Pharma WO 99/38976
Growth factor homologs
Palo Alto, Calif.
Human growth factor homologs, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 99/38981
Human protein kinase
Palo Alto, Calif.
Human protein kinase, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
INRA (Natl. Inst. Agron. Res.) WO 99/38956
Rhamnogalactoronane II hydrolase
Enzymes for modifying rhamnogalactoronane II, encoding gene sequences, production methods.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 99/38969
HIV antiviral screen
Methods for using human _-TrCP protein or its fragments for screening HIV-1 antiviral and anti-tumor agents.
Japan Sci. & Technol. WO 99/38523
Membrane proteins expressed in cells latently infected with mycoplasma; for inducing cytokines and immunoresponse.
Johns Hopkins Univ. WO 99/38954
Universal immunomodulatory cytokine-expressing cell line, methods of manufacture; for therapy.
Karo Bio EPO 935 000
Estrogen receptor family
Estrogen receptor-related nuclear receptor, encoding genes; for diagnosis and therapy of endocrine diseases.
Lilly WO 99/38994
Translation initiation kinase
Pancreatic eukaryotic translation initiation factor 2a kinase, encoding gene sequences, antibodies.
Ludwig Inst. Cancer Res. WO 99/38377
STAT transcription factors
Transgenics with targeted disruptions in gp130 gene binding motif for latent STAT transcription factors.
Marine Biotech Inst. EPO 935 003
PCR-based amplification methods for using primers to the gyrase gene to detect microorganisms.
Mass. Gen. Hosp. WO 99/38880
Hepatitis C vaccine
Hepatitis C non-structural proteins, encoding gene sequences; for DNA vaccination.
Maxygen EPO 934 999
Directed DNA evolution
Redwood City, Calif.
DNA mutagenesis by random fragmentation and reassembly; for directed evolution to obtain a desired property.
MRC (Med. Res. Counc.) WO 99/38886
HSV-2 antibody production
Multiply-displayed peptide structures; for detecting herpes simplex virus (HSV)-2 antibodies in serum samples.
Meiji Milk Products WO 99/38971
Midkine binding protein
Brain cell extract protein that binds to midkine; for screening anti-cancer agents.
Mendel Biotech. WO 99/38977
Environmental stress tolerance
Transgenic plants having inserted genes that confer resistance to environmental stress.
Meristem Therapeutics WO 99/38987
Transgenic plants with inserted genes for a1-antitrypsin; for protein production.
Nakamura, M., et al. WO 99/39002
VEGF expression patterns
Examining the expression pattern of a vascular endothelial growth factor (VEGF) isoform using specific probes.
NIH (Natl. Inst. Hlth.) WO 99/38526
T cell apoptosis
Induction of T cell apoptosis without releasing non-death inducing cytokines; for treating T cell disorders.
Neurovex WO 99/38955
Mutant HSV strain
Mutant herpes simplex virus (HSV) strain; for treating disorders of and injuries to the nervous system.
Novadx WO 99/39204
Immunoprecipitation of albumins from serum samples using a collapsible affinity matrix.
Novartis WO 99/38986
Herbicide resistance screens
Plant riboflavin biosynthesis genes, encoding gene sequences; for screening herbicide resistance.
Oklahoma, Univ. of WO 99/38980
Tyrosylprotein sulfotransferase polypeptides, encoding gene sequences; for post-translational modification of proteins.
Princeton Univ. WO 99/38958
Substrate analogs for MurG, an N-acetyl galactose transferase used in bacterial cell wall biosynthesis.
Rockefeller Univ. WO 99/38988
Inducible inserted genes
Glucocorticoid-inducible promoter inserted into plants; for expressing inserted genes under glucocorticoid control.
Rutgers Univ. WO 99/38990
Plant protein production
New Brunswick, N.J.
Methods of using plants to produce and exude heterologous proteins.
Sepracor WO 99/38961
Gene regulator fusion proteins used in bacterial reporter systems; for finding resistance to chemotherapeutics.
SmithKline Beecham WO 99/38885
Polypeptides involved in neurodegeneration, encoding gene sequences, production methods; for therapeutics.
SmithKline Beecham WO 99/38966
Wnt-10a polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/38983
Sphingosine-1 phosphate lyase
Sphingosine-1 phosphate lyase, encoding gene sequences, production methods; for diagnostics and therapeutics.
Stevens Inst. Technol. WO 99/39008
DNA lesion-induced resonances
Detection of lesion-induced resonances in DNA via millimeter and sub-millimeter wave absorption spectroscopy.
Suntory WO 99/38984
Protein production methods using an attached carrier protein that prevents aggregation during purification.
Takara Shuzo WO 99/38991
Germ cell gene transfer
Inserting foreign genes into testicular cells; for transferring genes to male germ cells.
Tredegar WO 99/38960
Plastic film body coverings
Thin plastic films used in body coverings; for making joints that have high shear adhesion.
Universal Healthwatch WO 99/38887
HIV peptide antigens obtained by varying the gp41 immunodominant consensus sequence; for diagnostics.
University Technology WO 99/38975
CNS depressant activity
Genes associated with CNS depressant activity, encoded proteins; for identifying modulators.
Washington St. Univ. WO 99/38957
Plant pathogen resistance
Germacrene C synthase genes from Lycopersicon esculentum; for transgenic plants with increased pathogen resistance.
XY WO 99/38883
Detecting male chromosomes
Ft. Collins, Colo.
Specific oligonucleotide primers for the detection of cow male chromosome sequences by PCR amplification.
Yale Univ. WO 99/38380
New Haven, Conn.
Enhancing antigen presentation and immune responsiveness in cells treated extracorporeally.
Yale Univ. WO 99/38889
Modulating sodium channels
New Haven, Conn.
Modulation of voltage-gated sodium channels in dorsal root ganglia; for neural therapy.
- Compiled By Chester A. Bisbee