Published August 11 (EPO); August 5 (WO)

Advanced Tissue Sciences WO 99/38952

Regulatory protein increase

La Jolla, Calif.

Cells and tissues having increased amounts of regulatory proteins induced by cryopreservation; for therapy.

Akzo Nobel WO 99/39000

Nucleic acid isolation

Arnhem, Netherlands

Isolation of nucleic acids using chaotropic agents and solid phase binding.

Alabama, Univ. of WO 99/39007

Ureaplasma detection

Birmingham, Ala.

Nucleic acid probes for detecting Ureaplasma urealyticum using PCR amplification and DNA chip analysis.

Amgen WO 99/38985

E. coli expression system

Thousand Oaks, Calif.

Vectors using transcriptional control and translational repressor systems to express exogenous gene in E. coli.

Angeletti Inst. Molec. Biol. Res. WO 99/38888

Hepatitis C diagnostics

Pomezia, Italy

Peptide inhibitors of hepatitis C virus NS3 protein serine protease activity; for diagnostics.

Arkansas, Univ. of WO 99/38978

Masking IgE binding sites

Little Rock, Ark.

Masking of immunoglobulin (Ig) E binding sites in allergens; for decreasing allergic reactions.

Baylor Coll. Med. WO 99/38992

Enhanced ovarian cancer therapy


Adenovirus-mediated thymidine kinase gene therapy enhances ovarian cancer cell sensitivity to topoisomerase inhibitors.

Beth Israel Deaconess Hosp. WO 99/38890

Altered EPO


Secretable erythropoietin (EPO) with altered biological activity, methods of altering EPO activity.

Biochemie WO 99/38982

Cephalosporin preparation

Kundl, Austria

Cephalosporin acetyltransferase from Bacillus subtilis, encoding gene sequences; for preparing cephalosporins.

Boehringer Mannheim EPO 934 953

Prostate cancer diagnostics

Indianapolis, Ind.

Preparation of monoclonal antibodies to a prostate specific antigen/anti-chymotrypsin complex; for diagnostics.

California, Univ. of WO 99/38989

Plant disease resistance

Oakland, Calif.

Constitutively active genetically engineered plant disease resistance genes, encoded proteins.

Cancer Res. Camp. Technol. WO 99/38964

Telomerase modulation


Promoter regions of the mouse and human telomerase RNA component genes; for identifying modulators.

Chiron WO 99/38972

Human genes

Emeryville, Calif.

Human genes, encoded protein, variants, probes, antisense, antibodies; for diagnostics and therapeutics.

Chugai Molec. Med. Res. Inst. EPO 935 001

VEGF-like genes

Ibaraki, Japan

Vascular endothelial growth factor (VEGF)-like genes, encoded proteins, production methods; for therapeutics.

Columbia Univ. WO 99/38965

Human hairless gene

New York

Human hairless gene, mutations, encoded proteins, transgenics; for therapeutics.

Corixa WO 99/38973

Lung cancer therapeutics


Lung cancer antigens or fragments, encoding gene sequences; for immunotherapy and vaccines.

Diagnostic Technologies WO 99/38970

Placental protein 13

Haifa, Israel

Placental protein 13, fragments, encoding gene sequences; for diagnosing pregnancy-related complications.

Dompe WO 99/38967 & 38968

Apoptosis control

L'Aquila, Italy

Recombined proteins of HGF and MSP growth factor structural domains; for preventing chemotherapeutic-induced apoptosis.

Dow Agrosciences WO 99/38979

Plant cell transformation


Transformation of plant cell aggregates and tissues using elongated needle-like structures called whiskers.

Duke Univ. WO 99/39011

RNA-protein interactions

Durham, N.C.

In vivo methods for assaying RNA-protein interactions, measurement kits.

GeneSense Technol. WO 99/38963

Cancer therapy antisense

Toronto, Ont.

Oligonucleotide sequences complementary to thioredoxin or thioredoxin reductase genes; for cancer therapy.

Genetics Inst. WO 99/38959

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences; for diagnostics and therapeutics.

Genoplex WO 99/39006

Therapeutic sequence targeting


Comparison of human and primate gene sequences; for identifying potential therapeutic targets.

Gentra Systems WO 99/38962

DNA isolation by lysis


Compositions and methods for using a lysing matrix for isolating DNA.

Gentra Systems WO 99/39009 & 39010

DNA characterization


Isolation, amplification, and characterization of DNA from biological materials, methods, reagents, kits.

Genzyme WO 99/39003

Detecting mutations

Framingham, Mass.

Methods for detecting and identifying mutations and alterations in nucleic acid sequences.

Hemosol WO 99/38953

Th2-like cells

Etobicoke, Ont.

Developing T cell populations enriched in cells having production profiles characteristic of Th2-like cells.

Heska WO 99/38974

IgE detection

Ft. Collins, Colo.

Horse Fc epsilon receptor a chain gene sequences, encoded proteins, antibodies; for detecting immunoglobulin (Ig) E.

Human Genome Sciences WO 99/38881

67 secreted protein

Rockville, Md.

67 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics,

Human Genome Sciences WO 99/38882

Cytostatin F

Rockville, Md.

Human cytostatin F, encoding gene sequences, modulators, production methods; for diagnostics and therapeutics.

Incyte Pharma WO 99/38976

Growth factor homologs

Palo Alto, Calif.

Human growth factor homologs, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 99/38981

Human protein kinase

Palo Alto, Calif.

Human protein kinase, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

INRA (Natl. Inst. Agron. Res.) WO 99/38956

Rhamnogalactoronane II hydrolase


Enzymes for modifying rhamnogalactoronane II, encoding gene sequences, production methods.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 99/38969

HIV antiviral screen


Methods for using human _-TrCP protein or its fragments for screening HIV-1 antiviral and anti-tumor agents.

Japan Sci. & Technol. WO 99/38523

Immunoresponse induction

Saitama, Japan

Membrane proteins expressed in cells latently infected with mycoplasma; for inducing cytokines and immunoresponse.

Johns Hopkins Univ. WO 99/38954

Cytokine-expressing cells


Universal immunomodulatory cytokine-expressing cell line, methods of manufacture; for therapy.

Karo Bio EPO 935 000

Estrogen receptor family

Huddinge, Sweden

Estrogen receptor-related nuclear receptor, encoding genes; for diagnosis and therapy of endocrine diseases.

Lilly WO 99/38994

Translation initiation kinase


Pancreatic eukaryotic translation initiation factor 2a kinase, encoding gene sequences, antibodies.

Ludwig Inst. Cancer Res. WO 99/38377

STAT transcription factors

Parkville, Australia

Transgenics with targeted disruptions in gp130 gene binding motif for latent STAT transcription factors.

Marine Biotech Inst. EPO 935 003

Detecting microorganisms


PCR-based amplification methods for using primers to the gyrase gene to detect microorganisms.

Mass. Gen. Hosp. WO 99/38880

Hepatitis C vaccine


Hepatitis C non-structural proteins, encoding gene sequences; for DNA vaccination.

Maxygen EPO 934 999

Directed DNA evolution

Redwood City, Calif.

DNA mutagenesis by random fragmentation and reassembly; for directed evolution to obtain a desired property.

MRC (Med. Res. Counc.) WO 99/38886

HSV-2 antibody production


Multiply-displayed peptide structures; for detecting herpes simplex virus (HSV)-2 antibodies in serum samples.

Meiji Milk Products WO 99/38971

Midkine binding protein


Brain cell extract protein that binds to midkine; for screening anti-cancer agents.

Mendel Biotech. WO 99/38977

Environmental stress tolerance

Hayward, Calif.

Transgenic plants having inserted genes that confer resistance to environmental stress.

Meristem Therapeutics WO 99/38987

Plant a1-antitrypsin

Clermont-Ferrand, France

Transgenic plants with inserted genes for a1-antitrypsin; for protein production.

Nakamura, M., et al. WO 99/39002

VEGF expression patterns


Examining the expression pattern of a vascular endothelial growth factor (VEGF) isoform using specific probes.

NIH (Natl. Inst. Hlth.) WO 99/38526

T cell apoptosis

Bethesda, Md.

Induction of T cell apoptosis without releasing non-death inducing cytokines; for treating T cell disorders.

Neurovex WO 99/38955

Mutant HSV strain


Mutant herpes simplex virus (HSV) strain; for treating disorders of and injuries to the nervous system.

Novadx WO 99/39204

Albumin removal

San Diego

Immunoprecipitation of albumins from serum samples using a collapsible affinity matrix.

Novartis WO 99/38986

Herbicide resistance screens

Basel, Switzerland

Plant riboflavin biosynthesis genes, encoding gene sequences; for screening herbicide resistance.

Oklahoma, Univ. of WO 99/38980

Tyrosylprotein sulfotransferase

Norman, Okla.

Tyrosylprotein sulfotransferase polypeptides, encoding gene sequences; for post-translational modification of proteins.

Princeton Univ. WO 99/38958

Antibacterial screens

Princeton, N.J.

Substrate analogs for MurG, an N-acetyl galactose transferase used in bacterial cell wall biosynthesis.

Rockefeller Univ. WO 99/38988

Inducible inserted genes

New York

Glucocorticoid-inducible promoter inserted into plants; for expressing inserted genes under glucocorticoid control.

Rutgers Univ. WO 99/38990

Plant protein production

New Brunswick, N.J.

Methods of using plants to produce and exude heterologous proteins.

Sepracor WO 99/38961

Chemotherapeutic resistance

Marlborough, Mass.

Gene regulator fusion proteins used in bacterial reporter systems; for finding resistance to chemotherapeutics.

SmithKline Beecham WO 99/38885

Neurodegeneration peptides

Brentford, U.K.

Polypeptides involved in neurodegeneration, encoding gene sequences, production methods; for therapeutics.

SmithKline Beecham WO 99/38966

Wnt-10a polypeptides

Brentford, U.K.

Wnt-10a polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 99/38983

Sphingosine-1 phosphate lyase

Brentford, U.K.

Sphingosine-1 phosphate lyase, encoding gene sequences, production methods; for diagnostics and therapeutics.

Stevens Inst. Technol. WO 99/39008

DNA lesion-induced resonances

Hoboken, N.J.

Detection of lesion-induced resonances in DNA via millimeter and sub-millimeter wave absorption spectroscopy.

Suntory WO 99/38984

Preventing aggregation

Osaka, Japan

Protein production methods using an attached carrier protein that prevents aggregation during purification.

Takara Shuzo WO 99/38991

Germ cell gene transfer

Kyoto, Japan

Inserting foreign genes into testicular cells; for transferring genes to male germ cells.

Tredegar WO 99/38960

Plastic film body coverings

Richmond, Va.

Thin plastic films used in body coverings; for making joints that have high shear adhesion.

Universal Healthwatch WO 99/38887

HIV diagnostics

Columbia, Md.

HIV peptide antigens obtained by varying the gp41 immunodominant consensus sequence; for diagnostics.

University Technology WO 99/38975

CNS depressant activity

Boulder, Colo.

Genes associated with CNS depressant activity, encoded proteins; for identifying modulators.

Washington St. Univ. WO 99/38957

Plant pathogen resistance

Pullman, Wash.

Germacrene C synthase genes from Lycopersicon esculentum; for transgenic plants with increased pathogen resistance.

XY WO 99/38883

Detecting male chromosomes

Ft. Collins, Colo.

Specific oligonucleotide primers for the detection of cow male chromosome sequences by PCR amplification.

Yale Univ. WO 99/38380

Enhanced immunoresponse

New Haven, Conn.

Enhancing antigen presentation and immune responsiveness in cells treated extracorporeally.

Yale Univ. WO 99/38889

Modulating sodium channels

New Haven, Conn.

Modulation of voltage-gated sodium channels in dorsal root ganglia; for neural therapy.

- Compiled By Chester A. Bisbee