Published July 14 (EPO); July 8 (WO); July 14 (GB)
Abbott Labs WO 99/3401
Breast cancer cDNAs
Abbott Park, Ill.
Contiguous and partially overlapping cDNA sequences from breast tissue; for diagnosing and treating cancer.
AgrEvo GB 2 333 043
Transgenic plants having transfected fungal resistance genes; for making fungicide-resistant plants.
Akzo Nobel WO 99/34020
Dengue virus detection
Isothermal transcription-based assay for the detection and genotyping of Dengue virus.
Allelix Pharma WO 99/33972
EDG-5 receptor homologs
Human EDG-5 receptor homologs, encoding gene sequences; for identifying modulators.
Asahi WO 99/33876
Seven-pass transmembrane receptor
Seven-pass transmembrane receptor protein, encoding gene sequences, antibodies; for modulator screens.
Asahi WO 99/33961
Apoptosis-associated kinase, encoding gene sequences; for screening regulators of apoptosis.
Ascorbex WO 99/33995
Plant L-galactose dehydrogenase; for converting L-galactose to L-galactonolactone.
Banyu Pharma WO 99/33978
Guanosine triphosphate (GTP)-binding protein conjugate type receptor proteins, encoding genes; for ligand screens.
BASF WO 99/33993
Promoter sequences from Ashbya gossypii; for making expression vectors.
Bayer WO 99/33998
Catalytic telomerase gene promoter
Regulatory DNA sequences of the human catalytic telomerase subunit gene that have promoters and intervening sequences.
Brigham & Women's Hosp. WO 99/34209
Measuring CD4-CD8- Va24JQ+ T cells or their cytokine patterns; for diagnosing and treating autoimmunity.
Bristol, Univ. of WO 99/33958
Fatty acid desaturases
Fatty acid desaturases, encoding gene sequences, production methods.
California, Univ. of WO 99/33987
High growth knock-out
Mouse cDNA that prevents high growth, knock-out transgenics exhibiting high growth.
California, Univ. of WO 99/34018
CDK2 kinase inhibitors
Identifying inhibitors of the ATP binding site of human CDK2 kinase using high-density oligonucleotide probe arrays.
Chicago, Univ. of WO 99/33996
IMP dehydrogenase inhibitors
High throughput systems for screening inhibitors of IMP dehydrogenase generated by combinatorial chemistry.
Chiron WO 99/33962
Human cyclin-dependent kinase, encoding gene sequences; for detecting migrating and metastasizing cells.
Chiron WO 99/33963
Aspartyl protease, encoding gene sequences; for diagnosing and suppressing tumor metastases.
Chiron WO 99/33979
Bone marrow proteins
Bone marrow secreted proteins, encoding gene sequences; for diagnosis and therapy in bone marrow transplantation.
Chiron WO 99/33980
TNF superfamily proteins
Tumor necrosis factor (TNF) and TNF receptor superfamily proteins, encoding gene sequences; for apoptosis induction.
Chiron WO 99/33982
Human polypeptides, variants, encoding gene sequences, antibodies, antisense, probes; for therapeutics.
Chiron WO 99/33985
Cell cycle gene promoters
Human protein that recognizes and selects TATA-less core promoters for cell cycle-specific genes, encoding gene.
Chiron WO 99/33986
Mammalian tumor suppressor gene termed enhancer of polycomb; for diagnosis and therapy of cell growth disorders.
Chiron WO 99/33990
CXC chemokine Tim-1
Human CXC chemokine Tim-1, encoding gene sequences; for treating inflammation-based diseases.
Chiron WO 99/33999
Mitogen-activated protein kinase
Mitogen-activated protein kinase 7, encoding gene sequences; for controlling apoptosis.
Chiron WO 99/34000
I-kappa B kinase
I-kappa B kinase; for regulating transcription factors and screening anti-inflammatory compounds.
Chiron WO 99/34004
Metastatic breast and colon cancer-associated genes; for diagnosis and therapy.
Chong Kun Dang WO 99/33988
Seoul, S. Korea
Process for preparing proinsulin; for making easily manufactured recombinant insulin.
Diatech WO 99/33965
Chimeric antibody conjugates
Chimeric antibody conjugates having domains from two species; for labelling antibodies in diagnostic tests.
Forssmann, W.-G. WO 99/33974
Serine protease inhibitors
Serine protease inhibitors; for treating inflammatory diseases and preventing pulmonary emphysema.
Genena WO 99/34016
Expression pattern comparison
Tel-Mond Mail, Israel
Comparing cellular gene expression patterns to determine genetic relatedness.
Genencor Intl. WO 99/33959, 33960 & 34001-34003
Metalloproteases from gram positive microorganisms, muteins, encoding gene sequences.
Genera WO 99/34006
Anti-HIV gene transduction
Positive selection of CD4+ T cells that are able to sustain HIV infection; for transduction with anti-HIV genes.
Georgia, Med. Coll. of WO 99/33971
Autoimmune disease oligos
Oligonucleotides that bind to the Ku protein; for inhibiting activation of DNA-PK and treating autoimmune disease.
Glasgow, Univ. of WO 99/34217
Inlammation drug screens
Antibodies, ligands, and modulators of the membrane bound form of ST2 protein; for inflammation drug screens.
HSP Res. Inst. WO 99/33975
Heat shock transcription factor
Heat shock transcription factor binding protein, encoding gene sequences, production methods, antisense, primers.
Immunex WO 99/33877
V196, 197, & 201 peptides
V196, 197 and 201 polypeptides, encoding gene sequences; for diagnostics and therapeutics.
Imp. Cancer Res. Technol. WO 99/34015
Ovarian cancer diagnosis
Polymorphisms in the p90 ribosomal S6 kinase-3 gene that is mutated in ovarian cancer; for diagnosis and therapy.
Incyte Pharma WO 99/33870
Human regulatory proteins
Palo Alto, Calif.
Human regulatory proteins, encoding gene sequences, antibodies, modulators; for diagnosis and therapy.
Incyte Pharma WO 99/33981
Signal-peptide containing proteins
Palo Alto, Calif.
Human signal peptide-containing proteins, encoding gene sequences, antibodies, modulators; for therapeutics.
Indian Counc. Sci. & Ind. Res. EPO 928 831
New Delhi, India
Isolation of non-toxic Vibrio cholerae strains, transfection with immunogenic cholera toxin gene; for vaccines.
Isis Innovation WO 99/33994
Cephalosporin synthesis inhibitors
Modified deacetoxycephalosporin C synthase, X-ray crystallographic structure; for designing inhibitors.
Itoh, K., et al. WO 99/33977
Tumor antigen protein, encoding gene sequences, antibodies; for cancer diagnosis and therapy.
Japan Tobacco WO 99/33878
Monoclonal antibodies to connective tissue growth factor (CTGF); for diagnosis and therapy.
Julich Res. Ctr. WO 99/33973
Octopamine receptor genes
Transfecting octopamine receptor genes into host cells; for expression to identify neurotransmitter receptor subtypes.
Kikkoman WO 99/33997
Luciferase that is tolerant to surfactants; for assaying extracted intracellular ATP.
Leuven Res. & Develop. WO 99/33966
Increased nitrogen fixation
Mutant Rhizobium etli having an inactivated rafI gene; for increased nodules and nitrogen fixation in legumes.
Ludwig Inst. Cancer Res. WO 99/33485
Expression vectors and cell lines expressing vascular endothelial growth factor D; for treating melanomas.
Martin, W.J. WO 99/34019
Stealth virus detection
S. Pasadena, Calif.
Detection of stealth viruses in clinical and other samples using molecular probes.
McGill Univ. WO 99/33875
Cadherin recognition peptides
Cyclic peptides having a cadherin adhesion recognition sequence; for modulating synaptic stability.
MRC (Med. Res. Counc.) GB 2 333 102
Pig retroviral typing
Nucleic acid and antibody probes for pig endogenous retroviral envelope proteins; for viral subtyping.
MRC (Med. Res. Counc.) WO 99/34012
Cell cycle modulators
Anaphase promoting complex component from yeast; for identifying modulators of cell cycle progression.
Millennium Pharma WO 99/33871
Streptococcus pneumoniae genes within operons essential for survival, related Bacillus subtilis gene; for therapeutics.
Mycogen WO 99/33991
Plant pest control
Bacillus thuringiensis toxins for the control of the European corn borer, encoding gene sequences.
NIH (Natl. Inst. Hlth.) WO 99/33992
Intracisternal A particle
Post-transcriptional RNA nucleocytoplasmic transport element from an intracisternal particle; for HIV therapeutics.
NeoVacs WO 99/33872
Viral regulation proteins, fragments, carboxymethylated interferons; for preparing HIV vaccines.
Ono Pharma WO 99/33873
Polypeptides from brain, bone marrow, and umbilical cord endothelial cell lines, encoding gene sequences, antibodies.
Pincus, S.H. WO 99/33969
Immunological peptide mimics of group B streptococcal carbohydrates; for vaccines.
Rational Drug Design Labs WO 99/33970
Capped oligonucleotides capable of binding to the PB2 protein of influenza virus RNA polymerase; for therapeutics.
Regeneron Pharma WO 99/33967
Mammalian receptor polypeptides, encoding gene sequences; for diagnostics and therapeutics.
Res. Develop. Fdn. WO 99/33854
Circadian regulator gene
Carson City, Nev.
Mammalian circadian regulator gene and regulatory elements, transfected host cells, production methods.
Rhone-Poulenc Agro WO 99/34005
Maize promoter linked to the first actin intron from rice; for transgenic expression in plants.
Roche Diagnostics WO 99/34014
Nucleic acid sequencing
Determination of nucleic acid sequences using multiple extension reactions interspersed with nuclease treatments.
San Raffaele del Monte Tabor Fdn. WO 99/33989
RANTES mutants with variations in the N-terminal, N-loop, or 40's loop regions; for making anti-inflammatory agents.
Schering WO 99/34007
Bacterial gene delivery
Delivery of polypeptide encoding plasmid DNA into macrophage cytosol by attenuated suicide bacteria; for gene therapy.
Takeda WO 99/33976
Peptides that modulate nervous system, circulatory, immune, gastrointestinal, metabolic, and reproductive function.
Uda, T., et al. WO 99/33968
HIV antigen cleavage
Antibody catalyst that cleaves a target HIV surface protein antigen; for therapeutics.
U.S. Navy WO 99/34215
Scrub typhus vaccines
Expression and refolding of truncated major outer membrane protein antigen of scrub typhus; for vaccines.
Utah, Univ. of WO 99/33865
Salt Lake City
Contryphan peptides with tryptophan and leucine residues, propeptides, encoding gene sequences; for anticonvulsants.
XY WO 99/33956
Ft. Collins, Colo.
Methods for sex-specific insemination of mammals with a low number of sperm cells.
Zeneca EPO 928 832
Cystic fibrosis gene mutations
Primers specific for mutations in the cystic fibrosis conductor regulator gene; for disease diagnosis.