Published July 7 (EPO); July 1 (WO); July 7 (GB)

Affymetrix WO 99/32660

Gene chip assays

Santa Clara, Calif.

Monitoring of the cellular effects of therapeutic compounds on a genome-wide scale using mRNAs and nucleotide arrays.

American Home Products WO 99/31969

Cartilage disease transgenics

Madison, N.J.

Transgenics expressing matrix-degrading enzymes; for modeling cartilage degenerative diseases.

American Home Products WO 99/32621

Steroid hormone transcription activator

Madison, N.J.

Steroid hormone nuclear receptor transcriptional co-activator, encoding gene sequences.

Applied Res. Systems WO 99/32141

Interferon complex

Curacao, Netherlands Antilles

Interferon (IFN) complexed with the IFN binding chain of the human IFN receptor; for prolonged therapeutic effect.

Astra Pharma WO 99/32519

G-protein coupled receptors

Mississauga, Ont.

G-protein coupled receptors found in dorsal root ganglia, encoding gene sequences; for affecting calcium signalling.

BASF EPO 927 761

Purine biosynthesis genes

Ludwigshafen, Germany

Purine biosynthesis genes from Ashbya gossypii; for affecting microbial riboflavin synthesis [in German].

BCM Develop. WO 99/32651

Taxane production

Quebec, Que.

Bacterial strains that are able to mass produce taxanes and paclitaxel.

Bio-Technical Resources WO 99/32604

Linoleate isomerase

Manitowoc, Wis.

Linoleate isomerase, encoding gene sequences; for producing CLA from oils.

British Defense Ministry WO 99/32636

TNT biodegradation

Farnborough, U.K.

Enterobacter cloacae strain that can enzymatically degrade trinitrotoluene (TNT); for biodegradation of explosives.

Brustle, O. WO 99/32606

Neural precursor cells

Meckenheim, Germany

Neural precursor cells, methods of production from embryonal stem cells; for therapy of neural defects.

Canadian Natl. Res. Counc. GB 2 332 908

Flax promoters

Ottawa, Ont.

Flax promoter sequences; for modifying flax and expressing heterologous genes in this plant.

Carnegie Inst. WO 99/32619

Gene expression inhibition

Washington, D.C.

Sequence-specific inhibition of gene expression using double-stranded nucleic acids that recombine with mRNAs.

Cell Genesys WO 99/32145

Transgene delivery

Foster City, Calif.

Delivery of multiple transgenes to cells using several adeno-associated viral vectors.

Celltech Therapeutics EPO 927 758

TNF-a antibodies

Slough, U.K.

Recombinant, humanized antibodies to tumor necrosis factor (TNF)-a; for treating immunoregulatory diseases.

Children's Hosp. WO 99/32628

Wiskott-Aldrich Syndrome proteins


WIP, a WASP-associated protein; for identifying drugs to treat Wiskott-Aldrich Syndrome.

Columbia Univ. WO 99/32615

Gated ion channel

New York

Cyclic nucleotide gated ion channel derived from brain or heart, encoding gene sequences; for identifying modulators.

Cornell Univ. WO 99/32149

Toxic insect proteins

Ithaca, N.Y.

Drosophila melanogaster male accessory gland protein genes, encoded proteins; for insect cell toxicity.

Dade Behring EPO 927 759 & 760

Varicella virus diagnostics

Marburg, Germany

Immunoreactive proteins, glycoproteins, and fragments from Varicella zoster virus; for diagnostics [in German].

Daicel Chemical WO 99/32638

Dihydroxyacetone 3-phosphate

Osaka, Japan

Bacterial strains transformed with a dihydroxyacetone kinase gene; for dihydroxyacetone 3-phosphate production.

DeKalb Genetics WO 99/32642

Reduced transgene copy number

DeKalb, Ill.

End-modification and the use of limited quantities of transforming DNA; for reducing transgene copy number.

DSM WO 99/32617

Fungi production system

Heerlen, Netherlands

Expression of heterologous genes in filamentous fungi; for recombinant protein production.

Forssmann, W.-G. WO 99/32620

Insulin-like growth factor

Hannover, Germany

Insulin-like growth factor binding protein fragments and derivatives.

Genencor Intl. WO 99/32612 & 32613

Fluidized bed matrix granule

Rochester, N.Y.

Fluidized bed matrix granule having a protein core and covering matrix; for presenting therapeutic proteins.

Genesis Res. & Develop. WO 99/32634

Infectious disease treatment

Parnell, New Zealand

Mycobacterium vaccae antigens and cells; for preventing and treating infectious diseases.

Genetics Inst. WO 99/32614

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Genset WO 99/32644

Prostate cancer gene


Prostate cancer-associated gene, biallelic markers; for diagnosing predisposition to prostate cancer.

Heska WO 99/32633

Ovarian cyst detection

Fort Collins, Colo.

Toxoplasma gondii proteins, encoding gene sequences, antibodies; for detecting ovarian cysts.

Hitachi Chemical WO 99/32654

Simplified PCR


Reverse transcription-PCR on microplates having immobilized oligonucleotides; for simplified PCR.

Hoffmann-La Roche GB 2 332 906

TTX-resistant Na+ channel

Basel, Switzerland

Gene sequences encoding a tetrodotoxin (TTX)-resistant sodium (Na+) channel, encoded protein, antibodies.

Hormos Medical WO 99/32518

Mutant prepro-neuropeptide Y

Turku, Finland

Mutant prepro-neuropeptide Y, mutant signal peptide, encoding genes; for high serum cholesterol diagnosis.

Hyseq WO 99/32631

Liver-spleen chemokine

Sunnyvale, Calif.

Chemokine gene isolated from a fetal liver-spleen library, encoded protein; for diagnostics and therapeutics.

Immunex WO 99/32138

HIV infection inhibition


Treating cells with CD40-binding proteins to reduce CCR5 chemokine receptor expression; for HIV infection inhibition.

Immunex WO 99/32626

SIGIRR polypeptides


SIGIRR polypeptides, encoding gene sequences; for diagnostics and therapeutics.

Immunex WO 99/32629

TIGIRR polypeptides


TIGIRR polypeptides, encoding gene sequences; for diagnostics and therapeutics.

Incyte Pharma WO 99/32610

Nucleotide pyrophosphohydrolase-2

Palo Alto, Calif.

Human nucleotide pyrophosphohydrolase-2, encoding gene sequences, antibodies, modulators; for therapeutics.

Introgene WO 99/32647

AAV gene therapy vectors

Leiden, Netherlands

Adeno-associated virus (AAV) vectors; for efficient integration of foreign genetic material into transformants.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 99/32658

Xenohormone detection


Overlapping nucleotide sequences responsive to various steroid hormones; for detecting xenohormones.

Invitek WO 99/32616

Nucleic acid purification


Matrix- and filter-based methods for isolating nucleic acids; for purification.

Japan Tobacco EPO 927 765

Rice transformation


High efficiency of transformation of rice using paromomycin as a selection drug.

Japanese Ind. Sci. & Tech. Ministry EPO 927 756

Cellulase protein


Protein having cellulase activity, encoding gene sequences, expression vector, production methods.

Karolinska Innovations WO 99/32517 & 32609

Cancer treatment protein

Stockholm, Sweden

Human homolog of Drosophila suppressor of fused gene, encoded protein, associated molecules; for treating cancer.

Leadd EPO 927 757

Apoptosis induction

Leiderdorp, Netherlands

Induction of apoptosis by interfering with Bip-like proteins; for treating cancer and autoimmune disease.

Lilly WO 99/32142


Indianapolis, Ind.

_-lipotropin, encoding gene sequences, analogs, fragments, fusions; for treating diabetes.

Lilly WO 99/32505 & 32608

Multiple drug resistance gene

Indianapolis, Ind.

Multiple drug resistance gene from Aspergillus nidulans fungi, encoded protein; for assays using transformed cells.

Michigan, Univ. of WO 99/32147

Ebola virus vaccines

Ann Arbor, Mich.

Ebola virus glycoproteins, encoding gene sequences; for vaccines.

Michigan, Univ. of WO 99/32625


Ann Arbor, Mich.

Mammastatin, encoding gene sequences; for inhibiting mammary cancer cell growth.

Microcide Pharma WO 99/32657

Antibacterial screens

Mountain View, Calif.

Staphylococcus aureus histidine protein kinase essential genes, encoded proteins; for antibacterial screens.

Millennium Biotherapeutics WO 99/32632

Interleukin-related factor

Cambridge, Mass.

Embryo-derived interleukin-related factor, encoding gene sequences, antibodies, transgenics; for therapeutics.

Mitsubishi Rayon EPO 927 762

Removing fumarase


Removing fumarase activity by enzymatic processing, microorganisms derived using these methods.

NIH (Natl. Inst. Hlth.) WO 99/32627

Protein tyrosine kinase substrate

Bethesda, Md.

Protein tyrosine kinase substrate LAT; for identification of modulators for these signaling pathways.

Novo Nordisk WO 99/32605

Production methods

Bagsvaerd, Denmark

Arresting cell growth with a cAMP manipulating agent; for increasing heterologous protein expression in eukaryotes.

Nuvas WO 99/32143

Thrombosis-initiating peptides

San Diego

Thrombosis-initiating chimeric peptides, conjugates, encoding genes; for treating cancer neovascularization.

Oxford Biomedica WO 99/32646

Retroviral vectors

Oxford, U.K.

Retroviral vectors based on equine infectious anemia virus; for transferring genes.

Pharmacia & Upjohn WO 99/32623

Human sel-10 peptides

Kalamazoo, Mich.

Human sel-10 polypeptides, encoding gene sequences, alternative splice variants.

Pioneer Hi-Bred WO 99/31964

Soybean polymorphisms

Johnston, Iowa

Nucleotide polymorphisms at 53 loci in soybean; for fingerprinting in selective breeding experiments.

Pioneer Hi-Bred WO 99/32661

Plant phenotype alteration

Johnston, Iowa

Selective alteration of a quantitative phenotypic trait in plant populations using genetic trait association.

Progenitor WO 99/32611

Endothelial lipase

Menlo Park, Calif.

Lipase expressed in endothelial cells, encoding gene, antibodies; for diagnosis and therapy of vascular disorders

Proscript WO 99/32624

Modulating NEDD8 activation

Cambridge, Mass.

Detecting and modulating NEDD8 activation and conjugation; for identifying modulating compounds.

Purdue Univ. WO 99/32607

Cell culture substrate

W. Lafayette, Ind.

Biomaterial derived from follicle cell basement membranes; for use as cell culture substrates.

Queensland Inst. Med. Res. GB 2 332 907

EBV T cell epitopes

Herston, Australia

Epstein-Barr virus (EBV) cytotoxic T cell epitopes; for vaccines.

Regeneron Pharma WO 99/32639

Angiogenesis regulation

Tarrytown, N.Y.

Receptor tyrosine kinase involved in the regulation of angiogenesis, encoding gene sequences, antibodies.

Roche Diagnostics EPO 927 764

Chimeric serine proteases

Mannheim, Germany

Chimeric serine proteases, individual domains and fragments, crystal structure [in German].

Ste. Justine Hosp. WO 99/32640

Intracellular receptor antagonists


G-protein-coupled receptor antagonists that bind at the intracellular interface of G-protein and the receptor.

Sigma-Tau Pharma WO 99/32516

Long pentraxin


Human long pentraxin PTX3, encoding gene sequences, production methods; for treating cancer.

SmithKline Beecham EPO 927 763

Antibacterial screens


aroA polypeptides, encoding gene sequences, production methods; for antibacterial screens.

Stiftelsen Univ. Res. Inst. WO 99/32659

Immune disease prognosis

Bergen, Norway

Human Fc receptor genotyping; for immune system and cardiovascular disease prognosis.

Stinson, J.L., et al. WO 99/32645

Shiga toxin antibodies

Davie, Fla.

Humanized monoclonal antibodies to Shiga toxin, encoding gene sequences; for disease treatment.

Strata Biosciences WO 99/32618

Gene function assay

Alameda, Calif.

Transfection of ribozyme genes that cleave mRNAs; for altering cell phenotype and assigning gene functions.

Tennessee, Univ. of WO 99/32648

Paramyxovirus therapeutics

Knoxville, Tenn.

Recombinant rhabdoviruses expressing paramyxovirus SV5 strain fusion protein; for diagnostics and therapeutics.

TM Technol. WO 99/32664

Ligand binding site reactivity

Woburn, Mass.

Ranking relative reactivity of nucleotide sequences flanking a ligand binding site.

Unilever WO 99/32641

Mold production system


Site-directed integration of multiple copies of genes into mold strains; for producing recombinant proteins.

Vlaams Inst. Biotech WO 99/32643

Mood disorder gene

Zwijnaarde, Netherlands

Human chromosome 18 gene associated with mood disorders, polymorphisms, detection of trinucleotide repeats.

Warner-Lambert WO 99/32514

Apoptosis protection

Morris Plains, N.J.

Redox-sensitive protein promoting cell growth and protecting against apoptosis, encoding gene; for drug development.

Zeneca WO 99/32630

Herbicide-binding proteins


Herbicide-binding proteins; for making transgenic plants having herbicide resistance.

Zeneca WO 99/32635

Acetyl-CoA carboxylase


Candida yeast acetyl-CoA carboxylase, encoding gene sequences.

Zeneca WO 99/32637

Serine hreonine kinase


Human signal transduction serine/threonine kinase, encoding gene sequences; for identifying modulators.

Zymogenetics WO 99/32515

Angiopoietin homolog


Angiopoietin homolog, encoding gene sequences; for regulating angiogenesis.

Zymogenetics WO 99/32622



Semaphorin polypeptides, encoding gene sequences; for detecting receptors mediating neurite outgrowth.