Published July 7 (EPO); July 1 (WO); July 7 (GB)
Affymetrix WO 99/32660
Gene chip assays
Santa Clara, Calif.
Monitoring of the cellular effects of therapeutic compounds on a genome-wide scale using mRNAs and nucleotide arrays.
American Home Products WO 99/31969
Cartilage disease transgenics
Transgenics expressing matrix-degrading enzymes; for modeling cartilage degenerative diseases.
American Home Products WO 99/32621
Steroid hormone transcription activator
Steroid hormone nuclear receptor transcriptional co-activator, encoding gene sequences.
Applied Res. Systems WO 99/32141
Curacao, Netherlands Antilles
Interferon (IFN) complexed with the IFN binding chain of the human IFN receptor; for prolonged therapeutic effect.
Astra Pharma WO 99/32519
G-protein coupled receptors
G-protein coupled receptors found in dorsal root ganglia, encoding gene sequences; for affecting calcium signalling.
BASF EPO 927 761
Purine biosynthesis genes
Purine biosynthesis genes from Ashbya gossypii; for affecting microbial riboflavin synthesis [in German].
BCM Develop. WO 99/32651
Bacterial strains that are able to mass produce taxanes and paclitaxel.
Bio-Technical Resources WO 99/32604
Linoleate isomerase, encoding gene sequences; for producing CLA from oils.
British Defense Ministry WO 99/32636
Enterobacter cloacae strain that can enzymatically degrade trinitrotoluene (TNT); for biodegradation of explosives.
Brustle, O. WO 99/32606
Neural precursor cells
Neural precursor cells, methods of production from embryonal stem cells; for therapy of neural defects.
Canadian Natl. Res. Counc. GB 2 332 908
Flax promoter sequences; for modifying flax and expressing heterologous genes in this plant.
Carnegie Inst. WO 99/32619
Gene expression inhibition
Sequence-specific inhibition of gene expression using double-stranded nucleic acids that recombine with mRNAs.
Cell Genesys WO 99/32145
Foster City, Calif.
Delivery of multiple transgenes to cells using several adeno-associated viral vectors.
Celltech Therapeutics EPO 927 758
Recombinant, humanized antibodies to tumor necrosis factor (TNF)-a; for treating immunoregulatory diseases.
Children's Hosp. WO 99/32628
Wiskott-Aldrich Syndrome proteins
WIP, a WASP-associated protein; for identifying drugs to treat Wiskott-Aldrich Syndrome.
Columbia Univ. WO 99/32615
Gated ion channel
Cyclic nucleotide gated ion channel derived from brain or heart, encoding gene sequences; for identifying modulators.
Cornell Univ. WO 99/32149
Toxic insect proteins
Drosophila melanogaster male accessory gland protein genes, encoded proteins; for insect cell toxicity.
Dade Behring EPO 927 759 & 760
Varicella virus diagnostics
Immunoreactive proteins, glycoproteins, and fragments from Varicella zoster virus; for diagnostics [in German].
Daicel Chemical WO 99/32638
Bacterial strains transformed with a dihydroxyacetone kinase gene; for dihydroxyacetone 3-phosphate production.
DeKalb Genetics WO 99/32642
Reduced transgene copy number
End-modification and the use of limited quantities of transforming DNA; for reducing transgene copy number.
DSM WO 99/32617
Fungi production system
Expression of heterologous genes in filamentous fungi; for recombinant protein production.
Forssmann, W.-G. WO 99/32620
Insulin-like growth factor
Insulin-like growth factor binding protein fragments and derivatives.
Genencor Intl. WO 99/32612 & 32613
Fluidized bed matrix granule
Fluidized bed matrix granule having a protein core and covering matrix; for presenting therapeutic proteins.
Genesis Res. & Develop. WO 99/32634
Infectious disease treatment
Parnell, New Zealand
Mycobacterium vaccae antigens and cells; for preventing and treating infectious diseases.
Genetics Inst. WO 99/32614
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Genset WO 99/32644
Prostate cancer gene
Prostate cancer-associated gene, biallelic markers; for diagnosing predisposition to prostate cancer.
Heska WO 99/32633
Ovarian cyst detection
Fort Collins, Colo.
Toxoplasma gondii proteins, encoding gene sequences, antibodies; for detecting ovarian cysts.
Hitachi Chemical WO 99/32654
Reverse transcription-PCR on microplates having immobilized oligonucleotides; for simplified PCR.
Hoffmann-La Roche GB 2 332 906
TTX-resistant Na+ channel
Gene sequences encoding a tetrodotoxin (TTX)-resistant sodium (Na+) channel, encoded protein, antibodies.
Hormos Medical WO 99/32518
Mutant prepro-neuropeptide Y
Mutant prepro-neuropeptide Y, mutant signal peptide, encoding genes; for high serum cholesterol diagnosis.
Hyseq WO 99/32631
Chemokine gene isolated from a fetal liver-spleen library, encoded protein; for diagnostics and therapeutics.
Immunex WO 99/32138
HIV infection inhibition
Treating cells with CD40-binding proteins to reduce CCR5 chemokine receptor expression; for HIV infection inhibition.
Immunex WO 99/32626
SIGIRR polypeptides, encoding gene sequences; for diagnostics and therapeutics.
Immunex WO 99/32629
TIGIRR polypeptides, encoding gene sequences; for diagnostics and therapeutics.
Incyte Pharma WO 99/32610
Palo Alto, Calif.
Human nucleotide pyrophosphohydrolase-2, encoding gene sequences, antibodies, modulators; for therapeutics.
Introgene WO 99/32647
AAV gene therapy vectors
Adeno-associated virus (AAV) vectors; for efficient integration of foreign genetic material into transformants.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 99/32658
Overlapping nucleotide sequences responsive to various steroid hormones; for detecting xenohormones.
Invitek WO 99/32616
Nucleic acid purification
Matrix- and filter-based methods for isolating nucleic acids; for purification.
Japan Tobacco EPO 927 765
High efficiency of transformation of rice using paromomycin as a selection drug.
Japanese Ind. Sci. & Tech. Ministry EPO 927 756
Protein having cellulase activity, encoding gene sequences, expression vector, production methods.
Karolinska Innovations WO 99/32517 & 32609
Cancer treatment protein
Human homolog of Drosophila suppressor of fused gene, encoded protein, associated molecules; for treating cancer.
Leadd EPO 927 757
Induction of apoptosis by interfering with Bip-like proteins; for treating cancer and autoimmune disease.
Lilly WO 99/32142
_-lipotropin, encoding gene sequences, analogs, fragments, fusions; for treating diabetes.
Lilly WO 99/32505 & 32608
Multiple drug resistance gene
Multiple drug resistance gene from Aspergillus nidulans fungi, encoded protein; for assays using transformed cells.
Michigan, Univ. of WO 99/32147
Ebola virus vaccines
Ann Arbor, Mich.
Ebola virus glycoproteins, encoding gene sequences; for vaccines.
Michigan, Univ. of WO 99/32625
Ann Arbor, Mich.
Mammastatin, encoding gene sequences; for inhibiting mammary cancer cell growth.
Microcide Pharma WO 99/32657
Mountain View, Calif.
Staphylococcus aureus histidine protein kinase essential genes, encoded proteins; for antibacterial screens.
Millennium Biotherapeutics WO 99/32632
Embryo-derived interleukin-related factor, encoding gene sequences, antibodies, transgenics; for therapeutics.
Mitsubishi Rayon EPO 927 762
Removing fumarase activity by enzymatic processing, microorganisms derived using these methods.
NIH (Natl. Inst. Hlth.) WO 99/32627
Protein tyrosine kinase substrate
Protein tyrosine kinase substrate LAT; for identification of modulators for these signaling pathways.
Novo Nordisk WO 99/32605
Arresting cell growth with a cAMP manipulating agent; for increasing heterologous protein expression in eukaryotes.
Nuvas WO 99/32143
Thrombosis-initiating chimeric peptides, conjugates, encoding genes; for treating cancer neovascularization.
Oxford Biomedica WO 99/32646
Retroviral vectors based on equine infectious anemia virus; for transferring genes.
Pharmacia & Upjohn WO 99/32623
Human sel-10 peptides
Human sel-10 polypeptides, encoding gene sequences, alternative splice variants.
Pioneer Hi-Bred WO 99/31964
Nucleotide polymorphisms at 53 loci in soybean; for fingerprinting in selective breeding experiments.
Pioneer Hi-Bred WO 99/32661
Plant phenotype alteration
Selective alteration of a quantitative phenotypic trait in plant populations using genetic trait association.
Progenitor WO 99/32611
Menlo Park, Calif.
Lipase expressed in endothelial cells, encoding gene, antibodies; for diagnosis and therapy of vascular disorders
Proscript WO 99/32624
Modulating NEDD8 activation
Detecting and modulating NEDD8 activation and conjugation; for identifying modulating compounds.
Purdue Univ. WO 99/32607
Cell culture substrate
W. Lafayette, Ind.
Biomaterial derived from follicle cell basement membranes; for use as cell culture substrates.
Queensland Inst. Med. Res. GB 2 332 907
EBV T cell epitopes
Epstein-Barr virus (EBV) cytotoxic T cell epitopes; for vaccines.
Regeneron Pharma WO 99/32639
Receptor tyrosine kinase involved in the regulation of angiogenesis, encoding gene sequences, antibodies.
Roche Diagnostics EPO 927 764
Chimeric serine proteases
Chimeric serine proteases, individual domains and fragments, crystal structure [in German].
Ste. Justine Hosp. WO 99/32640
Intracellular receptor antagonists
G-protein-coupled receptor antagonists that bind at the intracellular interface of G-protein and the receptor.
Sigma-Tau Pharma WO 99/32516
Human long pentraxin PTX3, encoding gene sequences, production methods; for treating cancer.
SmithKline Beecham EPO 927 763
aroA polypeptides, encoding gene sequences, production methods; for antibacterial screens.
Stiftelsen Univ. Res. Inst. WO 99/32659
Immune disease prognosis
Human Fc receptor genotyping; for immune system and cardiovascular disease prognosis.
Stinson, J.L., et al. WO 99/32645
Shiga toxin antibodies
Humanized monoclonal antibodies to Shiga toxin, encoding gene sequences; for disease treatment.
Strata Biosciences WO 99/32618
Gene function assay
Transfection of ribozyme genes that cleave mRNAs; for altering cell phenotype and assigning gene functions.
Tennessee, Univ. of WO 99/32648
Recombinant rhabdoviruses expressing paramyxovirus SV5 strain fusion protein; for diagnostics and therapeutics.
TM Technol. WO 99/32664
Ligand binding site reactivity
Ranking relative reactivity of nucleotide sequences flanking a ligand binding site.
Unilever WO 99/32641
Mold production system
Site-directed integration of multiple copies of genes into mold strains; for producing recombinant proteins.
Vlaams Inst. Biotech WO 99/32643
Mood disorder gene
Human chromosome 18 gene associated with mood disorders, polymorphisms, detection of trinucleotide repeats.
Warner-Lambert WO 99/32514
Morris Plains, N.J.
Redox-sensitive protein promoting cell growth and protecting against apoptosis, encoding gene; for drug development.
Zeneca WO 99/32630
Herbicide-binding proteins; for making transgenic plants having herbicide resistance.
Zeneca WO 99/32635
Candida yeast acetyl-CoA carboxylase, encoding gene sequences.
Zeneca WO 99/32637
Serine hreonine kinase
Human signal transduction serine/threonine kinase, encoding gene sequences; for identifying modulators.
Zymogenetics WO 99/32515
Angiopoietin homolog, encoding gene sequences; for regulating angiogenesis.
Zymogenetics WO 99/32622
Semaphorin polypeptides, encoding gene sequences; for detecting receptors mediating neurite outgrowth.