Published June 23 (EPO); June 17 (WO); June 23 (GB)

Anton Dohrn Zoological Stn. WO 99/29866

Light hypersensitivity genes

Naples, Italy

Gene sequences encoding the tomato light hypersensitive phenotype, encoded proteins; for transgenics.

Arch Develop. WO 99/29891

Amyloid protein aggregation

Chicago, Ill.

Rapid screening methods for factors controlling amyloid protein aggregation using a yeast cell-based system.

Arkansas, Univ. of WO 99/29835

_1,2-xylotransferase

Little Rock, Ark.

Purified _1,2-xylotransferase that links xylose to mannose residues on N-linked oligosaccharides, antibodies.

Auvergne, Univ. of WO 99/29844

Site-specific gene transfer

Clermont-Ferrand, France

Drosophila melanogaster retroelements; for inserting heterologous sequences into specific sites.

Beth Israel Deaconess Med. Ctr. WO 99/29855

Endostatin mutants

Boston, Mass.

Mutants of endostatin that have anti-angiogenic activity, encoding gene sequences, antibodies.

Beth Israel Deaconess Med. Ctr. WO 99/29856

Anti-angiogenic protein

Boston, Mass.

Restin, an anti-angiogenic protein, fragments, encoding gene sequences, expression methods.

Beth Israel Deaconess Med. Ctr. WO 99/29878

Anti-angiogenic protein production

Boston, Mass.

Yeast production strains for the expression of anti-angiogenic proteins.

Bio Merieux WO 99/29867

Chagas disease therapeutic

Marcy l'Etoile, France

Trypanosoma cruzi antigen, fragments, encoding gene sequences; for detecting and treating Chagas disease.

Bolaks WO 99/29836

Salmon endoproteases

Eikelandsosen, Norway

Extraction of endoproteases called zonases from the hatchery fluid of atlantic salmon; for increased stability enzymes.

Bristol-Myers Squibb WO 99/29838

Fibrinogen-converting enzyme fusions

Skillman, N.J.

Fibrinogen-converting enzyme fusion proteins having binding pair moieties.

California, Univ. of WO 99/29841

Urine hyaluronidase isozymes

Oakland, Calif.

Purification and microsequencing of urine hyaluronidase isozymes, antibodies, production methods.

California, Univ. of WO 99/29877

Gene expression profiling

Oakland, Calif.

Gene expression profiling using cell-specific mRNA isolated from various tissues.

California, Univ. of WO 99/29907

Making nucleic acids

Oakland, Calif.

Making nucleic acids by adding a known nucleotide sequence to the 3' end of known sequence RNAs.

Calif. Inst. Technol. WO 99/29902

Sequence evolution

Pasadena, Calif.

Polynucleotide sequence evolution using cellular DNA repair systems to generate sequence diversity.

Cambridge Antibody Technol. GB 332 433

Antibody libraries

Royston, U.K.

Antibody libraries having variable domain moieties with cysteine nooses; for making ligand mimetics.

Cancer Res. Camp. Technol. GB 2 332 515

Cancer screen antibodies

London

Antibodies that detect DNA preinitiation complex proteins; for cancer screening.

Cedars-Sinai Med. Ctr. WO 99/29859

Liver cancer protein

Los Angeles, Calif.

Liver cell polypeptide associated with cancer, encoding gene sequences, antibodies; for diagnosis and therapy.

Children's Hosp. WO 99/29857

Kinase-like proteins

Boston, Mass.

Two members of the sterile-20 serine/threonine kinase-like protein family.

Children's Hosp. WO 99/29858

Soluble VEGF inhibitors

Boston, Mass.

Soluble neuropilin inhibitors of vascular endothelial growth factor (VEGF), encoding gene sequences.

Children's Hosp. WO 99/29861

Peptide VEGF antagonists

Boston, Mass.

Peptide antagonists of vascular endothelial growth factor (VEGF), analogs, derivatives, encoding gene sequences.

Children's Hosp. WO 99/30157

Neuropilins for cancer diagnosis

Boston, Mass.

Neuropilins and vascular endothelial growth factor receptors; for diagnosis and treatment of cancer.

Chiron WO 99/29850 & 29851

Chromosome 16 oncogene

Emeryville, Calif.

Human kismet protein oncogene, encoded tumor suppressor; for probing chromosome 16 for cancer-related changes.

Commonwealth Serum Labs WO 99/29870

Gingivitis treatment

Parkville, Australia

Porphorymonas gingivalis polypeptides, encoding gene sequences; for treating gingivitis.

Corixa WO 99/29341

Cancer vaccine enhancement

Seattle, Wash.

Enhancing or eliciting immunoresponses using Leishmania braziliensis antigens; for treating cancer.

Corixa WO 99/29869

B. microti antigens

Seattle, Wash.

B. microti antigens, fragments, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Digene WO 99/29890

HPV infection monitoring

Beltsville, Md.

Monitoring gene expression levels for the progression of human papillomavirus (HPV) infection to malignancy.

Duke Univ. WO 99/29842

Tagging RNAs

Durham, N.C.

Identification of accessible regions in target RNAs using trans-splicing nucleic acid molecules; for tagging.

European Molec. Biol. Labs WO 99/29837

DNA cloning method

Heidelberg, Germany

DNA cloning method that uses homologous recombination between two DNA molecules.

Expression Genetics WO 99/29839

Grafted copolymer gene carriers

Salt Lake City, Utah

Grafted copolymers having amphiphilic side polymers that reduce cytotoxicity; for use as gene carriers.

Fordham Univ. WO 99/29834

Cancer vaccines

Bronx, N.Y.

Preparing immunogenic complexes of tumor antigens with heat shock proteins; for making vaccines.

French Atomic Energy Comm. WO 99/29845

Cell growth regulation

Paris

Cell proliferation regulating protein, fragments, encoding gene sequences, production methods.

Gallo Winery WO 99/29899

Pathogenic fungi detection

Modesto, Calif.

Detection of pathogenic fungi affecting grape vines by using unique gene sequences of ribosomal RNA.

Gene Logic WO 99/29903

BRCA1 gene mutations

Gaithersburg, Md.

Mutations in the BRCA1 gene that increase susceptibility to breast cancer; for diagnosis.

Genencor Intl. WO 99/29876

Mutant a-amylases

Rochester, N.Y.

Mutant Bacillus licheniformis a-amylase, encoding gene sequences; for improved enzymatic performance.

Genentech WO 99/29863

Interferon-epsilon

S. San Francisco

Human interferon-epsilon, a type I interferon, variants, derivatives, encoding gene sequences, production methods.

Genetics Inst. WO 99/29718

BMP-17/18

Cambridge, Mass.

Bone morphogenic protein (BMP)-17 and -18, encoding gene sequences; for inducing connective tissue growth.

Genetics Inst. WO 99/29853

Cadherin-like peptides

Cambridge, Mass.

Cadherin-like polypeptides, encoding gene sequences; for tissue homeostasis.

Genzyme WO 99/29832

Plasmid DNA purification

Framington, Mass.

Methods for purifying plasmid DNA substantially free from genomic DNA; for producing gene therapy vectors.

Georgia, Med. Coll. of WO 99/29852

Tryptophan transporter

Augusta, Ga.

High-affinity tryptophan transporter from human monocyte-derived macrophages; for uptake during inflammation.

Georgia, Univ. of WO 99/29724

Pasteurella vaccines

Athens, Ga.

Pasteurella multocida outer membrane protein, encoding gene sequences; for vaccines.

Harvard Univ. WO 99/30164

Transcription components

Cambridge, Mass.

Selected ligands linked to transcriptional modulators; for identifying transcriptional machinery components.

Hewlett-Packard GB 2 332 516

DNA amplification

Palo Alto, Calif.

Amplification of target nucleic acids using rolling circle replication and bidirectional primers.

Hoechst Schering Agrevo EPO 924 300

Amino acid transporter

Berlin

Amino acid transporter, encoding gene sequences; for modifying metabolite transfer in plants.

Hoechst Schering Agrevo WO 99/29880

ALAS modulators

Berlin, Germany

Transgenic plants having modified 5-aminolevulonic acid synthase (ALAS); for finding modulators.

Human Genome Sciences WO 99/29862

Synferon

Rockville, Md.

Synferon, a synthetic type I interferon, encoding gene sequences, production methods; for finding modulators.

Immune Response WO 99/29848

Increased expression vectors

Carlsbad, Calif.

Vectors with genes having inserted introns and 5' or 3' untranslated regions; for increased expression.

Incyte Pharma WO 99/29849

G-protein coupled receptors

Palo Alto, Calif.

G-protein coupled receptors associated with immunoresponse, encoding gene sequences, antibodies, modulators.

Incyte Pharma WO 99/29873

Cyclic GMP phosphodiesterase

Palo Alto, Calif.

Cyclic GMP phosphodiesterase, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Intercell Biomed. Res. WO 99/30151

Combinatorial library screen

Vienna, Austria

Methods for screening combinatorial libraries using cell surface expressing systems.

Intergen WO 99/29905

Apoptosis generated gene fragments

Purchase, N.Y.

Ligand-mediate PCR methods for detecting double-stranded nucleic acids generated during apoptosis.

Itoh, K., et al. WO 99/29715

Tumor antigen peptides

Saga, Japan

Tumor antigen peptide derivatives that bind HLA-A24 antigen and are recognized by cytotoxic T cells.

Johns Hopkins Univ. WO 99/29883

Myasthenia gravis therapy

Baltimore, Md.

Targeting antigen-specific T cells for destruction; for immunotherapy of myasthenia gravis.

Johns Hopkins Univ. WO 99/29906

Prostate cancer diagnosis

Baltimore, Md.

Differentiation-regulated pp32 nuclear proteins associated with human prostatic adenocarcinoma; for cancer diagnosis.

Leadd EPO 924 296

Apoptosis induction

Leiden, Belgium

Apoptosis induction by interfering with ribonucleoprotein processing of RNA; for treating cancer and autoimmunity.

Lexigen Pharma WO 99/29732

Targeted immunotherapy

Lexington, Mass.

Methods for producing fusion proteins with the heterodimeric cytokine, interleukin-12; for targeted immunotherapy.

LG Chemical WO 99/29846

Mammary tumor model

Seoul, S. Korea

Transgenic mice that express the H/K-ras 4B chimeric gene; for forming and studying mammary tumors.

Loyola Univ. WO 99/29847

Calcium channels

Chicago, Ill.

T-type voltage-gated calcium channels, encoding gene sequences, antibodies.

Maryland, Univ. Biotech Inst. WO 99/29728

Chemokine vaccine adjuvants

College Park, Md.

Enhancing vaccine efficacy using concurrent chemokine administration; for combination vaccines.

Mass. Inst. Technol. WO 99/29304

Supercoiled DNA microspheres

Cambridge, Mass.

Methods for formulating highly supercoiled DNA content microspheres.

Mass. Gen. Hosp. WO 99/29901

Polymorphic sequence identification

Boston, Mass.

Broad range PCR amplification techniques for identifying polymorphic sequences.

McGill Univ. WO 99/29896

Muscular dystrophy diagnosis

Montreal, Que.

Human PAB II gene with transcribed polymorphic GCG repeats, allelic variants; for muscular dystrophy diagnosis.

Medeva Europe WO 99/29342

Attenuated bacteria vaccines

London

Vaccines containing attenuated bacteria having non-reverting mutations; for protective immunity.

Merck WO 99/29722 & 29725

Nuclear receptor protein

Rahway, N.J.

Vertebrate nuclear receptor protein, encoding gene sequences, antibodies, fragments; for modulator screens.

NIH (Natl. Inst. Hlth.) WO 99/29868

Malaria therapeutic

Bethesda, Md.

Plasmodium vivax proteins; for enhancing immunoresponse and blocking malaria transmission.

Natl. Veterinary Studies Ctr. WO 99/29871

Piglet weight loss virus

Maisons-Alfort, France

Circovirus sequences related to piglet weight loss disease, encoded polypeptides; for making vaccines.

Northeastern Univ. WO 99/29160

Edible seaweed strains

Boston, Mass.

Strain manipulation of the edible seaweed Porphyra using protoplast fusion techniques.

Novo Nordisk Biotech WO 99/29874

Hemoprotein production

Davis, Calif.

Fungal cells having modified heme catabolic enzymes; for hemoprotein production.

Ontogeny WO 99/29719

TGF-_ superfamily proteins

Cambridge, Mass.

TGF-_ superfamily proteins involved in signal transduction derived from pancreas, encoding gene sequences.

Ontogeny WO 99/29854 & 29860

Human patched protein

Cambridge, Mass.

Human patched protein of the hedgehog receptor family; for ordered spatial arrangements of tissues.

Pentamer Pharma WO 99/29723

Nodavirus vector targeting

San Diego, Calif.

Recombinant nodavirus vectors encoding heterologous proteins; for targeting cell types.

Perkin-Elmer WO 99/29840

RNA:DNA separation

Foster City, Calif.

Methods of separating RNA from DNA using guanidine hydrochloride and thiocyanate.

Perkin-Elmer WO 99/29900

Cycle sequence thermal profiles

Foster City, Calif.

Improved methods of generating polynucleotide sequencing reaction products using step-down thermal profiles.

Pfizer EPO 924 295

Neospora vaccines

Groton, Conn.

Neospora dihydrofolate reductase-thymidylate synthase gene, encoded protein; for fungus vaccines.

Pioneer Hi-Bred Intl. WO 99/29875

Corn UDPGdH

Des Moines, Iowa

Corn uridine diphosphate-glucose dehydrogenase (UDPGdH) genes, encoded proteins, variants; for plant transgenics.

Pioneer Hi-Bred Intl. WO 99/29882

Plant protein nutritional value

Des Moines, Iowa

Altering the nutritional value of vegetative storage protein by residue substitution and antibody conformation selection.

Rhone-Poulenc Agro EPO 924 299

Herbicide resistance protein

Lyon, France

Transit peptide DNA sequence, encoding gene sequences; for transgenics and conferring herbicide resistance [in French].

Rockefeller Univ. WO 99/29865

TNF superfamily protein

New York

Tumor necrosis factor (TNF) superfamily protein, variants, fusions, encoding genes; for increasing immunoresponse.

St. Louis Univ. WO 99/29334

Cancer protein diagnostic

St. Louis, Mo.

Human CtIP protein that interacts with CtBP, encoding gene sequences; for finding modulators and diagnosing cancer.

Salk Inst. WO 99/29730

HIV infectivity modulation

La Jolla, Calif.

Transcriptional activator that interacts with HIV Tat protein; for modifying HIV infectivity.

Saskatchewan, Univ. of WO 99/29717

Pig virus

Saskatoon, Saskatchewan

Post-weaning multi-systemic wasting syndrome virus from pigs, encoded proteins; for diagnostics and vaccines.

Schubert, W. WO 99/29731

ALS therapy

Biodoritz, Germany

Selective destruction of immunoglobulin C proteins; for treating amyotrophic lateral sclerosis (ALS).

Scripps Res. Inst. WO 99/29888

Humanized mouse antibodies

La Jolla, Calif.

Humanized mouse antibodies made by grafting mouse antibody CDRs onto human light chains, library production.

Seminis Vegetable Seeds WO 99/29161

Starchless peas

Saticoy, Calif.

Starchless variety of peas having a recessive gene causing elevated levels of sucrose.

SmithKline Beecham EPO 924 297

Sialoadhesin protein

Philadelphia, Penn.

Sialoadhesin family member, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 99/29843

Antiviral screens

Philadelphia, Penn.

Hepatitis C virus truncated protein, encoding gene sequences, production methods; for antiviral screens.

Stichting Inst. EPO 924 298

Baculovirus expression system

Lelystad, Netherlands

Methods for increased expression of recombinant proteins in an insect baculovirus expression system.

Synaptic Pharma WO 99/29887

Mammalian LPA receptor

Paramus, N.J.

Mammalian LPA receptor, encoding gene sequences, antisense, vectors, antibodies; for making transgenics.

Thomas Jefferson Univ. WO 99/29343

Bladder cancer vaccine

Philadelphia, Penn.

Methods for treating bladder cancer by administering wild type vaccinia viruses.

Tularik WO 99/29727

Transcription activation

S. San Francisco

CPF proteins that regulate transcriptional activation, encoding gene sequences, antibodies, probes.

Virginia Tech. WO 99/29340

Attenuated microorganism vaccines

Blacksburg, Va.

Attenuated or avirulent microorganisms overexpressing a homologous antigen; for making vaccines.

Virogenetics WO 99/29864

Cat tumor vaccines

Troy, N.Y.

Recombinant vaccinia virus vectors expressing cat interleukin-12; for enhancing immunoresponse to tumors.

Virogenetics WO 99/29872

Dog parainfluenza vaccines

Troy, N.Y.

Dog parainfluenza type 2F virus gene sequences, encoded antigens; for vaccines.

Vitality Biotech WO 99/29159

Plant senescence genes

Columbia, Md.

Plant senescence-associated genes encoding a receptor-like protein kinase in leaves; for tissue-specific expression.

Von Eichel-Streiber, C. WO 99/29884

Targeted somatic transgenesis

Schweppenhausen, Germany

Targeting bacteria with foreign DNA in an episomal vector to specific tissues; for somatic transgenesis.

Von Schaewen, A. WO 99/29879

Vegetable transgenics

Osnabruck, Germany

Vegetable N-acetylglucosaminyltransferase I, encoding gene sequences, antisense; for making transgenics.

Washington Univ. WO 99/29721

Pathogen targeting fusions

St. Louis, Mo.

Fusion proteins having transduction and cytotoxic domains; for targeting various pathogens.

Zeneca WO 99/29881

Plant growth alteration

London

Gene sequences for proteins involved in sucrose transport; for altering plant growth and flowering.