Published June 23 (EPO); June 17 (WO); June 23 (GB)
Anton Dohrn Zoological Stn. WO 99/29866
Light hypersensitivity genes
Gene sequences encoding the tomato light hypersensitive phenotype, encoded proteins; for transgenics.
Arch Develop. WO 99/29891
Amyloid protein aggregation
Rapid screening methods for factors controlling amyloid protein aggregation using a yeast cell-based system.
Arkansas, Univ. of WO 99/29835
Little Rock, Ark.
Purified _1,2-xylotransferase that links xylose to mannose residues on N-linked oligosaccharides, antibodies.
Auvergne, Univ. of WO 99/29844
Site-specific gene transfer
Drosophila melanogaster retroelements; for inserting heterologous sequences into specific sites.
Beth Israel Deaconess Med. Ctr. WO 99/29855
Mutants of endostatin that have anti-angiogenic activity, encoding gene sequences, antibodies.
Beth Israel Deaconess Med. Ctr. WO 99/29856
Restin, an anti-angiogenic protein, fragments, encoding gene sequences, expression methods.
Beth Israel Deaconess Med. Ctr. WO 99/29878
Anti-angiogenic protein production
Yeast production strains for the expression of anti-angiogenic proteins.
Bio Merieux WO 99/29867
Chagas disease therapeutic
Marcy l'Etoile, France
Trypanosoma cruzi antigen, fragments, encoding gene sequences; for detecting and treating Chagas disease.
Bolaks WO 99/29836
Extraction of endoproteases called zonases from the hatchery fluid of atlantic salmon; for increased stability enzymes.
Bristol-Myers Squibb WO 99/29838
Fibrinogen-converting enzyme fusions
Fibrinogen-converting enzyme fusion proteins having binding pair moieties.
California, Univ. of WO 99/29841
Urine hyaluronidase isozymes
Purification and microsequencing of urine hyaluronidase isozymes, antibodies, production methods.
California, Univ. of WO 99/29877
Gene expression profiling
Gene expression profiling using cell-specific mRNA isolated from various tissues.
California, Univ. of WO 99/29907
Making nucleic acids
Making nucleic acids by adding a known nucleotide sequence to the 3' end of known sequence RNAs.
Calif. Inst. Technol. WO 99/29902
Polynucleotide sequence evolution using cellular DNA repair systems to generate sequence diversity.
Cambridge Antibody Technol. GB 332 433
Antibody libraries having variable domain moieties with cysteine nooses; for making ligand mimetics.
Cancer Res. Camp. Technol. GB 2 332 515
Cancer screen antibodies
Antibodies that detect DNA preinitiation complex proteins; for cancer screening.
Cedars-Sinai Med. Ctr. WO 99/29859
Liver cancer protein
Los Angeles, Calif.
Liver cell polypeptide associated with cancer, encoding gene sequences, antibodies; for diagnosis and therapy.
Children's Hosp. WO 99/29857
Two members of the sterile-20 serine/threonine kinase-like protein family.
Children's Hosp. WO 99/29858
Soluble VEGF inhibitors
Soluble neuropilin inhibitors of vascular endothelial growth factor (VEGF), encoding gene sequences.
Children's Hosp. WO 99/29861
Peptide VEGF antagonists
Peptide antagonists of vascular endothelial growth factor (VEGF), analogs, derivatives, encoding gene sequences.
Children's Hosp. WO 99/30157
Neuropilins for cancer diagnosis
Neuropilins and vascular endothelial growth factor receptors; for diagnosis and treatment of cancer.
Chiron WO 99/29850 & 29851
Chromosome 16 oncogene
Human kismet protein oncogene, encoded tumor suppressor; for probing chromosome 16 for cancer-related changes.
Commonwealth Serum Labs WO 99/29870
Porphorymonas gingivalis polypeptides, encoding gene sequences; for treating gingivitis.
Corixa WO 99/29341
Cancer vaccine enhancement
Enhancing or eliciting immunoresponses using Leishmania braziliensis antigens; for treating cancer.
Corixa WO 99/29869
B. microti antigens
B. microti antigens, fragments, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Digene WO 99/29890
HPV infection monitoring
Monitoring gene expression levels for the progression of human papillomavirus (HPV) infection to malignancy.
Duke Univ. WO 99/29842
Identification of accessible regions in target RNAs using trans-splicing nucleic acid molecules; for tagging.
European Molec. Biol. Labs WO 99/29837
DNA cloning method
DNA cloning method that uses homologous recombination between two DNA molecules.
Expression Genetics WO 99/29839
Grafted copolymer gene carriers
Salt Lake City, Utah
Grafted copolymers having amphiphilic side polymers that reduce cytotoxicity; for use as gene carriers.
Fordham Univ. WO 99/29834
Preparing immunogenic complexes of tumor antigens with heat shock proteins; for making vaccines.
French Atomic Energy Comm. WO 99/29845
Cell growth regulation
Cell proliferation regulating protein, fragments, encoding gene sequences, production methods.
Gallo Winery WO 99/29899
Pathogenic fungi detection
Detection of pathogenic fungi affecting grape vines by using unique gene sequences of ribosomal RNA.
Gene Logic WO 99/29903
BRCA1 gene mutations
Mutations in the BRCA1 gene that increase susceptibility to breast cancer; for diagnosis.
Genencor Intl. WO 99/29876
Mutant Bacillus licheniformis a-amylase, encoding gene sequences; for improved enzymatic performance.
Genentech WO 99/29863
S. San Francisco
Human interferon-epsilon, a type I interferon, variants, derivatives, encoding gene sequences, production methods.
Genetics Inst. WO 99/29718
Bone morphogenic protein (BMP)-17 and -18, encoding gene sequences; for inducing connective tissue growth.
Genetics Inst. WO 99/29853
Cadherin-like polypeptides, encoding gene sequences; for tissue homeostasis.
Genzyme WO 99/29832
Plasmid DNA purification
Methods for purifying plasmid DNA substantially free from genomic DNA; for producing gene therapy vectors.
Georgia, Med. Coll. of WO 99/29852
High-affinity tryptophan transporter from human monocyte-derived macrophages; for uptake during inflammation.
Georgia, Univ. of WO 99/29724
Pasteurella multocida outer membrane protein, encoding gene sequences; for vaccines.
Harvard Univ. WO 99/30164
Selected ligands linked to transcriptional modulators; for identifying transcriptional machinery components.
Hewlett-Packard GB 2 332 516
Palo Alto, Calif.
Amplification of target nucleic acids using rolling circle replication and bidirectional primers.
Hoechst Schering Agrevo EPO 924 300
Amino acid transporter
Amino acid transporter, encoding gene sequences; for modifying metabolite transfer in plants.
Hoechst Schering Agrevo WO 99/29880
Transgenic plants having modified 5-aminolevulonic acid synthase (ALAS); for finding modulators.
Human Genome Sciences WO 99/29862
Synferon, a synthetic type I interferon, encoding gene sequences, production methods; for finding modulators.
Immune Response WO 99/29848
Increased expression vectors
Vectors with genes having inserted introns and 5' or 3' untranslated regions; for increased expression.
Incyte Pharma WO 99/29849
G-protein coupled receptors
Palo Alto, Calif.
G-protein coupled receptors associated with immunoresponse, encoding gene sequences, antibodies, modulators.
Incyte Pharma WO 99/29873
Cyclic GMP phosphodiesterase
Palo Alto, Calif.
Cyclic GMP phosphodiesterase, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Intercell Biomed. Res. WO 99/30151
Combinatorial library screen
Methods for screening combinatorial libraries using cell surface expressing systems.
Intergen WO 99/29905
Apoptosis generated gene fragments
Ligand-mediate PCR methods for detecting double-stranded nucleic acids generated during apoptosis.
Itoh, K., et al. WO 99/29715
Tumor antigen peptides
Tumor antigen peptide derivatives that bind HLA-A24 antigen and are recognized by cytotoxic T cells.
Johns Hopkins Univ. WO 99/29883
Myasthenia gravis therapy
Targeting antigen-specific T cells for destruction; for immunotherapy of myasthenia gravis.
Johns Hopkins Univ. WO 99/29906
Prostate cancer diagnosis
Differentiation-regulated pp32 nuclear proteins associated with human prostatic adenocarcinoma; for cancer diagnosis.
Leadd EPO 924 296
Apoptosis induction by interfering with ribonucleoprotein processing of RNA; for treating cancer and autoimmunity.
Lexigen Pharma WO 99/29732
Methods for producing fusion proteins with the heterodimeric cytokine, interleukin-12; for targeted immunotherapy.
LG Chemical WO 99/29846
Mammary tumor model
Seoul, S. Korea
Transgenic mice that express the H/K-ras 4B chimeric gene; for forming and studying mammary tumors.
Loyola Univ. WO 99/29847
T-type voltage-gated calcium channels, encoding gene sequences, antibodies.
Maryland, Univ. Biotech Inst. WO 99/29728
Chemokine vaccine adjuvants
College Park, Md.
Enhancing vaccine efficacy using concurrent chemokine administration; for combination vaccines.
Mass. Inst. Technol. WO 99/29304
Supercoiled DNA microspheres
Methods for formulating highly supercoiled DNA content microspheres.
Mass. Gen. Hosp. WO 99/29901
Polymorphic sequence identification
Broad range PCR amplification techniques for identifying polymorphic sequences.
McGill Univ. WO 99/29896
Muscular dystrophy diagnosis
Human PAB II gene with transcribed polymorphic GCG repeats, allelic variants; for muscular dystrophy diagnosis.
Medeva Europe WO 99/29342
Attenuated bacteria vaccines
Vaccines containing attenuated bacteria having non-reverting mutations; for protective immunity.
Merck WO 99/29722 & 29725
Nuclear receptor protein
Vertebrate nuclear receptor protein, encoding gene sequences, antibodies, fragments; for modulator screens.
NIH (Natl. Inst. Hlth.) WO 99/29868
Plasmodium vivax proteins; for enhancing immunoresponse and blocking malaria transmission.
Natl. Veterinary Studies Ctr. WO 99/29871
Piglet weight loss virus
Circovirus sequences related to piglet weight loss disease, encoded polypeptides; for making vaccines.
Northeastern Univ. WO 99/29160
Edible seaweed strains
Strain manipulation of the edible seaweed Porphyra using protoplast fusion techniques.
Novo Nordisk Biotech WO 99/29874
Fungal cells having modified heme catabolic enzymes; for hemoprotein production.
Ontogeny WO 99/29719
TGF-_ superfamily proteins
TGF-_ superfamily proteins involved in signal transduction derived from pancreas, encoding gene sequences.
Ontogeny WO 99/29854 & 29860
Human patched protein
Human patched protein of the hedgehog receptor family; for ordered spatial arrangements of tissues.
Pentamer Pharma WO 99/29723
Nodavirus vector targeting
San Diego, Calif.
Recombinant nodavirus vectors encoding heterologous proteins; for targeting cell types.
Perkin-Elmer WO 99/29840
Foster City, Calif.
Methods of separating RNA from DNA using guanidine hydrochloride and thiocyanate.
Perkin-Elmer WO 99/29900
Cycle sequence thermal profiles
Foster City, Calif.
Improved methods of generating polynucleotide sequencing reaction products using step-down thermal profiles.
Pfizer EPO 924 295
Neospora dihydrofolate reductase-thymidylate synthase gene, encoded protein; for fungus vaccines.
Pioneer Hi-Bred Intl. WO 99/29875
Des Moines, Iowa
Corn uridine diphosphate-glucose dehydrogenase (UDPGdH) genes, encoded proteins, variants; for plant transgenics.
Pioneer Hi-Bred Intl. WO 99/29882
Plant protein nutritional value
Des Moines, Iowa
Altering the nutritional value of vegetative storage protein by residue substitution and antibody conformation selection.
Rhone-Poulenc Agro EPO 924 299
Herbicide resistance protein
Transit peptide DNA sequence, encoding gene sequences; for transgenics and conferring herbicide resistance [in French].
Rockefeller Univ. WO 99/29865
TNF superfamily protein
Tumor necrosis factor (TNF) superfamily protein, variants, fusions, encoding genes; for increasing immunoresponse.
St. Louis Univ. WO 99/29334
Cancer protein diagnostic
St. Louis, Mo.
Human CtIP protein that interacts with CtBP, encoding gene sequences; for finding modulators and diagnosing cancer.
Salk Inst. WO 99/29730
HIV infectivity modulation
La Jolla, Calif.
Transcriptional activator that interacts with HIV Tat protein; for modifying HIV infectivity.
Saskatchewan, Univ. of WO 99/29717
Post-weaning multi-systemic wasting syndrome virus from pigs, encoded proteins; for diagnostics and vaccines.
Schubert, W. WO 99/29731
Selective destruction of immunoglobulin C proteins; for treating amyotrophic lateral sclerosis (ALS).
Scripps Res. Inst. WO 99/29888
Humanized mouse antibodies
La Jolla, Calif.
Humanized mouse antibodies made by grafting mouse antibody CDRs onto human light chains, library production.
Seminis Vegetable Seeds WO 99/29161
Starchless variety of peas having a recessive gene causing elevated levels of sucrose.
SmithKline Beecham EPO 924 297
Sialoadhesin family member, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/29843
Hepatitis C virus truncated protein, encoding gene sequences, production methods; for antiviral screens.
Stichting Inst. EPO 924 298
Baculovirus expression system
Methods for increased expression of recombinant proteins in an insect baculovirus expression system.
Synaptic Pharma WO 99/29887
Mammalian LPA receptor
Mammalian LPA receptor, encoding gene sequences, antisense, vectors, antibodies; for making transgenics.
Thomas Jefferson Univ. WO 99/29343
Bladder cancer vaccine
Methods for treating bladder cancer by administering wild type vaccinia viruses.
Tularik WO 99/29727
S. San Francisco
CPF proteins that regulate transcriptional activation, encoding gene sequences, antibodies, probes.
Virginia Tech. WO 99/29340
Attenuated microorganism vaccines
Attenuated or avirulent microorganisms overexpressing a homologous antigen; for making vaccines.
Virogenetics WO 99/29864
Cat tumor vaccines
Recombinant vaccinia virus vectors expressing cat interleukin-12; for enhancing immunoresponse to tumors.
Virogenetics WO 99/29872
Dog parainfluenza vaccines
Dog parainfluenza type 2F virus gene sequences, encoded antigens; for vaccines.
Vitality Biotech WO 99/29159
Plant senescence genes
Plant senescence-associated genes encoding a receptor-like protein kinase in leaves; for tissue-specific expression.
Von Eichel-Streiber, C. WO 99/29884
Targeted somatic transgenesis
Targeting bacteria with foreign DNA in an episomal vector to specific tissues; for somatic transgenesis.
Von Schaewen, A. WO 99/29879
Vegetable N-acetylglucosaminyltransferase I, encoding gene sequences, antisense; for making transgenics.
Washington Univ. WO 99/29721
Pathogen targeting fusions
St. Louis, Mo.
Fusion proteins having transduction and cytotoxic domains; for targeting various pathogens.
Zeneca WO 99/29881
Plant growth alteration
Gene sequences for proteins involved in sucrose transport; for altering plant growth and flowering.