Published June 9 (EPO); June 3 (WO); June 9 (GB)

Amylogene EPO 921 191

Amylopectin-like starch

Svalov, Sweden

Genetically engineered potato that makes amylopectin-like starch; starch purification methods.

Angeletti Molec. Biol. Res. Inst. WO 99/27110

AAV vector control

Pomezia, Italy

Hormone-dependent adeno-associated virus (AAV) Rep protein forms; for steroid hormone control of AAV vector function.

Arc Genomic Res. WO 99/27076

Pluripotent ES cells

Foster City, Calif.

Pluripotent embryonic stem (ES) cells with selectable markers; for making chimeric embryos and transgenics.

Arch Development WO 99/26974

Kidney growth factors

Chicago, Ill.

Growth factors that affect kidney epithelial cells, encoding genes; for kidney disease diagnostics and therapeutics.

Beth Israel Deaconess Med. Ctr. 99/26980

Signal transducers

Boston, Mass.

SAP family proteins, encoding genes, antibodies; for modulating antigen-specific T cell activation.

Biogen WO 99/26977

TNF family receptors

Cambridge, Mass.

Tumor necrosis factor (TNF) family receptors called OPG-2, encoding gene sequences; for diagnostics and therapeutics.

Biotech Res. Inst. WO 99/26975

Cysteine knot growth factors

Braunschweig, Germany

Obtaining biologically active dimers of human growth factors of the cysteine knot family from bacterial inclusion bodies.

Biotech. Res. Inst. WO 99/27121

Modified mouse retroviral vectors

Braunschweig, Germany

Modification of mouse retroviral env protein; for overcoming expression vector inactivation by human complement factors.

Brax Genomics WO 99/27086

TNF-a antisense

Cambridge, U.K.

Chimeric antisense against tumor necrosis factor (TNF)-a; for inhibiting TNF-a expression.

Bristol, Univ. of WO 99/27111

Desaturase genes

Bristol, U.K.

Caenorabditis elegans desaturase genes, encoded proteins; for making useful metabolites.

Calgene WO 99/27114

Stress-responsive expression

Davis, Calif.

Pathogen inducible-rapid response grape stilbene synthase gene, vectors; for stress-responsive gene expression.

Chugai WO 99/26978

Signal sequence trapping

Tokyo

Detection of cDNAs encoding secretory proteins using a signal sequence trapping method; for library construction.

Clariant Finance EPO 921 188

Truncated cellulases

Tortola, Virgin Islands

Truncated cellulases having increased alkali and temperature stability, encoding gene sequences.

Daiichi EPO 921 198

Glycated protein measure

Kyoto, Japan

Methods for reacting glycated proteins such that the amount of sugars present is measured.

Flinders Technologies WO 99/27072

Sequence diversity

Bedford Park, Australia

Recombination hotspots functionally linked to heterologous DNA; for generating sequence diversity.

Fudan Univ. WO 99/27115

Phosphoesterase

Shanghai, China

Thermophilic alkaline phosphoesterase, encoding gene sequences, production methods, biological tagging methods.

Genencor Intl. WO 99/27081

Bacterial hydrolases

Rochester, N.Y.

a/_ hydrolase-fold enzymes from Gram-positive bacteria, encoding gene sequences; for animal feeds and cleansers.

Genencor Intl. WO 99/27107

Formate transport enzymes

Rochester, N.Y.

Formate transport enzymes from Gram-positive bacteria, encoding gene sequences; for recombinant production.

Genentech WO 99/27098

Inflammation antigens

S. San Francisco

Antigens associated with inflammatory disease, encoding gene sequences, expressed sequence tags, probes, vectors.

Genentech WO 99/27100

FGF-19

S. San Francisco

Fibroblast growth factor (FGF)-19, encoding gene sequences, antibodies; for cancer diagnosis and therapeutics.

Genetics Inst. WO 99/26961, 26967, 26972, 26973 & 27079

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.

Genetix Pharma WO 99/26480

Anti-angiogenesis therapy

Cambridge, Mass.

Administration of gene sequences encoding anti-angiogenic proteins; for inhibiting tumor growth.

Genset WO 99/27105

Chlamydia antigens

Paris

Antigenic proteins from Chlamydia pneumoniae, fragments, encoding gene sequences; for diagnosis and treatment.

Georgia, Med. Coll. of WO 99/27097

TTX-resistant Na+ channel

Augusta, Ga.

Tetrodotoxin (TTX)-resistant sodium (Na+) channel a-subunit, encoding gene sequences; for screening modulators.

Geron WO 99/27113

Telomerase reverse transcriptase

Menlo Park, Calif.

Mouse telomerase reverse transcriptase, encoding gene sequences; for controlling cell growth and aging.

Glasgow, Univ. of WO 99/27091

Cell cycle modulators

Glasgow, U.K.

DP transcription factor-interacting protein, encoding gene sequences; for identifying cell cycle modulators.

Human Genome Sciences WO 99/27078

Chemokine a-5

Rockville, Md.

Chemokine a-5 polypeptides, encoding gene sequences, production methods; for identifying modulators.

Human Genome Sciences WO 99/27112

IL-1 receptor-associated kinase

Rockville, Md.

Human interleukin (IL)-1 receptor-associated kinase-2, encoding gene sequences; for diagnostics and therapeutics.

Hybridon WO 99/27087

CDK4 antisense

Cambridge, Mass.

CDK4 antisense; for inhibiting growth of cancer cells having aberrant CDK4- and CDK3-associated protein expression.

Hyseq WO 99/27096

EGF-repeat domain proteins

Sunnyvale, Calif.

EGF-repeat domain proteins expressed in liver and spleen, encoding gene sequences; for diagnostics and therapeutics.

Incyte Pharma WO 99/27080

Human protein kinase

Palo Alto, Calif.

Human protein kinase, kinase inhibitors, encoding gene sequences; for diagnostics and identifying modulators.

Incyte Pharma WO 99/27095

Human CDC10 homolog

Palo Alto, Calif.

Human CDC10 homolog, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Inhibitex WO 99/27109

Staphylococcus infection diagnosis

Norcross, Ga.

Extracellular matrix-binding proteins from Staphylococcus aureus, encoding gene sequences; for infection diagnosis.

Innovir Labs WO 99/27135

Functional sequences

New York

Identification of functional nucleic acid molecules using a cell-based assay; for identifying inhibitors.

Inst. Human Genetics & Biochem WO 99/26656

Human IgM monoclonal antibodies

Geneva, Switzerland

Monoclonal human immunoglobulin M (IgM) antibodies; for treating HIV-infected individuals.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 99/27089

Doublecortin

Paris

Doublecortin, encoding gene sequences; for diagnostics and therapeutics.

Iowa St. Univ. WO 99/26664

Pig pneumonia vaccine

Ames, Iowa

Mycoplasma hyopneumoniae proteins, encoding gene sequences, production methods; for making pig pneumonia vaccines.

Japan Tobacco EPO 921 195

Repetitive antisense

Tokyo

Antisense with two or more successive repeats of the active sequences; for more effective expression inhibition.

Junghans, C. WO 99/27131

Antibiotic screens

Berlin, Germany

Topologically-fixed matrix-bonded nucleic acid molecules; for automated searches for cytostatics and antibiotics.

Kreatsch Biotech EPO 921 397

Mycobacterial assay

Amsterdam, Netherlands

Measuring the presence of mycobacteria in body fluids using mycobacterial antigens and antibodies to them.

Leadd EPO 921 192

Apoptosis induction

Leiden, Belgium

Molecules interacting with Hou- and IFP35-like compounds; for apoptin-like induction of apoptosis.

Lilly EPO 921 194 & WO 99/26463 & 26976

TNF ligands

Indianapolis, Ind.

Tumor necrosis factor (TNF) ligand family proteins and fragments, encoding gene sequences; for treating cancer.

Manitoba, Univ. of WO 99/27093

Nip3 family proteins

Winnipeg, Manitoba

Nip3 family proteins, encoding gene sequences; for making transgenics and inducing apoptosis.

Mass. Gen. Hosp. WO 99/27129

Bacterial virulence peptides

Boston, Mass.

Bacterial virulence polypeptides, encoding gene sequences, production methods; for antibacterial screens.

Millennium Pharma WO 99/26960

Frizzled-like proteins

Cambridge, Mass.

Frizzled-like proteins, encoding gene sequences; for diagnostics and therapeutics.

Mixson, A.J. EPO 921 193

Anti-angiogenesis

Rockville, Md.

Carrier-DNA complexes having anti-angiogenic genes or peptides; for inhibiting tumor growth.

Mt. Sinai Hosp. WO 99/27088

Neural expressed protein

Toronto, Ont.

Sel-1 like gene, encoded protein expressed in neural and pancreatic tissues and localized to intracellular vesicles.

Myriad Genetics WO 99/27075

BRCA1 binding protein

Salt Lake City, Utah

Protein interacting with the carboxy terminus of the BRCA1 protein; for controlling cancer cell gene transcription.

Novartis WO 99/27119

Silent gene activation

Basel, Switzerland

Fusing DNA binding and transcription activating domains; for binding synthetic promoters that activate silent transgenes.

Novo Nordisk WO 99/27082

Protease variants

Bagsvaerd, Denmark

Protease subtilase variants having an insertion in one active site loop; for improved detergents.

Novo Nordisk WO 99/27083

Pectin-degrading enzymes

Bagsvaerd, Denmark

Pectin-degrading enzymes from Bacillus lichenformis, encoding gene sequences; for improved detergents.

Novo Nordisk WO 99/27084

Pectate lyases

Bagsvaerd, Denmark

Pectate lyases from Bacillus species; for improved detergent action in alkaline conditions.

Novo Nordisk WO 99/27124

Syrup production

Bagsvaerd, Denmark

Producing syrups from liquefied starch solutions using saccharification enzymes.

Otago, Univ. of WO 99/26969

Zoocin A immunity factor

Dunedin, New Zealand

Bacterial zoocin A immunity factor, encoding gene; for transforming bacteria to use as antibacterial agents.

Oxford Vacs WO 99/27104

Histamine binding proteins

London

Histamine/serotonin binding proteins, encoding gene sequences; for histamine detection and allergy treatment.

Oxford BioMedica GB 2 331 989

HIV-dependent expression

Oxford, U.K.

HIV-dependent expression of foreign genes located within an intron of a viral transcription unit in retroviral vectors.

Pfizer EPO 921 395

Collagen antibodies

Groton, Conn.

Engineered antibodies that react with collagen fragments; for measuring collagenase cleavage of type II collagen.

Pfizer EPO 921 396

Cytochrome phenotyping

Groton, Conn.

Measurement of the ratio of dextromethorphan to its metabolites; for determining cytochrome cyp2d6 phenotype.

Plant Biosciences WO 99/27120

Plant glucosinolates

Norwich, U.K.

Genes encoding enzymes involved in plant glucosinolate synthesis; for regulating levels of this metabolite.

Princeton Univ. WO 99/27101

Adenovirus vectors

Princeton, N.J.

Adenovirus vectors, method of adenovirus vector preparation; for gene therapy.

Prolifix WO 99/27092

Viral replication modulators

Abingdon, U.K.

CDF-1 transcription factor, encoding gene sequences; for identifying modulators of viral replication.

Rice Univ. WO 99/27108

Altered lac repressors

Houston, Texas

Lactose repressor proteins with altered ligand responsivity, encoding gene sequences; for induction by other sugars.

Roche Diagnostics EPO 921 196

Modified DNA polymerase

Mannheim, Germany

DNA polymerase from Carboxydothermus hydrogenoformans, modified forms; for coupled reverse transcription and PCR.

Sagami Chem. Res. Ctr. WO 99/27094

Transmembrane proteins

Sagami, Japan

Human proteins having transmembrane domains, encoding gene sequences; for controlling cell growth and differentiation.

Sankyo EPO 921 189

Allergy transgenics

Tokyo

Transgenics with an IgE heavy chain constant region gene specific for a pre-defined antigen; for modeling allergy.

Shionogi EPO 921 132

Tyrosine kinase-like protein

Osaka, Japan

Receptor type tyrosine kinase-like protein having Eph family structure; for signal modification or amplification.

SmithKline Beecham EPO 921 197

Disintegrin metalloprotease

Philadelphia, Penn.

Human disintegrin metalloprotease gene related to Drosophila kuz gene, encoded protein; for diagnostics and therapeutics.

SmithKline Beecham WO 99/26475 & 27126

Antibacterial screen

Philadelphia, Penn.

ribG polypeptides, encoding gene sequences, production methods; for screening antibacterials.

SmithKline Beecham WO 99/26646 & 27125

Antibacterial screen

Philadelphia, Penn.

ribA polypeptides, encoding gene sequences, production methods; for screening antibacterials.

SmithKline Beecham WO 99/26650 & 27127

Antibacterial screen

Philadelphia, Penn.

ribB polypeptides, encoding gene sequences, production methods; for screening antibacterials.

SmithKline Beecham WO 99/26651 & 27128

Antibacterial screen

Philadelphia, Penn.

ribH polypeptides, encoding gene sequences, production methods; for screening antibacterials.

SmithKline Beecham WO 99/26959

Antibacterial screen

Philadelphia, Penn.

recJ polypeptides, encoding gene sequences, production methods; for screening antibacterials.

SmithKline Beecham WO 99/26970

Antibacterial screen

Philadelphia, Penn.

pth polypeptides, encoding gene sequences, production methods; for screening antibacterials.

SmithKline Beecham WO 99/27073

Antibacterial screen

Philadelphia, Penn.

deoD polypeptides, encoding gene sequences, production methods; for screening antibacterials.

SmithKline Beecham WO 99/27074

Antibacterial screen

Philadelphia, Penn.

tig polypeptides, encoding gene sequences, production methods; for screening antibacterials.

SmithKline Beecham WO 99/27090

Transcription fingerprint

Philadelphia, Penn.

Methods for identifying toxic or pathological environmental stimuli by fingerprinting gene transcription.

SmithKline Beecham WO 99/27106

Antibacterial screen

Philadelphia, Penn.

guaA polypeptides, encoding gene sequences, production methods; for screening antibacterials.

South Alabama Med. Sci. Fdn. WO 99/27134

Phosphatase antisense

Mobile, Ala.

Antisense oligos for human serine/threonine phosphatases; for inhibiting abnormal cell growth.

Sugen WO 99/27099

Kinase substrate

S. San Francisco

Extracellular signal-regulated kinase ERK-6 substrate, encoding gene sequences, antibodies; for therapeutics.

Takara Shuzo WO 99/27117

Cold-inducible vector

Kyoto, Japan

Vector having cold shock protein gene promoter sequences; for recombinant protein expression controlled by cold.

Texas, Univ. of WO 99/27123

Modified SV40 viral vectors

Austin, Texas

Modified SV40 viral vectors incorporating other viral sequences; for protein expression.

Transgene WO 99/27122

Inhibiting HIV binding

Strasbourg, France

Recombinant viral vectors having inserted sequences that encode a protein that inhibits HIV binding to cells.

U.S. Army WO 99/26653

Encephalitis vaccines

Frederick, Md.

Particle-mediated DNA immunization against tick-borne flaviviruses; for encephalitis vaccines.

Univ. Technol. WO 99/27102

CD4+ T cell protease

Boulder, Colo.

Dibasic amino acid processing endoprotease from CD4+ T cells, encoding gene sequences; for therapeutics.

Vlamms Inst. Molec. Biol. WO 99/27085

Insertion mutant screen

Zwijinaarde, Belgium

Parallel screening for insertion mutants using transposon display PCR; for developing an insertion library.

Wisconsin, Univ. of WO 99/27118

BAC vector

Madison, Wis.

Conditionally amplifiable bacterial artificial chromosome (BAC) vector; for making large amounts of genomic DNA.

Yeda Res. & Develop. WO 99/27116

Dehalogenase

Rehovot, Israel

Dehalogenase that degrades the herbicide dalapon, encoding gene sequences; for transforming grain plants.

Zymogenetics WO 99/27103

Cytokine-like peptide

Seattle, Wash.

Mammalian cytokine-like polypeptide-10, encoding gene sequences, antibodies; for wound healing.