Published May 12 (EPO); May 6 (WO)
Abbott Labs WO 99/22027
Breast cancer diagnosis
Abbott Park, Ill.
Overlapping breast tissue cDNA sequences, encoded proteins; for breast cancer diagnostics and therapeutics.
Applied Imaging WO 99/22026
Karotyping method
Santa Clara, Calif.
Method for producing karyotypes by labeling chromosomes during metaphase and generating an intensity profile.
Astra WO 99/21890
GABAB receptor
Sodertalje, Sweden
GABAB receptor, functional equivalents, encoding gene sequences.
Australian Natl. Univ. WO 99/21975
Endoglucuronidases
Acton, Australia
Mammalian endoglucuronidases, fragments, encoding gene sequences; for gene therapy.
Baylor Coll. Med. WO 99/21891
Octopamine receptor
Houston, Texas
Invertebrate octopamine receptor; for finding modulators of adenylyl cyclase and internal calcium regulatory systems.
Boehringer Mannheim WO 99/21967
Retroviral packaging cells
Mannheim, Germany
Suspension-based packaging cell lines for retroviral vectors; for producing recombinant vectors.
Boston Probes WO 99/22018
PNA fluorescent probes
Bedford, Mass.
Protein-nucleic acid (PNA) fluorescent probes whose donor-acceptor moiety interactions are reduced upon hybridization.
Boston Univ. WO 99/22025
Sequencing speed increase
Boston, Mass.
Interference sequencing by hybridization using small degenerate probe arrays; for increased speed of sequencing.
British Defense Ministry WO 99/22004
Denaturing contaminants
Farnborough, U.K.
Expression system in which contaminants that are produced are unstable and are eliminated by denaturation.
Cadus Pharma EPO 915 154
Selectable trait screen
New York
Yeast cells engineered to produce pheromone system protein surrogates; for screening selectable traits.
Children's Hosp. WO 99/21584
Cell transfection promotion
Boston, Mass.
Promotion of in vivo cell transfection using ultrasound devices attached to catheters.
Crop Design WO 99/22002
Mitogenic cyclin
Zwijnaarde-Ghent, Belgium
Mitogenic cyclin, encoding gene sequences, antibodies; for controlling the cell cycle.
Dade Behring EPO 915 157
Recombinant tissue factor
Marburg, Germany
Production of functional recombinant tissue factor using prokaryotic host cells [in German].
Dai Nippon Printing EPO 915 174
Target nucleotide detection
Tokyo
Method for detecting target nucleotide sequences with improved sensitivity.
Ganimed Pharma WO 99/21992
Glutamate receptor
Martinsreid, Germany
Glutamate receptor, encoding gene sequences, transgenics; for identifying modulators.
Genentech WO 99/21998 & 21999
Wnt-1 induced secreted peptides
S. San Francisco
Wnt-1 induced secreted polypeptides, encoding gene sequences, antibodies, chimeras, production methods.
Genetics Inst. WO 99/21976
High level production
Cambridge, Mass.
Gene sequences for the rapid generation of stable mammalian cell lines making high levels of recombinant proteins.
Genome Therapeutics WO 99/21959
Ulcer vaccines
Waltham, Mass.
Live attenuated Helicobacter pylori vaccine formulations; for prevention and treatment of ulcers.
Georgetown Univ. WO 99/21964 & 22217
Breast cancer detection
Washington, D.C.
Monitoring chromosomal changes in breast cells using nipple aspirate fluid; for cancer detection.
German Hlth. & Welfare Res. Ctr. EPO 915 165
DNA vector packaging
Oberschleissheim, Germany
Helper virus-free packaging of a DNA vector in eukaryotic cells, production methods [in German].
German Hlth. & Welfare Res. Ctr. EPO 915 166
Epstein Barr virus vector
Oberschleissheim, Germany
DNA virus vector based on Epstein Barr virus, production in eukaryotes and prokaryotes [in German].
Gross, M. WO 99/22022
Mismatch repair defects
Oberpframmem, Germany
PCR amplification of genetic material from cells to find individuals with defective mismatch repair system.
Harvard Univ. WO 99/21965
Smooth muscle cell differentiation
Boston, Mass.
Cell culture system for smooth muscle cell differentiation from neural crest cells; for arteriosclerotic disease.
Hoechst Marion Roussel EPO 915 168
BMP production
Tokyo
Bone morphogenic protein (BMP) produced from its precursor in cells transfected with a BMP processing enzyme gene.
Human Genome Sciences WO 99/21575
Chemokine a -6
Rockville, Md.
Human chemokine a -6, encoding gene sequences; for finding modulators and treating immune system disorders.
Human Genome Sciences WO 99/22243
148 secreted proteins
Rockville, Md.
148 human secreted proteins, encoding gene sequences, antibodies, production; for diagnostics and therapeutics.
Hunan Med. Univ. WO 99/21982
Genetic disease gene
Changsha, China
Human M6b1 polypeptides, encoding gene sequences, production methods; for diagnosing and treating genetic diseases.
Hunan Med. Univ. WO 99/21983
Human atrophin-1 related gene
Changsha, China
Human atrophin-1 related gene, encoded protein, production methods; for diagnosing and treating genetic diseases.
Immunex WO 99/21997
Viral semaphorin protein receptor
Seattle, Wash.
Viral encoded semaphorin protein receptor, encoding gene sequences, production methods, vectors, host cells.
Incyte Pharma WO 99/21994
Vesicle membrane protein
Palo Alto, Calif.
Human vesicle membrane protein-like proteins, encoding gene, antibodies, modulators; for diagnostics and therapeutics.
Iowa, Univ. of WO 99/21996
Cataract protein
Iowa City, Iowa
Peptides playing a role in eye structure development, encoding gene sequences, homologs; for treating cataracts.
Isis Innovation WO 99/21576
Soluble CD8
Oxford, U.K.
Inhibition of cytotoxic lymphocytes using soluble CD8; for immunosuppressive therapy during transplantation.
Japan Tobacco EPO 915 153 & 163
ß-galactosidase-a 2,6 sialyltransferase
Tokyo
ß-galactosidase-a 2,6 sialyltransferase, versions modified for secretion, encoding gene sequences.
Kirin Beer WO 99/22001
Stem cell control
Tokyo
Methods of affecting differentiation and growth of hematopoietic stem cells by transfection of control genes.
Krebs Res. Inst. WO 99/22000
Wnt pathway inhibitor
Heidelberg, Germany
Inhibitor protein of the wnt signaling pathway, encoding gene sequences, antibodies, production methods.
Kyowa Hakko Kogyo EPO 915 100 & 156
Nephropathy protein
Tokyo
Leukocyte protein from IgA nephropathy patients, encoding gene, antibodies; for diagnostics and therapeutics.
Life Technologies WO 99/21977
Recombinatorial cloning
Rockville, Md.
Recombinatorial cloning using nucleic acid cassettes having recombination sites; for making chimeric proteins.
Los Alamos Natl. Labs WO 99/22029 & 22030
DNA polymorphism detection
Los Alamos, N.M.
Detection of DNA polymorphisms by using mismatch binding protein-coated microspheres; for detecting mutations.
Mass. Inst. Technol. WO 99/22005
Glycosaminoglycan sequencing
Cambridge, Mass.
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase, encoding gene sequences; for sequencing glycosaminoglycans.
Maxygen WO 99/21979
Papillomavirus vectors
Santa Clara, Calif.
Human papillomavirus vectors derived from benign viral strains; for gene therapy for hair growth or color change.
McGill Univ. WO 99/21980
Multidrug resistance protein
Montreal, Que.
P-40, a new multidrug resistance-associated protein, encoding gene sequences, homologs, antibodies.
McGill Univ. WO 99/21981
Proton-gated ion channel
Montreal, Que.
Human proton-gated ion channel present in a variety of tissues, encoding gene sequences.
Megabios WO 99/22009
Transfection complexes
Burlingame, Calif.
Preparing polynucleotide-polycation transfection complexes using a reduced-volume dual-feed process.
Merck WO 99/21590
Angiogenesis induction
Rahway, N.J.
Gene therapy to promote angiogenesis using vectors encoding vascular endothelial growth factor.
Miriam Hosp. WO 99/21978
Non-transgenic Alzheimer's model
Providence, R.I.
Amyloid plaque deposition induced by infusing brains with amyloid peptide at basic pH; for modeling Alzheimer's.
Mochida Pharma EPO 915 155
TNF receptor-associated factor
Tokyo
TNF receptor-associated factor, encoding gene sequences, antibodies, for screening modulators.
Neurospheres WO 99/21966
EPO-mediated neurogenesis
Calgary, Alberta
Treating neural stem cells with erythropoietin (EPO) to form neuronal progenitor cells.
New England Biolabs WO 99/21973
Tsp45I restriction endonuclease
Beverly, Mass.
Recombinant DNA molecules encoding Tsp45I from Thermus species YS45, expression in E. coli.
Otsuka Pharma WO 99/21577
Arteriosclerosis therapeutic
Tokyo
Fat tissue-specific factor apM1, antibodies; for inhibiting expression of adhesion molecules in vascular endothelium.
Pluckthun, A. WO 99/22010
Increased periplasmic yields
Zurich, Switzerland
Proteins that increase yields of functional recombinant proteins from the periplasm, encoding gene sequences.
Puratose WO 99/21972
Epoxide hydrolase
Groot-Bijgarden, Netherlands
Microbial epoxide hydrolase, encoding gene sequences, host cells, production methods.
Queensland Dept. Hlth. WO 99/21882
Hepatitis B vaccines
Herston, Australia
Hepatitis B virus binding polypeptide, variants, encoding gene sequences, transgenics, vaccines and therapeutics.
Rhone-Poulenc WO 99/21886
Alzheimer's inhibitory peptides
Antony, France
Peptides inhibiting presenilin interaction with ß-amyloid peptide; for Alzheimer's diagnostics and therapeutics.
Rockefeller Univ. WO 99/21995
Alzheimer's therapeutic
New York
Modulators affecting the interaction of a PI domain peptide with amyloid precursor protein; for Alzheimer's therapy.
Rutgers Univ. WO 99/22019
Protein function analysis
Piscataway, N.J.
High-throughput determination of protein function using three-dimensional structure analysis.
Shanghai Second Med. Univ. WO 99/21884
G protein gamma-5 subunit
Shanghai, China
G protein gamma-5 subunit polypeptides, encoding gene sequences, production; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/21885
Human ABC transporter
Shanghai, China
Human ABC transporter polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/21984
Human E2 homolog
Shanghai, China
Human E2 polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics for bone diseases.
Shanghai Second Med. Univ. WO 99/21985
Translation initiation factor
Shanghai, China
Human translation initiation factor polypeptides, encoding gene sequences; for diagnostics and therapeutics for cancer.
Shanghai Second Med. Univ. WO 99/21986
Human SL15 homolog
Shanghai, China
Human SL15 peptides, encoding gene sequences, production; for mannose metabolism disease diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/21987
Synaptic glycoprotein homolog
Shanghai, China
Human synaptic glycoprotein SC2 polypeptides, encoding gene sequences, production; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/21988
Vesicle trafficking protein
Shanghai, China
Human vesicle trafficking protein polypeptides, encoding gene sequences; for cancer diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/21989
Human cofactor-A
Shanghai, China
Human cofactor-A polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/21990
Voltage dependent anion channel
Shanghai, China
Human voltage dependent anion channel polypeptides, encoding gene sequences; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/21991
Zinc finger gene
Shanghai, China
Zinc finger gene cloned from bone marrow, encoded polypeptides; for cancer diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/22006
Vacuolar H+-ATPase
Shanghai, China
Vacuolar H+-ATPase polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/22007
Human SKD1
Shanghai, China
Human SKD1 polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham EPO 915 159
Antibacterial screens
Philadelphia, Penn.
Xanthine phosphoribosyl transferase polypeptides, encoding gene sequences, production methods; for antibacterials.
SmithKline Beecham EPO 915 161
Staphylococcus antibacterials
Philadelphia, Penn.
Staphylococcus pneumoniae DnaG DNA primase polypeptides, encoding gene sequences; for antibacterial screens.
SmithKline Beecham EPO 915 162
Antibacterial screens
Philadelphia, Penn.
Adenine phosphoribosyl transferase polypeptides, encoding gene sequences, production methods; for antibacterials.
SmithKline Beecham EPO 915 164
Staphylococcus antibacterials
Philadelphia, Penn.
Staphylococcus aureus ribonuclease polypeptides, encoding gene sequences, production methods; for antibacterials.
Stem Cell Sciences WO 99/21415
Xenotransplant pigs
Oakleigh, Australia
Nuclear transfer for producing transgenic pigs expressing a 1,3-galactosyl transferase; for xenotransplantation.
Sumitomo Electric WO 99/22008
Antigen-specific antibodies
Osaka, Japan
Inducer of an antigen-B cell activation signal chimera; for activating B cells to produce antigen-specific antibodies.
Unilever EPO 915 158
Salmonella antibody
Rotterdam, Netherlands
Immunoglobulin that binds a Salmonella typhimurium flagellin epitope; for detection of infection.
Utah, Univ. of WO 99/21875
Epilepsy potassium channels
Salt Lake City, Utah
Potassium channel genes from chromosome 20 that are mutated in benign familial neonatal convulsions.
Vanderbilt Univ. WO 99/21883
Parasite dopamine receptor
Nashville, Tenn.
Nematode dopamine receptor, encoding gene sequences; for screening antiparasitic and psychoactive drugs.
Vlamms Inst. Biotech. WO 99/21968
Cellular immunity induction
Zwijnaarde, Netherlands
Induction of cellular immunity by activating Th1 and suppressing Th2 responses using macrophages.
Washington, Univ. of WO 99/22028
Actin modulators
Seattle, Wash.
Modulators of actin derived from the human diaphanous gene product; for modulating actin filament stabilization.
Zeneca WO 99/21993
IL-4 gene transactivator
London
Interleukin (IL)-4 gene transcriptional transactivator, encoding gene sequences; for identifying modulators.