I. COMMENCED TRADING IN JUNE

Company (Symbol)

Date Filed

Date Comm.

Shares/ Units (M)

Price

Shares Out (M)

Lead, Other Underwriters

Gross ($M)

Net ($M)

INITIAL OFFERINGS

VaxGen Inc. (VXGN)

5/7

6/30

3.1S

$13

10.8

Prudential Securities; Punk, Ziegel & Co.

$40.3

$37.5E

FOLLOW-ON OFFERINGS

Alliance Pharmaceutical Corp. (ALLP)

4/15

6/11

9.5

$2.45

33.2

Cruttendon Roth Inc.

$23.275

$22.1E

TOTAL: $63.6M

II. FILED AND PENDING

Company (Symbol)

Date Filed

Shares/ Units (M)

Price Range

Shares Out (M)

Lead, Other UWs

Value (M)

INITIAL OFFERINGS

BioMarin1 Pharmaceutical Inc. (Proposed NASDAQ symbol:BMRN)

5/4

N/A

N/A

N/A

U.S. Bancorp Piper Jaffray; Vontobel Securities Ltd.; Schroders Securities Co. Ltd.; Leerink Swann & Company

N/A

Biopure Corp.2 (Proposed NASDAQ symbol: BPUR)

5/19

N/A

N/A

N/A

J.P. Morgan & Co.; Adams, Harkness & Hill Inc.; Robert W. Baird& Co.

N/A

1 BioMarin's registration statement leaves blank information on the number of shares to be offered, number outstanding following the offering and price per share. The offering is international ­ the company has applied for listings on both the Nasdaq National Market and the Swiss Exchange. The maximum aggregate price, for the purpose of determining SEC fees, is $58.5 million.

2 Biopure's registration statement leaves blank information on the number of shares to be offered, number outstanding following the offering and price per share. The maximum aggregate price, for the purpose of determining SEC fees, is $86.25 million.

N/A = Information not available.

FOLLOW-ON OFFERINGS

Angiotech Pharmaceuticals Inc. (TSE:ANP)1

6/17

N/A

N/A

11.8 (pre- offering)

Levasque Beaubien Geoffren Inc.; Loewen, Ondaatje, McCutcheon Ltd.

C$15M (US$10.2)*

Aquila Biopharmaceuticals Inc.2 (AQLA)

6/4

0.75

$2

6.9

-

$1.5

NeoTherapeutics Inc. (NEOT)

6/18

3.5

$13

10.2

Joseph Charles & Associates

$45.5

Ribozyme Pharmaceuticals Inc. (RZYM)

3/26

1.8

$5

11

-

$9

* Canadian dollars converted to U.S. dollars at a rate of C$1.00=US$0.68.

1 Angiotech filed a prospectus to raise C$15M. Based on the June 17 closing price of $11.25 per share, the company would have to sell 1.33M shares to meet that target.

2 Aquila registered 750,000 shares to be sold in a direct limited placement to be negotiated by the company.