Published March 10 (EPO); March 4 (WO)
Ariad Gene Therapeutics WO 99/10508 & 10510
Chimeric transcriptional activators
Chimeric transcriptional activators; for ligand-dependent and -independent gene transcription.
Biogen WO 99/10516
Secreted protein expression
Secreted protein expression system for in vivo or ex vivo administration to patients; for interferon-_ treatment.
Biotech & Biol. Sci. Res. Counc. WO 99/09817
Foreign genes into transgenics
Transgenic animals containing mariner-like transposon elements; for introducing foreign genes.
CDC (Ctr. Dis. Control) WO 99/10506
Hepatitis C mosaic protein
Mosaic protein with antigenic epitopes of several hepatitis C virus genotypes, methods of design; for diagnostics.
Chiron WO 99/10501
Apoptosis-associated nuclease, encoding gene sequences; for screening modulators of the apoptotic pathway.
Connaught Labs WO 99/10475
North York, Ont.
Attenuated Mycobacterium strains having the cell entry gene functionally disabled; for tuberculosis vaccines.
Diversa WO 99/10539
Expression libraries inserted into cells sorted for their ligand binding capabilities; for bioactivity screen.
Duke Univ. WO 99/10368
Presenilin-1 gene promoter
Presenilin-1 gene promoter, vectors containing this promoter; for directing neuron-specific gene transcription.
Genentech WO 99/10484
S. San Francisco
RTD receptors that bind TNF and the Apo-2 ligand, encoding gene sequences, antibodies; for inhibiting apoptosis.
Genentech WO 99/10494
Thrombopoietin receptor antibodies
S. San Francisco
Agonist antibodies to the thrombopoietin receptor; for affecting megakaryocytes and treating thrombocytopenia.
Gist-Brocades WO 99/10499
Fungal host cells that produce compactin and are transformed with hydroxylase genes; for one-step pravastatin production.
Guelph, Univ. of WO 99/10505
Egg recombinant proteins
Preparing antibodies and other proteins by secretion into eggs; for edible pharmaceutical preparations.
Harvard Univ. WO 99/10487
RNAs affecting transcription rate from promoters to which they are recruited, methods of isolating riboregulators.
Human Genome Sciences WO 99/10363
29 secreted proteins
29 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Human Genome Sciences WO 99/10364
Follistatin-3, encoding gene sequences; for identifying modulators and treating reproductive system disorders.
Hybridon WO 99/10486
Tumor suppressor activation
MDM2-specific antisense oligos; for gene therapy to activate tumor suppressors in conjunction with DNA damage inducers.
Idun Pharma WO 99/10504
La Jolla, Calif.
Apoptotic-associated caspase-14, fragments, variants, encoding gene sequences; for screening modulators.
Immunex WO 99/10495
Cytokine LERK-6, encoding gene sequences, transfected cells; for therapeutics.
Incyte Pharma WO 99/10491
G-protein coupled receptor
Palo Alto, Calif.
Human G-protein coupled receptor, encoding gene sequences, antibodies, modulators; for therapeutics.
Incyte Pharma WO 99/10502
Palo Alto, Calif.
Human nucleotide pyrophosphohydrolase, encoding gene sequences, antibodies, modulators; for therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) EPO 900 841
LAG-3 splice variants
LAG-3 splice variants, nucleic acid code variants, encoded proteins.
Julich Res. Ctr. WO 99/10511
Saccharose synthase expression
Saccharose synthase gene sequences under the control of the proton-ATPase promoter; for increased gene expression.
Karolinska Innovations WO 99/10517
Organic molecule introduction
Introduction of organic molecules into target cells using a fluidized layer of target cells.
Lexicon Genetics WO 99/10479
Impaired BRCA2 function
The Woodlands, Texas
Cells and transgenic mice having impaired BRCA2 radiation repair function; for studying premature cell death.
Life Technol. WO 99/10366
High fidelity polymerases
High fidelity DNA and RNA polymerases, encoding gene sequences, methods of making; for sequencing.
Lopez, O.J., et al. WO 99/10540
DNA methyltransferases used to determine variations, mutations, and polymorphisms in DNA sequences.
Louisiana St. Univ. WO 99/10005
Baton Rouge, La.
Chlamydia psittaci major outer membrane protein lacking specific domains, encoding gene sequences; for vaccines.
Mass. Gen. Hosp. WO 99/09815
Vitamin D receptor knockouts
Transgenic mice with ablated vitamin D receptors; for drug screening.
Max Planck Inst. WO 99/10496
Recombinant nucleic acids, encoded proteins, transfected cells; for vaccines against tuberculosis.
McGill Univ. WO 99/10482
Physiological clock gene
Nematode worm gro-1 gene and related genes; for controlling the physiological clock.
Merck WO 99/10367
Nuclear receptor proteins
Human nuclear receptor proteins, encoding gene sequences; methods for producing antibodies and screening modulators.
Minato, N., et al. WO 99/10380
Human G protein activator
Human SPA-1 protein, muteins having deleted, added, or substituted amino acid residues; for activating G proteins.
NIH (Natl. Inst. Hlth.) WO 99/10493
Variant Stat6 cDNAs
Attenuated and dominant negative variant cDNAs of Stat6, encoded proteins, production methods.
NIH (Natl. Inst. Hlth.) WO 99/10509
Inhibiting RNA destabilization
Polynucleotide inhibition of RNA destabilization and sequestration; for enhancing cytoplasmic translocation.
Netherlands Health Ministry WO 99/10497
Lipopolysaccharide-deficient mucosal Gram-negative bacteria; for isolating endotoxin-free proteins for vaccines.
North Carolina St. Univ. WO 99/10514
Gene sequences encoding proteins providing resistance to the mycotoxins of the fumonosin family; for cell transfection.
Orchid Biocomputer WO 99/10538
Automated amplification of polynucleotides using primer extension or joining-type protocols.
Perkin-Elmer WO 99/10541
Foster City, Calif.
Chimeric phosphoramidate-phosphodiester oligonucleotides; for sequencing and amplification primer extension methods.
Roche Diagnostics WO 99/09816
Insulin precursor protein
Expression of insulin precursor protein in the milk of transgenics; for producing insulin.
Roche Diagnostics WO 99/10483
Microbial protease precursor
Microbial protease precursor expression in bacterial inclusion bodies; for autocatalytic activation.
Roche Diagnostics WO 99/10503
Zymogenic protease precursor
Zymogenic protease precursor expression in bacterial inclusion bodies; for autocatalytic activation.
Sagami Chemical Res. Ctr. WO 99/10490
Human galectin-9-like proteins, encoding gene sequences, expression in E. coli; for determining lactose binding.
Salk Inst. WO 99/10488
La Jolla, Calif.
Transgenic mice with Cre recombinase genes under the control of the protamine 1 gene promoter; for gene targeting.
Scriptgen Pharma WO 99/10474
Yeast strains in which gene expression is modulated by metal ions; for determining growth and viability requirements.
Selective Genetics WO 99/10014
Phage gene delivery system
San Diego, Calif.
Filamentous phage particles having coat protein fusions with cell receptor ligands; for gene delivery.
Selective Genetics WO 99/10485
Selecting internalizing ligands
Bacteriophage with coat reporter/selectable marker proteins; for screening internalizing ligands for gene delivery.
Shanghai Cancer Inst. EPO 900 849
Tumor gene therapy
Gene transfer vector with growth factor receptor ligand, cationic peptide, and gene of interest; for tumor targeting.
SmithKline Beecham EPO 900 843
Streptococcus ffH polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline Beecham EPO 900 844
Staphylococcus aureus membrane protein polypeptides, encoding gene sequences; for antibacterials.
SmithKline Beecham EPO 900 845
Histidine kinase antibacterials
Histidine kinase polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline Beecham EPO 900 846
Streptococcus pneumoniae response regulator polypeptides, encoding gene sequences; for antibacterial screens.
SmithKline Beecham EPO 900 847
Staphylococcus aureus phosphoribosyl transferase peptides, encoding gene sequences; for antibacterial screens.
SmithKline Beecham EPO 900 848
Staphylococcus aureus MecB ATPase polypeptides, encoding gene sequences; for antibacterial screens.
SmithKline Beecham WO 99/10012
Bacterial pri peptides
Bacterial pri polypeptides, encoding gene sequences, production methods; for antibacterial screens.
Soc. Res. Counc. & Sci. Appl. WO 99/10361
Amidated peptide hormone precursors
Oligonucleotide probes to amidated polypeptide hormone precursor genes; for identification of encoded proteins.
Stanford Univ. WO 99/10478
Lymphoid progenitor cells
Palo Alto, Calif.
Mammalian common lymphoid progenitor cell preparations enriched using reagents recognizing specific receptors.
Takara Shuzo WO 99/10001
Mannan-binding proteins, variants, encoding gene sequences; for use as carcinostatic agents.
Texas, Univ. of WO 99/10537
Chromosome 10 tumor suppressor
Tumor suppressor gene on chromosome 10 that is involved in gliomas and prostate cancer; for analyzing gene mutations.
Thomas Jefferson Univ. WO 99/10369
Mismatched DNA binding proteins
MutS and MutR homologs that bind mismatched duplex DNA in the presence of ADP; for affecting mismatch recognition.
Univ. Technol. Intl. WO 99/10489
Secretion efficiency improvement
Juvenile hormone esterase gene sequences for directing secretion of non-secreted proteins in eukaryotic cells.
Univ. Technol. Intl. WO 99/10515
Baculovirus artificial chromosomes
Baculovirus artificial chromosomes containing heterologous genes; for expression in eukaryotic cells.
Washington Univ. WO 99/10376
Inducible regulatory system
Fusion proteins with transcription activator and protein transduction domains; for fusion protein entry into cells.
Wisconsin, Univ. of WO 99/10507
Transglutaminase, encoding gene sequences, probes; for identifying related gene products.
Yale Univ. WO 99/10535
Stem cell expression profiles
New Haven, Conn.
Expression profiles of stem cell populations, profile comparison; for identifying therapeutics.
Yale Univ. WO 99/10536
Granulocyte expression profiles
New Haven, Conn.
Expression profiles of granulocytes, profile comparison; for identifying genes differentially expressed during disease.
Zeneca WO 99/10529
LTC4 synthase polymorphisms
Single nucleotide polymorphisms in the LTC4 synthase gene; for treating leukotriene-mediated diseases.
Zymogenetics WO 99/10492
Adipocyte-specific protein homologs
Adipocyte-specific protein homologs having collagen-like and globular domains, encoding gene sequences, antibodies.
- Compiled by Chester A. Bisbee