Published March 10 (EPO); March 4 (WO)

Ariad Gene Therapeutics WO 99/10508 & 10510
Chimeric transcriptional activators
Cambridge, Mass.
Chimeric transcriptional activators; for ligand-dependent and -independent gene transcription.

Biogen WO 99/10516
Secreted protein expression
Cambridge, Mass.
Secreted protein expression system for in vivo or ex vivo administration to patients; for interferon-_ treatment.

Biotech & Biol. Sci. Res. Counc. WO 99/09817
Foreign genes into transgenics
Swindon, U.K.
Transgenic animals containing mariner-like transposon elements; for introducing foreign genes.

CDC (Ctr. Dis. Control) WO 99/10506
Hepatitis C mosaic protein
Mosaic protein with antigenic epitopes of several hepatitis C virus genotypes, methods of design; for diagnostics.

Chiron WO 99/10501
Apoptosis-associated nuclease
Emeryville, Calif.
Apoptosis-associated nuclease, encoding gene sequences; for screening modulators of the apoptotic pathway.

Connaught Labs WO 99/10475
Tuberculosis vaccines
North York, Ont.
Attenuated Mycobacterium strains having the cell entry gene functionally disabled; for tuberculosis vaccines.

Diversa WO 99/10539
Bioactivity screens
San Diego
Expression libraries inserted into cells sorted for their ligand binding capabilities; for bioactivity screen.

Duke Univ. WO 99/10368
Presenilin-1 gene promoter
Durham, N.C.
Presenilin-1 gene promoter, vectors containing this promoter; for directing neuron-specific gene transcription.

Genentech WO 99/10484
Apoptosis inhibition
S. San Francisco
RTD receptors that bind TNF and the Apo-2 ligand, encoding gene sequences, antibodies; for inhibiting apoptosis.

Genentech WO 99/10494
Thrombopoietin receptor antibodies
S. San Francisco
Agonist antibodies to the thrombopoietin receptor; for affecting megakaryocytes and treating thrombocytopenia.

Gist-Brocades WO 99/10499
Pravastatin production
Delft, Netherlands
Fungal host cells that produce compactin and are transformed with hydroxylase genes; for one-step pravastatin production.

Guelph, Univ. of WO 99/10505
Egg recombinant proteins
Guelph, Ont.
Preparing antibodies and other proteins by secretion into eggs; for edible pharmaceutical preparations.

Harvard Univ. WO 99/10487
Cambridge, Mass.
RNAs affecting transcription rate from promoters to which they are recruited, methods of isolating riboregulators.

Human Genome Sciences WO 99/10363
29 secreted proteins
Rockville, Md.
29 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Human Genome Sciences WO 99/10364
Rockville, Md.
Follistatin-3, encoding gene sequences; for identifying modulators and treating reproductive system disorders.

Hybridon WO 99/10486
Tumor suppressor activation
Milford, Mass.
MDM2-specific antisense oligos; for gene therapy to activate tumor suppressors in conjunction with DNA damage inducers.

Idun Pharma WO 99/10504
La Jolla, Calif.
Apoptotic-associated caspase-14, fragments, variants, encoding gene sequences; for screening modulators.

Immunex WO 99/10495
Cytokine LERK-6
Cytokine LERK-6, encoding gene sequences, transfected cells; for therapeutics.

Incyte Pharma WO 99/10491
G-protein coupled receptor
Palo Alto, Calif.
Human G-protein coupled receptor, encoding gene sequences, antibodies, modulators; for therapeutics.

Incyte Pharma WO 99/10502
Nucleotide pyrophosphohydrolase
Palo Alto, Calif.
Human nucleotide pyrophosphohydrolase, encoding gene sequences, antibodies, modulators; for therapeutics.

INSERM (Natl. Inst. Hlth. & Med. Res.) EPO 900 841
LAG-3 splice variants
LAG-3 splice variants, nucleic acid code variants, encoded proteins.

Julich Res. Ctr. WO 99/10511
Saccharose synthase expression
Julich, Germany
Saccharose synthase gene sequences under the control of the proton-ATPase promoter; for increased gene expression.

Karolinska Innovations WO 99/10517
Organic molecule introduction
Stockholm, Sweden
Introduction of organic molecules into target cells using a fluidized layer of target cells.

Lexicon Genetics WO 99/10479
Impaired BRCA2 function
The Woodlands, Texas
Cells and transgenic mice having impaired BRCA2 radiation repair function; for studying premature cell death.

Life Technol. WO 99/10366
High fidelity polymerases
Rockville, Md.
High fidelity DNA and RNA polymerases, encoding gene sequences, methods of making; for sequencing.

Lopez, O.J., et al. WO 99/10540
Gene mapping
Lincoln, Neb.
DNA methyltransferases used to determine variations, mutations, and polymorphisms in DNA sequences.

Louisiana St. Univ. WO 99/10005
Chlamydia vaccines
Baton Rouge, La.
Chlamydia psittaci major outer membrane protein lacking specific domains, encoding gene sequences; for vaccines.

Mass. Gen. Hosp. WO 99/09815
Vitamin D receptor knockouts
Transgenic mice with ablated vitamin D receptors; for drug screening.

Max Planck Inst. WO 99/10496
Tuberculosis vaccine
Munich, Germany
Recombinant nucleic acids, encoded proteins, transfected cells; for vaccines against tuberculosis.

McGill Univ. WO 99/10482
Physiological clock gene
Nematode worm gro-1 gene and related genes; for controlling the physiological clock.

Merck WO 99/10367
Nuclear receptor proteins
Rahway, N.J.
Human nuclear receptor proteins, encoding gene sequences; methods for producing antibodies and screening modulators.

Minato, N., et al. WO 99/10380
Human G protein activator
Kyoto, Japan
Human SPA-1 protein, muteins having deleted, added, or substituted amino acid residues; for activating G proteins.

NIH (Natl. Inst. Hlth.) WO 99/10493
Variant Stat6 cDNAs
Bethesda, Md.
Attenuated and dominant negative variant cDNAs of Stat6, encoded proteins, production methods.

NIH (Natl. Inst. Hlth.) WO 99/10509
Inhibiting RNA destabilization
Bethesda, Md.
Polynucleotide inhibition of RNA destabilization and sequestration; for enhancing cytoplasmic translocation.

Netherlands Health Ministry WO 99/10497
Endotoxin-free proteins
Rijswijk, Netherlands
Lipopolysaccharide-deficient mucosal Gram-negative bacteria; for isolating endotoxin-free proteins for vaccines.

North Carolina St. Univ. WO 99/10514
Raleigh, N.C.
Gene sequences encoding proteins providing resistance to the mycotoxins of the fumonosin family; for cell transfection.

Orchid Biocomputer WO 99/10538
Polynucleotide amplification
Princeton, N.J.
Automated amplification of polynucleotides using primer extension or joining-type protocols.

Perkin-Elmer WO 99/10541
Chimeric oligos
Foster City, Calif.
Chimeric phosphoramidate-phosphodiester oligonucleotides; for sequencing and amplification primer extension methods.

Roche Diagnostics WO 99/09816
Insulin precursor protein
Mannheim, Germany
Expression of insulin precursor protein in the milk of transgenics; for producing insulin.

Roche Diagnostics WO 99/10483
Microbial protease precursor
Mannheim, Germany
Microbial protease precursor expression in bacterial inclusion bodies; for autocatalytic activation.

Roche Diagnostics WO 99/10503
Zymogenic protease precursor
Mannheim, Germany
Zymogenic protease precursor expression in bacterial inclusion bodies; for autocatalytic activation.

Sagami Chemical Res. Ctr. WO 99/10490
Galectin-9-like proteins
Sagamihara, Japan
Human galectin-9-like proteins, encoding gene sequences, expression in E. coli; for determining lactose binding.

Salk Inst. WO 99/10488
Site-specific recombination
La Jolla, Calif.
Transgenic mice with Cre recombinase genes under the control of the protamine 1 gene promoter; for gene targeting.

Scriptgen Pharma WO 99/10474
Yeast strains
Waltham, Mass.
Yeast strains in which gene expression is modulated by metal ions; for determining growth and viability requirements.

Selective Genetics WO 99/10014
Phage gene delivery system
San Diego, Calif.
Filamentous phage particles having coat protein fusions with cell receptor ligands; for gene delivery.

Selective Genetics WO 99/10485
Selecting internalizing ligands
San Diego
Bacteriophage with coat reporter/selectable marker proteins; for screening internalizing ligands for gene delivery.

Shanghai Cancer Inst. EPO 900 849
Tumor gene therapy
Shanghai, China
Gene transfer vector with growth factor receptor ligand, cationic peptide, and gene of interest; for tumor targeting.

SmithKline Beecham EPO 900 843
Streptococcus antibacterials
Streptococcus ffH polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline Beecham EPO 900 844
Staphylococcus antibacterials
Staphylococcus aureus membrane protein polypeptides, encoding gene sequences; for antibacterials.

SmithKline Beecham EPO 900 845
Histidine kinase antibacterials
Histidine kinase polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline Beecham EPO 900 846
Streptococcus antibacterials
Streptococcus pneumoniae response regulator polypeptides, encoding gene sequences; for antibacterial screens.

SmithKline Beecham EPO 900 847
Staphylococcus antibacterials
Staphylococcus aureus phosphoribosyl transferase peptides, encoding gene sequences; for antibacterial screens.

SmithKline Beecham EPO 900 848
Staphylococcus antibacterials
Staphylococcus aureus MecB ATPase polypeptides, encoding gene sequences; for antibacterial screens.

SmithKline Beecham WO 99/10012
Bacterial pri peptides
Bacterial pri polypeptides, encoding gene sequences, production methods; for antibacterial screens.

Soc. Res. Counc. & Sci. Appl. WO 99/10361
Amidated peptide hormone precursors
Oligonucleotide probes to amidated polypeptide hormone precursor genes; for identification of encoded proteins.

Stanford Univ. WO 99/10478
Lymphoid progenitor cells
Palo Alto, Calif.
Mammalian common lymphoid progenitor cell preparations enriched using reagents recognizing specific receptors.

Takara Shuzo WO 99/10001
antitumor agents
Kyoto, Japan
Mannan-binding proteins, variants, encoding gene sequences; for use as carcinostatic agents.

Texas, Univ. of WO 99/10537
Chromosome 10 tumor suppressor
Austin, Texas
Tumor suppressor gene on chromosome 10 that is involved in gliomas and prostate cancer; for analyzing gene mutations.

Thomas Jefferson Univ. WO 99/10369
Mismatched DNA binding proteins
MutS and MutR homologs that bind mismatched duplex DNA in the presence of ADP; for affecting mismatch recognition.

Univ. Technol. Intl. WO 99/10489
Secretion efficiency improvement
Calgary, Alberta
Juvenile hormone esterase gene sequences for directing secretion of non-secreted proteins in eukaryotic cells.

Univ. Technol. Intl. WO 99/10515
Baculovirus artificial chromosomes
Calgary, Alberta
Baculovirus artificial chromosomes containing heterologous genes; for expression in eukaryotic cells.

Washington Univ. WO 99/10376
Inducible regulatory system
St. Louis
Fusion proteins with transcription activator and protein transduction domains; for fusion protein entry into cells.

Wisconsin, Univ. of WO 99/10507
Madison, Wis.
Transglutaminase, encoding gene sequences, probes; for identifying related gene products.

Yale Univ. WO 99/10535
Stem cell expression profiles
New Haven, Conn.
Expression profiles of stem cell populations, profile comparison; for identifying therapeutics.

Yale Univ. WO 99/10536
Granulocyte expression profiles
New Haven, Conn.
Expression profiles of granulocytes, profile comparison; for identifying genes differentially expressed during disease.

Zeneca WO 99/10529
LTC4 synthase polymorphisms
Single nucleotide polymorphisms in the LTC4 synthase gene; for treating leukotriene-mediated diseases.

Zymogenetics WO 99/10492
Adipocyte-specific protein homologs
Adipocyte-specific protein homologs having collagen-like and globular domains, encoding gene sequences, antibodies.
- Compiled by Chester A. Bisbee