Published Feb. 10 (EPO); Feb. 4 (WO)
AffymetrixWO 99/05323
Database query system
Santa Clara, Calif.
Query system for gene expression databases; for correlating gene expression to disease states.
AffymetrixWO 99/05324
Polymorphism databases
Santa Clara, Calif.
Methods and systems for organizing polymorphism information in databases that permit large-scale data storage.
Agene Res. Inst.WO 99/05284
Human helicase gene
Kanagawa, Japan
Human RecQ4 helicase gene, encoded proteins, variant active proteins with amino acid substitutions.
Alabama, Univ. ofWO 99/05259
Transmitochondrial transgenics
Birmingham, Ala.
Heteroplasmic transmitochondrial transgenics; for studying human mitochondrial diseases.
AvigenWO 99/04632
Immunization AAV vectors
Alameda, Calif.
Delivery of antigenic compositions using adeno-associated virus (AAV) vectors; for immunization.
BASFWO 99/05285
Biotin production
Ludwigshafen, Germany
Biotin gene, organisms containing this gene; for biotin production.
BioneerWO 99/05316
Mycobacterial diagnostics
Choongeheongbuk-do, S. Korea
PCR-mediated comparative sequence analysis of the rpoB gene from mycobacterial species.
Biotech Res. Inst.WO 99/05269
Transcriptional silencer
Braunschweig, Germany
Transcriptional silencer protein NRF that binds to NF-kappaB binding sites, encoding gene sequences.
Boehringer MannheimWO 99/05264
Mutant human proteins
Mannheim, Germany
Mutant human proteins produced by homologous recombination, cells for production; for therapeutics.
Boehringer MannheimWO 99/05267 & 05268
Endogenous gene activation
Mannheim, Germany
Selection of cells for making erythropoietin by endogenous gene activation; for producing recombinant proteins.
Boston Univ.WO 99/04637
Bacterial vaccine targets
Boston, Mass.
Methods of determining a statistically significant number of bacterial strains; for evaluating vaccine targets.
Boston Univ.WO 99/05299
Enhancing chemotherapy
Boston, Mass.
Gene transfer of genes for cytochrome P450 and its reductase to cancer cells; for enhancing sensitivity to cancer drugs.
Brigham & Women's Hosp.WO 99/05278
Lens epithelial growth factor
Boston, Mass.
Lens epithelial cell-derived growth factor, fragments, encoding gene sequences; for identifying modulators.
California, Univ. ofWO 99/05177
G protein-coupled receptors
Oakland, Calif.
Methods and compositions for identifying modulators of G protein-coupled receptors.
California, Univ. ofWO 99/05258
Insulin deficient transgenics
Oakland, Calif.
Human Nkx gene, encoded protein, antibodies; for transgenics having decreased insulin-producing cell numbers.
ChugaiWO 99/05292
Nuclear receptor ligands
Tokyo
Reporter gene vector system for identifying nuclear receptor ligands and their precursors.
Columbia Univ.WO 99/05307
Alzheimer's-related gene
New York
SEL-10 gene, alleles, encoded protein, muteins, transgenics; for finding modulators and treating Alzheimer's disease.
Dedhar, S., et al.WO 99/05172
Calreticulin
North Vanvouver, B.C.
Calreticulin, mimetics, inhibitors, encoding gene sequences; for modulating hormone responsiveness.
Du Pont PharmaWO 99/05291
Aggrecan-degrading metalloproteases
Wilmington, Del.
Aggrecan-degrading metalloproteases, encoding genes; for identifying inhibitors of cartilage degradation.
Duke Univ.WO 99/05294
Myocardial hypertrophy
Durham, N.C.
Agents that inhibit cardiac Gq-coupled receptor signalling; for treating myocardial hypertrophy.
Fox Chase Cancer Ctr.WO 99/04626
DNA repair endonuclease
Philadelphia, Penn.
Human DNA mismatch repair endonuclease, encoding gene sequences; for cancer screening and diagnosis.
French Inst. Ocean Res.WO 99/05270
Crustacean antimicrobials
Issy-les-Moulineaux, France
Antimicrobial proteins from penaeid prawn crustaceans, encoding gene sequences.
GeneMedicineWO 99/05300
Growth hormone expression
The Woodlands, Texas
Growth hormone releasing hormone gene expression system; for transfection and stimulation of growth hormone expression.
Genencor Intl.EPO 896 062
Bacillus production strains
Palo Alto, Calif.
Temperature-sensitive Bacillus strains; for producing serine proteases.
GenitrixWO 99/04800
Transfecting nucleic acids
Cambridge, Mass.
Bifunctional nucleic acids that bind cell surfaces and genes of interest; for cell transfection.
Gould, H.J., et al.WO 99/05271
Soluble IgE binding protein
London
Soluble variants of a peptide with IgE-binding capability; for reducing excessive IgE action in allergic responses.
Harvard Univ.WO 99/05256
Cloning secreted proteins
Cambridge, Mass.
Nucleic acid sequences for signal peptides; for cloning secreted proteins.
Hoechst Marion RousselWO 99/05283
Antibiotic synthesis genes
Puteaux, France
Erythromycin and oleandomycin biosynthesis gene sequences; for making antibiotics.
ImmunovaWO 99/05289
Lysostaphin analogs
Sainte-Foy, Que.
Modified lysostaphin protected against post-translational modification, encoding gene sequences, production methods.
Inex PharmaWO 99/05303
Lipid-nucleic acid complexes
Burnaby, B.C.
Preparation of lipid-nucleic acid particles by solvent extraction and direct hydration; for increased stability.
Kohle Res. Inst.WO 99/05288
Hydrolase mutants
Mulheim an der Ruhr, Germany
Methods for identifying and producing hydrolase mutants with improved stereoselectivity, site selectivity, and catalysis.
Lee, K.S.WO 99/05260
Cortical malformation rats
Charlottesville, Va.
Mutant rats having telencephalic internal structural heterotopia; for studying human cortical malformation.
Leiden State Univ.WO 99/05173, 05174 & 05313
HA-1 minor antigen
Leiden, Netherlands
HA-1 minor antigen amino acid sequence; for vaccines and bone marrow transplantation therapy.
Ligand PharmaWO 99/05161
Peroxisome receptor promoter
San Diego, Calif.
Promoter and control regions of human peroxisome proliferator activated receptor gamma; for therapy.
Maryland, Univ. ofWO 99/05162
Butyrophilin modification
College Park, Md.
N-terminal modification of butyrophilin, transgenics; for eliminating autoimmune responses and diagnostics.
Mass. Gen. Hosp.WO 99/04636
Heart gene therapy
Boston, Mass.
Phospholamban gene, encoded protein; for gene therapy of heart tissue disorders.
Matossian-Rogers, A.WO 99/05175
Autoimmune tissue antibodies
London
Antibodies against autoimmune disease tissue targets, encoding gene sequences; for developing therapeutics.
MRC (Med. Res. Counc.)WO 99/05163
Protein refolding
London
Method of refolding a protein by contacting the protein with a molecular chaperone and a foldase.
MedigenWO 99/05527
Autoimmune superantigens
Geneva, Switzerland
Endogenous human retroviruses having superantigen activity, antibodies; for diagnosing autoimmune disease.
Millennium PharmaWO 99/04825
Manic-depressive gene
Cambridge, Mass.
Bipolar affective disorder-associated gene, encoded protein, variants, antibodies; for diagnosis and therapeutics.
Mogam Biotech Res. Inst.WO 99/05277
Parathyroid hormone production
Kyonggi-do, S. Korea
Vector with the human parathyroid hormone gene linked to an arabinose-inducible promoter; for bacterial production.
Mt. Sinai Sch. Med.WO 99/05293
Enriched expression libraries
New York
Gene expression libraries constructed using differential hybridization; for preparing enriched libraries.
NIH (Natl. Inst. Hlth.)WO 99/05273
GMEB gene sequences
Bethesda, Md.
GMEB gene sequences, allelic variants, encoded polypeptides, antibodies; for enhancing gene expression from vectors.
New York Blood Ctr.WO 99/04812
Chronic HBV immunotherapy
New York
Transcription units encoding hepatitis B virus (HBV) surface antigens; for chronic hepatitis B infection immunotherapy.
New York Blood Ctr.WO 99/05176
Fibrinogen antibodies
New York
Monospecific antibodies to fibrinogen, fibrinopeptide B, and fragments; for detecting thrombogenesis or atherogenesis.
New York Blood Ctr.WO 99/05261
Fibrinogen fragment antibodies
New York
Monospecific antibodies to metalloproteinase cleavage products of fibrinogen; for detecting thrombogenesis.
New York Blood Ctr.WO 99/05317
Viral RNA purification
New York
Purification of viral RNA using filters and subsequent low ionic strength washes.
Northeastern Univ.WO 99/05255
Enhanced embryo implantation
Boston, Mass.
Painting of preimplantation embryos with lipid-modified proteins; for enhancing development and implantation.
OntogenyWO 99/04775
Hedgehog proteins
Cambridge, Mass.
Hedgehog proteins and mimics; for promoting dopaminergic neuron survival in the midbrain.
Pasteur Inst.WO 99/05168
Mycobacterium vaccine
Paris
Mycobacterium strain having a modified erp virulence gene; for vaccines.
Penn State Univ.WO 99/04811
HPV 18 production
University Park, Penn.
Infection of keratinocytes by human papillomavirus (HPV) type 18, production of HPV 18 in organotype cultures.
Perkin-ElmerWO 99/05302
Transporting genes
Foster City, Calif.
Nucleic acids and peptide nucleic acids conjugated to peptides that transport the complex into cells.
Pharmacia & UpjohnWO 99/04820
Directed cytolysis
Stockholm, Sweden
Contacting T cells and their targets with a superantigen and immune modulator; for directed cytolysis of target cells.
PhosphosorbWO 99/04807
Recombinant immunotoxin
Moscow, Russia
Recombinant immunotoxin having diphtherial toxin and interleukin-2 domains; for therapeutics.
Sagami ChemicalEPO 896 056
Mutant thermolysin
Sagamihara, Japan
Thermolysin-like protease with amino acid substitutions resulting in improved stability.
ScheringWO 99/05280
Interleukin-B30
Kenilworth, N.J.
Interleukin-B30, encoding gene sequences, antibodies; for diagnostics and therapeutics.
SmithKline BeechamEPO 896 060 & 061
Staphylococcus antibacterials
Philadelphia, Penn.
Staphylococcus aureus RpoA polypeptides, encoding gene sequences; production methods; for antibacterials.
SmithKline BeechamWO 99/05274
7-transmembrane receptors
Philadelphia, Penn.
Methods for identifying 7-transmembrane receptors and their ligands as well as discerning their function.
Sumitomo PharmaEPO 896 058
Semaphorin Z
Osaka, Japan
Semaphorin Z gene, partial peptides, antibodies; for screening inhibitors causing CNS neuron regeneration.
SuntoryWO 99/05290
Serine protease
Osaka, Japan
Serine protease, analogs having deletions and substitutions, encoding gene sequences.
Takara ShuzoWO 99/05301
Retroviral transfection
Kyoto, Japan
Retroviral vector transfection using serum-free medium having low-density lipoprotein, cytokines, and fibronectin.
Tamura, R., et al.WO 99/05282
Hepatitis diagnosis
Saitama, Japan
Non-B, C, and G hepatitis virus genes, encoded polypeptides, virions; for diagnosis.
Temple Univ.WO 99/05304
Rhodococcus vaccines
Philadelphia, Penn.
Expression of recombinant nucleic acids in Rhodococcus cells; for vaccination against pneumonia.
Thomas Jefferson Univ.WO 99/05295
Site-specific integration vector
Philadelphia, Penn.
Vector with a gene sequence of interest inserted in a Tn7 transposon; for site-specific integration.
Univ. CollegeWO 99/05272
Brn-3a transcription factor
London
Transcription factor Brn-3a polypeptide; for use as a therapeutic.
Wisconsin, Univ. ofWO 99/05266
Trans-species transgenics
Madison, Wis.
Nuclear transfer into cow oocytes using nuclei from serum-starved cells from other species; for making transgenics.
Yale Univ.WO 99/04746
Activated Notch forms
New Haven, Conn.
Activated forms of Notch; for detecting the levels on the surfaces of differentiating cells.
Yale Univ.WO 99/05170 & 05171
Estrogen receptor-ß
New Haven, Conn.
Estrogen receptor-ß, isoforms, encoding gene sequences; for identifying transcriptional modulators.
ZenecaWO 99/05279
MCP-1 analogs
London
Monocyte chemoattractant protein (MCP)-1 analogs, corresponding gene sequences, production methods.
ZenecaWO 99/05297
T7 promoter-based expression system
London
T7-based promoter-driven expression system with operators both upstream and downstream of the promoter.
ZymogeneticsWO 99/05275
Chromosome 13 secreted proteins
Seattle, Wash.
Secreted proteins encoded by genes on chromosome 13, encoding genes, antibodies; for therapeutics.
ZymogeneticsWO 99/05276
Human chloride ion channel
Seattle, Wash.
Human chloride ion channel, encoding gene from chromosome 10, antibodies; for diagnosis and therapeutics.