Published Feb. 10 (EPO); Feb. 4 (WO)
Database query system
Santa Clara, Calif.
Query system for gene expression databases; for correlating gene expression to disease states.
Santa Clara, Calif.
Methods and systems for organizing polymorphism information in databases that permit large-scale data storage.
Agene Res. Inst.WO 99/05284
Human helicase gene
Human RecQ4 helicase gene, encoded proteins, variant active proteins with amino acid substitutions.
Alabama, Univ. ofWO 99/05259
Heteroplasmic transmitochondrial transgenics; for studying human mitochondrial diseases.
Immunization AAV vectors
Delivery of antigenic compositions using adeno-associated virus (AAV) vectors; for immunization.
Biotin gene, organisms containing this gene; for biotin production.
Choongeheongbuk-do, S. Korea
PCR-mediated comparative sequence analysis of the rpoB gene from mycobacterial species.
Biotech Res. Inst.WO 99/05269
Transcriptional silencer protein NRF that binds to NF-kappaB binding sites, encoding gene sequences.
Boehringer MannheimWO 99/05264
Mutant human proteins
Mutant human proteins produced by homologous recombination, cells for production; for therapeutics.
Boehringer MannheimWO 99/05267 & 05268
Endogenous gene activation
Selection of cells for making erythropoietin by endogenous gene activation; for producing recombinant proteins.
Boston Univ.WO 99/04637
Bacterial vaccine targets
Methods of determining a statistically significant number of bacterial strains; for evaluating vaccine targets.
Boston Univ.WO 99/05299
Gene transfer of genes for cytochrome P450 and its reductase to cancer cells; for enhancing sensitivity to cancer drugs.
Brigham & Women's Hosp.WO 99/05278
Lens epithelial growth factor
Lens epithelial cell-derived growth factor, fragments, encoding gene sequences; for identifying modulators.
California, Univ. ofWO 99/05177
G protein-coupled receptors
Methods and compositions for identifying modulators of G protein-coupled receptors.
California, Univ. ofWO 99/05258
Insulin deficient transgenics
Human Nkx gene, encoded protein, antibodies; for transgenics having decreased insulin-producing cell numbers.
Nuclear receptor ligands
Reporter gene vector system for identifying nuclear receptor ligands and their precursors.
Columbia Univ.WO 99/05307
SEL-10 gene, alleles, encoded protein, muteins, transgenics; for finding modulators and treating Alzheimer's disease.
Dedhar, S., et al.WO 99/05172
North Vanvouver, B.C.
Calreticulin, mimetics, inhibitors, encoding gene sequences; for modulating hormone responsiveness.
Du Pont PharmaWO 99/05291
Aggrecan-degrading metalloproteases, encoding genes; for identifying inhibitors of cartilage degradation.
Duke Univ.WO 99/05294
Agents that inhibit cardiac Gq-coupled receptor signalling; for treating myocardial hypertrophy.
Fox Chase Cancer Ctr.WO 99/04626
DNA repair endonuclease
Human DNA mismatch repair endonuclease, encoding gene sequences; for cancer screening and diagnosis.
French Inst. Ocean Res.WO 99/05270
Antimicrobial proteins from penaeid prawn crustaceans, encoding gene sequences.
Growth hormone expression
The Woodlands, Texas
Growth hormone releasing hormone gene expression system; for transfection and stimulation of growth hormone expression.
Genencor Intl.EPO 896 062
Bacillus production strains
Palo Alto, Calif.
Temperature-sensitive Bacillus strains; for producing serine proteases.
Transfecting nucleic acids
Bifunctional nucleic acids that bind cell surfaces and genes of interest; for cell transfection.
Gould, H.J., et al.WO 99/05271
Soluble IgE binding protein
Soluble variants of a peptide with IgE-binding capability; for reducing excessive IgE action in allergic responses.
Harvard Univ.WO 99/05256
Cloning secreted proteins
Nucleic acid sequences for signal peptides; for cloning secreted proteins.
Hoechst Marion RousselWO 99/05283
Antibiotic synthesis genes
Erythromycin and oleandomycin biosynthesis gene sequences; for making antibiotics.
Modified lysostaphin protected against post-translational modification, encoding gene sequences, production methods.
Inex PharmaWO 99/05303
Lipid-nucleic acid complexes
Preparation of lipid-nucleic acid particles by solvent extraction and direct hydration; for increased stability.
Kohle Res. Inst.WO 99/05288
Mulheim an der Ruhr, Germany
Methods for identifying and producing hydrolase mutants with improved stereoselectivity, site selectivity, and catalysis.
Lee, K.S.WO 99/05260
Cortical malformation rats
Mutant rats having telencephalic internal structural heterotopia; for studying human cortical malformation.
Leiden State Univ.WO 99/05173, 05174 & 05313
HA-1 minor antigen
HA-1 minor antigen amino acid sequence; for vaccines and bone marrow transplantation therapy.
Ligand PharmaWO 99/05161
Peroxisome receptor promoter
San Diego, Calif.
Promoter and control regions of human peroxisome proliferator activated receptor gamma; for therapy.
Maryland, Univ. ofWO 99/05162
College Park, Md.
N-terminal modification of butyrophilin, transgenics; for eliminating autoimmune responses and diagnostics.
Mass. Gen. Hosp.WO 99/04636
Heart gene therapy
Phospholamban gene, encoded protein; for gene therapy of heart tissue disorders.
Matossian-Rogers, A.WO 99/05175
Autoimmune tissue antibodies
Antibodies against autoimmune disease tissue targets, encoding gene sequences; for developing therapeutics.
MRC (Med. Res. Counc.)WO 99/05163
Method of refolding a protein by contacting the protein with a molecular chaperone and a foldase.
Endogenous human retroviruses having superantigen activity, antibodies; for diagnosing autoimmune disease.
Millennium PharmaWO 99/04825
Bipolar affective disorder-associated gene, encoded protein, variants, antibodies; for diagnosis and therapeutics.
Mogam Biotech Res. Inst.WO 99/05277
Parathyroid hormone production
Kyonggi-do, S. Korea
Vector with the human parathyroid hormone gene linked to an arabinose-inducible promoter; for bacterial production.
Mt. Sinai Sch. Med.WO 99/05293
Enriched expression libraries
Gene expression libraries constructed using differential hybridization; for preparing enriched libraries.
NIH (Natl. Inst. Hlth.)WO 99/05273
GMEB gene sequences
GMEB gene sequences, allelic variants, encoded polypeptides, antibodies; for enhancing gene expression from vectors.
New York Blood Ctr.WO 99/04812
Chronic HBV immunotherapy
Transcription units encoding hepatitis B virus (HBV) surface antigens; for chronic hepatitis B infection immunotherapy.
New York Blood Ctr.WO 99/05176
Monospecific antibodies to fibrinogen, fibrinopeptide B, and fragments; for detecting thrombogenesis or atherogenesis.
New York Blood Ctr.WO 99/05261
Fibrinogen fragment antibodies
Monospecific antibodies to metalloproteinase cleavage products of fibrinogen; for detecting thrombogenesis.
New York Blood Ctr.WO 99/05317
Viral RNA purification
Purification of viral RNA using filters and subsequent low ionic strength washes.
Northeastern Univ.WO 99/05255
Enhanced embryo implantation
Painting of preimplantation embryos with lipid-modified proteins; for enhancing development and implantation.
Hedgehog proteins and mimics; for promoting dopaminergic neuron survival in the midbrain.
Pasteur Inst.WO 99/05168
Mycobacterium strain having a modified erp virulence gene; for vaccines.
Penn State Univ.WO 99/04811
HPV 18 production
University Park, Penn.
Infection of keratinocytes by human papillomavirus (HPV) type 18, production of HPV 18 in organotype cultures.
Foster City, Calif.
Nucleic acids and peptide nucleic acids conjugated to peptides that transport the complex into cells.
Pharmacia & UpjohnWO 99/04820
Contacting T cells and their targets with a superantigen and immune modulator; for directed cytolysis of target cells.
Recombinant immunotoxin having diphtherial toxin and interleukin-2 domains; for therapeutics.
Sagami ChemicalEPO 896 056
Thermolysin-like protease with amino acid substitutions resulting in improved stability.
Interleukin-B30, encoding gene sequences, antibodies; for diagnostics and therapeutics.
SmithKline BeechamEPO 896 060 & 061
Staphylococcus aureus RpoA polypeptides, encoding gene sequences; production methods; for antibacterials.
SmithKline BeechamWO 99/05274
Methods for identifying 7-transmembrane receptors and their ligands as well as discerning their function.
Sumitomo PharmaEPO 896 058
Semaphorin Z gene, partial peptides, antibodies; for screening inhibitors causing CNS neuron regeneration.
Serine protease, analogs having deletions and substitutions, encoding gene sequences.
Takara ShuzoWO 99/05301
Retroviral vector transfection using serum-free medium having low-density lipoprotein, cytokines, and fibronectin.
Tamura, R., et al.WO 99/05282
Non-B, C, and G hepatitis virus genes, encoded polypeptides, virions; for diagnosis.
Temple Univ.WO 99/05304
Expression of recombinant nucleic acids in Rhodococcus cells; for vaccination against pneumonia.
Thomas Jefferson Univ.WO 99/05295
Site-specific integration vector
Vector with a gene sequence of interest inserted in a Tn7 transposon; for site-specific integration.
Univ. CollegeWO 99/05272
Brn-3a transcription factor
Transcription factor Brn-3a polypeptide; for use as a therapeutic.
Wisconsin, Univ. ofWO 99/05266
Nuclear transfer into cow oocytes using nuclei from serum-starved cells from other species; for making transgenics.
Yale Univ.WO 99/04746
Activated Notch forms
New Haven, Conn.
Activated forms of Notch; for detecting the levels on the surfaces of differentiating cells.
Yale Univ.WO 99/05170 & 05171
New Haven, Conn.
Estrogen receptor-ß, isoforms, encoding gene sequences; for identifying transcriptional modulators.
Monocyte chemoattractant protein (MCP)-1 analogs, corresponding gene sequences, production methods.
T7 promoter-based expression system
T7-based promoter-driven expression system with operators both upstream and downstream of the promoter.
Chromosome 13 secreted proteins
Secreted proteins encoded by genes on chromosome 13, encoding genes, antibodies; for therapeutics.
Human chloride ion channel
Human chloride ion channel, encoding gene from chromosome 10, antibodies; for diagnosis and therapeutics.