Published February 3 (EPO); January 28 (WO)

AjinomotoWO 99/03988
Nucleoside production
Tokyo,
Modified enzymes that produce nucleosides; for bacterial insertion and nucleoside production by fermentation.

BAI99/04017
Staphylokinase
Shandong, China
Staphylokinase producing Staphylococcus aureus strain, amplified genes; for increased production.

Beth Israel Deaconess Hosp.WO 99/03495
Megakaryocyte antibodies
Boston.
Mouse monoclonal antibodies against human megakaryocytes; for megakaryocytopoiesis and thrombocytopenia treatment.

Biotech. Res. Inst.EPO 894 853
NF-kappaB silencer
Braunschweig, Germany
Transcriptional silencer that binds to NF-kappaB sites, encoding gene sequences, antisense; for therapeutics.

Boulder Biotechnol.WO 99/03887
Growth hormone family variants
Louisville, Colo.
Addition of cysteines to growth hormone superfamily proteins; for making biologically active conjugates.

Brigham & Women's Hosp.WO 99/03883
Tuberous sclerosis tumor suppressor
Boston.
Tumor suppressor derived from tuberous sclerosis, encoding gene sequences; for diagnosis and therapy.

California, Univ. ofWO 99/03974
Calcium-activated potassium channel
Oakland, Calif.
Human calcium-activated potassium channel, encoding gene; for diagnosing susceptibility to bipolar disease.

California, Univ. ofWO 99/03889
Signal transduction modulators
Oakland, Calif.
Identification of transducisome protein modulators; for designing signal transduction modulators.

California, Univ. ofWO 99/03991
Switch recombination proteins
Oakland, Calif.
Proteins that mediate switch recombination, encoding gene sequences; for identifying modulators.

ChironWO 99/04026
Lentiviral vectors
Emeryville, Calif.
Lentiviral vectors containing nuclear transport elements, expression cassettes, packaging cell lines.

Chirotech Technol.WO 99/04015
Purified chiral derivatives
Cambridge, U.K.
Microorganisms and encoded esterase; for producing enantioselective compounds.

Connaught LabsWO 99/04010
RSV DNA vaccines
North York, Ont.
Nucleic acid vaccines encoding the G protein of respiratory syncytial virus (RSV), non-replicating vectors.

D'Auvergne, Univ. ofWO 99/03890
Neural regeneration peptides
Clermont-Ferrand, France
Peptides and polypeptides that cause regeneration of nervous system cells and treat neuroblastomas.

DNAVec Res.EPO 894 866
Liver-specific promoter
Ibaraki, Japan
Tec tyrosine kinase promoter, vector; for endogenous gene expression in hematopoietic stem cells and liver.

Du PontWO 99/04014
Yeast carboxylate production
Wilmington, Del.
Yeast strains genetically engineered to produce mono- and diterminal aliphatic carboxylates.

Florida, Univ. ofWO 99/03997
Humanized green fluorescent protein
Gainesville, Fla.
Humanized versions of green fluorescent protein genes; for high level expression in mammalian cells.

Genencor Intl.WO 99/04006 & 04007
Bacillus
production system
Rochester, N.Y.
Bacillus subtilis
secretion factor SecG, encoding gene sequences; for increasing protein production.

Genencor Intl.WO 99/04016
Bacillus
proteases
Rochester, N.Y.
Proteases from the Gram-positive bacteria Bacillus subtilis; for increased enzyme production.

Genencor Intl.WO 99/04019
Bacterial production system
Rochester, N.Y.
Bacillus subtilis
disulfide bond isomerases, encoding genes, strains; for increased heterologous protein production.

Hoffmann-La RocheEPO 894 860
Thermostable DNA polymerases
Basel, Switzerland
Thermostable DNA polymerases, deletion mutants, encoding gene sequences; for nucleic acid sequencing.

Human Genome SciencesWO 99/03982
Interleukin-20
Rockville, Md.
Interleukin-20, encoding gene, production methods; for screening modulators and treating immune disorders.

Human Genome SciencesWO 99/03990
64 secreted proteins
Rockville, Md.
64 human secreted proteins, encoding genes, antibodies, production methods; for diagnosis and therapy.

ImmunexWO 99/03992
TRAIL
Seattle.
TNF-related apoptosis-inducing ligand (TRAIL), encoding gene sequences, antibodies; for identifying modulators.

Incyte PharmaWO 99/03989
ATP-binding cassette transport protein
Palo Alto, Calif.
Human ATP-binding cassette transport protein, encoding gene sequences, antibodies, modulators; for therapeutics.

Incyte PharmaWO 99/03995
T cell receptor ß-like protein
Palo Alto, Calif.
T cell receptor ß-like protein, encoding gene sequences, antibodies, modulators; for therapeutics.

Incyte PharmaWO 99/04002
Human matrilin-3
Palo Alto, Calif.
Human matrilin-3 polypeptides, encoding gene sequences, antibodies, modulators; for therapeutics.

InnogeneticsWO 99/04011
HIV-1 O antigens
Ghent, Belgium
HIV-1 group O antigens, encoding gene sequences; for diagnosis and therapy.

KirinWO 99/03980
Hematopoiesis facilitation cells
Tokyo
Cell line derived from the mammalian fetal AGM region; for supporting hematopoiesis.

Kosan BiosciencesWO 99/03986
Polyketide antibiotics
Burlingame, Calif.
Modified polyketide synthesis genes; for producing different polyketides for antibiotics.

Max Planck Inst.WO 99/04020
Viral promoters for production
Berlin
Coconut foliar decay virus promoters used in bacterial vectors; for increased gene expression.

MRC (Med. Res. Counc.)WO 99/04025
Neural cell gene expression
London
5' portion of the gamma-aminobutyric acid type A receptor a6 subunit gene; for gene expression in cerebellar cells.

Michigan, Univ. ofWO 99/03998 & 03999
FasL inflammation
Ann Arbor, Mich.
Methods for identifying modulators of FasL stimulation of localized proinflammatory responses; for tumor reduction.

NIH (Natl. Inst. Hlth.)WO 99/04008
Hepatitis C genomes
Bethesda, Md.
Cloned genomes of hepatitis C virus, encoded proteins; for antiviral screens, diagnostics, and therapeutics.

New Mexico, Univ. ofWO 99/03874
Transplantation injury diagnostic
Albuquerque, N.M.
Human liver cytosolic ß-glucosidase, encoding gene; for diagnosing ischemic liver injury during transplantation.

New York Univ.WO 99/03888
Alternate HIV translocators
New York
Alternate HIV cell translocation receptors, encoding gene sequences; antibodies.

Nippon Meat PackersWO 99/03336
Complement regulation transgenics
Osaka, Japan
Transgenics expressing human complement regulator gene in vascular endothelial cells; for designing therapeutics.

North Carolina, Univ. ofWO 99/03496
Factor IX variants
Chapel Hill, N.C.
Factor IX variants with substituted amino acid residues; for increased clotting activity and hemophilia treatment.

Northwestern Univ.WO 99/03490
Male contraceptives
Evanston, Ill.
Sperm- and testes-specific proteins, encoding gene sequences; for fertility diagnosis and contraception.

Osiris TherapeuticsWO 99/03973
Heart cell generation
Baltimore, Md.
Injecting mesenchymal stem cells into hearts; for producing cardiomyocytes and heart valve cells for transplantation.

Pasteur Inst.WO 99/04005
Mycobacterium
diagnostic
Paris
Mycobacterium tuberculosis
LHP protein, encoding gene sequences, derivatives, fragments; for diagnostics.

Pierre FabreWO 99/03987
RSV detection
Boulogne-Billancourt, France
Monoclonal antibodies to respiratory syncytial virus (RSV) protein epitopes; for detection and therapy.

PPL TherapeuticsWO 99/03981
Intronic vector
Roslin, U.K.
Insertion of an intronic sequence into an expression vector; for increased heterologous protein production.

Regeneron PharmaWO 99/03996
Dorsal tissue factor
Tarrytown, N.Y.
Modified Noggin mutants, encoding gene sequences, antisense; for affecting dorsal tissue differentiation.

ScheringWO 99/03993 & 03994
Cytokine signalling suppressors
Kenilworth, N.J.
Intracellular regulatory molecules that suppress cytokine signalling, encoding gene sequences, antibodies.

SmithKline BeechamEPO 894 806
pheS polypeptides
Philadelphia.
pheS polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline BeechamEPO 894 854
Virus-induced receptor variant
Philadelphia.
Splice variant of Epstein-Barr virus-induced G-protein coupled receptor, encoding gene sequences.

SmithKline BeechamEPO 894 855
IkappaB-ß transcription factor
Philadelphia.
Human IkappaB-ß transcription factor, encoding gene sequences; for diagnostics and therapeutics.

SmithKline BeechamEPO 894 856
sMAD3 splice variant
Philadelphia.
Human sMAD3 splice variant, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline BeechamEPO 894 857
Streptococcus
antibacterials
Philadelphia.
Streptococcus pneumoniae
SecA polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline BeechamEPO 894 858
Streptococcus
antibacterials
Philadelphia.
Streptococcus pneumoniae
prolyl tRNA synthetase peptides, encoding gene sequences; for antibacterial screens.

SmithKline BeechamEPO 894 859
Streptococcus
antibacterials
Philadelphia.
Streptococcus pneumoniae
asparaginyl tRNA synthetase, encoding gene sequences; for antibacterial screens.

SmithKline BeechamEPO 894 861
Streptococcus
antibacterials
Philadelphia.
Streptococcus pneumoniae
glycogen phosphorylase peptides, encoding gene sequences; for antibacterial screens.

SmithKline BeechamEPO 894 862
cysS polypeptides
Philadelphia.
cysS polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline BeechamEPO 894 863
YAK-1 related protein kinase
Philadelphia.
YAK-1 related serine/threonine protein kinase polypeptides, encoding gene sequences; for diagnostics and therapeutics.

Sydney, Univ. ofWO 99/03886
Tropoelastin derivatives
Sydney, Australia
Tropoelastin derivatives, variants, hybrids, production methods; for implants and therapeutics.

Texas, Univ. ofWO 99/03875
Oropouche virus detection
Austin, Texas
Oropouche virus nucleocapsid protein, encoding gene sequences; for immunodetection.

TransgeneWO 99/03885
Papillomavirus therapeutic
Strasbourg, France
Immunogenic polypeptides from papillomaviruses, expression vector, viral particle; for cancer therapy.

Washington St. Univ.WO 99/04018
Immunocontraception
Pullman, Wash.
Chimeric proteins having carrier and reproduction-related peptide domains, encoding genes; for immunocontraception.

Wisconsin, Univ. ofWO 99/04009
Combination DNA vaccine
Madison, Wis.
DNA vaccines using a combination of antigen and interleukin-6 genes; for enhanced immunoresponse.

Yale Univ.WO 99/03494
Ankyrin binding modulators
New Haven, Conn.
Structure of the ankyrin binding domain of a-Na,K-ATPase, peptide analogs; for designing binding modulators.

ZymogeneticsWO 99/04000
Adipocyte-specific proteins
Seattle.
Adipocyte-specific protein homolog polypeptides, encoding gene sequences, antibodies; for therapeutics.

ZymogeneticsWO 99/04001
TNF receptor 5
Seattle.
Tumor necrosis factor (TNF) receptor 5 soluble peptides, encoding gene sequences, homologs, modulators, ligands.