Published Jan. 27 (EPO); Jan. 21 (WO); Jan. 27 (GB)

Abbott LabsWO 99/02559 & 02714

Breast expressed genes

Abbott Park, Ill.

Breast tissue cDNAs from transcribed genes; for designing inhibitors and making diagnostics and therapeutics.

AffymetrixWO 99/02682

Cancerous p53 mutations

Santa Clara, Calif.

Mutations of p53 found in human cancers, primers, probes, antibodies; for diagnosis and therapy monitoring.

AjinomotoWO 99/02692

Corynebacteria surfactant genes


Temperature-sensitive genes from corynebacteria that affect responses to surfactants, encoded proteins, variants.

Allegheny Hlth. Sci. Univ.WO 99/02715

Breast cancer markers


Nucleic acids encoding splice variants of BRCA1 and BRCA2; for diagnosis of breast cancer.

BASFWO 99/02564

Ancrod antibodies

Ludwigshafen, Germany

Ancrod-specific monoclonal antibodies, antibody fragments, mixtures, and derivatives.

Beth Israel Deaconess Hosp.WO 99/02709-02711

EPO-Ig fusions


Recombinant erythropoietin (EPO)-immunoglobulin (Ig) fusions with Ig hinge region linkers; for improved bioactivity.

Bio MerieuxWO 99/02666

Multiple sclerosis retrovirus

Marcy l'Etoile, France

Retroviral nucleic acid material and fragments associated with multiple sclerosis and rheumatoid arthritis.

Bio MerieuxWO 99/02696

Autoimmune retroviruses

Marcy l'Etoile, France

Endogenetic retroviral gene sequences associated with autoimmune diseases or pregnancy disorders.

BiotestEPO 893 504

Kaposi virus peptide

Dreieich, Germany

Polypeptide coded for by the Kaposi sarcoma-associated virus, encoding gene sequences; for diagnosis [in German].

Boehringer IngelheimWO 99/02686

Tumor inhibitor genes

Ingelheim, Germany

Human and mouse genes that inhibit tumor growth and induce apoptosis, gene sequences, encoded proteins.

Brax GenomicsWO 99/02725-02728

Categorizing nucleic acids

Cambridge, U.K.

Categorizing nucleic acids by separating fragments after endonuclease digestion then doing mass spectrometry.

British Columbia, Univ. ofWO 99/02719

Gene trap vector

Vancouver, B.C.

Gene trap vector whose reporter genes are expressed when integrated into a tissue-specifically expressed gene.

British Ministry of AgricultureWO 99/02706

Glycosylated proteins


Gene sequences for proteins glycosylated when expressed in actinomycetes hosts; for recombinant protein production.

Cadus PharmaWO 99/02699

Signal transduction kinase

Tarrytown, N.Y.

KDS signal transduction-associated kinase, encoding gene sequences, antibodies; for modulating cell signalling.

California, Univ. ofWO 99/02556

Semaphorin receptors

Oakland, Calif.

Semaphorin receptors, encoding gene sequences, primers, probes, antibodies; for diagnostics and therapeutics.

Cancer Res. Camp. Technol.GB 2 327 498

p53 kinases


Assays measuring the interaction of ATM and other kinases with p53; for diagnostics and therapeutics.

Cold Spring Harb. LabsWO 99/02704

Prostate phosphatase

Cold Spring Harb., N.Y.

Dual specificity phosphatase, encoding gene sequences, mutants; for diagnosing and treating prostate cancer.

Columbia Univ.WO 99/02179

Axin gene

New York

Axin gene, encoded protein, variants, mutations; for suppressing uncontrolled cell growth and treating cancer.

Cornell Univ.WO 99/02731

Rod-cone degeneration

Ithaca, N.Y.

Genetic markers on chromosome 9 that are associated with progressive rod-cone degeneration; for diagnosis.

ChugaiWO 99/02677

Differentiated chondrocyte gene


Gene expressed in differentiated chondrocytes; for detecting gene expression differences in these cells.

Dainippon PrintingWO 99/02730

PNA probes


Method for detecting a target nucleotide sequence by hybridization with probe protein-nucleic acids (PNAs).

DompeWO 99/02676

GEF protein mutants

L'Aquila, Italy

GEF protein mutants, encoding gene sequences; for disrupting the ras/GEF complex.

Dundee, Univ. ofWO 99/02674

Cell migration modulators

Dundee, U.K.

Peptides containing isoleucine-glycine-asparagine (IGD) motifs; for modulating cell migration and angiogenesis.

EuroscreenWO 99/02675

G-coupled receptor

Brussells, Belgium

G-coupled receptor having a selective affinity for ATP; for therapeutics.

GeneMedicineWO 99/02737

Transcription regulatory elements

The Woodlands, Texas

Identification of synthetic cell- or tissue-specific transcriptional regulatory regions of genes.

Genencor Intl.WO 99/02702

Mutant a-amylase

Rochester, N.Y.

Mutant a-amylase having disulfide bonds; for altered or improved stability.

GenentechWO 99/02681

Neuregulin-related ligand

S. San Francisco

ERBB4 receptor-specific neuregulin, fragments, variants, related ligands, encoding gene sequences.

Genesense Technol.WO 99/02673

Antisense antibacterials


Antisense oligos to nucleoside reductase or secA genes of microorganisms; for use as antibacterials.

Genetics Inst.WO 99/02678

TGF-ß growth factors

Cambridge, Mass.

TGF-ß superfamily growth factors, encoding gene sequences; for treating connective tissue defects.

Genetics Inst.WO 99/02679

Frazzled proteins

Cambridge, Mass.

Frazzled proteins that bind Wnt genes, encoding gene sequences; for affecting tissue formation and growth.

Gerlach, G.-F.WO 99/02661

M. paratuberculosis diagnostic

Hannover, Germany

Microbacterium paratuberculosis extracellular iron reductase, fragments; for diagnosis and therapy.

Gustave Roussy Inst.EPO 893 507

Cancer immunotherapy

Villejuif, France

Using MHC class II ligands to prevent or treat antigen-specific immune responses in cancer.

Hepavec Gene TherapyWO 99/02647

Minimal adenoviruses


Cloning vectors that allow the production of viruses with minimal adenoviral content.

Hoechst Marion RousselEPO 893 493

Genetically modified cells

Frankfurt, Germany

Genetically modified cells; for use in gene therapy and the treatment of diseases [in German].

Human Genome SciencesWO 99/02546

123 secreted human proteins

Rockville, Md.

123 secreted human proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Human Genome SciencesWO 99/02700

Candida vaccines

Rockville, Md.

Candida albicans histidine kinase, encoding gene sequences, antibodies; for vaccines.

Incyte PharmaWO 99/02680

Human growth regulator protein

Palo Alto, Calif.

Human growth regulator protein, encoding gene sequences, antibodies, modulators; for therapeutics.

Inst. Phys. & Chem. Res.WO 99/02543, 02544 & 02729

Fluorescent sequencing

Saitama, Japan

3'-deoxyribonucleotide derivative having fluorescence donor and acceptor groups; for DNA base sequencing.

Inst. Phys. & Chem. Res.WO 99/02698

Mutant RNA polymerase

Saitama, Japan

Mutated RNA polymerase having higher ability to incorporate 3'-deoxyribonucleotides.

IntrogeneWO 99/02685

IL-3 cancer treatment

Leiden, Netherlands

Adenoviral vectors encoding interleukin (IL)-3; for treating solid tumors using perfusion.

Isis PharmaWO 99/02732

Antisense for ras

Carlsbad, Calif.

Antisense oligonucleotides that hybridize with various forms of ras gene mRNAs; for diagnostics and therapeutics.

KikkomanWO 99/02697

Luciferase mutant

Chiba, Japan

Bacterial luciferase mutant having high catalytic efficiency and heat resistance.

La Jolla Inst. Allergy & Immunol.WO 99/02563

Herpes infection inhibitor

San Diego, Calif.

Ligand that binds to herpes simplex virus cell entry mediator; for treating infection.

Liege, Univ. ofWO 99/02667

Muscle hyperplasia

Liege, Belgium

Gene for cow myostatin protein, encoded protein, mutant gene; for detecting muscle hyperplasia.

Ludwig Inst. Cancer Res.WO 99/02174

Diabetic vascular disease transgenics

New York

Transgenics deficient in PDGF-ß causing pericyte loss and microvessel damage; for studying diabetic vascular disease.

Maryland, Univ. Biotech. Inst.WO 99/02554

Herpes vaccine


Human herpes virus-7 gene U14, encoded protein; for diagnosis and immunization.

Massachusetts, Univ. ofWO 99/02547

Mitogen-activated kinase kinase


Mitogen-activated kinase kinase isoforms that activate transcription factors and c-Jun; for finding modulators.

Mass. Gen. Hosp.WO 99/02652

Neurodegenerative transgenics


Transgenic nematode model having gene with triplet repeats that are characteristic of neurodegenerative diseases.

Max Planck Inst.WO 99/02558

GTP-binding protein ligands


Ligands binding to normal or mutated GTP-binding protein surfaces; for finding modulators and treating cancer.

MRC (Med. Res. Counc.)WO 99/02671

In vitro gene sorting


Encapsulation and mutation of genetic elements; for in vitro sorting of gene function and directed evolution.

MRC (Med. Res. Counc.)WO 99/02707 & 02708

Small peptide production


Fusion proteins having coiled-coil structures; for producing small polypeptides, such as truncated cow ATPase inhibitor.

MerckWO 99/02701

Pak Ras-associated kinase

Rahway, N.J.

Pak kinase, encoding gene sequences; for inhibiting Ras-mediated cell transformation.

Millennium PharmaWO 99/02735 & 02736

Cardiovascular disorder genes

Cambridge, Mass.

Polymorphic regions of the human SR-BI gene; for diagnosing body mass and cardiovascular disorders.

Mt. Sinai Hosp.WO 99/02724

Cell lineage genes


Methods for identifying genes expressed in selected cell lineages, encoding genes, encoded proteins, variants.

NIH (Natl. Inst. Hlth.)WO 99/02670

Mycobacterial attenuation

Bethesda, Md.

Attenuation of mycobacterial strains by reducing a-crystallin gene expression; for vaccines.

NIH (Natl. Inst. Hlth.)WO 99/02712 & 02713

IgA immunoresponse

Bethesda, Md.

Pseudomonas exotoxin A-like chimeric immunogens; for eliciting a secretory IgA-mediated immune response.

NestleWO 99/02705


Vevey, Switzerland

Mold prolyl-dipeptidyl-peptidase, encoding gene sequence, production methods.

New Jersey, Univ. Med. & Dent.WO 99/02488

HIV replication inhibitor

Piscataway, N.J.

Oligocarbamate derivatives specifically bind to HIV-1 Tat RNA; for inhibiting HIV replication.

North Texas, Univ. ofWO 99/02721

E. coli metabolic products

Fort Worth, Texas

E. coli csrB gene and transcribed RNA; for antagonizing genes that down-regulate metabolic product production.

Novo NordiskWO 99/02663

Alkaline xyloglucanase

Bagsvaerd, Denmark

Alkaline xyloglucanase from Bacillus agadhaerens, encoding gene sequences.

Novopharm BiotechWO 99/02545

Melanoma antibodies

Winnipeg, Manitoba

Monoclonal antibodies and cancer antigens they bind; for detecting and treating melanomas and neural cancers.

Pennsylvania, Univ. ofWO 99/02653

Apoptosis inducing protein


Gene for a mammalian signal transducing protein involved in apoptosis induction, antibodies; for inducing cell death.

Queensland, Univ. ofWO 99/02694

Translation alteration genes

St. Lucia, Australia

Synthetic nucleic acids modified to alter translational kinetics; for directing protein expression in target cells.

Queensland Inst. Med. Res.WO 99/02550

Epstein-Barr antigens

Herson, Australia

Antigenic epitopes from Epstein-Barr virus that activate cytotoxic T cells.

Res. Develop. Fdn.WO 99/02991

Fire ant antibodies

Carson City, Nevada

Monoclonal antibodies and scFv heavy and/or light chain Ig fragments that bind to fire ant midgut microvilli.

St. Louis Univ.WO 99/02658

Viral apoptosis inhibitor

St. Louis

Receptor internalization and degradation protein complex encoded by adenoviral E3 region; for inhibiting apoptosis.

Salk Inst.WO 99/02683

Modified moth receptors

La Jolla, Calif.

Modified silk moth receptors, hybrid multifunctional proteins; for regulating transgene expression.

ScheringWO 99/02562

Dendritic cell membrane proteins

Kenilworth, N.J.

Genes for dendritic lymphocyte membrane proteins, encoded proteins, antibodies; for diagnostics and therapeutics.

SeikagakuEPO 893 506

Hyaluronate synthetase


Human hyaluronate synthetase, encoding gene sequences, variants, mutations.

SmithKline BeechamEPO 893 494

Chlamydia antibacterials


Chlamydia trachomatis aspartyl tRNA synthetase polypeptides, encoding gene sequences; for antibacterial screens.

SmithKline BeechamEPO 893 495

Chlamydia antibacterials


Chlamydia trachomatis isoleucyl tRNA synthetase peptides, encoding gene sequences; for antibacterial screens.

SmithKline BeechamEPO 893 496

Chlamydia antibacterials


Chlamydia trachomatis histidyl tRNA synthetase polypeptides, encoding gene sequences; for antibacterial screens.

SmithKline BeechamEPO 893 498

Human 7-transmembrane receptor


Human 7-transmembrane receptor polypeptides, encoding gene sequences; for diagnostics and therapeutics.

SmithKline BeechamEPO 893 499

Staphylococcus antibacterials


Staphylococcus aureus tetracycline resistance protein, encoding gene sequences; for antibacterial screens.

SmithKline BeechamEPO 893 500

Staphylococcus antibacterials


Staphylococcus aureus bmrU polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline BeechamEPO 893 501

Ferrichrome transport ATP-binding protein


Ferrichrome transport ATP-binding protein, encoding gene sequences, production methods; for antibacterial screens.

SmithKline BeechamEPO 893 502

Staphylococcus antibacterials


Staphylococcus aureus greA polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline BeechamEPO 893 503

Staphylococcus antibacterials


Staphylococcus aureus regulator protein, encoding gene sequences, production methods; for antibacterial screens.

SmithKline BeechamEPO 893 505

Glucose kinase for antibacterials


Glucose kinase polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline BeechamWO 98/02560

HOQBQ59 polypeptides


HOQBQ59 polypeptides, encoding gene sequences; for diagnostics and therapeutics.

SmithKline BeechamWO 99/02561

Human platelet antigen


Human F11 antigen involved in platelet aggregation, encoding gene sequences; for diagnostics and therapeutics.

SmithKline BeechamWO 99/02664

N-arginine dibasic convertase


Human N-arginine dibasic convertase, encoding gene sequences; for diagnostics and therapeutics.

Stichting Inst.WO 99/02695

Paramyxoviridae vaccines

Lelystad, Netherlands

Epitopes and active sites of paramyxoviridae proteins; for infection diagnostics and therapeutics.

Texas Heart Inst.WO 99/02171

Vasoprotective vector


Adenoviral vectors encoding human tissue factor pathway inhibitor; for targeting vascular smooth muscle cells.

Texas, Univ. ofWO 99/02567

Anti-tumor antibody conjugates

Austin, Texas

Monoclonal antibodies that become potent anti-tumor agents inducing apoptosis when converted into homoconjugates.

ThymonWO 99/02185

HIV vaccines

Short Hills, N.J.

Production of antibodies against the consensus sequence of HIV-1 Tat protein; for HIV diagnostics and therapeutics.

Uhlenkuken, J., et al.WO 99/02566

Standardized protein

Munster, Germany

Standardized protein having specific binding sites for enzymes and/or antibody constant regions.

Univ. Technol.WO 99/02684

Longevity genes

Boulder, Colo.

Transgenic nematode system for identifying genes associated with increased longevity and slowed aging.

ValtionWO 99/02716

Yeast production strains

Vuorimichentie, Finland

Yeast cell strains transformed with the SEB1 gene; for increased production of recombinant proteins.

Yale Univ.WO 99/02657

HIV vaccines

New Haven, Conn.

Replication-competent recombinant vesicular stomatitis viruses with inserted HIV gene; for HIV vaccines.

ZenecaGB 2 327 497

K-ras diagnostic


Primer for mutations in the K-ras gene; for diagnosis of mutations and related cancers.

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