Published Jan. 27 (EPO); Jan. 21 (WO); Jan. 27 (GB)
Abbott LabsWO 99/02559 & 02714
Breast expressed genes
Abbott Park, Ill.
Breast tissue cDNAs from transcribed genes; for designing inhibitors and making diagnostics and therapeutics.
Cancerous p53 mutations
Santa Clara, Calif.
Mutations of p53 found in human cancers, primers, probes, antibodies; for diagnosis and therapy monitoring.
Corynebacteria surfactant genes
Temperature-sensitive genes from corynebacteria that affect responses to surfactants, encoded proteins, variants.
Allegheny Hlth. Sci. Univ.WO 99/02715
Breast cancer markers
Nucleic acids encoding splice variants of BRCA1 and BRCA2; for diagnosis of breast cancer.
Ancrod-specific monoclonal antibodies, antibody fragments, mixtures, and derivatives.
Beth Israel Deaconess Hosp.WO 99/02709-02711
Recombinant erythropoietin (EPO)-immunoglobulin (Ig) fusions with Ig hinge region linkers; for improved bioactivity.
Bio MerieuxWO 99/02666
Multiple sclerosis retrovirus
Marcy l'Etoile, France
Retroviral nucleic acid material and fragments associated with multiple sclerosis and rheumatoid arthritis.
Bio MerieuxWO 99/02696
Marcy l'Etoile, France
Endogenetic retroviral gene sequences associated with autoimmune diseases or pregnancy disorders.
BiotestEPO 893 504
Kaposi virus peptide
Polypeptide coded for by the Kaposi sarcoma-associated virus, encoding gene sequences; for diagnosis [in German].
Boehringer IngelheimWO 99/02686
Tumor inhibitor genes
Human and mouse genes that inhibit tumor growth and induce apoptosis, gene sequences, encoded proteins.
Brax GenomicsWO 99/02725-02728
Categorizing nucleic acids
Categorizing nucleic acids by separating fragments after endonuclease digestion then doing mass spectrometry.
British Columbia, Univ. ofWO 99/02719
Gene trap vector
Gene trap vector whose reporter genes are expressed when integrated into a tissue-specifically expressed gene.
British Ministry of AgricultureWO 99/02706
Gene sequences for proteins glycosylated when expressed in actinomycetes hosts; for recombinant protein production.
Cadus PharmaWO 99/02699
Signal transduction kinase
KDS signal transduction-associated kinase, encoding gene sequences, antibodies; for modulating cell signalling.
California, Univ. ofWO 99/02556
Semaphorin receptors, encoding gene sequences, primers, probes, antibodies; for diagnostics and therapeutics.
Cancer Res. Camp. Technol.GB 2 327 498
Assays measuring the interaction of ATM and other kinases with p53; for diagnostics and therapeutics.
Cold Spring Harb. LabsWO 99/02704
Cold Spring Harb., N.Y.
Dual specificity phosphatase, encoding gene sequences, mutants; for diagnosing and treating prostate cancer.
Columbia Univ.WO 99/02179
Axin gene, encoded protein, variants, mutations; for suppressing uncontrolled cell growth and treating cancer.
Cornell Univ.WO 99/02731
Genetic markers on chromosome 9 that are associated with progressive rod-cone degeneration; for diagnosis.
Differentiated chondrocyte gene
Gene expressed in differentiated chondrocytes; for detecting gene expression differences in these cells.
Dainippon PrintingWO 99/02730
Method for detecting a target nucleotide sequence by hybridization with probe protein-nucleic acids (PNAs).
GEF protein mutants
GEF protein mutants, encoding gene sequences; for disrupting the ras/GEF complex.
Dundee, Univ. ofWO 99/02674
Cell migration modulators
Peptides containing isoleucine-glycine-asparagine (IGD) motifs; for modulating cell migration and angiogenesis.
G-coupled receptor having a selective affinity for ATP; for therapeutics.
Transcription regulatory elements
The Woodlands, Texas
Identification of synthetic cell- or tissue-specific transcriptional regulatory regions of genes.
Genencor Intl.WO 99/02702
Mutant a-amylase having disulfide bonds; for altered or improved stability.
S. San Francisco
ERBB4 receptor-specific neuregulin, fragments, variants, related ligands, encoding gene sequences.
Genesense Technol.WO 99/02673
Antisense oligos to nucleoside reductase or secA genes of microorganisms; for use as antibacterials.
Genetics Inst.WO 99/02678
TGF-ß growth factors
TGF-ß superfamily growth factors, encoding gene sequences; for treating connective tissue defects.
Genetics Inst.WO 99/02679
Frazzled proteins that bind Wnt genes, encoding gene sequences; for affecting tissue formation and growth.
Gerlach, G.-F.WO 99/02661
M. paratuberculosis diagnostic
Microbacterium paratuberculosis extracellular iron reductase, fragments; for diagnosis and therapy.
Gustave Roussy Inst.EPO 893 507
Using MHC class II ligands to prevent or treat antigen-specific immune responses in cancer.
Hepavec Gene TherapyWO 99/02647
Cloning vectors that allow the production of viruses with minimal adenoviral content.
Hoechst Marion RousselEPO 893 493
Genetically modified cells
Genetically modified cells; for use in gene therapy and the treatment of diseases [in German].
Human Genome SciencesWO 99/02546
123 secreted human proteins
123 secreted human proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Human Genome SciencesWO 99/02700
Candida albicans histidine kinase, encoding gene sequences, antibodies; for vaccines.
Incyte PharmaWO 99/02680
Human growth regulator protein
Palo Alto, Calif.
Human growth regulator protein, encoding gene sequences, antibodies, modulators; for therapeutics.
Inst. Phys. & Chem. Res.WO 99/02543, 02544 & 02729
3'-deoxyribonucleotide derivative having fluorescence donor and acceptor groups; for DNA base sequencing.
Inst. Phys. & Chem. Res.WO 99/02698
Mutant RNA polymerase
Mutated RNA polymerase having higher ability to incorporate 3'-deoxyribonucleotides.
IL-3 cancer treatment
Adenoviral vectors encoding interleukin (IL)-3; for treating solid tumors using perfusion.
Isis PharmaWO 99/02732
Antisense for ras
Antisense oligonucleotides that hybridize with various forms of ras gene mRNAs; for diagnostics and therapeutics.
Bacterial luciferase mutant having high catalytic efficiency and heat resistance.
La Jolla Inst. Allergy & Immunol.WO 99/02563
Herpes infection inhibitor
San Diego, Calif.
Ligand that binds to herpes simplex virus cell entry mediator; for treating infection.
Liege, Univ. ofWO 99/02667
Gene for cow myostatin protein, encoded protein, mutant gene; for detecting muscle hyperplasia.
Ludwig Inst. Cancer Res.WO 99/02174
Diabetic vascular disease transgenics
Transgenics deficient in PDGF-ß causing pericyte loss and microvessel damage; for studying diabetic vascular disease.
Maryland, Univ. Biotech. Inst.WO 99/02554
Human herpes virus-7 gene U14, encoded protein; for diagnosis and immunization.
Massachusetts, Univ. ofWO 99/02547
Mitogen-activated kinase kinase
Mitogen-activated kinase kinase isoforms that activate transcription factors and c-Jun; for finding modulators.
Mass. Gen. Hosp.WO 99/02652
Transgenic nematode model having gene with triplet repeats that are characteristic of neurodegenerative diseases.
Max Planck Inst.WO 99/02558
GTP-binding protein ligands
Ligands binding to normal or mutated GTP-binding protein surfaces; for finding modulators and treating cancer.
MRC (Med. Res. Counc.)WO 99/02671
In vitro gene sorting
Encapsulation and mutation of genetic elements; for in vitro sorting of gene function and directed evolution.
MRC (Med. Res. Counc.)WO 99/02707 & 02708
Small peptide production
Fusion proteins having coiled-coil structures; for producing small polypeptides, such as truncated cow ATPase inhibitor.
Pak Ras-associated kinase
Pak kinase, encoding gene sequences; for inhibiting Ras-mediated cell transformation.
Millennium PharmaWO 99/02735 & 02736
Cardiovascular disorder genes
Polymorphic regions of the human SR-BI gene; for diagnosing body mass and cardiovascular disorders.
Mt. Sinai Hosp.WO 99/02724
Cell lineage genes
Methods for identifying genes expressed in selected cell lineages, encoding genes, encoded proteins, variants.
NIH (Natl. Inst. Hlth.)WO 99/02670
Attenuation of mycobacterial strains by reducing a-crystallin gene expression; for vaccines.
NIH (Natl. Inst. Hlth.)WO 99/02712 & 02713
Pseudomonas exotoxin A-like chimeric immunogens; for eliciting a secretory IgA-mediated immune response.
Mold prolyl-dipeptidyl-peptidase, encoding gene sequence, production methods.
New Jersey, Univ. Med. & Dent.WO 99/02488
HIV replication inhibitor
Oligocarbamate derivatives specifically bind to HIV-1 Tat RNA; for inhibiting HIV replication.
North Texas, Univ. ofWO 99/02721
E. coli metabolic products
Fort Worth, Texas
E. coli csrB gene and transcribed RNA; for antagonizing genes that down-regulate metabolic product production.
Novo NordiskWO 99/02663
Alkaline xyloglucanase from Bacillus agadhaerens, encoding gene sequences.
Novopharm BiotechWO 99/02545
Monoclonal antibodies and cancer antigens they bind; for detecting and treating melanomas and neural cancers.
Pennsylvania, Univ. ofWO 99/02653
Apoptosis inducing protein
Gene for a mammalian signal transducing protein involved in apoptosis induction, antibodies; for inducing cell death.
Queensland, Univ. ofWO 99/02694
Translation alteration genes
St. Lucia, Australia
Synthetic nucleic acids modified to alter translational kinetics; for directing protein expression in target cells.
Queensland Inst. Med. Res.WO 99/02550
Antigenic epitopes from Epstein-Barr virus that activate cytotoxic T cells.
Res. Develop. Fdn.WO 99/02991
Fire ant antibodies
Carson City, Nevada
Monoclonal antibodies and scFv heavy and/or light chain Ig fragments that bind to fire ant midgut microvilli.
St. Louis Univ.WO 99/02658
Viral apoptosis inhibitor
Receptor internalization and degradation protein complex encoded by adenoviral E3 region; for inhibiting apoptosis.
Salk Inst.WO 99/02683
Modified moth receptors
La Jolla, Calif.
Modified silk moth receptors, hybrid multifunctional proteins; for regulating transgene expression.
Dendritic cell membrane proteins
Genes for dendritic lymphocyte membrane proteins, encoded proteins, antibodies; for diagnostics and therapeutics.
SeikagakuEPO 893 506
Human hyaluronate synthetase, encoding gene sequences, variants, mutations.
SmithKline BeechamEPO 893 494
Chlamydia trachomatis aspartyl tRNA synthetase polypeptides, encoding gene sequences; for antibacterial screens.
SmithKline BeechamEPO 893 495
Chlamydia trachomatis isoleucyl tRNA synthetase peptides, encoding gene sequences; for antibacterial screens.
SmithKline BeechamEPO 893 496
Chlamydia trachomatis histidyl tRNA synthetase polypeptides, encoding gene sequences; for antibacterial screens.
SmithKline BeechamEPO 893 498
Human 7-transmembrane receptor
Human 7-transmembrane receptor polypeptides, encoding gene sequences; for diagnostics and therapeutics.
SmithKline BeechamEPO 893 499
Staphylococcus aureus tetracycline resistance protein, encoding gene sequences; for antibacterial screens.
SmithKline BeechamEPO 893 500
Staphylococcus aureus bmrU polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline BeechamEPO 893 501
Ferrichrome transport ATP-binding protein
Ferrichrome transport ATP-binding protein, encoding gene sequences, production methods; for antibacterial screens.
SmithKline BeechamEPO 893 502
Staphylococcus aureus greA polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline BeechamEPO 893 503
Staphylococcus aureus regulator protein, encoding gene sequences, production methods; for antibacterial screens.
SmithKline BeechamEPO 893 505
Glucose kinase for antibacterials
Glucose kinase polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline BeechamWO 98/02560
HOQBQ59 polypeptides, encoding gene sequences; for diagnostics and therapeutics.
SmithKline BeechamWO 99/02561
Human platelet antigen
Human F11 antigen involved in platelet aggregation, encoding gene sequences; for diagnostics and therapeutics.
SmithKline BeechamWO 99/02664
N-arginine dibasic convertase
Human N-arginine dibasic convertase, encoding gene sequences; for diagnostics and therapeutics.
Stichting Inst.WO 99/02695
Epitopes and active sites of paramyxoviridae proteins; for infection diagnostics and therapeutics.
Texas Heart Inst.WO 99/02171
Adenoviral vectors encoding human tissue factor pathway inhibitor; for targeting vascular smooth muscle cells.
Texas, Univ. ofWO 99/02567
Anti-tumor antibody conjugates
Monoclonal antibodies that become potent anti-tumor agents inducing apoptosis when converted into homoconjugates.
Short Hills, N.J.
Production of antibodies against the consensus sequence of HIV-1 Tat protein; for HIV diagnostics and therapeutics.
Uhlenkuken, J., et al.WO 99/02566
Standardized protein having specific binding sites for enzymes and/or antibody constant regions.
Univ. Technol.WO 99/02684
Transgenic nematode system for identifying genes associated with increased longevity and slowed aging.
Yeast production strains
Yeast cell strains transformed with the SEB1 gene; for increased production of recombinant proteins.
Yale Univ.WO 99/02657
New Haven, Conn.
Replication-competent recombinant vesicular stomatitis viruses with inserted HIV gene; for HIV vaccines.
ZenecaGB 2 327 497
Primer for mutations in the K-ras gene; for diagnosis of mutations and related cancers.