Published Dec. 30 (EPO); Dec. 23 (WO); Dec. 30 (GB)
AmradGB 2 326 643
Catalytic antibodies
Victoria, Australia
Linkage of B cell mitogenesis factors with antigens; for generating catalytic antibodies.
ApotechWO 98/57992
Anti-FLIP antibodies
Genf, Switzerland
Anti-FLIP antibodies, encoding gene sequences; for regulating programmed cytolysis.
BioinventWO 98/58080
Protein molecular evolution
Lund, Sweden
Shuffling of nucleotide segments obtained from exonuclease digestion; for molecular evolution of protein function.
California, Univ. ofWO 98/57993
Secretory immunoglobulin
Oakland, Calif.
Transfection of cells with secretory signal sequences; for inducing secretory immunoglobulin.
ChironWO 98/57985
RIP-interacting factor
Emeryville, Calif.
Human RIP-interacting factor, encoding gene sequences; for studying and treating apoptosis.
Columbia Univ.WO 98/58054
Stat5-specific protease
New York
Stat5-specific protease, antibodies; for developing assays for inhibitors.
DNAVecEPO 887 404
Selective proliferation fusion
Ibaraki, Japan
Fusion protein with ligand binding, association, and cell growth domains; for selective proliferation.
Edge BiosystemsWO 98/58067
DNA libraries
Gaithersburg, Md.
DNA libraries in which the inserted cDNA is flanked by intron endonuclease recognition sites.
Gene ShearsEPO 887 405
Stabilizing RNA
North Ryde, Australia
Production of stabilized non-translated RNAs using secondary structure inducing sequences.
GenentechWO 98/58062
Apo-2 ligand binding proteins
S. San Francisco
Polypeptides that can bind the Apo-2 ligand, chimeras, antibodies, encoding gene sequences.
Genetics Inst.WO 98/57976
Secreted protein genes
Cambridge, Mass.
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Genzyme TransgenicsWO 98/58051
Transgenically produced prolactin
Framingham, Mass.
Transgenic animals having inserted prolactin genes; for recombinant prolactin production.
Henry Jackson Fdn. Military Med.WO 98/57994
Gram positive bacteria vaccines
Rockville, Md.
Protective monoclonal and chimeric antibodies against lipoteichoic acid from Gram positive bacteria; for vaccines.
Human Genome SciencesWO 98/57989
Heregulin-like factor
Rockville, Md.
Heregulin-like factor, encoding gene sequences, production methods; for finding modulators and making diagnostics.
Incyte PharmaWO 98/57986
Preprotachykinin B
Palo Alto, Calif.
Human preprotachykinin B, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte PharmaWO 98/57987
Tyrosine kinase substrate
Palo Alto, Calif.
Insulin receptor tyrosine kinase substrate, encoding gene sequences, antibodies, modulators; for therapeutics.
Incyte PharmaWO 98/58052
Disease-associated protein kinases
Palo Alto, Calif.
Disease-associated protein kinases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte PharmaWO 98/58063
CTGF homolog
Palo Alto, Calif.
Connective tissue growth factor (CTGF) homolog, encoding gene sequences.
Incyte PharmaWO 98/58064
Kinesin-related protein
Palo Alto, Calif.
Kinesin-related protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte PharmaWO 98/58066
Human lysophospholipase
Palo Alto, Calif.
Human lysophospholipase, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Innovir LabsWO 98/58057 & 58058
Hammerhead ribozymes
New York
Chimeric RNA oligomers having hammerhead and stem-loop structures; for cleaving specific RNA sequences.
INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/58059
LAG-3 splice variants
Paris
LAG-3 gene sequences, splice variants, encoded proteins and genetic variants.
Krebs Res. Inst.WO 98/58055
Hepatitis B antisense
Heidelberg, Germany
Antisense nucleic acids that target specific RNAs from hepatitis B virus, vectors, host cells.
Krull, U.J., et al.WO 98/58079
Nucleic acid biosensor diagnostics
Mississauga, Ont.
Hybridization of nucleic acids tagged with fluorescent probes on optical fibers; for biosensor diagnostics.
Mass. Gen. Hosp.WO 98/57658
Epstein-Barr replicons
Boston
Nucleic acid sequences from Epstein-barr virus that support episomal replication in cells.
MerckWO 98/58053
Human receptor tyrosine kinase
Rahway, N.J.
Human receptor tyrosine kinase, encoding gene sequences, production methods.
NIH (Natl. Inst. Hlth.)WO 98/57982
Steroid receptor coactivator
Bethesda, Md.
Steroid receptor coactivator overexpressed in breast cancer cells, encoding gene sequences; for diagnostics.
North Carolina, Univ. ofWO 98/58050
Immortalized liver cells
Chapel Hill, N.C.
Human liver cells immortalized using c-myc exons that retain several differentiated characteristics.
Ozelius, L.J., et al.WO 98/57984
Torsion dystonia protein
Charlestown, Mass.
Torsin genes, encoded proteins, antibodies, probes; for diagnosing and treating torsion dystonia.
PfizerEPO 887 410
Plasminogen activating proteins
New York
Plasminogen activating proteins from Streptococcus uberis, encoding gene sequences; for treating mastitis.
ScheringWO 98/58061
Cysteine-rich soluble proteins
Kenilworth, N.J.
Small cysteine-rich soluble proteins, encoding genes, antibodies; for diagnostics and therapeutics.
SmithKline BeechamEPO 887 406
Frazzled polypeptides
Philadelphia
Frazzled polypeptides, encoding gene sequences, production method; for diagnostics and therapeutics.
SmithKline BechamEPO 887 407
Human 7-transmembrane receptor
Philadelphia
Human 7-transmembrane receptor polypeptides, encoding gene sequences; for diagnostics and therapeutics.
SmithKline BeechamEPO 887 408
Wnt-3 oncogene
Brentford, U.K.
Wnt-3 polypeptides, encoding gene sequences, production method; for diagnostics and therapeutics.
SmithKline BeechamEPO 887 411
Streptococcus antibacterials
Philadelphia
Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase, encoding sequences; for antibacterials.
SmithKline BeechamEPO 887 413
Antibacterial screen
Philadelphia
Histidine kinase polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline BeechamEPO 887 414
Human serine proteases
Brentford, U.K.
Human serine protease polypeptides, encoding gene sequences, production method; for diagnostics and therapeutics.
SmithKline BeechamEPO 887 415
Human RCE1
Philadelphia
Human RCE1 polypeptides, encoding gene sequences, production method; for diagnostics and therapeutics.
SmithKline BeechamEPO 887 416
Human AFC1
Philadelphia
Human AFC1 polypeptides, encoding gene sequences, production method; for diagnostics and therapeutics.
SmithKline BeechamWO 98/58060
Alzheimer's disease model
Munich, Germany
Human amyloid precursor protein gene sequences encoding mutations that allow transgenics to develop amyloid plaques.
TakedaEPO 887 417
Prolactin-modulating ligand
Osaka, Japan
Ligand with prolactin secretion-modulating activity, fusion protein; for diagnostics and therapeutics.
Thomas Jefferson Univ.WO 98/58056
Cartilage-specific expression
Philadelphia
Promoter fragments that induce expression in cartilage, bone, and other connective tissue; for therapy.
Werner, E., et al.EPO 887 409
Chemokine MIG-ß
Innsbruck, Austria
Chemokine MIG-ß, cDNA fragment, expression vector; for diagnostics and therapeutics [in German].
Yuan, J., et al.WO 98/57664
ICE gene mutants
Boston
Treatment of central nervous system damage (CNS) using mutant interleukin converting enzyme (ICE) gene.
ZymogeneticsWO 98/57983
Neural growth factor
Seattle
Mammalian neural growth factor polypeptides, encoding gene sequences, antibodies, anti-idiotypic antibodies.