Published Dec. 30 (EPO); Dec. 23 (WO); Dec. 30 (GB)

AmradGB 2 326 643

Catalytic antibodies

Victoria, Australia

Linkage of B cell mitogenesis factors with antigens; for generating catalytic antibodies.

ApotechWO 98/57992

Anti-FLIP antibodies

Genf, Switzerland

Anti-FLIP antibodies, encoding gene sequences; for regulating programmed cytolysis.

BioinventWO 98/58080

Protein molecular evolution

Lund, Sweden

Shuffling of nucleotide segments obtained from exonuclease digestion; for molecular evolution of protein function.

California, Univ. ofWO 98/57993

Secretory immunoglobulin

Oakland, Calif.

Transfection of cells with secretory signal sequences; for inducing secretory immunoglobulin.

ChironWO 98/57985

RIP-interacting factor

Emeryville, Calif.

Human RIP-interacting factor, encoding gene sequences; for studying and treating apoptosis.

Columbia Univ.WO 98/58054

Stat5-specific protease

New York

Stat5-specific protease, antibodies; for developing assays for inhibitors.

DNAVecEPO 887 404

Selective proliferation fusion

Ibaraki, Japan

Fusion protein with ligand binding, association, and cell growth domains; for selective proliferation.

Edge BiosystemsWO 98/58067

DNA libraries

Gaithersburg, Md.

DNA libraries in which the inserted cDNA is flanked by intron endonuclease recognition sites.

Gene ShearsEPO 887 405

Stabilizing RNA

North Ryde, Australia

Production of stabilized non-translated RNAs using secondary structure inducing sequences.

GenentechWO 98/58062

Apo-2 ligand binding proteins

S. San Francisco

Polypeptides that can bind the Apo-2 ligand, chimeras, antibodies, encoding gene sequences.

Genetics Inst.WO 98/57976

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Genzyme TransgenicsWO 98/58051

Transgenically produced prolactin

Framingham, Mass.

Transgenic animals having inserted prolactin genes; for recombinant prolactin production.

Henry Jackson Fdn. Military Med.WO 98/57994

Gram positive bacteria vaccines

Rockville, Md.

Protective monoclonal and chimeric antibodies against lipoteichoic acid from Gram positive bacteria; for vaccines.

Human Genome SciencesWO 98/57989

Heregulin-like factor

Rockville, Md.

Heregulin-like factor, encoding gene sequences, production methods; for finding modulators and making diagnostics.

Incyte PharmaWO 98/57986

Preprotachykinin B

Palo Alto, Calif.

Human preprotachykinin B, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte PharmaWO 98/57987

Tyrosine kinase substrate

Palo Alto, Calif.

Insulin receptor tyrosine kinase substrate, encoding gene sequences, antibodies, modulators; for therapeutics.

Incyte PharmaWO 98/58052

Disease-associated protein kinases

Palo Alto, Calif.

Disease-associated protein kinases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte PharmaWO 98/58063

CTGF homolog

Palo Alto, Calif.

Connective tissue growth factor (CTGF) homolog, encoding gene sequences.

Incyte PharmaWO 98/58064

Kinesin-related protein

Palo Alto, Calif.

Kinesin-related protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte PharmaWO 98/58066

Human lysophospholipase

Palo Alto, Calif.

Human lysophospholipase, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Innovir LabsWO 98/58057 & 58058

Hammerhead ribozymes

New York

Chimeric RNA oligomers having hammerhead and stem-loop structures; for cleaving specific RNA sequences.

INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/58059

LAG-3 splice variants

Paris

LAG-3 gene sequences, splice variants, encoded proteins and genetic variants.

Krebs Res. Inst.WO 98/58055

Hepatitis B antisense

Heidelberg, Germany

Antisense nucleic acids that target specific RNAs from hepatitis B virus, vectors, host cells.

Krull, U.J., et al.WO 98/58079

Nucleic acid biosensor diagnostics

Mississauga, Ont.

Hybridization of nucleic acids tagged with fluorescent probes on optical fibers; for biosensor diagnostics.

Mass. Gen. Hosp.WO 98/57658

Epstein-Barr replicons

Boston

Nucleic acid sequences from Epstein-barr virus that support episomal replication in cells.

MerckWO 98/58053

Human receptor tyrosine kinase

Rahway, N.J.

Human receptor tyrosine kinase, encoding gene sequences, production methods.

NIH (Natl. Inst. Hlth.)WO 98/57982

Steroid receptor coactivator

Bethesda, Md.

Steroid receptor coactivator overexpressed in breast cancer cells, encoding gene sequences; for diagnostics.

North Carolina, Univ. ofWO 98/58050

Immortalized liver cells

Chapel Hill, N.C.

Human liver cells immortalized using c-myc exons that retain several differentiated characteristics.

Ozelius, L.J., et al.WO 98/57984

Torsion dystonia protein

Charlestown, Mass.

Torsin genes, encoded proteins, antibodies, probes; for diagnosing and treating torsion dystonia.

PfizerEPO 887 410

Plasminogen activating proteins

New York

Plasminogen activating proteins from Streptococcus uberis, encoding gene sequences; for treating mastitis.

ScheringWO 98/58061

Cysteine-rich soluble proteins

Kenilworth, N.J.

Small cysteine-rich soluble proteins, encoding genes, antibodies; for diagnostics and therapeutics.

SmithKline BeechamEPO 887 406

Frazzled polypeptides

Philadelphia

Frazzled polypeptides, encoding gene sequences, production method; for diagnostics and therapeutics.

SmithKline BechamEPO 887 407

Human 7-transmembrane receptor

Philadelphia

Human 7-transmembrane receptor polypeptides, encoding gene sequences; for diagnostics and therapeutics.

SmithKline BeechamEPO 887 408

Wnt-3 oncogene

Brentford, U.K.

Wnt-3 polypeptides, encoding gene sequences, production method; for diagnostics and therapeutics.

SmithKline BeechamEPO 887 411

Streptococcus antibacterials

Philadelphia

Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase, encoding sequences; for antibacterials.

SmithKline BeechamEPO 887 413

Antibacterial screen

Philadelphia

Histidine kinase polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline BeechamEPO 887 414

Human serine proteases

Brentford, U.K.

Human serine protease polypeptides, encoding gene sequences, production method; for diagnostics and therapeutics.

SmithKline BeechamEPO 887 415

Human RCE1

Philadelphia

Human RCE1 polypeptides, encoding gene sequences, production method; for diagnostics and therapeutics.

SmithKline BeechamEPO 887 416

Human AFC1

Philadelphia

Human AFC1 polypeptides, encoding gene sequences, production method; for diagnostics and therapeutics.

SmithKline BeechamWO 98/58060

Alzheimer's disease model

Munich, Germany

Human amyloid precursor protein gene sequences encoding mutations that allow transgenics to develop amyloid plaques.

TakedaEPO 887 417

Prolactin-modulating ligand

Osaka, Japan

Ligand with prolactin secretion-modulating activity, fusion protein; for diagnostics and therapeutics.

Thomas Jefferson Univ.WO 98/58056

Cartilage-specific expression

Philadelphia

Promoter fragments that induce expression in cartilage, bone, and other connective tissue; for therapy.

Werner, E., et al.EPO 887 409

Chemokine MIG-ß

Innsbruck, Austria

Chemokine MIG-ß, cDNA fragment, expression vector; for diagnostics and therapeutics [in German].

Yuan, J., et al.WO 98/57664

ICE gene mutants

Boston

Treatment of central nervous system damage (CNS) using mutant interleukin converting enzyme (ICE) gene.

ZymogeneticsWO 98/57983

Neural growth factor

Seattle

Mammalian neural growth factor polypeptides, encoding gene sequences, antibodies, anti-idiotypic antibodies.

No Comments