Published Dec. 16 (EPO); Dec. 10 (WO)

Alberta, Univ. ofWO 98/55630

Ulcer therapeutic

Edmonton, Alberta

Helicobacter pylori alpha-1,3-fucosyltransferase, encoding gene sequences; for ulcer and cancer diagnostics/therapeutics.

Applied Res. SystemsEPO 884 385

Apoptosis modulation protein

Curacao, Netherlands Antilles

Glucocorticoid-induced leucine-zipper protein, encoding gene sequence, fragments, analogs; for apoptosis modulation.

Applied Science & Technol.WO 98/55619

Blood platelet antibodies

Zug, Switzerland

Human autoantibodies and anti-idiotypic antibodies against blood platelet membrane proteins, encoding gene sequences.

Bio MerieuxWO 98/55646

Chlamydia diagnostics

Marcy l'Etoile, France

Single-stranded nucleotide fragment from Chlamydia trachomatis 23S ribosome RNA; for diagnostics.

California, Univ. ofWO 98/55133

Melanoma-associated antigen

Oakland, Calif.

Melanoma-associated antigen, T cell epitopes, encoding gene sequences; for diagnostics and therapeutics.

California, Univ. ofWO 98/55609

DNA vaccine oligos

Oakland, Calif.

Oligos that inhibit the action of immunostimulatory oligodeoxynucleotides; for use with DNA vaccines.

Chartrand, P., et al.WO 98/55610

Interacting chromosome regions

Laval, Que.

Mapping interacting regions in chromosomes by inserting known gene sequences and measuring recombination by PCR.

Connaught LabsWO 98/55606

Moraxella lactoferrin receptors

N. York, Ont.

Lactoferrin receptor proteins of Moraxella, encoding gene sequences; for infection diagnosis.

Duke Univ.WO 98/55635

G-protein coupled receptor

Durham, N.C.

G-protein coupled receptor activity detection, ligand identification; for therapeutics.

GenentechWO 98/55615

Apoptosis modulator

S. San Francisco

Apaf-1, the CED-4 human homolog and caspase-3 activator, encoding gene sequences; for modulating apoptosis.

Genetics Inst.WO 98/55614

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Human Genome SciencesWO 98/54963

207 human secreted proteins

Rockville, Md.

207 human secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.

Incyte PharmaWO 98/55509

Human DanJ-like proteins

Palo Alto, Calif.

Human DanJ-like proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte PharmaWO 98/55510

Cyclin-related proteins

Palo Alto, Calif.

Cyclin-related proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte PharmaWO 98/55600

Human ribonuclease

Palo Alto, Calif.

Human ribonuclease, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte PharmaWO 98/55613

Zinc ring protein

Palo Alto, Calif.

Zinc ring protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte PharmaWO 98/55616

BRCA2 locus-associated protein

Palo Alto, Calif.

BRCA2 locus-associated protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte PharmaWO 98/55617

Human translational regulator

Palo Alto, Calif.

Human translational regulator, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Interpharm LabsWO 98/55622

Glycosylated TNF

Ness-Ziona, Israel

Glycosylated tumor necrosis factor (TNF) produced from Chinese hamster ovary cells.

Johns Hopkins Univ.WO 98/55146

Human platelet autoantigen fragment

Baltimore

Isolation of a heavy chain antibody fragment directed against human platelet autoantigen; for therapeutics.

Karolinska InnovationsWO 98/55603

Na+,K+-ATPase mutant

Stockholm, Sweden

Mutated version of sodium, potassium-ATPase, encoding gene sequences; for diagnostics and therapeutics.

Kureha ChemicalsWO 98/55643

Blood cell type modulator

Tokyo

Human ADAMTS protein, encoding gene sequence; for diagnostics and modulating levels of blood cell types.

Max Planck Inst.WO 98/55638

Vascular disease vector

Berlin

Vectors having vascular endothelial growth factor (VEGF) receptor-2 gene regulatory sequences; for vascular disease.

Michigan, Univ. ofWO 98/55611

Neuregulin response element

Ann Arbor, Mich.

Neuregulin response regulatory element; for identifying modulators of epsilon-subunit gene expression in muscles.

Osaka Univ.WO 98/55627

Mutant measles antigens

Osaka, Japan

Mutant measles virus antigens, fragments, encoding gene sequences; for diagnostics and attenuated vaccines.

Oxford BiomedicaWO 98/55607

Cancer gene therapy vector

Oxford, U.K.

Gene therapy vector with a gene encoding a therapeutic protein; for delivery to tumors.

Oxford BiomedicaWO 98/55640

Retroviral vector production

Oxford, U.K.

Vectors having retroviral and baculoviral elements; for producing retroviral vectors in baculoviruses.

PangeneticsWO 98/55623

Cancer immunotoxin

Amsterdam, Netherlands

Ribosome-binding protein from Bougainvillea spectabilis, immunotoxin conjugate; for cancer therapy.

Regeneron PharmaWO 98/55620 & 55621

TNF ligand protein

Tarrytown, N.Y.

Human NTN-2, a tumor necrosis factor (TNF) ligand protein, encoding gene sequences, modulators; for therapeutics.

Rochester, Univ. ofWO 98/55652

HIV replication inhibition

Rochester, N.Y.

Modified tRNAs; for inhibiting HIV reverse transcription and viral replication.

Sagami Chem. Res. Ctr.WO 98/55508

Transmembrane proteins

Kanagawa, Japan

Human proteins having transmembrane domains, encoding gene sequences.

Shaw, P.H., et al.WO 98/55641

Post-operative cataract inhibition

Lausanne, Switzerland

Adenoviral vector expressing genes that inhibit cell growth of lens epithelium; for treating post-operative cataracts

ShiseidoEPO 884 389

C-terminal amidation enzyme

Tokyo

Enzyme involved in C-terminal protein amidation reactions, preparation methods.

SmithKline BeechamEPO 884 387

Human 7-transmembrane receptor

Philadelphia

Human 7-transmembrane receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline BeechamWO 98/55502

Full-length cDNA cloning

Philadelphia

Rapid cloning of full-length cDNAs using arrays enriched for 5' mRNA sequences that are size fractionated.

Stanford Univ.WO 98/55618

Mitofusin

Palo Alto, Calif.

Mitofusin, encoding gene sequences, missense mutations; for mediating post-meiotic mitochondrial fusion.

SynthelaboEPO 884 386

Sodium channel receptor

Le Plessis Robinson

Sodium channel receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.

TransgeneWO 98/55639

Adenoviral gene therapy vector

Strasbourg, France

Adenoviral vector having splicing sequences and E1-region deletions; for gene therapy.

Vlaams Biotech. Inst.WO 98/55512

Smad-interacting proteins

Zwijnaarde, Belgium

Smad-interacting zinc finger/homeodomain proteins, encoding gene sequences; for diagnostics and therapeutics.

Wales, Univ. ofWO 98/55624

Bacterial RP-factors

Aberystwyth, U.K.

Bacterial RP-factors, receptors, encoding gene sequences, antibodies, inhibitors; for diagnostics and therapeutics.

Wistar Inst.WO 98/55151

Myc-interacting protein

Philadelphia

Box-dependent myc-interacting protein, encoding gene sequences; for diagnosing and treating cancers.

Yeda Res. & Develop.WO 98/55507

Inflammation modulator protein

Rehovot, Israel

B1 protein, isoforms, analogs, fragments, encoding gene sequences, production method; for treating inflammation.

ZymogeneticsWO 98/55612

Neurokinin B precursors

Seattle

Neurokinin B precursors, encoding gene sequences, antibodies; for studying prohormone convertase function.

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