Published Dec. 16 (EPO); Dec. 10 (WO)
Alberta, Univ. ofWO 98/55630
Ulcer therapeutic
Edmonton, Alberta
Helicobacter pylori alpha-1,3-fucosyltransferase, encoding gene sequences; for ulcer and cancer diagnostics/therapeutics.
Applied Res. SystemsEPO 884 385
Apoptosis modulation protein
Curacao, Netherlands Antilles
Glucocorticoid-induced leucine-zipper protein, encoding gene sequence, fragments, analogs; for apoptosis modulation.
Applied Science & Technol.WO 98/55619
Blood platelet antibodies
Zug, Switzerland
Human autoantibodies and anti-idiotypic antibodies against blood platelet membrane proteins, encoding gene sequences.
Bio MerieuxWO 98/55646
Chlamydia diagnostics
Marcy l'Etoile, France
Single-stranded nucleotide fragment from Chlamydia trachomatis 23S ribosome RNA; for diagnostics.
California, Univ. ofWO 98/55133
Melanoma-associated antigen
Oakland, Calif.
Melanoma-associated antigen, T cell epitopes, encoding gene sequences; for diagnostics and therapeutics.
California, Univ. ofWO 98/55609
DNA vaccine oligos
Oakland, Calif.
Oligos that inhibit the action of immunostimulatory oligodeoxynucleotides; for use with DNA vaccines.
Chartrand, P., et al.WO 98/55610
Interacting chromosome regions
Laval, Que.
Mapping interacting regions in chromosomes by inserting known gene sequences and measuring recombination by PCR.
Connaught LabsWO 98/55606
Moraxella lactoferrin receptors
N. York, Ont.
Lactoferrin receptor proteins of Moraxella, encoding gene sequences; for infection diagnosis.
Duke Univ.WO 98/55635
G-protein coupled receptor
Durham, N.C.
G-protein coupled receptor activity detection, ligand identification; for therapeutics.
GenentechWO 98/55615
Apoptosis modulator
S. San Francisco
Apaf-1, the CED-4 human homolog and caspase-3 activator, encoding gene sequences; for modulating apoptosis.
Genetics Inst.WO 98/55614
Secreted protein genes
Cambridge, Mass.
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Human Genome SciencesWO 98/54963
207 human secreted proteins
Rockville, Md.
207 human secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.
Incyte PharmaWO 98/55509
Human DanJ-like proteins
Palo Alto, Calif.
Human DanJ-like proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte PharmaWO 98/55510
Cyclin-related proteins
Palo Alto, Calif.
Cyclin-related proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte PharmaWO 98/55600
Human ribonuclease
Palo Alto, Calif.
Human ribonuclease, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte PharmaWO 98/55613
Zinc ring protein
Palo Alto, Calif.
Zinc ring protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte PharmaWO 98/55616
BRCA2 locus-associated protein
Palo Alto, Calif.
BRCA2 locus-associated protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte PharmaWO 98/55617
Human translational regulator
Palo Alto, Calif.
Human translational regulator, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Interpharm LabsWO 98/55622
Glycosylated TNF
Ness-Ziona, Israel
Glycosylated tumor necrosis factor (TNF) produced from Chinese hamster ovary cells.
Johns Hopkins Univ.WO 98/55146
Human platelet autoantigen fragment
Baltimore
Isolation of a heavy chain antibody fragment directed against human platelet autoantigen; for therapeutics.
Karolinska InnovationsWO 98/55603
Na+,K+-ATPase mutant
Stockholm, Sweden
Mutated version of sodium, potassium-ATPase, encoding gene sequences; for diagnostics and therapeutics.
Kureha ChemicalsWO 98/55643
Blood cell type modulator
Tokyo
Human ADAMTS protein, encoding gene sequence; for diagnostics and modulating levels of blood cell types.
Max Planck Inst.WO 98/55638
Vascular disease vector
Berlin
Vectors having vascular endothelial growth factor (VEGF) receptor-2 gene regulatory sequences; for vascular disease.
Michigan, Univ. ofWO 98/55611
Neuregulin response element
Ann Arbor, Mich.
Neuregulin response regulatory element; for identifying modulators of epsilon-subunit gene expression in muscles.
Osaka Univ.WO 98/55627
Mutant measles antigens
Osaka, Japan
Mutant measles virus antigens, fragments, encoding gene sequences; for diagnostics and attenuated vaccines.
Oxford BiomedicaWO 98/55607
Cancer gene therapy vector
Oxford, U.K.
Gene therapy vector with a gene encoding a therapeutic protein; for delivery to tumors.
Oxford BiomedicaWO 98/55640
Retroviral vector production
Oxford, U.K.
Vectors having retroviral and baculoviral elements; for producing retroviral vectors in baculoviruses.
PangeneticsWO 98/55623
Cancer immunotoxin
Amsterdam, Netherlands
Ribosome-binding protein from Bougainvillea spectabilis, immunotoxin conjugate; for cancer therapy.
Regeneron PharmaWO 98/55620 & 55621
TNF ligand protein
Tarrytown, N.Y.
Human NTN-2, a tumor necrosis factor (TNF) ligand protein, encoding gene sequences, modulators; for therapeutics.
Rochester, Univ. ofWO 98/55652
HIV replication inhibition
Rochester, N.Y.
Modified tRNAs; for inhibiting HIV reverse transcription and viral replication.
Sagami Chem. Res. Ctr.WO 98/55508
Transmembrane proteins
Kanagawa, Japan
Human proteins having transmembrane domains, encoding gene sequences.
Shaw, P.H., et al.WO 98/55641
Post-operative cataract inhibition
Lausanne, Switzerland
Adenoviral vector expressing genes that inhibit cell growth of lens epithelium; for treating post-operative cataracts
ShiseidoEPO 884 389
C-terminal amidation enzyme
Tokyo
Enzyme involved in C-terminal protein amidation reactions, preparation methods.
SmithKline BeechamEPO 884 387
Human 7-transmembrane receptor
Philadelphia
Human 7-transmembrane receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline BeechamWO 98/55502
Full-length cDNA cloning
Philadelphia
Rapid cloning of full-length cDNAs using arrays enriched for 5' mRNA sequences that are size fractionated.
Stanford Univ.WO 98/55618
Mitofusin
Palo Alto, Calif.
Mitofusin, encoding gene sequences, missense mutations; for mediating post-meiotic mitochondrial fusion.
SynthelaboEPO 884 386
Sodium channel receptor
Le Plessis Robinson
Sodium channel receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.
TransgeneWO 98/55639
Adenoviral gene therapy vector
Strasbourg, France
Adenoviral vector having splicing sequences and E1-region deletions; for gene therapy.
Vlaams Biotech. Inst.WO 98/55512
Smad-interacting proteins
Zwijnaarde, Belgium
Smad-interacting zinc finger/homeodomain proteins, encoding gene sequences; for diagnostics and therapeutics.
Wales, Univ. ofWO 98/55624
Bacterial RP-factors
Aberystwyth, U.K.
Bacterial RP-factors, receptors, encoding gene sequences, antibodies, inhibitors; for diagnostics and therapeutics.
Wistar Inst.WO 98/55151
Myc-interacting protein
Philadelphia
Box-dependent myc-interacting protein, encoding gene sequences; for diagnosing and treating cancers.
Yeda Res. & Develop.WO 98/55507
Inflammation modulator protein
Rehovot, Israel
B1 protein, isoforms, analogs, fragments, encoding gene sequences, production method; for treating inflammation.
ZymogeneticsWO 98/55612
Neurokinin B precursors
Seattle
Neurokinin B precursors, encoding gene sequences, antibodies; for studying prohormone convertase function.