Published Dec. 2 (EPO); Nov. 26 (WO)
Alabama, Univ. ofWO 98/53054
Canine IL-2 receptor antagonist
Birmingham, Ala.
Canine interleukin (IL)-1 receptor antagonist, encoding gene sequences, expression vectors.
Allelix PharmaWO 98/53062
Human EDG-6 receptor homolog
Mississauga, Ont.
Human EDG-6 receptor homolog, encoding gene sequences, methods for producing transgenics.
BiogenWO 98/53071
Tissue regeneration modulators
Cambridge, Mass.
Proteins upregulated in injured or regenerating tissues, encoding gene sequences; for therapeutics.
CorixaWO 98/53075 & 53076
Tuberculosis vaccine
Seattle
Antigenic portions of Mycobacteria tuberculosis, encoding gene sequences; for diagnosis and immunization.
Cornell Univ.WO 98/53087
Adenoviral vectors
Ithaca, N.Y.
Production of replication-deficient non-group C adenoviruses having essential gene function disruption; for vectors.
Daewoong PharmaWO 98/53082
Ulcer therapeutics
Sungnam, S. Korea
Chimeric gene with the H. pylori adhesin and Vibrio cholerae toxin B subunit sequences, encoded protein; for ulcers.
Genetics Inst.WO 98/53065
Human semaphorin E
Cambridge, Mass.
Human semaphorin E, encoding gene sequences.
GenolifeWO 98/53099
Genotoxicity detecting ligands
Saint-Beauzire, France
Ligands that can detect qualitative and quantitative alterations in DNA sequences; for measuring genotoxicity.
Groningen State Univ.WO 98/53081
Enantioselective epoxide hydrolases
Groningen, Netherlands
Enantioselective epoxide hydrolases from Agrobacterium species, encoding genes.
HeskaWO 98/52971
Parasite thioredoxin peroxidase
Fort Collins, Colo.
Thioredoxin peroxidase type 2 from parasitic helminth worms, encoding gene sequences, antibodies; for vaccines.
HoechstEPO 881 288
TATA-box binding protein
Frankfurt, Germany
Transgenics having a gene encoding epitope-tagged TATA-box binding protein; for identifying new transcription factors.
Human Genome SciencesWO 98/53069
GDNF receptor beta
Rockville, Md.
Glial cell line-derived neurotrophic factor (GDNF) receptor beta, encoding gene sequences; for screening modulators.
Incyte PharmaWO 98/53070
Human GP12 homolog
Palo Alto, Calif.
Human GP12 homolog, encoding gene sequences, antibodies, antagonists; for diagnostics and therapeutics.
Incyte PharmaWO 98/53079
Ubiquitin conjugation proteins
Palo Alto, Calif.
Human ubiquitin conjugation system protein, encoding gene sequences, antisense, antibodies, modulators; for therapy.
InsearchWO 98/53074
Neospora detection
Haymarket, Australia
Neospora large subunit ribosomal DNA; for detecting Neospora via PCR techniques.
Korea Res. Inst.WO 98/53072
G-CSF production
Taejon, S. Korea
Methods of producing human granulocyte colony stimulating factor (G-CSF) in E. coli.
Leuven Res. & Develop.WO 98/53063
Modified Factor VIII vector
Leuven, Belgium
Intron-deleted retroviral vector having a B-domain deleted human Factor VIII gene; for transfecting bone marrow cells.
Ludwig Inst.WO 98/53066
Smad2 phosphorylation fragments
New York
Smad2 polypeptide fragments important for phosphorylation activity, encoding gene sequences, variants, antibodies.
Ludwig Inst.WO 98/53068
Smad7 gene sequences
New York
Smad7 gene sequences, encoded proteins, fragments, variants, antibodies.
MRC (Med. Res. Counc.)WO 98/53057-53060
Zinc finger library
London
Randomized zinc finger library; for assembling a variety of zinc finger multimeric polypeptides.
MerckWO 98/52958
Human uncoupling protein 3
Rahway, N.J.
Human uncoupling protein 3, encoding gene sequences; for modulating energy metabolism using gene therapy.
Miyagi KenWO 98/53052
Plasma membrane sialidases
Miyagi, Japan
Plasma membrane sialidases, encoding gene sequences; for removing residues from ganglioside non-reducing ends.
MonsantoWO 98/53088
Amino acid biotransformation
St. Louis
Using transaminases to convert one amino acid into another amino acid; for synthesizing amino acids.
NIH (Natl. Inst. Hlth.)WO 98/53078
Parainfluenza vaccines
Bethesda, Md.
Recombinant, chimeric, and mutant parainfluenza virus genomes; for making attenuated, immunogenic vaccines.
Ottawa Civic Hosp.WO 98/52581
Enhanced DNA vaccines
Ottawa
DNA vaccine vectors having CpG-N motifs removed and CpG-S motifs added; for enhanced expression of encoded proteins.
Queensland Inst. Med. Res.WO 98/53061
Regulatory genes
Brisbane, Australia
Genes encoding a zinc finer, a guanine exchange factor, and a heat shock protein, encoded proteins; for gene therapy.
Schindelhauer, D.WO 98/53056
Artificial chromosome production
Munich, Germany
Production of large DNA constructs by combining DNAs in melted agarose; for producing artificial chromosomes.
SmithKline BeechamEPO 881 285
D-alanine transferase
Philadelphia
D-alanine transferase polypeptides, encoding gene sequences, production methods; for screening antibacterials.
SmithKline BeechamEPO 881 286 & 295-297
Histidine kinase
Philadelphia
Histidine kinase polypeptides, encoding gene sequences, production methods; for screening antibacterials.
SmithKline BeechamEPO 881 289
7-transmembrane receptor
Philadelphia
7-transmembrane receptor polypeptides, encoding gene sequences, production methods; for diagnostics/therapeutics.
SmithKline BeechamEPO 881 290
Neurotransmitter transporter
Brentford, U.K.
Neurotransmitter transporter polypeptides, encoding gene sequences, production methods; for diagnostics/therapeutics.
SmithKline BeechamEPO 881 291
Guanine exchange factor
Nanterre, France
Guanine exchange factor family polypeptides, encoding gene sequences, production methods; for diagnostics/therapeutics.
SmithKline BeechamEPO 881 292
Streptococcus antibacterials
Philadelphia
Peptide release factor from Streptococcus pneumoniae, encoding gene sequences; for screening antibacterials.
SmithKline BeechamEPO 881 294
HAS2 splicing variant
Philadelphia
HAS2 splicing variant, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline BeechamEPO 881 298
Metalloproteases
Brentford, U.K.
Metalloproteases, encoding gene sequences, production methods; for diagnostics and therapeutics.
SolidagoWO 98/53084
Enhanced erythromycin production
Bern, Switzerland
Erythromycin-producing organisms that express heterologous oxygen-binding proteins; for enhanced production.
Tanabe SeiyakuWO 98/53064
Organic anion transporter
Kanagawa, Japan
Organic anion transporter, encoding gene sequences; for screening drugs affecting nephrotoxicity.
Tensei SuisanWO 98/52972
Apoptosis-inducing protein
Saga, Japan
Apoptosis-inducing protein, encoding gene sequence, fragments, antibodies; for use against cancers.
Walter Reed Army Inst. Res.WO 98/53077
Encephalitis vaccines
Washington, D.C.
Equine encephalitis genomic and cDNA sequences, variants, attenuated chimeric alphaviruses; for vaccines.
Yale Univ.WO 98/53067
Bicarbonate transporter protein
New Haven, Conn.
Bicarbonate transporter protein, encoding gene sequences; for identifying modulators.
ZenecaWO 98/53083
Gene silencing vector
London
Insertion of an inverted polynucleotide repeat into a vector; for inhibiting expression of a target gene.