Published Dec. 2 (EPO); Nov. 26 (WO)

Alabama, Univ. ofWO 98/53054

Canine IL-2 receptor antagonist

Birmingham, Ala.

Canine interleukin (IL)-1 receptor antagonist, encoding gene sequences, expression vectors.

Allelix PharmaWO 98/53062

Human EDG-6 receptor homolog

Mississauga, Ont.

Human EDG-6 receptor homolog, encoding gene sequences, methods for producing transgenics.

BiogenWO 98/53071

Tissue regeneration modulators

Cambridge, Mass.

Proteins upregulated in injured or regenerating tissues, encoding gene sequences; for therapeutics.

CorixaWO 98/53075 & 53076

Tuberculosis vaccine


Antigenic portions of Mycobacteria tuberculosis, encoding gene sequences; for diagnosis and immunization.

Cornell Univ.WO 98/53087

Adenoviral vectors

Ithaca, N.Y.

Production of replication-deficient non-group C adenoviruses having essential gene function disruption; for vectors.

Daewoong PharmaWO 98/53082

Ulcer therapeutics

Sungnam, S. Korea

Chimeric gene with the H. pylori adhesin and Vibrio cholerae toxin B subunit sequences, encoded protein; for ulcers.

Genetics Inst.WO 98/53065

Human semaphorin E

Cambridge, Mass.

Human semaphorin E, encoding gene sequences.

GenolifeWO 98/53099

Genotoxicity detecting ligands

Saint-Beauzire, France

Ligands that can detect qualitative and quantitative alterations in DNA sequences; for measuring genotoxicity.

Groningen State Univ.WO 98/53081

Enantioselective epoxide hydrolases

Groningen, Netherlands

Enantioselective epoxide hydrolases from Agrobacterium species, encoding genes.

HeskaWO 98/52971

Parasite thioredoxin peroxidase

Fort Collins, Colo.

Thioredoxin peroxidase type 2 from parasitic helminth worms, encoding gene sequences, antibodies; for vaccines.

HoechstEPO 881 288

TATA-box binding protein

Frankfurt, Germany

Transgenics having a gene encoding epitope-tagged TATA-box binding protein; for identifying new transcription factors.

Human Genome SciencesWO 98/53069

GDNF receptor beta

Rockville, Md.

Glial cell line-derived neurotrophic factor (GDNF) receptor beta, encoding gene sequences; for screening modulators.

Incyte PharmaWO 98/53070

Human GP12 homolog

Palo Alto, Calif.

Human GP12 homolog, encoding gene sequences, antibodies, antagonists; for diagnostics and therapeutics.

Incyte PharmaWO 98/53079

Ubiquitin conjugation proteins

Palo Alto, Calif.

Human ubiquitin conjugation system protein, encoding gene sequences, antisense, antibodies, modulators; for therapy.

InsearchWO 98/53074

Neospora detection

Haymarket, Australia

Neospora large subunit ribosomal DNA; for detecting Neospora via PCR techniques.

Korea Res. Inst.WO 98/53072

G-CSF production

Taejon, S. Korea

Methods of producing human granulocyte colony stimulating factor (G-CSF) in E. coli.

Leuven Res. & Develop.WO 98/53063

Modified Factor VIII vector

Leuven, Belgium

Intron-deleted retroviral vector having a B-domain deleted human Factor VIII gene; for transfecting bone marrow cells.

Ludwig Inst.WO 98/53066

Smad2 phosphorylation fragments

New York

Smad2 polypeptide fragments important for phosphorylation activity, encoding gene sequences, variants, antibodies.

Ludwig Inst.WO 98/53068

Smad7 gene sequences

New York

Smad7 gene sequences, encoded proteins, fragments, variants, antibodies.

MRC (Med. Res. Counc.)WO 98/53057-53060

Zinc finger library


Randomized zinc finger library; for assembling a variety of zinc finger multimeric polypeptides.

MerckWO 98/52958

Human uncoupling protein 3

Rahway, N.J.

Human uncoupling protein 3, encoding gene sequences; for modulating energy metabolism using gene therapy.

Miyagi KenWO 98/53052

Plasma membrane sialidases

Miyagi, Japan

Plasma membrane sialidases, encoding gene sequences; for removing residues from ganglioside non-reducing ends.

MonsantoWO 98/53088

Amino acid biotransformation

St. Louis

Using transaminases to convert one amino acid into another amino acid; for synthesizing amino acids.

NIH (Natl. Inst. Hlth.)WO 98/53078

Parainfluenza vaccines

Bethesda, Md.

Recombinant, chimeric, and mutant parainfluenza virus genomes; for making attenuated, immunogenic vaccines.

Ottawa Civic Hosp.WO 98/52581

Enhanced DNA vaccines


DNA vaccine vectors having CpG-N motifs removed and CpG-S motifs added; for enhanced expression of encoded proteins.

Queensland Inst. Med. Res.WO 98/53061

Regulatory genes

Brisbane, Australia

Genes encoding a zinc finer, a guanine exchange factor, and a heat shock protein, encoded proteins; for gene therapy.

Schindelhauer, D.WO 98/53056

Artificial chromosome production

Munich, Germany

Production of large DNA constructs by combining DNAs in melted agarose; for producing artificial chromosomes.

SmithKline BeechamEPO 881 285

D-alanine transferase


D-alanine transferase polypeptides, encoding gene sequences, production methods; for screening antibacterials.

SmithKline BeechamEPO 881 286 & 295-297

Histidine kinase


Histidine kinase polypeptides, encoding gene sequences, production methods; for screening antibacterials.

SmithKline BeechamEPO 881 289

7-transmembrane receptor


7-transmembrane receptor polypeptides, encoding gene sequences, production methods; for diagnostics/therapeutics.

SmithKline BeechamEPO 881 290

Neurotransmitter transporter

Brentford, U.K.

Neurotransmitter transporter polypeptides, encoding gene sequences, production methods; for diagnostics/therapeutics.

SmithKline BeechamEPO 881 291

Guanine exchange factor

Nanterre, France

Guanine exchange factor family polypeptides, encoding gene sequences, production methods; for diagnostics/therapeutics.

SmithKline BeechamEPO 881 292

Streptococcus antibacterials


Peptide release factor from Streptococcus pneumoniae, encoding gene sequences; for screening antibacterials.

SmithKline BeechamEPO 881 294

HAS2 splicing variant


HAS2 splicing variant, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline BeechamEPO 881 298


Brentford, U.K.

Metalloproteases, encoding gene sequences, production methods; for diagnostics and therapeutics.

SolidagoWO 98/53084

Enhanced erythromycin production

Bern, Switzerland

Erythromycin-producing organisms that express heterologous oxygen-binding proteins; for enhanced production.

Tanabe SeiyakuWO 98/53064

Organic anion transporter

Kanagawa, Japan

Organic anion transporter, encoding gene sequences; for screening drugs affecting nephrotoxicity.

Tensei SuisanWO 98/52972

Apoptosis-inducing protein

Saga, Japan

Apoptosis-inducing protein, encoding gene sequence, fragments, antibodies; for use against cancers.

Walter Reed Army Inst. Res.WO 98/53077

Encephalitis vaccines

Washington, D.C.

Equine encephalitis genomic and cDNA sequences, variants, attenuated chimeric alphaviruses; for vaccines.

Yale Univ.WO 98/53067

Bicarbonate transporter protein

New Haven, Conn.

Bicarbonate transporter protein, encoding gene sequences; for identifying modulators.

ZenecaWO 98/53083

Gene silencing vector


Insertion of an inverted polynucleotide repeat into a vector; for inhibiting expression of a target gene.