Published Nov. 25 (EPO); Nov. 19 (WO); Nov. 25 (GB)
Abbott LabsWO 98/51695
Erythromycin polyketide derivatives
Abbott Park, Ill.
Erythromycin polyketide derivatives, genes for making such derivatives, recombinant host cells, production methods.
Abbott LabsWO 98/51805
Prostate cancer diagnostics
Abbott Park, Ill.
Overlapping cDNAs from prostate tissues, encoded polypeptides; for cancer diagnostics and therapeutics.
AmradWO 98/51790
Neocentromere nucleic acids
Richmond, Australia
Isolated nucleic acids that form the neocentromere; for developing artificial chromosomes for gene therapy.
AsahiWO 98/51799
Differentiation inhibiting protein
Osaka, Japan
Human delta 2 protein, encoding gene sequence; for growth of undifferentiated blood cells and differentiation inhibition.
Brigham & Women's Hosp.WO 98/51792
Hematopoietic therapeutics
Boston
Conjugates of FAC and targeting molecules that selectively bind hematopoietic progenitor cells; for therapeutics.
Celtrix PharmaWO 98/51780
Increased recombinant protein yields
Santa Clara, Calif.
Addition of protective agents such as sulfated heparins to production processes; for increasing protein yields.
Display Systems BiotechWO 98/51789
Expressed gene library
Copenhagen, Denmark
Methods of cloning cDNAs derived from mRNAs and display of differentially expressed transcripts; for drug development.
GenentechWO 98/51793
Apoptosis-modifying proteins
S. San Francisco
Apo-2 proteins that modify apoptosis, encoding gene sequences, chimeras, antibodies.
Groningen State Univ.EPO 879 890
Enantioselective epoxide hydrolases
Groningen, Netherlands
Enantioselective epoxide hydrolases, encoding genes, microorganisms transformed with these genes.
HSC Res. & Develop.WO 98/51807
Epithelial cancer vector
Toronto
Episomal expression vectors having cytokeratin regulatory elements and a transgene; for treating epithelial cancer.
Human Genome SciencesWO 98/51794
Human defensin-like protein
Rockville, Md.
Human antimicrobial defensin-like protein, encoding gene sequences; for diagnostics and therapeutics.
Imp. Cancer Res. Technol.WO 98/51798
Hepatocyte growth factor variant
London
Variant hepatocyte growth factor incapable of binding heparan sulfate but capable of binding its receptor.
Incyte PharmaWO 98/51782
3-hydroxyisobutyryl-coenzyme A hydrolase
Palo Alto, Calif.
Human 3-hydroxyisobutyryl-coenzyme A hydrolase, encoding gene sequences, vectors, antibodies; for diagnostics.
Incyte PharmaWO 98/51795
Double stranded RNA binding protein
Palo Alto, Calif.
Double stranded RNA binding protein, encoding gene sequences, antibodies, modulators; for diagnostics.
Incyte PharmaWO 98/51796
CD53-like transmembrane protein
Palo Alto, Calif.
CD53-like transmembrane protein, encoding gene sequences, antibodies, modulators, production methods; for diagnostics.
Incyte PharmaWO 98/51797
Human vesicle binding protein
Palo Alto, Calif.
Human vesicle binding protein, encoding gene sequences, antibodies, modulators, production methods; for diagnostics.
Kufer, P.EPO 879 884
CD4-derived polypeptides
Moosburg, Germany
Gene sequences encoding CD4-derived polypeptides, encoded peptides with increased gp120 affinity; for therapeutics.
Medical Academy Ctr.WO 98/51808
Altered retroviral vectors
Amsterdam
Retroviruses with altered tropism produced by inhibiting translation initiation sites; for multipurpose vectors.
MerckWO 98/51781
Alzheimer's transgenics
Rahway, N.J.
Transgenics having a gene expressing familial Alzheimer's disease mutant presinilin 1 protein on a null background.
Netherlands Res. Org.WO 98/51788
Gene therapy vector
Delft, Netherlands
Vector encoding peptides with binding function and effector domains; for gene therapy.
New England BiolabsWO 98/51783
PspG1 endonuclease
Beverly, Mass.
Type II restriction endonuclease PspG1 from Pyrococcus, encoding gene; for DNA cloning and sequencing.
North Carolina, Univ. ofWO 98/51810
Lentivirus-based vector
Chapel Hill, N.C.
Lentivirus-based vector derived from equine infectious anemia virus; for broad range gene therapy.
Novo Nordisk BiotechWO 98/51803
Prolyl dipeptidyl aminopeptidase
Davis, Calif.
Polypeptides with prolyl dipeptidyl aminopeptidase activity, encoding gene sequences from Aspergillus oryzae.
Novo Nordisk BiotechWO 98/51804
Aminopeptidase
Davis, Calif.
Polypeptides having aminopeptidase activity, encoding gene sequences from Aspergillus oryzae.
Pittsburgh, Univ. ofWO 98/51809
Herpes simplex vectors
Pittsburgh, Pa.
Mutating cassette designed to replace genes in herpes simplex virus; for designing cancer therapy vectors.
Shiozawa, S., et al.WO 98/51791
Rheumatoid arthritis gene
Hyogo, Japan
Gene sequences associated with rheumatoid arthritis; for diagnostics and therapeutics.
SmithKline BeechamEPO 879 879
Polypeptide deformylase
Philadelphia
Polypeptide deformylase 1, encoding gene sequences, production methods; for screening antibacterials.
SmithKline BeechamEPO 879 880, 882 & 883
Allograft inflammatory factor homolog
Philadelphia
Homolog of allograft inflammatory factor, encoding gene sequences and splice variants; for diagnostics.
SmithKline BeechamEPO 879 881
Human frizb gene homolog
Philadelphia
Human gene similar to the secreted protein frizb, encoding gene sequences, production methods; for diagnostics.
SmithKline BeechamEPO 879 885
Human sFRP-1 homolog
Philadelphia
Human gene similar to that for secreted mouse protein sFRP-1, encoded protein, production methods; for therapeutics.
SmithKline BeechamEPO 879 886
Human Wnt-1 homolog
Brentford, U.K.
Human Wnt-4 signal transduction homolog, encoding gene sequences, production methods; for therapeutics.
SmithKline BeechamEPO 879 887
Human SDF5 homolog
Philadelphia
Human gene similar to that for secreted mouse protein SDF5, encoded protein, production methods; for therapeutics.
SmithKline BeechamEPO 879 888
Patched-2 polypeptides
Brentford, U.K.
Patched-2 polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline BeechamEPO 879 889
IL-1 delta
Philadelphia
Interleukin (IL)-1 delta peptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
Southern California, Univ. ofWO 98/51700
Targeting retroviral envelopes
Los Angeles
Retroviral envelopes with hypervariable polyproline regions for insertion of heterologous proteins; for targeting cells.
ThermogenWO 98/51802
Directed protein evolution
Chicago
Directed evolution of proteins; for improved thermostability of alcohol dehydrogenases.
ZenecaWO 98/51787
Cell targeting
London
Gene construct encoding a cell surface antigen targeting moiety and a prodrug activating enzyme.
ZetesisGB 2 325 466
Cytotoxic goat liver protein
Milan, Italy
Nucleic acid sequence isolated from goat liver, encoded protein having cytotoxic properties.