Published Nov. 4 (EPO); Oct. 29 (WO)
Akzo NobelEPO 875 574
Live, attenuated strains of Actinobacillus pleuropneumoniae having a mutation in their toxin genes; for therapeutics.
Increasing penicillin production
Inactivation of phenyl acetate catabolism enzyme genes in bacterial strains; for increased penicillin synthesis.
BASFEPO 875 567
Myc-binding zinc finger
Myc-binding zinc finger protein, encoding gene sequences; for therapeutics [in German].
TGF-beta receptor/Ig fusions
Type II TGF-beta receptor-immunoglobulin (Ig) constant region fusion proteins; for treating fibroproliferative disorders.
Boehringer MannheimWO 98/47914
Human cytomegalovirus US6 gene, encoded protein, antibodies; for reducing immunogenicity in transfected cells.
Brax GeneticsWO 98/48047
Characterizing DNA by cleaving at predetermined sequences and then ligating adapter oligos with recognition sites.
California, Univ. ofWO 98/48021
Kaposi's herpes protease
Kaposi's sarcoma herpesvirus protease and assembly protein, encoding gene sequences; for identifying inhibitors.
Cambridge Univ. Tech. ServicesWO 98/48048
DNA mismatch mapping
Locating mismatches in DNA pairing using fluorescence resonance energy transfer of labelled probes.
Cancer Res. Camp. Technol.WO 98/48013
Transcriptional activator domain encoded by BRCA2 exon 3, encoded peptide; for identifying modulators.
Chugai Res. Inst. Molec. Med.WO 98/47920 & 48015
Testis transcriptional regulator
Transcriptional regulator having a bromo domain that was isolated from a human testis cDNA library, encoding gene.
Dundee, Univ. ofWO 98/47919
Targeting of p53 by endogenous Mdm2 in cells; for delivering therapeutics to cancer cells.
European Inst. Oncol.WO 98/48020
Mammalian ubiquitin isopeptidases, encoding gene sequences; for regulating cellular activity of these enzymes.
Florida, Univ. ofWO 98/48009 & 48027
Retinal disease treatments
Ribozymes that cleave mutant mRNAs and adeno-associated gene therapy vectors; for treating retinal diseases.
Fraunhofer Res. Inst.WO 98/48018
More soluble beta-interferon
Recombinant human beta-interferon having hydrophilic amino acid residue replacements; for increased solubility.
Freiburg Univ.WO 98/48012
Wound healing cells
Fibroblasts transfected with foreign genes encoding cytokines; for promoting wound healing.
Garvan Inst. Med. Res.WO 98/48010
Tumor suppressor gene regulated by progestin, encoded protein; for diagnosis of predisposition to cancer.
Unglycosylated protein antibodies
Antibodies against unglycosylated erythropoietin; for quantifying glycosylated proteins in biological samples.
Hall Inst. Med. Res.WO 98/48011
Interspecies leukemia inhibitory factor (LIF) a-chain chimeras, LIF-immunoglobulin chimeras; for antagonists.
Harvard Univ.WO 98/47916
Directed gene therapy vector
Bifunctional binding molecules with cell and virus targeting moieties; for selective gene therapy vector delivery.
Parasitic worm ankyrins
Fort Collins, Colo.
Ankyrin proteins from parasitic helminth worms, encoding gene sequences, antibodies; for designing therapeutics.
Leukocyte immunoglobulin-like receptors
Leukocyte immunoglobulin-like receptors, encoding gene sequences, antibodies; for treating immune disorders.
Incyte PharmaWO 98/48016
Edg-1 like receptor
Palo Alto, Calif.
Edg-1 like receptor, encoding gene sequences, antibodies, modulators; for therapeutics.
Leicester, Univ. ofWO 98/48014
Cancer marker, encoding gene sequences, immunogenic fragments, analogs; for therapeutics.
LillyEPO 875 578
Penicillin binding protein
Staphylococcus aureus penicillin binding protein, encoding gene, derivatives; for combatting methicillin resistance.
Lindahl, U., et al.WO 98/48006
Gene for mammalian glucuronyl C5-epimerase, encoded protein, production process, transfected cell lines.
MBH Biotech Res. Inst.WO 98/48026
Bacterial oral immunization
Attenuated Salmonella with Listeria virulence factors; for oral immunization against transfected gene products.
Minnesota, Univ. ofWO 98/48022
Human complement C3-degrading proteinase expressed by Streptococcus pneumoniae, encoding gene sequences.
Pluckthun, A.WO 98/48008
Identification of nucleic acids encoding polypeptides that interact with target protein molecules.
QiagenEPO 875 271
Nucleic acid isolation
Methods for isolating nucleic acids from cells using columns and filtration [in German].
Mammalian cytokines, encoding gene sequences, fragments, antibodies; for diagnostics and therapeutics.
Singapore, Natl. Univ. ofEPO 875 576
Bst DNA polymerase
Bacillus sterothermophilus (Bst) DNA polymerase and mutants with reduced 3' to 5' exonuclease activity, encoding genes.
SmithKline BeechamEPO 875 565 & 566
G protein-coupled receptors
G protein-coupled receptor polypeptides, encoding gene sequences, production methods; for therapeutics.
SmithKline BeechamEPO 875 568
Human neurotensin receptor type 2, encoding gene sequences, splice variants, production methods; for therapeutics.
SmithKline BeechamEPO 875 569
Sodium-dependent phosphate transporter
Human sodium-dependent phosphate transporter, encoding gene sequences, production methods; for therapeutics.
SmithKline BeechamEPO 875 570
Neurodegenerative polypeptides, encoding gene sequences, production methods; for therapeutics.
SmithKline BeechamEPO 875 571-573
Chronic renal failure genes
Chronic renal failure gene polypeptides, encoding gene sequences, production methods; for therapeutics.
SmithKline BeechamEPO 875 577
Membrane-type matrix metalloproteinase polypeptides, encoding gene sequences; for therapeutics.
Tanzi, R.E., et al.WO 98/47917
Presenilin C-terminal fragment
Presenilin 2 C-terminal fragment, encoding gene sequences, antibodies; for finding presenilin proteolysis inhibitors.
Vlaams Inst. Biotechnol.WO 98/48025
Inducible gene expression
Inducible expression of genes having lambdoid promoters; for production of heterologous proteins.
Voerman, G.EPO 875 564
Anticoagulants and fibrinolytics derived from leeches, genetically engineered forms; for therapeutics.
Washington, Univ. ofWO 98/48005
Homologous recombination vectors
Parvoviruses, including adeno-associated viruses, that can target specific gene loci by homologous pairing.
Wistar Inst.WO 98/48004
Gene product sequence flanked by intron sequences; for stabilizing unstable mRNAs, thus enhancing expression.