Company, Symbol, 12/31/97*, 3/31/98, 6/30/98, 12/31,98, %YTD

Aastrom Biosci, ASTM, 4.375, 4.500, 3.750, 2.125, 2.875, -34

Abgenix, ABGX, 8.000, ——-, ———, 7.125, 16.250, 103

Adv Magnetics, AVM, 8.750, 13.062, 11.312, 7.500, 7.312, -16

Adv Poly Sys, APOS, 6.625, 8.625, 7.000, 5.437, 5.375, -19

Adv Tissue Sci, ATIS, 12.375, 9.343, 4.437, 3.031, 2.593, -79

Affymetrix, AFFX, 31.125, 34.812, 24.062, 25.750, 24.375, -22

Agouron, AGPH, 29.375, 37.875, 30.312, 34.437, 58.750, 100

Agritope, AGTO, 7.000, 4.500, 4.000, 1.375, 1.312, -81

Alexion Pharma, ALXN, 12.500, 12.375, 10.000, 9.250, 13.375, 7

Alkermes, ALKS, 19.875, 24.875, 17.875, 14.562, 22.187, 12

Allelix, AXB*, 11.500, 9.000, 8.000, 3.350, 4.190, -64

Alliance, ALLP, 7.250, 7.562, 4.187, 3.062, 3.281, -55

Alpha Beta, ABTI, 2.593, 2.125, 2.437, 1.343, 0.687, -74

AltaRex, AXO*, 3.000, 2.260, 1.050, 0.780, 0.460, -85

Alteon, ALTN, 7.312, 5.062, 3.500, 3.000, 0.781, -89

Alza, AZA, 31.812, 44.812, 43.250, 43.375, 52.250, 64

Am Bio Sci, MABXA, 1.906, 1.750, 1.156, 0.406, 0.750, -61

Amarillo Biosci, AMAR, 5.500, 3.250, 2.750, 2.000, 1.250, -77

AMBI Inc., AMBI, 1.937, 2.187, 1.406, 0.781, 1.062, -45

Amgen, AMGN, 54.125, 60.875, 65.375, 75.562, 104.562, 93

Amylin, AMLN, 5.437, 2.750, 3.781, 3.187, 0.500, -91

Anergen, ANRG, 2.125, 1.062, 1.937, 1.187, 0.406, -81

Anesta, NSTA, 16.375, 18.625, 14.437, 18.625, 26.625, 63

Angiotech Pharma, ANP*, 10.000, 16.500, 14.750, 9.000, 13.000, 30

Aphton, APHT, 10.125, 12.687, 16.625, 11.750, 12.750, 26

Aquila Biopharma, AQLA, 4.187, 7.125, 4.187, 2.875, 3.875, -7

Aradigm, ARDM, 8.500, 12.625, 13.562, 10.000, 12.500, 47

Ariad Pharm, ARIA, 4.250, 4.625, 3.562, 2.750, 1.687, -60

Aronex Pharma, ARNX, 4.250, 3.562, 3.937, 2.625, 2.000, -53

ArQule, ARQL, 22.937, 22.250, 12.937, 7.500, 4.937, -78

Atlantic Pharma, ATLC, 6.750, 6.500, 3.812, 1.750, 1.500, -78

Atrix Labs, ATRX, 14.750, 19.000, 13.375, 12.625, 8.875, -40

Aurora Bioscience, ABSC, 13.125, 11.500, 5.875, 6.000, 6.437, -51

AutoImmune, AIMM, 3.312, 2.312, 2.562, 1.875, 2.250, -32

Avanir Pharma (1), AVNR, 2.375, 1.781, 1.500, 1.125, 0.656, -72

Avant Immuno, AVAN, 2.437, 2.938, 2.500, 1.375, 1.750, -28

Avax Technologies, AVXT, 3.687, 4.250, 2.437, 1.750, 2.500, -32

AVI BioPharma, AVII, 6.812, 7.125, 6.250, 3.375, 4.000, -41

Avigen, AVGN, 2.250, 2.437, 3.500, 2.750, 7.812, 247

Aviron, AVIR, 27.125, 23.125, 31.187, 15.437, 25.875, -5

Axogen, AXG/U, 39.750, 57.000, 63.000, 69.250, 66.000, 66

Axys Pharma, AXPH, 8.375, 8.750, 7.125, 4.375, 5.875, -30

Bio-Tech Gen, BTGC, 10.750, 8.500, 7.093, 6.625, 6.937, -35

Biochem Pharma, BCHE, 20.875, 24.187, 26.500, 18.375, 28.625, 37

BioCryst, BCRX, 7.000, 7.500, 7.812, 7.000, 7.000, 0

Biogen, BGEN, 36.375, 48.187, 49.000, 65.812, 83.000, 128

Bioject, BJCT, 1.281, 1.500, 1.812, 1.562, 1.343, 5

Biomatrix, BXM, 30.000, 29.875, 41.000, 39.000, 58.250, 94

Biomira, BIOMF, 2.125, 2.500, 2.250, 1.531, 3.093, 46

Biora AB, BIORY, 20.750, 25.000, 26.500, 20.875, 13.000, -37

Bioreliance, BREL, 23.000, 16.500, 15.062, 10.500, 8.000, -65

Biotime, BTIM, 19.000, 14.250, 6.250, 9.000, 17.375, -9

BioTransplant, BTRN, 5.750, 4.250, 3.500, 1.500, 2.500, -57

Boston Life, BLSI, 2.281, 2.125, 3.125, 2.968, 3.250, 42

British Biotech, BBIOY, 16.625, 12.250, 6.375, 5.750, 5.875, -65

Cadus Pharma, KDUS, 6.375, 8.312, 7.750, 2.812, 1.937, -70

Calypte Biomed, CALY, 3.875, 5.187, 4.031, 1.750, 2.875, -26

Cambridge Neuro, CNSI, 1.968, 2.312, 0.593, 0.531, 0.718, -64

Cantab Pharm, CNTBY, 11.750, 13.573, 12.125, 10.125, 9.625, -18

Carrington, CARN, 4.312, 4.437, 4.812, 3.250, 2.125, -51

Cel-Sci, HIV, 6.625, 4.625, 4.937, 2.625, 1.750, -74

Celgene, CELG, 8.437, 10.875, 10.625, 9.812, 15.375, 82

Cell Genesys, CEGE, 8.500, 6.625, 8.562, 3.187, 6.000, -29

Cell Pathways (2), CLPA, 16.500, ————, ———-, ———-, 22.000, 33

Cell Therapeutics, CTIC, 17.000, 4.125, 2.687, 2.125, 3.000, -82

Cellegy Pharma, CLGY, 8.375, 7.125, 5.562, 4.125, 3.500, -58

Celtrix, CTRX, 1.812, 2.812, 2.062, 1.000, 1.687, -7

Centocor, CNTO, 33.250, 44.625, 36.250, 39.625, 45.125, 36

Cephalon, CEPH, 11.375, 14.000, 7.875, 7.312, 9.000, -21

Chiron, CHIR, 17.000, 20.937, 15.687, 19.875, 26.187, 54

Cholestech, CTEC, 12.500, 15.000, 6.750, 4.687, 3.812, -70

Chrysalis Intl, CRLS, 2.156, 3.000, 1.375, 0.812, 0.562, -74

CIMA Labs, CIMA, 4.250, 4.968, 3.343, 2.875, 2.625, -38

CliniChem Devlp, CCHE, 8.375, ——, 5.750, 4.687, 4.812, -43

ClinTrials, CCRO, 7.875, 7.125, 4.875, 4.750, 3.937, -50

CoCensys, COCN, 3.437, 3.062, 2.500, 2.031, 0.312, -91

Collab. Clin. Res, CCLR, 5.062, 4.250, 4.125, 2.812, 4.000, -21

CollaGenex, CGPI, 12.500, 9.343, 8.625, 13.250, 9.625, -23

Collateral Thera, CLTX, 7.250, ——-, ————, 6.000, 7.000, -3

Columbia Labs, COB, 16.250, 13.812, 5.750, 3.750, 3.062, -81

CombiChem, CCHM, 8.000, ————-, 6.937, 4.000, 4.312, -46

Connetics Corp., CNCT, 3.062, 5.312, 3.812, 3.687, 5.875, 92

Cor Thera, CORR, 22.500, 12.375, 13.875, 7.750, 13.250, -41

Corixa, CRXA, 8.937, 7.375, 6.875, 6.125, 9.250, 4

Cortecs Intl, DLVRY, 14.250, 14.375, 7.375, 3.500, 0.843, -94

Cortex, CORX, 1.500, 1.750, 1.875, 1.312, 0.656, -56

Corvas, CVAS, 3.875, 5.000, 4.125, 2.062, 2.812, -27

Coulter Pharma, CLTR, 20.250, 27.375, 30.375, 24.875, 30.000, 48

Creative Bio, CBMI, 7.375, 8.250, 4.812, 3.000, 3.687, -50

Crescendo Pharma, CNDO, 11.562, 12.625, 12.687, 13.187, 13.625, 18

Cubist Pharma, CBST, 5.812, 4.500, 4.750, 2.437, 3.812, -34

Curagen Corp., CRGN, 11.500, 11.562, 6.250, 6.000, 7.062, -39

CV Therapeutics, CVTX, 9.375, 9.500, 8.625, 5.750, 4.750, -49

Cyanotech, CYAN, 2.781, 3.437, 3.125, 1.687, 1.062, -62

Cygnus, CYGN, 19.875, 16.500, 10.437, 3.500, 4.875, -75

Cypress Bio, CYPB, 1.437, 2.625, 2.968, 2.765, 3.000, 109

Cypros Pharma, CYP, 4.250, 3.812, 4.062, 2.812, 3.250, -24

Cytel(3), CYTL, 10.500, 12.469, 9.625, 6.125, 2.250, -79

Cytoclonal Pharma, CYPH, 6.875, 10.250, 7.000, 6.250, 6.875, 0

Cytogen, CYTO, 1.625, 2.156, 0.781, 0.812, 0.843, -48

CytoTherapeut, CTII, 4.000, 3.375, 1.250, 0.937, 1.468, -63

CytRx, CYTR, 2.937, 3.375, 2.125, 0.906, 0.968, -67

DepoMed(4), DMI, 4.250, 12.375, 10.250, 8.750, 7.875, 85

DepoTech, DEPO, 3.562, 6.000, 1.562, 1.062, 2.312, -35

Diacrin, DCRN, 10.125, 9.750, 6.250, 7.281, 5.937, -41

Diagnostic Prod, DP, 27.750, 27.875, 28.812, 26.687, 31.125, 12

Dianon Systems, DIAN, 9.375, 9.750, 9.250, 6.125, 9.000, -4

Diatide, DITI, 9.125, 10.750, 8.750, 6.875, 7.250, -21

Digene, DIGE, 8.625, 8.875, 9.750, 7.250, 5.562, -36

Discovery Labs, DSCO, 4.000, 4.750, 4.250, 2.375, 2.625, -34

DNAP Holding, DNAP, 4.859, 4.000, 4.187, 3.625, 3.500, -28

Draxis Health, DRAXF, 3.062, 2.906, 2.562, 1.812, 2.859, -7

Dura Pharm, DURA, 45.875, 24.625, 22.375, 10.937, 15.187, -67

Dusa Pharma, DUSA, 11.500, 15.500, 6.812, 3.562, 7.375, -36

Ecogen, EECN, 1.937, 2.687, 2.625, 1.312, 1.687, -13

Elan, ELN, 51.187, 64.625, 64.312, 72.062, 69.937, 37

Embrex, EMBX, 5.312, 5.750, 6.187, 4.562, 5.000, -6

Emisphere, EMIS, 18.625, 17.875, 12.062, 7.875, 15.625, -16

Endorex, DOR, 5.500, 6.187, 4.250, 2.375, 2.062, -63

EntreMed, ENMD, 11.312, 12.812, 33.250, 24.125, 21.000, 86

Envirogen(5), ENVG, 9.000, 7.500, 7.500, 3.000, 1.375, -85

Enzo Biochem, ENZ, 14.625, 15.750, 13.375, 7.000, 10.312, -29

Enzon, ENZN, 5.500, 6.875, 6.375, 6.625, 13.312, 142

Epitope, EPTO, 5.000, 6.875, 6.500, 3.750, 5.875, 17

Epix Medical, EPIX, 13.000, 13.187, 10.250, 9.562, 9.312, -28

Ergo Science, ERGO, 15.250, 15.062, 3.562, 3.250, 1.000, -93

Ethical Hldgs, ETHCY, 3.125, 3.000, 0.375, 0.156, 3.562, 14

Flamel Tech, FLMLY, 1.812, 5.125, 5.000, 2.875, 4.375, 141

GalaGen, GGEN, 1.875, 1.625, 3.062, 1.812, 2.156, 15

GelTex, GELX, 26.500, 27.000, 18.625, 21.125, 22.625, -15

Gene Logic, GLGC, 8.000, 7.625, 7.000, 3.937, 6.968, -13

Genelabs, GNLB, 2.812, 4.000, 3.000, 2.312, 2.750, -2

GeneMedicine, GMED, 5.062, 2.875, 3.125, 2.437, 2.375, -53

Genentech, GNE, 60.625, 70.437, 67.875, 71.875, 79.687, 31

Genetronics, GEB*, 3.094, 3.550, 3.600, 4.300, 5.050, 63

Genome Thera, GENE, 6.312, 8.625, 4.500, 2.125, 2.750, -56

Genset, GENXY, 19.750, 29.000, 29.375, 25.750, 27.625, 40

Gensia Sicor, GNSA, 5.812, 5.000, 4.000, 4.062, 4.531, -22

Genta, GNTA, 0.781, 0.968, 1.343, 0.937, 1.281, 64

Genz Mol Oncol (6), GZMO, 7.750, ————, ———-, ———-, 3.250, -58

Genz Tiss Repair, GENZL, 6.875, 8.625, 6.562, 3.000, 2.250, -67

Genzyme, GENZ, 27.750, 32.000, 25.562, 36.125, 49.750, 79

Genzyme Trans, GZTC, 9.625, 11.562, 7.750, 4.000, 5.625, -42

Geron, GERN, 8.250, 12.375, 9.375, 6.125, 10.875, 32

Gilead Sciences, GILD, 38.250, 36.000, 32.062, 21.625, 41.062, 7

Gliatech, GLIA, 10.250, 12.125, 16.125, 16.125, 30.000, 193

Guilford Pharm, GLFD, 20.125, 22.000, 17.625, 14.000, 14.250, -29

Hemosol, HML*, 2.188, 1.797, 2.980, 2.500, 2.800, 28

Human Genome, HGSI, 39.750, 39.812, 35.687, 30.000, 35.562, -11

Hycor Bio, HYBD, 1.562, 1.750, 2.000, 1.750, 1.046, -33

Hyseq, HYSQ, 9.625, 12.500, 10.812, 5.437, 5.250, -45

Icon plc, ICLRY, 18.000, ———, 25.250, 32.625, 33.500, 86

Icos, ICOS, 18.312, 15.250, 19.125, 17.750, 29.750, 62

ID Biomed, IDB*, 3.400, 5.150, 6.050, 4.000, 3.070, -10

IDEC Pharm, IDPH, 34.375, 44.250, 23.562, 23.750, 47.000, 37

Idexx Labs, IDXX, 15.937, 18.000, 24.875, 23.875, 26.906, 69

Igen, IGEN, 13.250, 42.375, 40.875, 28.250, 30.625, 131

ILEX Oncology, ILXO, 7.375, 10.125, 9.875, 8.687, 11.125, 51

ImClone Sys, IMCL, 8.125, 8.312, 12.250, 8.750, 9.062, 12

Immucell, ICCC, 2.468, 1.937, 2.187, 1.937, 1.250, -49

Immucor, BLUD, 8.625, 9.625, 8.687, 9.750, 8.750, 1

ImmuLogic, IMUL, 1.875, 1.656, 1.625, 1.406, 1.218, -35

Immune Resp, IMNR, 11.125, 9.812, 15.000, 11.500, 10.875, -2

Immunex, IMNX, 54.000, 67.375, 66.250, 55.375, 125.812, 133

ImmunoGen, IMGN, 0.843, 1.687, 1.750, 1.312, 2.187, 159

Immunomed, IMMU, 3.625, 5.062, 4.437, 3.500, 4.125, 14

Incyte Pharm, INCY, 45.000, 46.750, 34.125, 21.250, 37.375, -17

Inhale Ther Sys, INHL, 26.000, 27.125, 24.750, 28.000, 33.000, 27

InKine Pharma, INKP, 1.375, 1.343, 1.281, 0.937, 1.687, 23

InSite Vision, ISV, 3.250, 3.375, 3.375, 1.937, 1.250, -62

Integra LifeScien, IART, 8.875, 8.875, 7.000, 4.687, 3.375, -62

Intercardia, ITRC, 17.875, 20.375, 10.000, 3.625, 9.000, -50

Interferon Sci, IFSC, 8.687, 7.125, 1.156, 0.625, 0.437, -95

Interneuron, IPIC, 9.500, 10.437, 3.625, 3.000, 3.281, -65

Isis Pharm, ISIP, 12.312, 15.250, 13.687, 11.375, 12.937, 5

La Jolla Pharm, LJPC, 4.437, 3.875, 3.500, 2.875, 4.500, 1

LeukoSite, LKST, 10.937, 9.250, 7.375, 7.500, 10.062, -8

Life Tech, LTEK, 33.250, 38.500, 31.375, 33.375, 38.875, 17

Lifecell, LIFC, 4.625, 5.093, 6.125, 3.937, 4.375, -5

Lifecore Bio, LCBM, 21.875, 23.375, 16.500, 7.500, 10.250, -53

Ligand, LGND, 12.875, 15.937, 12.875, 9.125, 11.625, -10

Liposome Co, LIPO, 4.625, 5.562, 5.406, 5.687, 15.437, 234

LJL Biosystems, LJLB, 7.000, 7.062, 4.875, 2.500, 3.125, -55

LXR Biotech, LXR, 2.375, 3.812, 1.937, 1.375, 1.250, -47

Lynx Therapeutics, LYNX, 16.250, 10.000, 9.375, 8.125, 11.500, -29