Published Oct. 21 (EPO); Oct. 15 (WO)

A+ Science InvestWO 98/44785, 44786, & 44787

CNS hypoxia transgenics

Goteborg, Sweden

Transgenics animals lacking functional intermediate filament genes; for studying hypoxic edema in the nervous system.

A+ Science InvestWO 98/45464 & 45465

Complement transgenics

Goteborg, Sweden

Transgenic animals having modifications in complement genes; for studying complement activation.

Akzo NobelEPO 872 486

Coccidiosis vaccines

Arnhem, Netherlands

Eimeria proteins isolated from a detergent hydrophilic phase; for use in preparing coccidiosis vaccines.

Amylin PharmaWO 98/45313

Obesity therapeutics

San Diego

Uncoupling protein expressed in skeletal muscle and brown adipose tissue, encoding gene; for obesity therapeutics.

Angeletti Molec. Biol. Res. Inst.WO 98/45462

Adeno-associated virus vectors

Pomezia, Italy

Adeno-associated virus vectors having inserted transgenes; for gene therapy.

Banyu PharmaWO 98/45431

Cancer metastasis gene

Tokyo

Isolation of a cancer metastasis-associated gene using differential display methods; for diagnostics/therapeutics.

BayerEPO 872 487

Factor VIII

Pittsburgh

Preparation of recombinant Factor VIII in a protein-free, completely defined cell culture medium

Beth Israel Deaconess Med. Ctr.WO 98/45438

Uncoupling protein

Boston

Uncoupling protein, fragments, encoding gene sequences, modulators; for therapeutics.

Bio MerieuxWO 98/45449

RNA quantification

Marcy l'Etoile, France

Mutated RNA polymerase that transcribes from an RNA matrix; for quantification of RNA.

Boehringer MannheimWO 98/45428

Fanconi anemia gene

Mannheim, Germany

Pathophysiologically-relevant Fanconi anemia-associated gene, encoded protein, antibodies; for diagnostics/therapeutics.

California, Univ. ofWO 98/45414

Infectious retroviral particles

La Jolla, Calif.

Infectious retroviral particles lacking the env protein that are produced from non-infectious particles.

California, Univ. ofWO 98/45423

Transcription factor modulators

Oakland, Calif.

Tethering a transcriptional coactivator to a DNA binding protein and a transcription factor; for modulator screens.

California, Univ. ofWO 98/45444

Chimeric immunogens

La Jolla, Calif.

Chimeric proteins acting as immunogens; encoding gene sequences; for inducing immune response.

Chang, L.-J.WO 98/44788

HIV vaccine animal model

Gainesville, Fla.

Humanized animal model systems; for studying the effects of HIV vaccines.

Chernajovsky, Y., et al.WO 98/45430

Soluble complement receptor 1

London

Soluble complement receptor 1, encoding gene sequences; for inhibiting B and T cell immune responses.

Daiichi PharmaWO 98/45463

Gene transfection facilitator

Tokyo

Substituted quaternary ammonium salt; for aiding in the transfection of genes.

DiagnocureWO 98/45420

Prostate-specific antigens

Ste-Foy, Que.

Prostate-specific antigens, encoding gene sequences, antibodies; for diagnostics and therapeutics.

EikenEPO 872 558

Amyloid A antibodies

Tokyo

Monoclonal antibodies to human serum amyloid A protein; for immunoassays.

French Atomic Energy Comm.WO 98/45454

Prolyl-peptidase activity

Paris

Modified recombinant cyclophilin with prolyl-peptidase activity, production methods.

GenentechWO 98/45427

IGF agonists

S. San Francisco

Insulin-like growth factor (IGF) agonists that interact with IGF but do not bind its receptor; for increasing serum IGF.

Genetics Inst.WO 98/45435, 45436, & 45437

Secreted ESTs

Cambridge, Mass.

Secreted expressed sequence tags (ESTs) that are isolated from a variety of human tissue sources.

GeronWO 98/45450

Telomerase purification

Menlo Park, Calif.

Affinity purification of human telomerase using charged matrix materials.

Glasgow, Univ. ofWO 98/45421

Hepatitis B diagnosis

Glasgow, U.K.

Hepatitis B mutated genes, encoded proteins; for detection and diagnosis.

Hoffmann-La RocheEPO 872 561

Gonorrhea diagnosis

Basel, Switzerland

Oligos to the cytosine DNA methyltransferase gene of Neisseria gonorrhoeae; for PCR-based diagnostics.

Human Gene Therapy Res. Inst.WO 98/45443

Radioisotope concentration

Des Moines, Iowa

Genetic engineering methods designed to concentrate radioisotopes in cells; for radiation therapy.

Human Genome SciencesWO 98/45712

20 secreted proteins

Rockville, Md.

20 human secreted proteins, encoding gene sequences, antibodies, production methods; for therapeutics.

Immune ResponseWO 98/44945

Non-infectious HIV

Carlsbad, Calif.

Non-infectious, protease-defective HIV particles, fragments, encoding DNA; for diagnostics and therapeutics.

Incyte PharmaWO 98/45416

Thioredoxin-like protein

Palo Alto, Calif.

Thioredoxin-like protein, encoding gene sequences, antibodies, modulators; for therapeutics.

Incyte PharmaWO 98/45439

Tumor-associated membrane protein

Palo Alto, Calif.

Human tumor-associated membrane protein, encoding gene sequences, antibodies, antagonists; for therapeutics,

Incyte PharmaWO 98/45440

Fatty acid binding protein

Palo Alto, Calif.

Human fatty acid binding protein, encoding gene sequences, antibodies, antagonists; for therapeutics.

Incyte PharmaWO 98/45441

GTP binding protein

Palo Alto, Calif.

Human GTP binding protein, encoding gene sequences, antibodies, antagonists; for therapeutics.

INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/45422

Diabetes transgenics

Paris

Transgenics having deleted insulin genes; for assessing diabetes therapeutics.

Laval Univ.WO 98/45419

Therapeutics from semen

Quebec City

Transgenic animals having genes expressed in their genital tracts; for producing recombinant proteins in semen.

LeaddEPO 872 552

Apoptosis-inducing protein

Leiden, Netherlands

Apoptosis-inducing proteins from chicken anemia virus, encoding gene sequences; for treating tumor cells.

LillyEPO 872 485 & WO 98/45426

Fungal IPC synthase genes

Indianapolis

Fungal IPC synthase genes, vectors, transformed cells; for identifying inhibitors.

MerckWO 98/44939

Cytochrome P450 3A4 antibodies

Rahway, N.J.

Antibodies against peptide fragments of cytochrome P450 3A4; for inhibiting biological activity.

Michigan St. Univ.WO 98/45417

Hyperthermostable alpha-amylase

Lansing, Mich.

Hyperthermostable extracellular alpha-amylase isolated from Pyrococcus furiosis, encoding gene sequences.

Millennium BiotherapeuticsWO 98/45434

Delta3 proteins

Cambridge, Mass.

Human delta3 proteins, encoding gene sequences, antibodies; for modulating cell growth and differentiation.

Millennium PharmaWO 98/45467

TGF-signalling pathway genes

Cambridge, Mass.

Genes involved in the TGF-beta signalling pathway, encoded proteins, antibodies, antisense, transgenics.

MindsetWO 98/44955

Alzheimer's therapeutic antibodies

Old Katamon, Israel

Recombinant antibody against beta-amyloid peptide, encoding gene sequences; for Alzheimer's therapeutics.

NASA (Natl. Aeron. Space Admin.)WO 98/45468

Shear stress genes

Washington

Cell types co-cultured in a three-dimensional bioreactor; for expressing shear stress-induced genes.

NIH (Natl. Inst. Hlth.)EPO 872 553

Encephalitis vaccines

Bethesda, Md.

Chimeric flavivirus having virulence-reducing mutations; for dengue and encephalitis vaccines.

NovartisWO 98/45429

Staurosporine-induced apoptosis

Vienna, Austria

Polypeptides involved in the staurosporine-induced apoptotic pathway, production methods; for diagnostics/therapeutics.

Osiris TherapeuticsWO 98/45326

Hematopoiesis transcription factors

Baltimore

Zinc finger transcription factors involved in hematopoiesis, encoding gene sequences; for therapeutics.

Pittsburgh, Univ. ofWO 98/45432

Renal nuclear matrix proteins

Pittsburgh

Renal nuclear matrix proteins, encoding gene sequences; for monitoring renal cancer.

Rockefeller Univ.WO 98/45452

Chromosomal replicase

New York

DNA polymerase isolated from Thermus thermophilus that functions as a chromosomal replicase, encoding genes.

ShionogiEPO 872 559

Multiple gene detection

Osaka, Japan

Simultaneous detection of multiple genes by making cDNAs and separating them on two-dimensional electrophoresis.

SmithKline BeechamEPO 872 550

Human 7-transmembrane receptor

Philadelphia

Human 7-transmembrane receptor HACCH94, encoding gene sequences, production methods; for therapeutics.

Southern California, Univ. ofWO 98/44938

ECM-targeting virions

Los Angeles

Virions having extracellular matrix (ECM)-binding proteins expressed on their surfaces; for targeting therapeutics.

SRLEPO 872 560

Frameshift mutation detection

Tokyo

Insertion of genes into vectors having reporter genes downstream; for detecting frameshift mutations.

Sumitomo ElectricEPO 872 488

Fas ligand antibodies

Osaka, Japan

Monoclonal antibodies against Fas ligand, hybridomas; for detection in biological samples.

Sumitomo ElectricEPO 872 555

Bacterial protein display library

Osaka, Japan

Recombinant fusion proteins expressed on bacterial surfaces; for constructing protein display libraries.

Texas, Univ. ofWO 98/45433

Mitosis modulator

Austin, Texas

Human gene encoding a protein that is critical for mitosis and has leucine heptad repeats; for modulating mitosis.

UnileverWO 98/45455

Proteins from fungi

Rotterdam, Netherlands

Agrobacterium-mediated transformation of fungi; for expressing and producing recombinant proteins.

ZymogeneticsWO 98/45442

Secreted F-spondin homologs

Seattle

Secreted F-spondin homologs expressed in prostate tissue, encoding gene sequences, antibodies; for diagnosis.