Published Oct. 21 (EPO); Oct. 15 (WO)
A+ Science InvestWO 98/44785, 44786, & 44787
CNS hypoxia transgenics
Transgenics animals lacking functional intermediate filament genes; for studying hypoxic edema in the nervous system.
A+ Science InvestWO 98/45464 & 45465
Transgenic animals having modifications in complement genes; for studying complement activation.
Akzo NobelEPO 872 486
Eimeria proteins isolated from a detergent hydrophilic phase; for use in preparing coccidiosis vaccines.
Amylin PharmaWO 98/45313
Uncoupling protein expressed in skeletal muscle and brown adipose tissue, encoding gene; for obesity therapeutics.
Angeletti Molec. Biol. Res. Inst.WO 98/45462
Adeno-associated virus vectors
Adeno-associated virus vectors having inserted transgenes; for gene therapy.
Banyu PharmaWO 98/45431
Cancer metastasis gene
Isolation of a cancer metastasis-associated gene using differential display methods; for diagnostics/therapeutics.
BayerEPO 872 487
Preparation of recombinant Factor VIII in a protein-free, completely defined cell culture medium
Beth Israel Deaconess Med. Ctr.WO 98/45438
Uncoupling protein, fragments, encoding gene sequences, modulators; for therapeutics.
Bio MerieuxWO 98/45449
Marcy l'Etoile, France
Mutated RNA polymerase that transcribes from an RNA matrix; for quantification of RNA.
Boehringer MannheimWO 98/45428
Fanconi anemia gene
Pathophysiologically-relevant Fanconi anemia-associated gene, encoded protein, antibodies; for diagnostics/therapeutics.
California, Univ. ofWO 98/45414
Infectious retroviral particles
La Jolla, Calif.
Infectious retroviral particles lacking the env protein that are produced from non-infectious particles.
California, Univ. ofWO 98/45423
Transcription factor modulators
Tethering a transcriptional coactivator to a DNA binding protein and a transcription factor; for modulator screens.
California, Univ. ofWO 98/45444
La Jolla, Calif.
Chimeric proteins acting as immunogens; encoding gene sequences; for inducing immune response.
Chang, L.-J.WO 98/44788
HIV vaccine animal model
Humanized animal model systems; for studying the effects of HIV vaccines.
Chernajovsky, Y., et al.WO 98/45430
Soluble complement receptor 1
Soluble complement receptor 1, encoding gene sequences; for inhibiting B and T cell immune responses.
Daiichi PharmaWO 98/45463
Gene transfection facilitator
Substituted quaternary ammonium salt; for aiding in the transfection of genes.
Prostate-specific antigens, encoding gene sequences, antibodies; for diagnostics and therapeutics.
EikenEPO 872 558
Amyloid A antibodies
Monoclonal antibodies to human serum amyloid A protein; for immunoassays.
French Atomic Energy Comm.WO 98/45454
Modified recombinant cyclophilin with prolyl-peptidase activity, production methods.
S. San Francisco
Insulin-like growth factor (IGF) agonists that interact with IGF but do not bind its receptor; for increasing serum IGF.
Genetics Inst.WO 98/45435, 45436, & 45437
Secreted expressed sequence tags (ESTs) that are isolated from a variety of human tissue sources.
Menlo Park, Calif.
Affinity purification of human telomerase using charged matrix materials.
Glasgow, Univ. ofWO 98/45421
Hepatitis B diagnosis
Hepatitis B mutated genes, encoded proteins; for detection and diagnosis.
Hoffmann-La RocheEPO 872 561
Oligos to the cytosine DNA methyltransferase gene of Neisseria gonorrhoeae; for PCR-based diagnostics.
Human Gene Therapy Res. Inst.WO 98/45443
Des Moines, Iowa
Genetic engineering methods designed to concentrate radioisotopes in cells; for radiation therapy.
Human Genome SciencesWO 98/45712
20 secreted proteins
20 human secreted proteins, encoding gene sequences, antibodies, production methods; for therapeutics.
Immune ResponseWO 98/44945
Non-infectious, protease-defective HIV particles, fragments, encoding DNA; for diagnostics and therapeutics.
Incyte PharmaWO 98/45416
Palo Alto, Calif.
Thioredoxin-like protein, encoding gene sequences, antibodies, modulators; for therapeutics.
Incyte PharmaWO 98/45439
Tumor-associated membrane protein
Palo Alto, Calif.
Human tumor-associated membrane protein, encoding gene sequences, antibodies, antagonists; for therapeutics,
Incyte PharmaWO 98/45440
Fatty acid binding protein
Palo Alto, Calif.
Human fatty acid binding protein, encoding gene sequences, antibodies, antagonists; for therapeutics.
Incyte PharmaWO 98/45441
GTP binding protein
Palo Alto, Calif.
Human GTP binding protein, encoding gene sequences, antibodies, antagonists; for therapeutics.
INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/45422
Transgenics having deleted insulin genes; for assessing diabetes therapeutics.
Laval Univ.WO 98/45419
Therapeutics from semen
Transgenic animals having genes expressed in their genital tracts; for producing recombinant proteins in semen.
LeaddEPO 872 552
Apoptosis-inducing proteins from chicken anemia virus, encoding gene sequences; for treating tumor cells.
LillyEPO 872 485 & WO 98/45426
Fungal IPC synthase genes
Fungal IPC synthase genes, vectors, transformed cells; for identifying inhibitors.
Cytochrome P450 3A4 antibodies
Antibodies against peptide fragments of cytochrome P450 3A4; for inhibiting biological activity.
Michigan St. Univ.WO 98/45417
Hyperthermostable extracellular alpha-amylase isolated from Pyrococcus furiosis, encoding gene sequences.
Millennium BiotherapeuticsWO 98/45434
Human delta3 proteins, encoding gene sequences, antibodies; for modulating cell growth and differentiation.
Millennium PharmaWO 98/45467
TGF-signalling pathway genes
Genes involved in the TGF-beta signalling pathway, encoded proteins, antibodies, antisense, transgenics.
Alzheimer's therapeutic antibodies
Old Katamon, Israel
Recombinant antibody against beta-amyloid peptide, encoding gene sequences; for Alzheimer's therapeutics.
NASA (Natl. Aeron. Space Admin.)WO 98/45468
Shear stress genes
Cell types co-cultured in a three-dimensional bioreactor; for expressing shear stress-induced genes.
NIH (Natl. Inst. Hlth.)EPO 872 553
Chimeric flavivirus having virulence-reducing mutations; for dengue and encephalitis vaccines.
Polypeptides involved in the staurosporine-induced apoptotic pathway, production methods; for diagnostics/therapeutics.
Osiris TherapeuticsWO 98/45326
Hematopoiesis transcription factors
Zinc finger transcription factors involved in hematopoiesis, encoding gene sequences; for therapeutics.
Pittsburgh, Univ. ofWO 98/45432
Renal nuclear matrix proteins
Renal nuclear matrix proteins, encoding gene sequences; for monitoring renal cancer.
Rockefeller Univ.WO 98/45452
DNA polymerase isolated from Thermus thermophilus that functions as a chromosomal replicase, encoding genes.
ShionogiEPO 872 559
Multiple gene detection
Simultaneous detection of multiple genes by making cDNAs and separating them on two-dimensional electrophoresis.
SmithKline BeechamEPO 872 550
Human 7-transmembrane receptor
Human 7-transmembrane receptor HACCH94, encoding gene sequences, production methods; for therapeutics.
Southern California, Univ. ofWO 98/44938
Virions having extracellular matrix (ECM)-binding proteins expressed on their surfaces; for targeting therapeutics.
SRLEPO 872 560
Frameshift mutation detection
Insertion of genes into vectors having reporter genes downstream; for detecting frameshift mutations.
Sumitomo ElectricEPO 872 488
Fas ligand antibodies
Monoclonal antibodies against Fas ligand, hybridomas; for detection in biological samples.
Sumitomo ElectricEPO 872 555
Bacterial protein display library
Recombinant fusion proteins expressed on bacterial surfaces; for constructing protein display libraries.
Texas, Univ. ofWO 98/45433
Human gene encoding a protein that is critical for mitosis and has leucine heptad repeats; for modulating mitosis.
Proteins from fungi
Agrobacterium-mediated transformation of fungi; for expressing and producing recombinant proteins.
Secreted F-spondin homologs
Secreted F-spondin homologs expressed in prostate tissue, encoding gene sequences, antibodies; for diagnosis.