Published October 7 (EPO); October 1 (WO)

Becton DickinsonEPO 869 187

Amplification efficiency increases

Franklin Lakes, N.J.

Single-stranded DNA binding proteins that increase efficiency of strand-displacement replication during amplification.

BiocineEPO 869 181

Immunogenic intestinal bacteria toxins

Siena, Italy

Immunogenic detoxified cholera toxin and E. coli heat labile toxin; for treating toxic intestinal bacterial strains.

BionebraskaWO 98/42822

Chlorella virus promoter

Lincoln, Neb.

Chlorella virus promoter sequences, vectors; for linking structural genes and expressing heterologous products.

Boehringer MannheimWO 98/42829

Proteosome purification

Mannheim, Germany

Purification and crystallization of proteosomes; for identifying inhibitors.

Boehringer MannheimWO 98/42871

Subtractive hybridization

Indianapolis

Procedure for subtractive hybridization and genomic difference analysis that reduces amplification cycles.

Brigham & Women's Hosp.WO 98/42752

T cell immunotherapy

Boston

Peptides that bind to CTLA-4 and stimulate T cell proliferation; for immunotherapy.

Bristol-Myers SquibbWO 98/43089

CD6 antibodies

Princeton, N.J.

Monoclonal antibodies to human CD6 that inhibit binding of activated leukocyte adhesion molecule; for inflammation.

Calif. Inst. Technol.WO 98/42728 & 42832

In vitro mutagenesis

Pasadena, Calif.

In vitro mutagenesis and recombination using short DNA fragments having a low level of point mutations.

Canadian Ministry Hlth. & WelfareWO 98/42842

Campylobacter jejuni porin gene

Ottawa

Porin gene from Campylobacter jejuni, encoded protein; for detection and diagnosis of infection.

Case Western Res. Univ.WO 98/42825

Colon cancer model

Cleveland

Transgenics with the human involucrin promoter linked to human papillomavirus oncogenes; for modeling colon cancer.

Case Western Res. Univ.WO 98/42875

Bacterial viability peptide

Cleveland

Oligonucleotide encoding a bacterial polypeptide essential for viability, encoded protein, antibodies; for diagnosis.

CellfactorsWO 98/42824

Cell selection methods

Cambridge, U.K.

Grafts, cells, and tissues for transplantation, transgenics, methods of cell selection.

ChironWO 98/42868

Pathogen vaccines

Siena, Italy

Identification of proline-rich cell surface proteins from pathogenic microorganisms; for vaccines.

Cincinnati, Univ. ofWO 98/42195

Neural tumor gene therapy

Cincinnati

Replication-competent, attenuated herpes simplex with a defective uracil DNA glycosylase gene; for neural tumors.

Columbia Univ.WO 98/42315

Tumor progression gene

New York

Progression Elevated Gene-3 protein, encoding gene sequences; for monitoring tumor progression and identifying modulators.

CorixaWO 98/42740

Granulocytic ehrlichiosis vaccine

Seattle

Ehrlichia antigen polypeptides, encoding gene sequences; for vaccines to treat human granulocytic ehrlichiosis.

Enzo TherapeuticsWO 98/42856

Cell type transfection

New York

Viral vectors and packaging cell lines specifically designed for transfecting specific cell types.

Firth, G.WO 98/42867

Polymorphic marker detection

Hitchin, U.K.

Methods for detection of polymorphic markers of inherited traits at multiple loci by simultaneous genome comparison.

Fuso PharmaWO 98/42843

Detecting Klebsiella infections

Osaka, Japan

Probes to DNA isolated from Klebsiella pneumoniae, for detection and diagnosis of infections.

Fuso PharmaWO 98/42844

Detecting Bacteroides infections

Osaka, Japan

Probes to DNA isolated from Bacteriodes fragilis, for detection and diagnosis of infections

Fuso PharmaWO 98/42845

Detecting Streptococcus infections

Osaka, Japan

Probes to DNA isolated from Streptococcus pyogenes, for detection and diagnosis of infections

Genetics Inst.WO 98/42739 & 42741

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences; for developing therapeutics.

Georgetown Univ.WO 98/43095

Antisense via liposomes

Washington

Delivering antisense oligonucleotides using liposomes; for radiosensitizing tumor cells.

GeronWO 98/42869

DNA primase modulators

Menlo Park, Calif.

DNA primase assays that are suitable for identifying modulators of biological activity.

Hoffmann-La RocheEPO 869 175

Cytochrome c551

Basel, Switzerland

Cytochrome c551, encoding gene sequences, production methods; for making vitamin C.

Human Genome SciencesWO 98/42738

87 human secreted proteins

Rockville, Md.

87 human secreted proteins, encoded genes, antibodies, vectors, production methods; for therapeutics.

ImmunoEPO 869 184

TBE virus infections

Vienna, Austria

TBE viral proteins E and prM/M; for immunization against TBE viral infections using vaccines [in German].

ImmunomedicsWO 98/42378

B cell lymphoma antibodies

Morris Plains, N.J.

Anti-CD22 antibodies; for treating otherwise resistant B cell lymphomas using low-dose and combination therapies.

Incyte PharmaWO 98/42837

Mitochondrial chaperone protein

Palo Alto, Calif.

Human mitochondrial chaperone protein, encoding gene sequences, antibodies, modulators; for treating cancer.

Incyte PharmaWO 98/42839

Human RAB protein

Palo Alto, Calif.

Human RAB protein, encoding gene sequences, antibodies, modulators, production methods; for therapeutics.

Incyte PharmaWO 98/42849

Human kallikrein

Palo Alto, Calif.

Human kallikrein, encoding gene sequences, antibodies, modulators, production methods; for therapeutics.

KanekaEPO 869 176

Arthritis autoantigen diagnostic

Osaka, Japan

Synovial cell cDNA library, genes encoding rheumatoid arthritis autoantigens; for diagnosis and therapy.

Karolinska InnovationsWO 98/42750

Tissue rejection treatment

Stockholm, Sweden

Fusion protein having multiple Gal-alpha1,3-Gal epitopes and immunoglobulin fragments; for treating tissue rejection.

Krebs Res. Inst.WO 98/42847

Papillomavirus capsid vaccines

Heidelberg, Germany

Gene sequences for the main capsid protein of papillomavirus, encoded protein, antibodies; for diagnosis and vaccines.

Kyowa Hakko KogyoWO 98/42744

Protein inhibiting cell death

Tokyo

Cell death-inhibiting IPIA-alpha protein, encoding gene sequences; for treating apoptosis-related diseases.

Leicester, Univ. ofWO 98/42751

LDL uptake inhibitors

Leicester, U.K.

Oxidized fragments of apolipoprotein B, modified forms, analogs; for inhibiting LDL uptake by its receptor.

LillyWO 98/42861

Obesity protein analogs

Indianapolis

Preparation of obesity protein analogs in high yield using a dipeptidylaminopeptidase from the slime mold.

Mayo ClinicWO 98/42846

Granulocytic ehrlichiosis detection

Rochester, Minn.

Gene sequences associated with granulocytic ehrlichiosis, encoded proteins, antibodies; for detection.

MerckEPO 868 920

Bladder cancer toxin

Rahway, N.J.

Chimeric protein having modified Pseudomonas exotoxin and TGF-alpha; for treating bladder cancer.

Millennium PharmaWO 98/42362,42723, 42724, 42726

Neuropsychiatric disorder genes

Cambridge, Mass.

Mammalian fsh genes, encoded proteins, variants, antibodies, modulator screens; for treating neuropsychiatric disorders.

MorphogenesisWO 98/42838

Stem cells for transplantation

Alachua, Fla.

Replacement of histocompatibility genes in stem cells; for preparing antigenically compatible tissues.

NIH (Natl. Inst. Hlth.)EPO 869 177

PDGF receptors

Bethesda, Md.

Human alpha- and beta-platelet-derived growth factor (PDGF) receptors, encoding gene sequences; for immunoassays.

New England BiolabsEPO 869 174

SpeI restriction endonuclease

Beverly, Mass.

Gene sequences encoding SpeI restriction endonuclease, encoded enzyme, production methods.

Nisshin Flour MillingEPO 868 847

Ulcer mouse model

Tokyo

Hairless mouse strain that can be easily infected by Helicobacter pylori; for ulcer etiology studies.

North Carolina, Univ. ofEPO 869 133

Gonorrhea vaccines

Chapel Hill, N.C.

Protein IB of Neisseria gonorrhoea, encoding gene sequences, production methods; for vaccines.

Novo NordiskWO 98/42747

Appetite regulating polypeptide

Bagsvaerd, Denmark

Polypeptide that regulates appetite and whose transcription is regulated by cocaine and amphetamine, encoding gene.

Otsuka PharmaWO 98/42835

Tumor suppressor controlled genes

Tokyo

Genes whose transcription is controlled by the tumor suppressor gene p53, encoded proteins; for therapeutics.

Palsson, B.O.WO 98/42356

Laser killing of tumors

La Jolla, Calif.

Tumor cell labelled with a laser-sensitive tag; for selectively killing these cells with high energy lasers.

PhogenWO 98/42742

Herpes cell growth inhibitors

Cambridge, U.K.

Herpes virus VP22 proteins; for binding to microtubules and retarding cell division in cancer cells

Proteome SciencesWO 98/42736

Colorectal cancer diagnosis

Cobham, U.K.

Colorectal cancer-associated proteins, antibodies; for two dimensional electrophoresis-based detection and diagnosis.

ReprogenWO 98/42185

Endometriosis mouse model

Irvine, Calif.

Severely compromised immune-deficient (SCID) mice with endometrial xenografts; for studying endometriosis.

Res. Corp. Technol.WO 98/42826

Colon cancer model

Tucson, Ariz.

Transgenics with the human involucrin promoter linked to human papillomavirus oncogenes; for modeling colon cancer.

RPMS Technol.WO 98/42850

Anticoagulant fusion proteins

London

Expression of anticoagulant fusion proteins at the surface of activated cells; for inhibiting delayed vascular rejection.

Sloan-Kettering Inst.WO 98/42855

Autologous tumor vaccines

New York

Autologous vaccination by transfecting tumor cells with herpes simplex virus vectors encoding interferons.

SmithKline BeechamEPO 869 178

Sialoadhesin family gene

Philadelphia

DNA sequences for a sialoadhesin family gene, encoded protein SAF-3; for diagnostics and therapy.

SmithKline BeechamEPO 869 179

Tumor necrosis-related receptor

Philadelphia

Tumor necrosis-related receptor TR7 polypeptides, encoding gene sequences; for diagnostics and therapeutics.

SmithKline BeechamEPO 869 180

TNF homolog TL5

Philadelphia

Tumor necrosis factor (TNF) homolog TL5 polypeptides, encoding gene sequences; for diagnostics and therapeutics.

SmithKline BeechamWO 98/42833

Potassium channel

Nanterre, France

Potassium channel protein, encoding gene sequences, production methods; for treating cardiac arrhythmias.

SmithKline BeechamWO 98/42841

Interferon-related protein

Brentford, U.K.

Interferon-related protein, encoding gene sequences; for treating CNS diseases.

SmithKline BeechamWO 98/43088

Subtraction library

Philadelphia

Subtraction library produced by hybridizing samples with defined nucleic acid sequences immobilized on surfaces.

South Carolina, Med. Univ. ofWO 98/42725

Breast cancer gene marker

Charleston, S.C.

Gene that is differentially expressed in infiltrating ductal carcinomas of the breast; for diagnosis and therapy.

Spectra BiomedicalWO 98/42872

Estrogen receptor and depression

Burlingame, Calif.

Correlation of molecular variations in the estrogen receptor with depression; for diagnosis.

SRI Intl.WO 98/42727

Targeted homologous recombination

Menlo Park, Calif.

Genomic sequence alteration using targeted homologous recombination.

SRLEPO 869 186

Spinocerebellar ataxia diagnosis

Tokyo

Probes for genes with CAG repeats that are associated with spinocerebellar ataxia type 2; for PCR-based diagnosis.

Stanford Univ.WO 98/42854

Regulatory RNA sequences

Palo Alto, Calif.

Functional genomic screen for regulatory RNA sequences; for mediating post-transcriptional regulation of genes.

StratageneWO 98/42860

Polymerase enhancing factors

San Diego

Polymerase enhancing factors, complexes, purification methods; for enhancing nucleic acid polymerase activity.

Texas, Univ. ofWO 98/42830

Mammary tumor suppressor

Austin, Texas

Tumor suppressor expressed in ovarian and mammary epithelial cells, encoding gene, antibodies; for therapeutics.

Third Wave Technol.WO 98/42873

Nucleic acid detection

Madison, Wis.

Site-specific cleavage of nucleic acids; for multiple sequential cleavage analysis and detection.

Thrombosis Res. Inst.WO 98/42834

Dendroaspin neurotoxin

London

Polypeptide neurotoxin analog dendroaspin, modified forms having added activities, encoding gene sequences.

Usina da BarraWO 98/42828

Fructosaccharides

Barra Bonita, Spain

Beta-fructofuranosidase from Aspergillus niger; for synthesizing fructosaccharides.

Virus Res. Inst.WO 98/42189, 42372

Ulcer vaccine

Cambridge, Mass.

Peptides and carbohydrates that immunoreact with Helicobacter pylori antisera, encoding gene sequences; for immunoresponse.

ZymogeneticsWO 98/42836

Mammalian cytokine receptors

Seattle

Mammalian cytokine receptor protein polypeptides, encoding gene sequences; for therapeutics.

ZymogeneticsWO 98/42840

Motilin homologs

Seattle

Motilin homologs, encoding gene sequences, antibodies, modulators; for increasing gastric motility.