Published Sept. 16 (EPO); Sept. 11 (WO)
Adprotech WO 98/39433
Complement receptor consensus sequences
Complement receptor type 1-like consensus amino acid sequences, encoding gene sequences.
Affymetrix WO 98/38846
Santa Clara, Calif.
Genetic compositions and methods of using them.
Ariad Gene Therapeutics WO 98/39418
Gene therapy technology
Applications of regulated gene therapy technology; for treating cancer and related disorders.
Baxter WO 98/39411
Adenovirus helper cells
Helper cell lines for the large-scale production of attenuated E1-deleted adenovirus under controlled conditions.
Bio Merieux WO 98/39360
Hepatitis C diagnostic
Marcy l'Etoile, France
Antigenic fragment from the N-terminal end of hepatitis C nucleocapsid; for diagnostic detection of antibodies.
Bio-Technology General WO 98/39469
Tissue-specific peptide libraries used to target pharmaceuticals to organs; for identifying receptors.
Biotechnol. & Genetic Engin. Ctr. EPO 864 649
Hepatitis B antigen production
High yield production method for hepatitis B antigen expressed in yeast cells; for vaccines.
Biotech Res. Inst. WO 98/39450
Streptococcus pneumoniae surface protein, deleted derivatives, expression system; for vaccines.
Boehringer Ingelheim WO 98/39034
CD44 antibodies; for immunomodulation and treating cancer and affecting Langerhans and dendritic cells.
Boehringer Mannheim WO 98/39033
T cell stimulating protein
Fusion protein having cell recognition and T cell proliferation stimulating domains; for T cell activation.
Bristol-Myers Squibb WO 98/39443
Scavenger receptor cysteine-rich domain-containing polypeptide, encoding gene sequences, monoclonal antibodies.
Calydon WO 98/39464-39467
Adenoviral vectors with heterologous transcription regulatory factors to express a-fetoprotein, androgen receptors, and carcinoembryonic antigen.
Children's Hosp. WO 98/39355
Antifungal drug targeting
Species-specific sequence region of the yeast IIB transcription factor; for targeting antifungal drugs.
Chiron WO 98/39449
M-CSF-alpha gene mutant
Vector containing a mutant M-CSF-alpha gene, encoded protein; for gene therapy.
Chugai WO 98/39414
Mesenchymal cell line
Undifferentiated mesenchymal cell line; for screening cell differentiation regulators and making chondrocytes.
Columbia Univ. WO 98/38861
Antisense oligos that prevent cell death; for treating neurodegenerative disorders.
Columbia Univ. WO 98/39356
Aortic aneurysm antigen
Purified, recombinant protein reactive with abdominal aortic aneurysm disease-associated antibodies; for diagnosis.
Dana-Farber Inst. WO 98/39658
Autoimmune disease diagnosis
Assaying for the presence of active protein kinase in cell extracts; for diagnosing autoimmune disease.
DNAVec Research EPO 864 645
Sendai virus vectors
Minus-strand RNA Sendai virus-based vector with early replication genes; for production.
Duke Univ. WO 98/39412
Methods for screening compounds for immunosuppressive activity; for therapeutics.
Eisai WO 98/39436
Fibroblast growth factor (FGF) muteins, encoding gene sequences; for treating heparin-related disorders.
Evotec Biosystems WO 98/39428
Method of inducing mutations in pathogenic microorganisms; for production of vaccines.
Exact Labs WO 98/39478
Contiguous genomic scanning
Contiguous genomic scanning that uses flanking regions only present in individuals with cancer-associated deletions.
Genta WO 98/39358 & 39359
Oligomeric cationic lipids
Oligomeric and dimeric cationic lipids; for interacting with anionic macromolecules and inhibiting protein expression.
Haqqi, T.M. WO 98/39480
Differentially expressed genes
Cleveland Heights, Ohio
Identification of expressed genes using conserved sequences; for measuring differentially expressed genes.
Harvard Univ. WO 98/39334
DNA glycolase inhibitors
DNA glycolase inhibitors; for affecting DNA repair and treating cancer and pathogen infection.
Hayashibara Seibutsu EPO 864 585
Interleukin (IL)-18 receptor proteins, encoding gene sequences; for treating autoimmune and allergic diseases.
Hepavec WO 98/39417
Human liver cell line
Human liver cell line; for toxicologic, physiologic, and gene therapy research.
Hoechst EPO 864 651
Promoter sequences from the cdc25B gene, recombinant production methods [in German].
Hoechst EPO 864 656
Transcription assay screen
In vitro transcription assay for the screening of natural products and other chemicals [in German].
Human Genome Sciences WO 98/39446 & 39448
256 secreted proteins
256 human secreted proteins, encoding gene sequences, vectors, host cells, antibodies, production methods.
Incyte Pharma WO 98/39441
Chemokine receptor-like chemokine
Palo Alto, Calif.
Human chemokine receptor-like chemokine, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte Pharma WO 98/39442
Mitochondrial membrane protein
Palo Alto, Calif.
Human mitochondrial membrane protein, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte Pharma WO 98/39444
Protein kinase C inhibitor-like protein
Palo Alto, Calif.
Protein kinase C inhibitor-like protein, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte Pharma WO 98/39445
Human tubby homolog
Palo Alto, Calif.
Human tubby homolog, encoding gene sequences, vectors, antisense, antibodies, modulators.
Infigen WO 98/39416
Transgenic cloning methods
Methods of producing totipotent cells for nuclear transplanation and the resulting transgenics.
Isis Innovation WO 98/39424
Pneumocystis carinii protease, encoding gene sequences; for treating infections.
Japan Sci. & Technol. WO 98/39415
Cultured microglia cells that proliferate when treated with GM-CSF; for treating nervous system diseases.
Kyowa Hakko Kogyo WO 98/39437
Apoptosis-related gene sequences, encoded proteins, vectors, antibodies; for inhibiting programmed cell death.
Ludwig Inst. WO 98/39413
In vitro and in vivo models of hematopoiesis, hematopoietic factors; for promoting neutrophil production.
Massachusetts, Univ. Med. Sch. WO 98/39427
Stem cell populations having tissue-specific promoters linked to therapeutic genes; for transplant transfection.
McGill Univ. WO 98/39434
Apoptosis protein p28 Bap31, fragments, encoding gene sequences, antisense, antibodies; for modulating cell death.
Medigene WO 98/39420
Method for separating viruses of various sizes using several filter membranes.
Merial WO 98/39028
Lyme disease antigen
Borrelia burgdorferi antigens, production methods; for eliciting an immunological response to Lyme disease.
Michigan, Univ. of WO 98/39485
cDNA positional mapping
Ann Arbor, Mich.
Use of double-stranded templates for positional mapping of sequences within cDNA clones.
Millennium Pharma WO 98/39431
Lipid disease genes
Genes regulating human SR-B1 receptor transcription; for identifying modulators and treating lipid diseases.
Mochida Pharma WO 98/39438
Antisense oligonucleotides for CD14; for treating systemic inflammatory response syndrome.
Molecular Tool WO 98/39481
Reusable nucleic acid arrays
Reversible solid phase attachment of nucleic acids via a disulfide bond; for making reusable arrays.
Monsanto WO 98/39453
Coexpression of polyhydroxyalkanoic acid synthase and acetyl-CoA transferase; for polyester biosynthesis.
Natl. Ctr. Vet. & Nutr. Studies (CNEVA) EPO 864 657
Oligos from E. coli vts genes that express verotoxins; for detecting these bacterial strains [in French].
Natl. Inst. Hlth. (NIH) WO 98/39363
Transplant rejection immunotoxin
Diphtheria toxin-based immunotoxin targeted to CD3 receptors on T cells; for treating graft-versus-host disease.
Natl. Inst. Hlth. (NIH) WO 98/39425
Engineered toxin production
Shuttle vector for expressing engineered toxin mutants in Corynebacteria, yeast, and CHO and insect cells.
Natl. Inst. Hlth. (NIH) WO 98/39439
Endocrine tumor suppressor
Tumor suppressor gene associated with multiple endocrine neoplasia, encoded protein; for diagnosis and therapy.
Nebraska, Univ. of WO 98/39426
Avoiding heart transplant rejection
Attenuated coxsackie virus vectors; for targeted delivery of immunomodulators to avoid heart transplant reje-tion.
New York Univ. WO 98/39440
Neurotransmitter release modulators
Calcium-independent a-latrotoxin receptor; for modulating neurotransmitter release.
Ontario WO 98/39022
CNS activity modulators
Trangenics with a disrupted GLP-1 receptor gene, use of exendin and GLP-1 modulators to affect CNS activity.
Pasteur Merieux WO 98/39030
Hepatitis C vaccine
Fusion protein including hepatitis C capsid polypeptides, encoding gene sequences; for vaccines.
Perkin-Elmer WO 98/39353
Homologous recombination alterations
Foster City, Calif.
Chimeric oligonucleotides in vectors; for affecting specific genetic alterations during homologous recombination.
Pharmacia & Upjohn WO 98/39458
Microorganisms with mutated daunorubicin metabolism gene; for preparing doxorubicin.
Reprogen WO 98/39447
Prostate cancer-specific protein
Prostate cancer-specific marker protein, encoding gene sequences; for diagnosis and therapy.
Reprogen WO 98/39661
Cultivating cells on two different grafts; for identifying hormone-regulated traits.
Ribogene WO 98/39487
Hepatitis C inhibition
Hepatitis C inhibition by agents that selectively interfere with viral proteins that override interferon effects.
Sagami Chemical Res. Ctr. WO 98/39476
Type II membrane proteins
Identifying genes encoding type II membrane proteins using a fused gene containing a reporter enzyme coding sequence.
St. Elizabeth's Med. Ctr. WO 98/39354
Fas ligand compositions; for treating vascular injury and assisting vascular remodeling.
St. Jude Children's Hosp. WO 98/39361
B cell receptor
Lymphocyte receptor protein from B cells, encoding gene sequences; for targeting calcium activation of B cells.
Schering WO 98/39421
Genes for mammalian proteinases, oxidoreductases, and GTP binding proteins, encoded proteins; for diagnostics.
Scriptgen Pharma WO 98/39484
RNA conformation modulators
Identification of agents that affect RNA conformation by measuring florescence polarization of probes.
SmithKline Beecham WO 98/39432
Gene sequences in the uncoupling proteins family, encoded proteins; for treating obesity and diabetes.
South Carolina, Med. Univ. WO 98/39430
Pancreatic cancer gene
Pancreatic cancer-associated gene, encoded protein, fusions, antisense, modulators, antibodies; for therapeutics.
Sumitomo Chemical WO 98/39452
Biotin synthetase gene
Biotin synthetase gene from a Sphingomonas species, encoded protein, production methods.
Sunol Molecular WO 98/39482
Phage display assays
Fusions made from bacteriophage coat proteins and T cell receptors; for phage display assays.
Suntory EPO 864 648
NO synthase modulator screen
Vector with a reporter gene controlled by the inducible nitric oxide (NO) synthase promoter; for modulator screen.
Suntory WO 98/39468
Unsaturated fatty acids
Culturing Mortierella species; for the production of highly unsaturated fatty acids.
Transgene EPO 864 652
Foamy virus envelope protein
Vectors for the expression of foamy virus envelope protein, cell line for viral particle production.
Tropix WO 98/39471
Protease inhibitor assay
Protease inhibitor assay using the chemiluminescence of 1,2-dioxetane.
Tularik WO 98/39410
S. San Francisco
IkappaB regulating proteins, encoding gene sequences, probes, primers, antibodies; for diagnosis and therapy.
Uberla, K. WO 98/39463
Lentivirus-based retroviral vectors; for efficient gene transfer to non-dividing cells and CNS gene therapy.
Vanderway WO 98/39362
Mammalian immunoglobulins M and G that are cytotoxic to tumor cells both in vitro and in vivo.
Ventana Genetics WO 98/39483
Cellular phenotype reporters
Salt Lake City
Identification of genes encoding agents affecting cellular phenotypes by using gene libraries attached to reporters.
Washington Univ. WO 98/39031
Hepatitis C vaccines
Hepatitis C genome RNA sequences, infectious DNA clones, gene therapy vectors; for vaccines and diagnostics.
Washington Univ. WO 98/39456
Factor X variant
Single substitution Factor X variant with reduced affinity for, but intact catalytic impact on, Factor Va.
Wistar Inst. WO 98/39035
Infecting transplantation tissue with viral vectors expressing VEGF or PDGF; for revascularization and transplantation.
Yeda Res. & Develop. WO 98/39429
Gene sequences that cause non-cytokine-induced apoptosis; for treating cancer.
Yeda Res. & Develop. WO 98/39435
Caspase homolog with death effector domain as modulator of Fas receptors, encoding gene sequences, production
Yissum Res. Develop. WO 98/39486
Treating CNS injury
Antisense or ribozyme inhibitors of acetylcholinesterase production; for treating CNS injury.