Published Sept. 16 (EPO); Sept. 11 (WO)

Adprotech WO 98/39433

Complement receptor consensus sequences

Royston, U.K.

Complement receptor type 1-like consensus amino acid sequences, encoding gene sequences.

Affymetrix WO 98/38846

Genetic compositions

Santa Clara, Calif.

Genetic compositions and methods of using them.

Ariad Gene Therapeutics WO 98/39418

Gene therapy technology

Cambridge, Mass.

Applications of regulated gene therapy technology; for treating cancer and related disorders.

Baxter WO 98/39411

Adenovirus helper cells

Deerfield, Ill.

Helper cell lines for the large-scale production of attenuated E1-deleted adenovirus under controlled conditions.

Bio Merieux WO 98/39360

Hepatitis C diagnostic

Marcy l'Etoile, France

Antigenic fragment from the N-terminal end of hepatitis C nucleocapsid; for diagnostic detection of antibodies.

Bio-Technology General WO 98/39469

Peptide libraries

Iselin, N.J.

Tissue-specific peptide libraries used to target pharmaceuticals to organs; for identifying receptors.

Biotechnol. & Genetic Engin. Ctr. EPO 864 649

Hepatitis B antigen production

Havana, Cuba

High yield production method for hepatitis B antigen expressed in yeast cells; for vaccines.

Biotech Res. Inst. WO 98/39450

Streptococcus vaccines

Braunschweig, Germany

Streptococcus pneumoniae surface protein, deleted derivatives, expression system; for vaccines.

Boehringer Ingelheim WO 98/39034

CD44 antibodies

Ingelheim, Germany

CD44 antibodies; for immunomodulation and treating cancer and affecting Langerhans and dendritic cells.

Boehringer Mannheim WO 98/39033

T cell stimulating protein

Mannheim, Germany

Fusion protein having cell recognition and T cell proliferation stimulating domains; for T cell activation.

Bristol-Myers Squibb WO 98/39443

Scavenger receptor

Princeton, N.J.

Scavenger receptor cysteine-rich domain-containing polypeptide, encoding gene sequences, monoclonal antibodies.

Calydon WO 98/39464-39467

Adenoviral vectors

Sunnyvale, Calif.

Adenoviral vectors with heterologous transcription regulatory factors to express a-fetoprotein, androgen receptors, and carcinoembryonic antigen.

Children's Hosp. WO 98/39355

Antifungal drug targeting

Cincinnati

Species-specific sequence region of the yeast IIB transcription factor; for targeting antifungal drugs.

Chiron WO 98/39449

M-CSF-alpha gene mutant

Emeryville, Calif.

Vector containing a mutant M-CSF-alpha gene, encoded protein; for gene therapy.

Chugai WO 98/39414

Mesenchymal cell line

Tokyo

Undifferentiated mesenchymal cell line; for screening cell differentiation regulators and making chondrocytes.

Columbia Univ. WO 98/38861

Preventing apoptosis

New York

Antisense oligos that prevent cell death; for treating neurodegenerative disorders.

Columbia Univ. WO 98/39356

Aortic aneurysm antigen

New York

Purified, recombinant protein reactive with abdominal aortic aneurysm disease-associated antibodies; for diagnosis.

Dana-Farber Inst. WO 98/39658

Autoimmune disease diagnosis

Boston

Assaying for the presence of active protein kinase in cell extracts; for diagnosing autoimmune disease.

DNAVec Research EPO 864 645

Sendai virus vectors

Ibaraki, Japan

Minus-strand RNA Sendai virus-based vector with early replication genes; for production.

Duke Univ. WO 98/39412

Immunosuppressor screen

Durham N.C.

Methods for screening compounds for immunosuppressive activity; for therapeutics.

Eisai WO 98/39436

FGF muteins

Tokyo

Fibroblast growth factor (FGF) muteins, encoding gene sequences; for treating heparin-related disorders.

Evotec Biosystems WO 98/39428

Pathogen vaccines

Hamburg, Germany

Method of inducing mutations in pathogenic microorganisms; for production of vaccines.

Exact Labs WO 98/39478

Contiguous genomic scanning

Maynard, Mass.

Contiguous genomic scanning that uses flanking regions only present in individuals with cancer-associated deletions.

Genta WO 98/39358 & 39359

Oligomeric cationic lipids

San Diego

Oligomeric and dimeric cationic lipids; for interacting with anionic macromolecules and inhibiting protein expression.

Haqqi, T.M. WO 98/39480

Differentially expressed genes

Cleveland Heights, Ohio

Identification of expressed genes using conserved sequences; for measuring differentially expressed genes.

Harvard Univ. WO 98/39334

DNA glycolase inhibitors

Cambridge, Mass.

DNA glycolase inhibitors; for affecting DNA repair and treating cancer and pathogen infection.

Hayashibara Seibutsu EPO 864 585

IL-18 receptor

Okayama, Japan

Interleukin (IL)-18 receptor proteins, encoding gene sequences; for treating autoimmune and allergic diseases.

Hepavec WO 98/39417

Human liver cell line

Berlin

Human liver cell line; for toxicologic, physiologic, and gene therapy research.

Hoechst EPO 864 651

cdc25B promoter

Frankfurt, Germany

Promoter sequences from the cdc25B gene, recombinant production methods [in German].

Hoechst EPO 864 656

Transcription assay screen

Frankfurt, Germany

In vitro transcription assay for the screening of natural products and other chemicals [in German].

Human Genome Sciences WO 98/39446 & 39448

256 secreted proteins

Rockville, Md.

256 human secreted proteins, encoding gene sequences, vectors, host cells, antibodies, production methods.

Incyte Pharma WO 98/39441

Chemokine receptor-like chemokine

Palo Alto, Calif.

Human chemokine receptor-like chemokine, encoding gene sequences, vectors, antisense, antibodies, modulators.

Incyte Pharma WO 98/39442

Mitochondrial membrane protein

Palo Alto, Calif.

Human mitochondrial membrane protein, encoding gene sequences, vectors, antisense, antibodies, modulators.

Incyte Pharma WO 98/39444

Protein kinase C inhibitor-like protein

Palo Alto, Calif.

Protein kinase C inhibitor-like protein, encoding gene sequences, vectors, antisense, antibodies, modulators.

Incyte Pharma WO 98/39445

Human tubby homolog

Palo Alto, Calif.

Human tubby homolog, encoding gene sequences, vectors, antisense, antibodies, modulators.

Infigen WO 98/39416

Transgenic cloning methods

DeForest, Wis.

Methods of producing totipotent cells for nuclear transplanation and the resulting transgenics.

Isis Innovation WO 98/39424

Pneumocystis protease

Oxford, U.K.

Pneumocystis carinii protease, encoding gene sequences; for treating infections.

Japan Sci. & Technol. WO 98/39415

Cultured microglia

Saitama, Japan

Cultured microglia cells that proliferate when treated with GM-CSF; for treating nervous system diseases.

Kyowa Hakko Kogyo WO 98/39437

Apoptosis-related genes

Tokyo

Apoptosis-related gene sequences, encoded proteins, vectors, antibodies; for inhibiting programmed cell death.

Ludwig Inst. WO 98/39413

Neutrophil inducers

Parkville, Australia

In vitro and in vivo models of hematopoiesis, hematopoietic factors; for promoting neutrophil production.

Massachusetts, Univ. Med. Sch. WO 98/39427

Transplant transfection

Worcester, Mass.

Stem cell populations having tissue-specific promoters linked to therapeutic genes; for transplant transfection.

McGill Univ. WO 98/39434

Apoptosis protein

Montreal

Apoptosis protein p28 Bap31, fragments, encoding gene sequences, antisense, antibodies; for modulating cell death.

Medigene WO 98/39420

Virus filtration

Martinsreid, Germany

Method for separating viruses of various sizes using several filter membranes.

Merial WO 98/39028

Lyme disease antigen

Athens, Ga.

Borrelia burgdorferi antigens, production methods; for eliciting an immunological response to Lyme disease.

Michigan, Univ. of WO 98/39485

cDNA positional mapping

Ann Arbor, Mich.

Use of double-stranded templates for positional mapping of sequences within cDNA clones.

Millennium Pharma WO 98/39431

Lipid disease genes

Cambridge, Mass.

Genes regulating human SR-B1 receptor transcription; for identifying modulators and treating lipid diseases.

Mochida Pharma WO 98/39438

CD14 antisense

Tokyo

Antisense oligonucleotides for CD14; for treating systemic inflammatory response syndrome.

Molecular Tool WO 98/39481

Reusable nucleic acid arrays

Baltimore

Reversible solid phase attachment of nucleic acids via a disulfide bond; for making reusable arrays.

Monsanto WO 98/39453

Polyester biosynthesis

St. Louis

Coexpression of polyhydroxyalkanoic acid synthase and acetyl-CoA transferase; for polyester biosynthesis.

Natl. Ctr. Vet. & Nutr. Studies (CNEVA) EPO 864 657

Verotoxin detection

Maisons-Alfort, France

Oligos from E. coli vts genes that express verotoxins; for detecting these bacterial strains [in French].

Natl. Inst. Hlth. (NIH) WO 98/39363

Transplant rejection immunotoxin

Bethesda, Md.

Diphtheria toxin-based immunotoxin targeted to CD3 receptors on T cells; for treating graft-versus-host disease.

Natl. Inst. Hlth. (NIH) WO 98/39425

Engineered toxin production

Bethesda, Md.

Shuttle vector for expressing engineered toxin mutants in Corynebacteria, yeast, and CHO and insect cells.

Natl. Inst. Hlth. (NIH) WO 98/39439

Endocrine tumor suppressor

Bethesda, Md.

Tumor suppressor gene associated with multiple endocrine neoplasia, encoded protein; for diagnosis and therapy.

Nebraska, Univ. of WO 98/39426

Avoiding heart transplant rejection

Lincoln, Neb.

Attenuated coxsackie virus vectors; for targeted delivery of immunomodulators to avoid heart transplant reje-tion.

New York Univ. WO 98/39440

Neurotransmitter release modulators

New York

Calcium-independent a-latrotoxin receptor; for modulating neurotransmitter release.

Ontario WO 98/39022

CNS activity modulators

Toronto

Trangenics with a disrupted GLP-1 receptor gene, use of exendin and GLP-1 modulators to affect CNS activity.

Pasteur Merieux WO 98/39030

Hepatitis C vaccine

Lyon, France

Fusion protein including hepatitis C capsid polypeptides, encoding gene sequences; for vaccines.

Perkin-Elmer WO 98/39353

Homologous recombination alterations

Foster City, Calif.

Chimeric oligonucleotides in vectors; for affecting specific genetic alterations during homologous recombination.

Pharmacia & Upjohn WO 98/39458

Doxorubicin preparation

Nerviano, Italy

Microorganisms with mutated daunorubicin metabolism gene; for preparing doxorubicin.

Reprogen WO 98/39447

Prostate cancer-specific protein

Irvine, Calif.

Prostate cancer-specific marker protein, encoding gene sequences; for diagnosis and therapy.

Reprogen WO 98/39661

Hormone-regulated traits

Irvine, Calif.

Cultivating cells on two different grafts; for identifying hormone-regulated traits.

Ribogene WO 98/39487

Hepatitis C inhibition

Hayward, Calif.

Hepatitis C inhibition by agents that selectively interfere with viral proteins that override interferon effects.

Sagami Chemical Res. Ctr. WO 98/39476

Type II membrane proteins

Kanagawa, Japan

Identifying genes encoding type II membrane proteins using a fused gene containing a reporter enzyme coding sequence.

St. Elizabeth's Med. Ctr. WO 98/39354

Fas ligand

Boston

Fas ligand compositions; for treating vascular injury and assisting vascular remodeling.

St. Jude Children's Hosp. WO 98/39361

B cell receptor

Memphis, Tenn.

Lymphocyte receptor protein from B cells, encoding gene sequences; for targeting calcium activation of B cells.

Schering WO 98/39421

Mammalian proteinases

Kenilworth, N.J.

Genes for mammalian proteinases, oxidoreductases, and GTP binding proteins, encoded proteins; for diagnostics.

Scriptgen Pharma WO 98/39484

RNA conformation modulators

Medford, Mass.

Identification of agents that affect RNA conformation by measuring florescence polarization of probes.

SmithKline Beecham WO 98/39432

Obesity-related genes

Brentford, U.K.

Gene sequences in the uncoupling proteins family, encoded proteins; for treating obesity and diabetes.

South Carolina, Med. Univ. WO 98/39430

Pancreatic cancer gene

Charleston, S.C.

Pancreatic cancer-associated gene, encoded protein, fusions, antisense, modulators, antibodies; for therapeutics.

Sumitomo Chemical WO 98/39452

Biotin synthetase gene

Osaka, Japan

Biotin synthetase gene from a Sphingomonas species, encoded protein, production methods.

Sunol Molecular WO 98/39482

Phage display assays

Miami

Fusions made from bacteriophage coat proteins and T cell receptors; for phage display assays.

Suntory EPO 864 648

NO synthase modulator screen

Osaka, Japan

Vector with a reporter gene controlled by the inducible nitric oxide (NO) synthase promoter; for modulator screen.

Suntory WO 98/39468

Unsaturated fatty acids

Osaka, Japan

Culturing Mortierella species; for the production of highly unsaturated fatty acids.

Transgene EPO 864 652

Foamy virus envelope protein

Strasbourg, France

Vectors for the expression of foamy virus envelope protein, cell line for viral particle production.

Tropix WO 98/39471

Protease inhibitor assay

Bedford, Mass.

Protease inhibitor assay using the chemiluminescence of 1,2-dioxetane.

Tularik WO 98/39410

IkappaB regulators

S. San Francisco

IkappaB regulating proteins, encoding gene sequences, probes, primers, antibodies; for diagnosis and therapy.

Uberla, K. WO 98/39463

Lentivirus vectors

Moehrendorf, Germany

Lentivirus-based retroviral vectors; for efficient gene transfer to non-dividing cells and CNS gene therapy.

Vanderway WO 98/39362

Cytotoxic immunoglobulins

Dublin, Ireland

Mammalian immunoglobulins M and G that are cytotoxic to tumor cells both in vitro and in vivo.

Ventana Genetics WO 98/39483

Cellular phenotype reporters

Salt Lake City

Identification of genes encoding agents affecting cellular phenotypes by using gene libraries attached to reporters.

Washington Univ. WO 98/39031

Hepatitis C vaccines

St. Louis

Hepatitis C genome RNA sequences, infectious DNA clones, gene therapy vectors; for vaccines and diagnostics.

Washington Univ. WO 98/39456

Factor X variant

St. Louis

Single substitution Factor X variant with reduced affinity for, but intact catalytic impact on, Factor Va.

Wistar Inst. WO 98/39035

Transplant transfection

Philadelphia

Infecting transplantation tissue with viral vectors expressing VEGF or PDGF; for revascularization and transplantation.

Yeda Res. & Develop. WO 98/39429

Apoptosis genes

Rehovot, Israel

Gene sequences that cause non-cytokine-induced apoptosis; for treating cancer.

Yeda Res. & Develop. WO 98/39435

Caspase homolog

Rehovot, Israel

Caspase homolog with death effector domain as modulator of Fas receptors, encoding gene sequences, production

method.

Yissum Res. Develop. WO 98/39486

Treating CNS injury

Jerusalem

Antisense or ribozyme inhibitors of acetylcholinesterase production; for treating CNS injury.

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