Published Sept. 9 (EPO); Sept. 3 (WO)
AutoimmuneEPO 863 155
Myelin basic protein fragments
Peptide fragments from myelin basic protein; for suppression of T cell proliferation.
Acarbose biosynthesis genes
Biosynthesis genes from the acarbose gene cluster from Actinoplanes; for transfer to heterologous host strains.
Baylor Coll. Med.WO 98/37764
Macular degeneration detection
ATP binding cassette transporter, encoding gene sequences, mutations; for detecting macular degeneration.
Bernofsky, C.WO 98/38282
Monocytic leukemia cells
Human monocytic leukemia cell line; for inducing immunoresponse and making hybridomas.
Boehringer MannheimWO 98/38324
Chimeric cell surface receptors that undergo antigen-induced association; for titrating cellular processes.
California, Univ. ofWO 98/38309
Clavaspirin peptides derived from microbial hosts, modified versions.
CortecsWO 98/38319 & 38320
Bromelain component useful as an immunostimulatory adjuvant for treating cancer and pathogens.
Control DNA element for activating transcription, homologs, variants; for activating heterologous gene transcription.
DNAVec Res.EPO 863 202
Sendai virus vector
Expression vector based on Sendai virus; for gene transfection.
Eberhard Karls Univ.EPO 863 157
Anti-megakaryocyte monoclonal antibodies, producing hybridoma cell line [in German].
Freiburg Univ.WO 98/38322
Transgenes having promoters that are constitutively active in host cells; for long-term stable gene expression.
GeneLabs TechnologiesWO 98/38306
Redwood City, Calif.
Transcripts encoding immunomodulatory polypeptides; for detecting the presence of activated T cells.
Genetics Inst.WO 98/38209
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Gesher-Israel Advanced BiotecsWO 98/38296-38299
Bet Neqofa, Israel
Methods for simultaneously ligating multiple DNA fragments to form a single and stable DNA construct.
Guelph, Univ. ofWO 98/38283
Methods for selecting germ-line competent cells in chicken embryos; for making chimeric chicken embryos.
Hoffmann-La RocheEPO 863 213
In situ PCR
Thermal cycler equipment for in situ PCR of nucleic acids within cells.
Hoffmann-La RocheWO 98/38302
Tetrodotoxin-sensitive sodium channel
Gene for tetrodotoxin-sensitive sodium channel alpha-subunit, encoded protein, antibodies, expression vectors.
Human Genome SciencesWO 98/38311
IL-1 receptor ligand family protein
Interleukin (IL)-1 receptor ligand family protein, encoding gene sequences; for treating immune system disorders.
ImmunoWO 98/38317 & 38318
Factor X analogs
Factor X analogs having modification at the Factor Xa activating cleavage site, Factor X deletion mutants.
Incyte PharmaWO 98/38307
Integral membrane protein
Palo Alto, Calif.
Human integral membrane protein, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte PharmaWO 98/38310
Palo Alto, Calif.
Human tumor-associated antigen, encoding gene sequences, vectors, antibodies, modulators.
Japan TobaccoWO 98/38289 & 38315
Beta-galactoside alpha-2,6-sialyltransferase, mutants; for secretion into culture medium and purification.
Japan TobaccoWO 98/38305
Protein expressed during arteriosclerosis or coronary restenosis, encoding gene sequences, antibodies.
LG ChemicalWO 9838290
Recombinant production method
Seoul, S. Korea
Methionine residue removal from protein N-terminal ends; for microbial production of recombinant proteins.
Life TechnologiesWO 98/38205
Positive selection cloning
Vector with a cloning cassette linked to a gene encoding a toxic protein; for deactivation of the toxin during cloning.
Mass. Gen. Hosp.WO 98/38204
Transgenics expressing proteins associated with Alzheimer's, antisense, ribozymes; for therapeutics for neural diseases.
Medeva HoldingsEPO 863 211
Tetanus toxin fusions
Expression of recombinant tetanus toxin fusion proteins in attenuated bacteria.
Millennium PharmaWO 98/38200
Two versions of caspase-8, encoding gene sequences; for therapeutics.
Nature Technol.WO 98/38326
Self-assembling gene libraries
Self-assembly of genes in expression vectors; for creating combinatorial libraries.
Neuromed Technol.WO 98/38301
Calcium channel subunits
Human calcium channel subunits, related probes, transfected cell lines; for identifying modulators.
Novo NordiskWO 98/38286 & 38287
Laccase mutants having increased oxidation potential and/or changed pH optimum, designing laccases using 3D structure.
Novo NordiskWO 98/38288
Microbial xyloglucan endotransglycosylase; production methods using microorganisms.
Ono PharmaWO 98/38304
Stromal cell peptide
Human stromal cell line polypeptide, encoding gene sequences, vector, host cells, antibodies.
Oriental YeastEPO 863 210
Immunoglobulin binding protein
Artificial protein containing immunoglobulin-binding domains of protein A; for binding immunoglobulin G.
Paul Ehrlich Inst.WO 98/38325
CD4+ cell vectors
Retroviral vectors with murine leukemia virus capsid and HIV envelope protein genes; for CD4+ cell-specific transfection.
Rochester, Univ. ofWO 98/38300
Circular DNA/RNA synthesis vectors
Small, circular DNA vectors for the synthesis of DNA and RNA oligonucleotides and their analogs.
SmithKline BeechamEPO 863 152 & 863 205
Streptococcus pneumoniae def1 polypeptides, encoding gene sequences; for screening antibacterials.
SmithKline BeechamEPO 863 207
Staphylococcus aureus RNA-dependent amidotransferase A polypeptides, encoding gene sequences; for antibacterials.
SmithKline BeechamEPO 863 208
Histidine kinase polypeptides; encoding gene sequences, production methods; for screening antibacterials.
SmithKline BeechamEPO 863 214
G protein coupled receptor activation
Reporter gene construct and transfected cells for measuring G protein coupled receptor activation.
SmithKline BeechamWO 98/37918
Staphylococcus 3-dehydroquinate synthase polypeptides, encoding gene sequences; for screening antibacterials.
Sumitomo ElectricEPO 863 204
Human cyclin-like protein, encoding gene, antisense, expression vector; for use as a cancer cell probe.
Genomic DNA and cDNA encoding microbial delta9-desaturase; for improved production of unsaturated fatty acids.
TaiseiEPO 863 209
Polyhydroxyalkanoate depolymerase; for decomposing copolymerized polyesters.
Tanaka, T.EPO 863 203
Protein kinase substrate protein
Gene for protein kinase substrate protein identified by expression cloning, encoded protein.
Victoria Univ.WO 98/38303
Methods for assembling desired procollagens or their derivatives in a coexpression system.
Vision PharmaWO 98/38308
Tazarotene-induced gene that is induced by retinoids and structurally related to a tumor suppressor gene.
Washington Univ.WO 98/38312
Bacterial elastin-binding protein
Bacterial elastin-binding protein, encoding gene sequences; for identifying modulators, diagnostics, and therapeutics.