Published Sept. 2 (EPO); Aug. 27 (WO)
Abbott LabsWO 98/37180
Abbott Park, Ill.
Hepatitis C virus NS3 protease-NS4A cofactor protein fusions, encoding gene sequences; for identifying inhibitors.
DNA binding protein library
In vitro peptide expression library for cis-acting proteins that bind DNA sequences.
Fungicide agent testing by measuring inhibition of 3-isopropylmalate dehydrogenase.
AsahiEPO 861 894
Differentiation suppressing protein
Protein that suppresses the growth and differentiation of undifferentiated blood cells; for therapeutics.
Bearsden BioWO 98/37422
RNA binding protein sites
Methods for identifying binding sites in RNA binding proteins; for drug design.
Burstein LabsWO 98/37238
Gene sequencer methods
San Juan Capistrano, Calif.
Gene sequencer, bio-compact disk, sample prep methods; for gene sequencing strategies.
California, Univ. ofWO 98/37085
Netrin receptors, encoding gene sequences, antibodies, production methods; for affecting cell guidance.
California, Univ. ofWO 98/37228
IkappaB kinase subunit peptides
IkappaB kinase catalytic subunit polypeptides that inhibit NF-kappaB transcription factor; encoding gene sequences.
California, Univ. ofWO 98/37415
Ulcerative colitis immunotherapy
Ulcerative colitis pANCA secretory vesicle antigen; for immunotherapy that causes tolerance.
Calif. Inst. Technol.WO 98/37066, 37067, 37087
Polyamides for specific DNA sequences, double-stranded DNA minor groove binding, and major groove binding inhibition.
Case Western Res. Univ.WO 98/37174
Transgenic IgG3 knockouts
Transgenic knockout animals having disrupted IgG3 genes and lacking IgG3; for screening therapeutics.
CNRS (Natl. Ctr. Sci. Res.)WO 98/37234
Characterizing nucleic acid duplexes
At least partially paired nucleic acid duplexes sorted by measuring the forces necessary to separate paired sequences.
Heterologous proteins from yeast
Yeast cell production system in which protein factors catalyzing disulfide bond formation are co-expressed.
Prostate cancer immunotherapy
Polypeptides derived from prostate tumor protein, encoding gene sequences; for prostate cancer immunotherapy.
Cornell Univ.WO 98/37235
Drug candidate screen
Promoter elements implicated in cancer and inflammation linked to reporter genes; for testing drug candidates.
Craig, N.WO 98/37205
Transposon insertion regulation
ATP-utilizing regulatory transposition proteins that allow insertion of transposons in a non-specific manner.
Dade BehringEPO 861 896
Cell volume-regulated kinase
Cell volume- and serum/glucocorticoid-regulated, serine-threonine kinase, encoding gene, antibodies [in German].
Forssmann, W.-G.WO 98/37191
Neutrophil lymphocyte peptides
Polypeptides of specific sequence that are human circulating neutrophil lymphocyte peptides.
French Atomic Energy Comm.WO 98/37098
Graft rejection transgenics
Cells and transgenics expressing HLA-G isoforms; for inhibiting natural killer cells and graft rejection.
Galderma Intl. Dermatol. Res. Ctr.WO 98/37053
Retinoid receptor involved in cellular apoptosis; for identifying apoptosis ligands.
GenentechEPO 861 893
High immunoglobulin expression
S. San Francisco
Production of immunoglobulin polypeptides at levels of one gram of protein per liter of cell culture medium.
S. San Francisco
Humanized anti-interleukin (IL)-8 monoclonal antibodies, vari-ants, conjugates; for treating inflammatory disorders.
Genetics Inst.WO 98/37094
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Genzyme TransgenicsWO 98/37224
Non-secreted proteins in milk
Production of normally non-secreted proteins in the milk of transgenic animals.
Fermentative production using microbial strains and chemically defined media.
Chronic fatigue syndrome
Measuring variations in arginine vasopressin gene; for diagnosing chronic fatigue syndrome.
Heidelberg Univ.WO 98/37231
In situ hybridization probes
DNA probe mixtures for in situ hybridization of nuclear DNA under non-denaturing conditions.
Hoechst Marion RousselWO 98/37215
Beta-amyloid processing assay
Construction of eukaryotic cell lines expressing proteins that inhibit beta-amyloid processing.
Human Genome SciencesWO 98/37194
RNA polymerase elongation factors
RNA polymerase II elongation factor peptides, encoding gene sequences; for diagnosis and treatment of cancers.
Bacterial antibiotic resistance
Synthetic oligos complementary to marORAB operon tran-scripts; for reducing bacterial antibiotic resistance.
Idec PharmaWO 98/37099
Monoclonal antibodies to CD23, the low affinity IgE receptor; for inhibiting allergic reactions and autoimmunity.
Imperial Cancer Res. Technol.WO 98/37207
Cytotoxins activated in tumors
Cytotoxic gene linked to a tumor suppressor-responsive promoter; for activation in cancer cells.
Incyte PharmaWO 98/37197
Palo Alto, Calif.
Microtubule-associated protein, encoding gene sequences, vectors, antisense, antibodies, modu-lators.
Incyte PharmaWO 98/37198
Sodium-dependent phosphate cotransporter
Palo Alto, Calif.
Human sodium-dependent phosphate cotransporter, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte PharmaWO 98/37199
Integral membrane protein
Palo Alto, Calif.
Human integral membrane protein, encoding gene sequences, vectors, antisense, antibodies, modulators.
INSERM (Natl. Inst. Hlth. Med. Res.)EPO 861 891
Negative cell signalling
Compounds that cross-link a stimulatory receptor and a killer inhibitory receptor; for modulating cell signalling.
INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/37192
Neurological cancer proteins
Use of ULIP proteins in the diagnosis and treatment of cancer and paraneoplastic neurological syndromes.
INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/37233
Damaged DNA assay
Isolation or assay of damaged DNA in biological samples; for screening cytotoxic products.
Isis InnovationWO 98/37217
Chemokine binding protein
Soluble vaccinia virus protein and fragments that bind CXC chemokines; for treating inflammatory diseases.
Johns Hopkins Univ.WO 98/36774
Cell growth control
Inhibition of cell growth by contacting cells with a glucose antimetabolite; for controlling proliferative disorders.
Johns Hopkins Univ.WO 98/37178
Proteolytically cleaved portion of MHC class II invariant chains, encoding gene sequences; for immunomodulation.
Kaji, A.WO 98/37202
Plasmids with genes encoding bacterial ribosome recycling factors; for developing antibacterials.
Krebs Res. Inst.WO 98/37209
Expressing heterologous proteins
Vector for expressing heterologous proteins with 3' sequences that prevent opposite direction transcription.
Laval Univ.WO 98/37182
Artificial insemination catalase
Oviductal catalase that binds to spermatozoa membranes; for sperm protection and use in artificial insemination.
Ludwig Inst.WO 98/37196
PARG, a GTPase activating protein, fragments, variants, encoding gene sequences, antibodies.
Mississippi St. Univ.WO 98/37177
Mississippi St., Miss.
Viable cultured nematode parasite intestinal cells; for making antibodies and inducing immunogenic responses.
Nehls, M., et al.WO 98/37175
Directed mutagenesis vectors
The Woodlands, Texas
Vectors for directed mutagenesis by homologous recombination in embryonic stem cells.
Neutec PharmaEPO 861 892
Stress protein epitopes
Function epitopes of human stress protein 90, derivatives, production methods.
North Carolina, Univ. ofWO 98/36779
Bone marrow gene therapy
Chapel Hill, N.C.
Specific targeting of immunogenic or therapeutic proteins to bone marrow cells using alphavirus vectors.
Novo NordiskEPO 861 851
Human insulin analogues
Human insulin analogues having specific amino acid residue substitutions.
Oklahoma Med. Res. Fdn.EPO 861 897
Bile salt-activated lipase
Oklahoma City, Okla.
Human milk bile-salt activated lipase, encoding gene sequences; for studying lipase function.
Oxford BiomedicaWO 98/37089
HIV-1 and 2 peptides, derivatives, encoding gene sequences; for treating HIV infections.
PPL TherapeuticsWO 98/37183
Transgenic donor cells
Production of transgenic donor cells for nuclear transfer and obtaining phenotype prediction information.
Procter & GambleWO 98/37092
Human disintegrin metalloprotease, fragments, mutants, modulators, encoding gene sequences; for osteoarthritis.
QBI EnterprisesWO 98/37189
Translational control elements
Internal ribosome entry site sequences as translational control elements for expression vectors.
Regeneron PharmaWO 98/37195
Antagonists of bone morphogenic protein (BMP) called b57 and DAN, encoding gene sequences; for therapeutics.
Diabetes susceptibility screen
Methods of detecting specific HLA alleles in biological samples that are associated with diabetes susceptibility.
Schepens Eye Res. Inst.WO 98/36641
CP2 function modulators
Small molecule modulators of CP2 function; for gene therapy to modulate Th1/Th2-mediated immunological responses.
SmithKline BeechamEPO 861 850
Tumor necrosis-related receptor
King of Prussia, Pa.
Tumor necrosis-related receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline BeechamEPO 861 889, 890, 899
Lic polypeptides, encoding gene sequences, production methods; for screening antibacterials.
SmithKline BeechamEPO 861 895
Staphylococcus aureus aroE shikimate 5-dehydrogenase polypeptides, encoding gene sequences; for antibacterials.
SmithKline BeechamEPO 861 898
Rat cathepsin K
Rat cathepsin K polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
Strauss, M., et al.WO 98/37190
Induction of apoptotic cell death in cancer cells by reducing the ratio of Rb to apoptosis-inducing proteins.
Takara ShuzoWO 98/37187
Cancer-associated genes; for measuring gene expression changes and diagnosing cancers.
Texas, Univ. ofWO 98/37091
Retinoblastoma tumor suppressors
Retinoblastoma tumor suppressor proteins that have modified N-terminal regions; for treating abnormal cell growth.
Texas, Univ. ofWO 98/37185
Tetracycline-regulated adenovirus vectors; for efficient gene expression in a broad range of hosts.
Therion BiologicsWO 98/37095
Recombinant pox virus encoding MUCI tumor-associated antigen immunogenic fragments; for immunization against cancer.
TM TechnologiesWO 98/37240
Antisense oligo agents
Antisense oligonucleotides for making pharmacologic agents, production methods.
Uhlenkuken, J., et al.WO 98/37222
Method of preparing defined, homogeneous length oligo- and polysaccharides using surface binding chemistry.
Virginia, Univ. ofWO 98/36771
Labelling of cell surface proteins, isolation and sequencing of labelled proteins; for contraceptive vaccines.
Whitehead Inst.WO 98/37181
Teleomerase catalytic subunit
Gene for the catalytic subunit of eukaryotic telomerase holoenzyme, encoded protein; for assessing malignancy.
Zurich CantonEPO 861 900 & WO 98/37210
Prion monoclonal antibodies
Monoclonal antibodies that are specific for prions; for detection in various tissues and use as therapeutics.
Cytokine receptor peptides
Cytokine receptor peptides from extracellular domains of neural tissue receptors; for detecting cell growth ligands.