Albert Einstein Coll. Med. WO 98/36055
Erectile dysfunction gene therapy
New York
Gene encoding a protein involved in regulating smooth muscle tone; for alleviating erectile dysfunction.
Alberta, Univ. of WO 98/35990
Nucleoside transport modulators
Edmonton, Alberta
Sodium-dependent nucleoside transport polypeptide, encoding gene sequences; for identifying modulators.
American Red Cross WO 98/35689
Mammary Factor IX
Rockville, Md.
Transgenic animals having mammary gland-directed expression of Factor IX; for production in milk.
American Red Cross WO 98/36087
HIV immunological tolerance
Falls Church, Va.
Fusions of HIV epitopes with immunoglobulins; for inducing tolerance in uninfected cells.
Amrad Operations WO 98/36054
Testicular cancer marker
Richmond, Australia
Serine proteinase, derivatives, agonists, antagonists; for identifying and suppressing testicular cancers.
Babraham Inst. WO 98/36082
Tumor formation transgenics
Babraham, U.K.
Yeast artificial chromosomes with a gene activation element and an oncogene, transgenics; for studying tumor forma-tion.
Ben Gurion Univ. WO 98/36079
HO-endonuclease
Beer Sheva, Israel
DNA segments encoding the N-terminus of HO-endonuclease containing the sequence-specific nuclease activity.
Berenson, J.R., et al. WO 98/35684
Kaposi's-associated herpes
Los Angeles
Detection of Kaposi's sarcoma-associated herpesvirus in patient samples using PCR probes; for diagnostics.
California, Univ. of WO 98/35981
Liver cancer antibodies
Los Angeles
Antibodies against alpha-fetoprotein and variants with greater immunogenicity; for treating liver cancer.
Calif. Inst. Technol. WO 98/35702
Transcription factor binding polyamides
Pasadena, Calif.
Polyamides that bind the minor groove of a transcription factor protein; for treating cancer and infections.
Canji WO 98/35554
Tumor suppressor
San Diego, Calif.
Tumor suppressor and/or its encoding gene combined with an adjunctive anti-cancer agent; for treating cancers.
Chugai WO 98/35698
Lymphocytic cancer antibodies
Tokyo
Antibodies that bind a lymphocyte tumor-associated protein; for treating non-myelogenous lymphocytic cancer.
Cobra Therapeutics WO 98/35984
Transfection enhancing peptides
Keele, U.K.
Polypeptides containing 29 amino acids with an overall net positive charge of 8; for enhancing gene transfection.
Connecticut, Univ. of WO 98/36098
Glaucoma diagnosis
Farmington, Conn.
Diagnosis of glaucoma using mutations in an associated gene and an amplification assay.
Dana-Farber Cancer Inst. WO 98/36057
Cell death thymocyte caspase
Boston
Thymocyte caspase that is activated by peptide/MHC ligands and causes cell death; for identifying modulators.
Dana-Farber Cancer Inst. WO 98/36065
Differentiation enhancing factors
Boston
SH3 domain binding protein that enhances differentiation, encoding gene sequences, antisense, transgenics.
de Rodriguez Leon Paz, G.E. WO 98/36093
Optical analysis of DNA
Hermosillo, Mexico
Visualization and analysis of DNA using an optical micro-scope.
Du Pont WO 98/36096
Food bacteria assay
Wilmington, Del.
Distinguishing between single- and double-stranded DNA by denaturation; for detecting pathogenic bacteria.
Genentech WO 98/36072
Neurturin receptor
S. San Francisco
Neurturin receptor, variants, extracellular domain, chime-ras, antibodies; for modulating cell activity and survival.
Genentech WO 98/36075
VEGF variants
S. San Francisco
Vascular endothelial growth factor (VEGF) vari-ants having modified heparin binding and re-duced clearance rates.
Genetics Inst. WO 98/36067
Secreted protein genes
Cambridge, Mass.
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
George Washington Univ. WO 98/36095
DNA synthesis measurement
Washington
Labelling of DNA precursors with stable isotopes; for non-radioactive measur-ement of DNA synthesis rates.
Guntaka, R.V. WO 98/35979
Collagen gene antisense
Columbia, Mo.
Phosphorothioate deoxyoligonucleotides that bind to and inhibit expression from collagen genes.
Higeta Shoyu WO 98/36076
Syphilis diagnostic
Tokyo
Modified Treponema palladum-derived antigen, encod-ing gene; for assaying antibodies and diagnosing syphilis infections.
Hoechst EPO 860 445
Cell cycle-regulated expression
Frankfurt, Germany
Promoter sequence that binds an E2F transcription factor attached to a structural gene; for treating cancer.
Immunex WO 98/35986
TNF-related ligand receptor
Seattle
Receptor for TNF-related apoptosis-inducing ligand, encoding gene sequences, antibodies.
Incyte Pharma WO 98/36063
H-rev 107-like protein
Palo Alto, Calif.
Human H-rev 107-like protein, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte Pharma WO 98/36068
p24 vesicle trafficking proteins
Palo Alto, Calif.
Human p24 vesicle trafficking proteins, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte Pharma WO 98/36069
Human mago nashi protein
Palo Alto, Calif.
Human mago nashi protein, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte Pharma WO 98/36071
Human cytochrome b5
Palo Alto, Calif.
Human cytochrome b5, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte Pharma WO 98/36077
Human parvulin-like protein
Palo Alto, Calif.
Human parvulin-like protein, encoding gene sequences, vectors, antisense, antibodies, modulators.
Isis Innovation WO 98/35692
Killer T cell protection
Oxford, U.K.
Reduction of depletion of activated Fas-expressing CD8+ killer T cells by interference with Fas ligand interaction.
INSERM (Natl. Inst. Hlth. Med. Res.) WO 98/36060
Myelin producing cell receptor
Paris
Receptor expressed in myelin producing cells; for diagnosis and treatment of neurological disorders.
Krebs Res. Inst. WO 98/36059
Prion vaccines
Heidelberg, Germany
Gene therapy vector encoding a mutated prion protein; for vaccination against prion diseases.
Kyowa Hakko EPO 860 447
Hematopoietic stem cell growth factor
Tokyo
Hematopoietic stem cell growth factor, encoding gene, antibody; for enhancing bone marrow transplantation.
Ludwig Inst. WO 98/36052
VEGF-B transgenics
New York
Transgenics having a modified vascular endothelial growth factor (VEGF)-B gene; for identifying modulators.
LXR Biotech WO 98/35659
Apoptosis regulators
Richmond, Calif.
BAK promoter sequences; for regulating apoptosis gene ex-pression and identifying modulators.
Neurocrine Bioscience EPO 860 501
CRF-2 receptors
San Diego
Corticotropin-releasing factor (CRF)-2 receptors, encoding gene, expression system.
Nexstar Pharma WO 98/35980
Nucleic acid CD4 ligands
Boulder, Colo.
Identification and preparation of high affinity nucleic acid ligands to CD4 using the SELEX method.
Otsuka Pharma EPO 860 505
Hepatitis genotyping
Tokyo
PCR primers to human hepatitis B virus regions; for genotyping variations in the pre-C region.
Ottawa, Univ. of WO 98/35693
Cancer therapeutics
Ottawa
IAP and NAIP polypeptides, antibodies, and antisense to encoding genes; for treating cancer.
Reprogen WO 98/36073
Human sperm protein
Irvine, Calif.
Human sperm protein, encoding gene sequences; for contraceptives, vaccines, and treating infertility.
Rockefeller Univ. WO 98/36066
Telomere repeat binding factor
New York
Isolated altered telomere repeat binding factor, encoding gene sequences; for treating ataxia telangiectasia.
St. Justine Hosp. WO 98/35987
Autoimmune hepatitis detection
Montreal
FTCD antigen that is specific to autoimmune hepatitis type II; for detection of antibodies and diagnosis.
Schering WO 98/35983
Cancer inhibiting peptides
Berlin
Oligopeptides containing phenylalanine and glycine; for cell growth inhibition and cancer treatment.
Schering WO 98/36074
EGF antibodies
Berlin
Single and double chain antibodies to the EGF receptor, toxin conjugates; for treating cancer.
Shionogi EPO 860 446
CC chemokine-like protein
Osaka, Japan
CC chemokine-like protein expressed in peripheral blood mononuclear cells, encoding gene, production system.
Signal Pharma WO 98/36070
NF-kappaB modulation
San Diego, Calif.
Modulation of nuclear factor (NF)-kappaB activation by peptides having an E3 ubiquitin ligase recognition domain.
Sloan-Kettering Inst. WO 98/36081
Monitoring exocytosis
New York
Luciferase-synaptic vesicle protein hybrids; for detecting exocytotic activity.
SmithKline Beecham EPO 860 502
G-protein 7-transmembrane receptor
Philadelphia
G-protein coupled 7-transmembrane receptor, encoding gene sequences, production methods; for therapeutics.
SmithKline Beecham EPO 860 506
Protein kinase
Philadelphia
Human protein kinase, encoding gene sequences; for treating infectious and inflammatory diseases.
SmithKline Beecham EPO 860 700
Herpes antivirals
Philadelphia
Method of identifying compounds inhibiting the interaction between products of herpes virus genes; for antivirals.
SmithKline Beecham WO 98/36062
NCAM splicing variants
Brentford, U.K.
Neural cell adhesion molecule (NCAM) splicing variants, encoding genes; for treating diabetes, obesity, and cancer.
SS Pharma EPO 860 503
Fungi detection
Tokyo
Nucleic acid probes and primers for detecting Aspergillus fungi species.
Tornell, J., et al. WO 98/35989
Lactogenic receptor ligands
Vastra Frolunda, Sweden
Transgenics that over-express lactogenic/somatogenic receptors; for identifying low molecular weight ligands.
Ventana Genetics WO 98/36097
Evolving regulatory elements
Salt Lake City, Utah
Identification and in vitro evolution of cis-acting regulatory nucleic acid sequences.
Victoria Univ. WO 98/36061
Wound healing treatment
Manchester, U.K.
Agents that inhibit interleukin (IL)-6 receptor-mediated activity in wound healing and fibrotic disorders.
Whitehead Inst. WO 98/35705
Cellular therapeutic delivery
Cambridge, Mass.
Use of therapeutic proteins covalently linked to heat shock proteins; for delivery to antigen presenting cells.
Zeneca WO 98/35988
Enhanced carboxypeptidase expression
London
Modified prodomain of carboxypeptidase B, encoding gene sequences; for enhanced recombinant protein expression.