Albert Einstein Coll. Med. WO 98/36055

Erectile dysfunction gene therapy

New York

Gene encoding a protein involved in regulating smooth muscle tone; for alleviating erectile dysfunction.

Alberta, Univ. of WO 98/35990

Nucleoside transport modulators

Edmonton, Alberta

Sodium-dependent nucleoside transport polypeptide, encoding gene sequences; for identifying modulators.

American Red Cross WO 98/35689

Mammary Factor IX

Rockville, Md.

Transgenic animals having mammary gland-directed expression of Factor IX; for production in milk.

American Red Cross WO 98/36087

HIV immunological tolerance

Falls Church, Va.

Fusions of HIV epitopes with immunoglobulins; for inducing tolerance in uninfected cells.

Amrad Operations WO 98/36054

Testicular cancer marker

Richmond, Australia

Serine proteinase, derivatives, agonists, antagonists; for identifying and suppressing testicular cancers.

Babraham Inst. WO 98/36082

Tumor formation transgenics

Babraham, U.K.

Yeast artificial chromosomes with a gene activation element and an oncogene, transgenics; for studying tumor forma-tion.

Ben Gurion Univ. WO 98/36079


Beer Sheva, Israel

DNA segments encoding the N-terminus of HO-endonuclease containing the sequence-specific nuclease activity.

Berenson, J.R., et al. WO 98/35684

Kaposi's-associated herpes

Los Angeles

Detection of Kaposi's sarcoma-associated herpesvirus in patient samples using PCR probes; for diagnostics.

California, Univ. of WO 98/35981

Liver cancer antibodies

Los Angeles

Antibodies against alpha-fetoprotein and variants with greater immunogenicity; for treating liver cancer.

Calif. Inst. Technol. WO 98/35702

Transcription factor binding polyamides

Pasadena, Calif.

Polyamides that bind the minor groove of a transcription factor protein; for treating cancer and infections.

Canji WO 98/35554

Tumor suppressor

San Diego, Calif.

Tumor suppressor and/or its encoding gene combined with an adjunctive anti-cancer agent; for treating cancers.

Chugai WO 98/35698

Lymphocytic cancer antibodies


Antibodies that bind a lymphocyte tumor-associated protein; for treating non-myelogenous lymphocytic cancer.

Cobra Therapeutics WO 98/35984

Transfection enhancing peptides

Keele, U.K.

Polypeptides containing 29 amino acids with an overall net positive charge of 8; for enhancing gene transfection.

Connecticut, Univ. of WO 98/36098

Glaucoma diagnosis

Farmington, Conn.

Diagnosis of glaucoma using mutations in an associated gene and an amplification assay.

Dana-Farber Cancer Inst. WO 98/36057

Cell death thymocyte caspase


Thymocyte caspase that is activated by peptide/MHC ligands and causes cell death; for identifying modulators.

Dana-Farber Cancer Inst. WO 98/36065

Differentiation enhancing factors


SH3 domain binding protein that enhances differentiation, encoding gene sequences, antisense, transgenics.

de Rodriguez Leon Paz, G.E. WO 98/36093

Optical analysis of DNA

Hermosillo, Mexico

Visualization and analysis of DNA using an optical micro-scope.

Du Pont WO 98/36096

Food bacteria assay

Wilmington, Del.

Distinguishing between single- and double-stranded DNA by denaturation; for detecting pathogenic bacteria.

Genentech WO 98/36072

Neurturin receptor

S. San Francisco

Neurturin receptor, variants, extracellular domain, chime-ras, antibodies; for modulating cell activity and survival.

Genentech WO 98/36075

VEGF variants

S. San Francisco

Vascular endothelial growth factor (VEGF) vari-ants having modified heparin binding and re-duced clearance rates.

Genetics Inst. WO 98/36067

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

George Washington Univ. WO 98/36095

DNA synthesis measurement


Labelling of DNA precursors with stable isotopes; for non-radioactive measur-ement of DNA synthesis rates.

Guntaka, R.V. WO 98/35979

Collagen gene antisense

Columbia, Mo.

Phosphorothioate deoxyoligonucleotides that bind to and inhibit expression from collagen genes.

Higeta Shoyu WO 98/36076

Syphilis diagnostic


Modified Treponema palladum-derived antigen, encod-ing gene; for assaying antibodies and diagnosing syphilis infections.

Hoechst EPO 860 445

Cell cycle-regulated expression

Frankfurt, Germany

Promoter sequence that binds an E2F transcription factor attached to a structural gene; for treating cancer.

Immunex WO 98/35986

TNF-related ligand receptor


Receptor for TNF-related apoptosis-inducing ligand, encoding gene sequences, antibodies.

Incyte Pharma WO 98/36063

H-rev 107-like protein

Palo Alto, Calif.

Human H-rev 107-like protein, encoding gene sequences, vectors, antisense, antibodies, modulators.

Incyte Pharma WO 98/36068

p24 vesicle trafficking proteins

Palo Alto, Calif.

Human p24 vesicle trafficking proteins, encoding gene sequences, vectors, antisense, antibodies, modulators.

Incyte Pharma WO 98/36069

Human mago nashi protein

Palo Alto, Calif.

Human mago nashi protein, encoding gene sequences, vectors, antisense, antibodies, modulators.

Incyte Pharma WO 98/36071

Human cytochrome b5

Palo Alto, Calif.

Human cytochrome b5, encoding gene sequences, vectors, antisense, antibodies, modulators.

Incyte Pharma WO 98/36077

Human parvulin-like protein

Palo Alto, Calif.

Human parvulin-like protein, encoding gene sequences, vectors, antisense, antibodies, modulators.

Isis Innovation WO 98/35692

Killer T cell protection

Oxford, U.K.

Reduction of depletion of activated Fas-expressing CD8+ killer T cells by interference with Fas ligand interaction.

INSERM (Natl. Inst. Hlth. Med. Res.) WO 98/36060

Myelin producing cell receptor


Receptor expressed in myelin producing cells; for diagnosis and treatment of neurological disorders.

Krebs Res. Inst. WO 98/36059

Prion vaccines

Heidelberg, Germany

Gene therapy vector encoding a mutated prion protein; for vaccination against prion diseases.

Kyowa Hakko EPO 860 447

Hematopoietic stem cell growth factor


Hematopoietic stem cell growth factor, encoding gene, antibody; for enhancing bone marrow transplantation.

Ludwig Inst. WO 98/36052

VEGF-B transgenics

New York

Transgenics having a modified vascular endothelial growth factor (VEGF)-B gene; for identifying modulators.

LXR Biotech WO 98/35659

Apoptosis regulators

Richmond, Calif.

BAK promoter sequences; for regulating apoptosis gene ex-pression and identifying modulators.

Neurocrine Bioscience EPO 860 501

CRF-2 receptors

San Diego

Corticotropin-releasing factor (CRF)-2 receptors, encoding gene, expression system.

Nexstar Pharma WO 98/35980

Nucleic acid CD4 ligands

Boulder, Colo.

Identification and preparation of high affinity nucleic acid ligands to CD4 using the SELEX method.

Otsuka Pharma EPO 860 505

Hepatitis genotyping


PCR primers to human hepatitis B virus regions; for genotyping variations in the pre-C region.

Ottawa, Univ. of WO 98/35693

Cancer therapeutics


IAP and NAIP polypeptides, antibodies, and antisense to encoding genes; for treating cancer.

Reprogen WO 98/36073

Human sperm protein

Irvine, Calif.

Human sperm protein, encoding gene sequences; for contraceptives, vaccines, and treating infertility.

Rockefeller Univ. WO 98/36066

Telomere repeat binding factor

New York

Isolated altered telomere repeat binding factor, encoding gene sequences; for treating ataxia telangiectasia.

St. Justine Hosp. WO 98/35987

Autoimmune hepatitis detection


FTCD antigen that is specific to autoimmune hepatitis type II; for detection of antibodies and diagnosis.

Schering WO 98/35983

Cancer inhibiting peptides


Oligopeptides containing phenylalanine and glycine; for cell growth inhibition and cancer treatment.

Schering WO 98/36074

EGF antibodies


Single and double chain antibodies to the EGF receptor, toxin conjugates; for treating cancer.

Shionogi EPO 860 446

CC chemokine-like protein

Osaka, Japan

CC chemokine-like protein expressed in peripheral blood mononuclear cells, encoding gene, production system.

Signal Pharma WO 98/36070

NF-kappaB modulation

San Diego, Calif.

Modulation of nuclear factor (NF)-kappaB activation by peptides having an E3 ubiquitin ligase recognition domain.

Sloan-Kettering Inst. WO 98/36081

Monitoring exocytosis

New York

Luciferase-synaptic vesicle protein hybrids; for detecting exocytotic activity.

SmithKline Beecham EPO 860 502

G-protein 7-transmembrane receptor


G-protein coupled 7-transmembrane receptor, encoding gene sequences, production methods; for therapeutics.

SmithKline Beecham EPO 860 506

Protein kinase


Human protein kinase, encoding gene sequences; for treating infectious and inflammatory diseases.

SmithKline Beecham EPO 860 700

Herpes antivirals


Method of identifying compounds inhibiting the interaction between products of herpes virus genes; for antivirals.

SmithKline Beecham WO 98/36062

NCAM splicing variants

Brentford, U.K.

Neural cell adhesion molecule (NCAM) splicing variants, encoding genes; for treating diabetes, obesity, and cancer.

SS Pharma EPO 860 503

Fungi detection


Nucleic acid probes and primers for detecting Aspergillus fungi species.

Tornell, J., et al. WO 98/35989

Lactogenic receptor ligands

Vastra Frolunda, Sweden

Transgenics that over-express lactogenic/somatogenic receptors; for identifying low molecular weight ligands.

Ventana Genetics WO 98/36097

Evolving regulatory elements

Salt Lake City, Utah

Identification and in vitro evolution of cis-acting regulatory nucleic acid sequences.

Victoria Univ. WO 98/36061

Wound healing treatment

Manchester, U.K.

Agents that inhibit interleukin (IL)-6 receptor-mediated activity in wound healing and fibrotic disorders.

Whitehead Inst. WO 98/35705

Cellular therapeutic delivery

Cambridge, Mass.

Use of therapeutic proteins covalently linked to heat shock proteins; for delivery to antigen presenting cells.

Zeneca WO 98/35988

Enhanced carboxypeptidase expression


Modified prodomain of carboxypeptidase B, encoding gene sequences; for enhanced recombinant protein expression.