Published July 15 (EPO); July 9 (WO); July 15 (GB)

BASF WO 98/29538

Adenylate cyclase

Ludwigshafen, Germany

Adenylate cyclase, encoding gene sequences, mutations; for diagnostics and therapeutics.

Biotech. Res. & Info. Network WO 98/29540

Mistletoe toxin fusions

Zwingenberg, Germany

Fusion proteins having a targeting moiety and a portion of mistletoe ribosome-inactivating protein; for therapeutics.

Biovector Therapeutics WO 98/29557

Cell transfection method

Labege, France

Conjugates of particle vectors and oligonucleotides; for facilitated cell transfection.

Boehringer Mannheim EPO 853 123

Filtered DNA purification

Mannheim, Germany

Preparation of nucleic acids using cross-flow filtration with semipermeable membranes; for PCR [in German].

British Defense Dept. GB 2 321 103

Poxvirus assay


Adenovirus vectors expressing poxvirus antigens; for detect-ing poxvirus in biological samples.

Chugai WO 98/29552

Serine-threonine kinase gene

Ibaraki, Japan

Serine-threonine kinase gene isolated from fetal cells; for developing cell growth and tumor inhibitors.

Fuji Yakuhin WO 98/29560

Collagenase antibodies

Toyama, Japan

Monoclonal antibodies to collagenase 3 and its precursor; for solid phase immunoassays of these two proteins.

Gaitanaris, G.A. WO 98/29533

Mutagenizing retroviral vectors

Frederick, Md.

Retroviral vectors with splice acceptor and transcription termination sequences; for integration and mutagenesis.

Genentech EPO 853 121

Human DNases

S. San Francisco

Human DNases, encoding genes, expression system, production methods; for diagnostics and therapeutics.

Hoechst Marion Roussel WO 98/29559

Purifying bone growth factor


Process for the preparation of purified dimers of bone-derived growth factor from bacterial inclusion bodies.

Hoffmann-La Roche EPO 853 127

Biotin production

Basel, Switzerland

Genes for the biosynthesis of biotin, expression vectors; for producing biotin by fermentation.

Incyte Pharma WO 98/29447

Apoptosis regulator

Palo Alto, Calif.

Human apoptosis regulator, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte Pharma WO 98/29448

Human pathogenesis-related protein

Palo Alto, Calif.

Human pathogenesis-related protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte Pharma WO 98/29449

Human thioredoxin

Palo Alto, Calif.

Human thioredoxin, encoding gene sequences, antibodies, modulators; for recombinant protein production.

Incyte Pharma WO 98/29546

Rhombotin-like protein

Palo Alto, Calif.

Human rhombotin-like protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte Pharma WO 98/29548

Human MAGE-like protein

Palo Alto, Calif.

Human MAGE-like protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte Pharma WO 98/29553

Guanosine monophosphate reductase

Palo Alto, Calif.

Guanosine monophosphate reductase, encoding gene sequences, expression vectors, antisense, antibodies, modu-lators.

INSERM (Natl. Inst. Hlth. Med. Res.) WO 98/29543

Killer cell inhibitory receptor


Compounds that cross-link stimulatory receptors with killer cell inhibitory receptor; for modulating cell functions.

Merck WO 98/29439, 29440, & 29441

Galanin receptors

Rahway, NJ

Galanin receptors, encoding genes; for identifying ligands to treat obesity, pain, and cognitive disorders.

Minas Gerais Fed. Univ. WO 98/29549

Bean virus growth factor

Belo Horizonte, Brazil

Growth factor from bean virus, encoding gene sequences, production process; for diagnostics and therapeutics.

Minas Gerais Fed. Univ. WO 98/29551

Hybrid HIV vaccine protein

Belo Horizonte, Brazil

Recombinant HIV p24/p17 hybrid protein, encoding gene sequences, production methods; for diagnostics and vaccines.

Mirus WO 98/29541

DNA template polymers

Madison, Wis.

Polymer formation on templates in the presence of nucleic acids; for delivering nucleic acids and binding polymers.

Onyx Pharma WO 98/29555

Cytopathic antitumor viruses

Richmond, Calif.

Cytopathic viruses that produce a replication phenotype when infecting neoplastic cells; for cancer therapy.

Ortho Pharma EPO 853 122

Altered transgenic histocompatibility

Raritan, NJ

Transgenic animals having an altered H2-M-alpha gene; for making animals with altered histocompatibility antigen expression.

Pharmacia & Upjohn WO 98/29545

p56 protein and homolog

Kalamazoo, Mich.

Human p56 protein and a homolog, encoding gene sequences; for affecting potassium-ATP cell membrane channels.

Rockefeller Univ. WO 98/29547

Radial glial differentiating factor

New York

Radial glial differentiating factor; for regulating cortical glial phenotype and treating nervous system trauma.

SmithKline Beecham EPO 853 125 & 126

Human 7-transmembrane receptor


Human 7-transmembrane receptor, encoding gene sequences; for diagnostics and therapeutics.

Southern Res. Inst. WO 98/29432

Mycobacterial therapeutics

Birmingham, Ala.

Mycobacterial dihydrofolate reductase gene, encoded protein; for diagnosing and treating infections.

Wistar Inst. WO 98/29556

Colorectal tumor antigens


Recombinant adenoviral vectors expressing colorectal tumor antigens; for diagnosis and therapy.