Published July 15 (EPO); July 9 (WO); July 15 (GB)
BASF WO 98/29538
Adenylate cyclase
Ludwigshafen, Germany
Adenylate cyclase, encoding gene sequences, mutations; for diagnostics and therapeutics.
Biotech. Res. & Info. Network WO 98/29540
Mistletoe toxin fusions
Zwingenberg, Germany
Fusion proteins having a targeting moiety and a portion of mistletoe ribosome-inactivating protein; for therapeutics.
Biovector Therapeutics WO 98/29557
Cell transfection method
Labege, France
Conjugates of particle vectors and oligonucleotides; for facilitated cell transfection.
Boehringer Mannheim EPO 853 123
Filtered DNA purification
Mannheim, Germany
Preparation of nucleic acids using cross-flow filtration with semipermeable membranes; for PCR [in German].
British Defense Dept. GB 2 321 103
Poxvirus assay
London
Adenovirus vectors expressing poxvirus antigens; for detect-ing poxvirus in biological samples.
Chugai WO 98/29552
Serine-threonine kinase gene
Ibaraki, Japan
Serine-threonine kinase gene isolated from fetal cells; for developing cell growth and tumor inhibitors.
Fuji Yakuhin WO 98/29560
Collagenase antibodies
Toyama, Japan
Monoclonal antibodies to collagenase 3 and its precursor; for solid phase immunoassays of these two proteins.
Gaitanaris, G.A. WO 98/29533
Mutagenizing retroviral vectors
Frederick, Md.
Retroviral vectors with splice acceptor and transcription termination sequences; for integration and mutagenesis.
Genentech EPO 853 121
Human DNases
S. San Francisco
Human DNases, encoding genes, expression system, production methods; for diagnostics and therapeutics.
Hoechst Marion Roussel WO 98/29559
Purifying bone growth factor
Tokyo
Process for the preparation of purified dimers of bone-derived growth factor from bacterial inclusion bodies.
Hoffmann-La Roche EPO 853 127
Biotin production
Basel, Switzerland
Genes for the biosynthesis of biotin, expression vectors; for producing biotin by fermentation.
Incyte Pharma WO 98/29447
Apoptosis regulator
Palo Alto, Calif.
Human apoptosis regulator, encoding gene sequences, expression vectors, antisense, antibodies, modulators.
Incyte Pharma WO 98/29448
Human pathogenesis-related protein
Palo Alto, Calif.
Human pathogenesis-related protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.
Incyte Pharma WO 98/29449
Human thioredoxin
Palo Alto, Calif.
Human thioredoxin, encoding gene sequences, antibodies, modulators; for recombinant protein production.
Incyte Pharma WO 98/29546
Rhombotin-like protein
Palo Alto, Calif.
Human rhombotin-like protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.
Incyte Pharma WO 98/29548
Human MAGE-like protein
Palo Alto, Calif.
Human MAGE-like protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.
Incyte Pharma WO 98/29553
Guanosine monophosphate reductase
Palo Alto, Calif.
Guanosine monophosphate reductase, encoding gene sequences, expression vectors, antisense, antibodies, modu-lators.
INSERM (Natl. Inst. Hlth. Med. Res.) WO 98/29543
Killer cell inhibitory receptor
Paris
Compounds that cross-link stimulatory receptors with killer cell inhibitory receptor; for modulating cell functions.
Merck WO 98/29439, 29440, & 29441
Galanin receptors
Rahway, NJ
Galanin receptors, encoding genes; for identifying ligands to treat obesity, pain, and cognitive disorders.
Minas Gerais Fed. Univ. WO 98/29549
Bean virus growth factor
Belo Horizonte, Brazil
Growth factor from bean virus, encoding gene sequences, production process; for diagnostics and therapeutics.
Minas Gerais Fed. Univ. WO 98/29551
Hybrid HIV vaccine protein
Belo Horizonte, Brazil
Recombinant HIV p24/p17 hybrid protein, encoding gene sequences, production methods; for diagnostics and vaccines.
Mirus WO 98/29541
DNA template polymers
Madison, Wis.
Polymer formation on templates in the presence of nucleic acids; for delivering nucleic acids and binding polymers.
Onyx Pharma WO 98/29555
Cytopathic antitumor viruses
Richmond, Calif.
Cytopathic viruses that produce a replication phenotype when infecting neoplastic cells; for cancer therapy.
Ortho Pharma EPO 853 122
Altered transgenic histocompatibility
Raritan, NJ
Transgenic animals having an altered H2-M-alpha gene; for making animals with altered histocompatibility antigen expression.
Pharmacia & Upjohn WO 98/29545
p56 protein and homolog
Kalamazoo, Mich.
Human p56 protein and a homolog, encoding gene sequences; for affecting potassium-ATP cell membrane channels.
Rockefeller Univ. WO 98/29547
Radial glial differentiating factor
New York
Radial glial differentiating factor; for regulating cortical glial phenotype and treating nervous system trauma.
SmithKline Beecham EPO 853 125 & 126
Human 7-transmembrane receptor
Philadelphia
Human 7-transmembrane receptor, encoding gene sequences; for diagnostics and therapeutics.
Southern Res. Inst. WO 98/29432
Mycobacterial therapeutics
Birmingham, Ala.
Mycobacterial dihydrofolate reductase gene, encoded protein; for diagnosing and treating infections.
Wistar Inst. WO 98/29556
Colorectal tumor antigens
Philadelphia
Recombinant adenoviral vectors expressing colorectal tumor antigens; for diagnosis and therapy.