Published September 23 (EPO); September 17 (WO); September 23 (GB)
Abbott LabsWO 98/40475
Human matrix metalloprotease
Abbott Park, Ill.
Human matrix metalloprotease 19 proteins, encoding gene sequences, production methods; for therapeutics.
AffymaxEPO 866 136
Phage display libraries
Willemstad, Netherlands Antilles
DNA libraries expressed on bacteriophage coat proteins; for screening and affinity purification of desired proteins.
Agricultural Victoria ServicesWO 98/40099
Immunoreactive molecules derived from Leptospira bacteria; for diagnostics and vaccines.
Albert Einstein Coll. Med.WO 98/40394
Open reading frame vector
Vectors containing splice junction sequences and a reporter gene; for identifying open reading frames.
Auburn Univ.WO 98/40089
Black fly vasodilators
Vasodilating proteins from the black fly with immunomodulating activity, encoding gene sequences; for therapeutics.
Auburn Univ.WO 98/40405
Salivary antithrombin proteins
Antithrombin proteins from the salivary glands of Simulium, production methods; for therapeutics.
Beth Israel Deaconess Hosp.WO 98/40495
Doublin neuronal protein
Neuronal development protein called doublin, encoding gene; for diagnosis and treatment of neuronal disorders.
Beth Israel Deaconess Hosp.WO 98/40743
Complement activation disorders
Use of SCR-containing proteins that bind Clq; for diagnosis and treatment of complement activation disorders.
Boehringer MannheimWO 98/40506
Inflammatory mediator expression
Vectors with genes controlled by acute phase amyloid A gene promoters; for inducing inflammatory mediator expression.
Boehringer MannheimWO 98/40744
Simultaneous detection of HIV antigens and antibodies; for diagnostics and therapeutics.
Boehringer MannheimWO 98/40745
Antigen-specific T cells
Cell populations enriched with antigen-specific T cells; for detecting T cell reactivity and producing therapeutics.
Boston Univ.WO 98/40396
Streptavidin mutants having changed amino acid residues that result in increased affinities for biotin substitutes.
Boston Univ.WO 98/40519
Trans-splicing of exons using intron sequences; for generating recombinant genes with ligated exons.
Brigham & Women's Hosp.EPO 866 133
Group B Streptococcus antigenic polysaccharides and protein; for production of conjugated vaccines.
Burnham Inst.WO 98/40397
Bax inhibitor proteins
La Jolla, Calif.
Bax inhibitor proteins, encoding gene sequences, production methods; for identifying modulators.
California, Univ. ofWO 98/40403
Prostate cancer diagnosis
Prostate stem cell antigen that is highly over-expressed in prostate cancer; for diagnosis.
California, Univ. ofWO 98/40477
Fluorescent protein sensors
Fluorescent indicators that can bind proteins; for detection of analytes and determination of concentrations in samples.
Cardiac CRC NomineesWO 98/40469
Serum albumin antibodies
St. Leonards, Australia
Human serum albumin antibodies that allow albumin to maintain its ability to prevent cell attachment to biomaterials.
ChironEPO 866 128
Recombinant ricin toxin
Ricin isotoxin, agglutinin, and linker, encoding gene sequences; for production.
Columbia Univ.WO 98/40484
Beta-amyloid binding protein
Endoplasmic reticulum-associated beta-amyloid peptide binding polypeptide, encoding gene sequences; for therapy.
Cornell Univ.WO 98/40098
Mycobacterium uptake protein
Gene for a protein that allows Mycobacterium tuberculosis to be taken up by cells, encoded protein, antibodies.
Cornell Univ.WO 98/40509
Chimeric viral coats
Chimeric adenoviral hexon protein as part of the viral coat; for modified recognition by neutralizing antibodies.
Davis, H.L., et al.WO 98/40499
Mucosal gene delivery
Nucleic acid/cationic lipid complexes for delivery of therapeutic proteins to mucosal epithelium; for immunization.
EppendorfEPO 866 123
Method and electrical circuit device for the electroporation or electropermeation of living cells [in German].
Ferrari, A.C., et al.WO 98/40513
Prostate cancer metastases
Detection of prostate cancer metastases in pelvic lymph nodes using PCR to detect prostate-specific antigen mRNA.
GenentechEPO 866 130
S. San Francisco
Isolation and cloning of CHO sialidase; for transfection into cells in which the sialidase gene is disrupted.
Genetics Inst.WO 98/40404 & 40486
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Genetics Inst.WO 98/40485
Human secreted protein
Human secreted protein BA3.1, encoding gene sequences; for therapeutics.
German Hlth. & Welfare Res. Ctr.EPO 866 124
Modifiers of endogenous T1-M protein activity; for affecting osteoblast differentiation [in German].
Hoechst Marion RousselEPO 866 125
Bone morphogenesis protein
HMW human MP52 proteins, encoding gene sequences, production method; for promoting bone morphogenesis.
HSP Res. Inst.EPO 866 132
E. coli production strain
Protease mutant strain of E. coli; for use in large scale production of foreign proteins.
Human Biol. Res. EndowmentWO 98/40487
Angiogenin receptor, fragments, encoding gene sequences, antibodies, antisense; for drug screening assays.
Human Genome SciencesWO 98/40483
28 secreted proteins
28 human secreted proteins, encoding gene sequences, vectors, host cells, antibodies, production methods.
Colorectal administration of antisense oligos; for developing therapeutically useful oligo blood concentrations.
Protein kinase A antisense
Modified oligos complementary to the nucleic acid encoding protein kinase A subunit RI-alpha; for expression inhibition.
Incyte PharmaWO 98/40481
Proline-rich acidic protein
Palo Alto, Calif.
Human proline-rich acidic protein, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte PharmaWO 98/40494
Growth factor receptor binding protein
Palo Alto, Calif.
Human growth factor receptor binding protein, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte PharmaWO 98/40482
RNA editing enzyme
Palo Alto, Calif.
Human RNA editing enzyme, encoding gene sequences, vectors, antisense, antibodies, modulators.
Japan TobaccoWO 98/40489
Linked antisense molecules for two or more structural genes or their parts; for inhibiting protein synthesis.
Johns Hopkins Univ.WO 98/40407
Synaptic activation proteins
Synaptic activation proteins that are induced in the CNS after hippocampal neuronal activity, encoding genes.
Life TechnologiesWO 98/40502
Transfection complexes that include proteins and cationic lipids; for peptide-enhanced gene delivery.
MRC (Med. Res. Counc.)GB 2 323 360
A defined 16 amino acid structure from herpes simplex virus type 2; for an ELISA diagnostic.
MRC (Med. Res. Counc.)WO 98/40492
Cancer gene therapy
Vector with a gene for a syncytium-inducing polypeptide; for gene therapy of cancer.
Minnesota, Univ. ofWO 98/40510
Transposon transfection system
DNA-based transposon system for the introduction of nucleic acid into cellular genomic DNA using inverted repeats.
NIH (Natl. Inst. Hlth.)WO 98/40498
Adenoviral vectors encoding immunoadhesins; for gene therapy to treat an inflammatory condition.
Northwestern Univ.WO 98/40514
Circadian rhythm gene
Purified peptide components of the mammalian circadian clock, encoding gene sequences, production methods.
Antisense to at least part of the mRNA encoding human Stat-6; for inhibition of expression.
Ottawa Civic Loeb Res. Inst.WO 98/40100
Unmethylated CpG dinucleotides
Oligos having unmethylated CpG dinucleotides; for use as an adjuvant in combination with an antigenic protein.
Pasteur Inst.WO 98/40480
V3 loop HIV receptor
V3 loop HIV receptor which consists of three associated receptors; for preventing binding to gp120.
Mutant DNA polymerases
Foster City, Calif.
DNA polymerases having mutations that reduce discrimination between labelled and non-labelled probes; for PCR.
Polytech. Res. Ctr.WO 98/40512
Transglycolytic enzymes for the synthesis of branched oligo-saccharides in vitro.
Res. Develop. Fdn.WO 98/40105
Photodynamic therapy genes
Carson City, Nev.
Selective and localized temporal expression of heterologous genes using photodynamic therapy inducible promoters.
Samadpour, M.WO 98/40515
Genetic subtype identification
Identification of genetic subtypes using specific restriction endonucleases and gel electrophoresis separation.
SankyoEPO 866 131
Humanized Fas antibodies
Humanized antibodies to Fas, encoding gene sequences; for apoptosis induction in cells expressing Fas.
Sloan-Kettering Inst.WO 98/40738
Prostate-specific antigen (PSA) substrates; for diagnostics and identifying inhibitors.
SmithKline BeechamEPO 866 126
Human 7-transmembrane receptor
Human 7-transmembrane receptor, encoding gene sequences, production methods; for therapeutics.
SmithKline BeechamEPO 866 127
Steroid receptor homolog
Steroid receptor homolog, encoding gene sequences, production methods; for therapeutics.
SmithKline BeechamWO 98/40488
Vitronectin alpha,beta-3 receptor antibodies
King of Prussia, Pa.
Humanized vitronectin alpha,beta-3 receptor antibodies, encoding gene sequences; for treating restenosis.
Sosnowski, B.A., et al.WO 98/40508
Gene therapy targeting
Adenoviral vectors used in virus-antibody-ligand conjugates; for targeting/delivering nucleic acids during gene therapy.
Stichting Inst.WO 98/40497
Intestinal parasite immunity
Ex vivo animal model for measuring protective immunity and identifying vaccine proteins from intestinal parasites.
Sunol Molecular SystemsWO 98/40408
Tissue Factor antibodies
Antibodies to human Tissue Factor (TF); for binding TF and its complexes and inhibiting blood coagulation.
Foamy virus envelope expression
Vectors for expressing modified foamy virus envelope protein; for treating infections.
Band array separations
San Jose, Calif.
Video display of band arrays of double-stranded polynucleotide separations.
Vanderbilt Univ.WO 98/40468
Gene mutation library
Construction of a gene mutation library using the insertion of reporter genes to identify functional genes.
VirogeneticsWO 98/40500 & 40501
Translation enhancing vectors
Viral vectors for the expression of translation factors; for enhancing expression in transfected cells.
Wisconsin, Univ. ofWO 98/40518
Nucleic acid indexing
Restriction site indexing method for selectively amplifying fragments generated by Class II restriction endonucleases.
Yale Univ.WO 98/40516
Potassium channel variants
New Haven, Conn.
Human ATP-sensitive potassium channel variants, encoding gene sequences; for diagnosing ion transport disorders.